1. Signaling Pathways
  2. GPCR/G Protein
  3. GPR68


G Protein-Coupled Receptor 68

GPR68 was first cloned from the HEY human ovarian cancer cell line and named ovarian cancer G protein-coupled receptor 1 (OGR1). GPR68 is a proton-sensing G-protein-coupled receptor (GPCR) that responds to extracellular acidity and regulates a variety of cellular functions. GPR68 mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca 2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8.

GPR68 Related Products (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-110279
    Modulator 99.58%
    Ogerin is a selective GPR68 positive aliasing modulator (PAM) (pEC50=6.83) with a moderate antagonistic effect on A2A (Ki=220 nM). Ogerin inhibits the fear conditioning reflex in mice and also inhibits TGF-β-induced myofibroblast differentiation of fibroblasts from multiple organ systems. Ogerin can be used in the studies of fibrotic diseases and neurological disorders.
  • HY-154954
    Inhibitor 99.65%
    Ogremorphin (GPR68-IN-1) is a potent GPR68 inhibitor with an EC50of 170 nM. Ogremorphin is extracted from patent WO2020214896 (OGM1), and can be used for autoimmune chronic inflammatory diseases research.
  • HY-134494
    MS48107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68). MS48107 is selective for GPR68 over the closely related proton GPCRs, neurotransmitter transporters, and hERG ion channels. MS48107 can readily cross the blood-brain barrier (BBB) in mice.