GRK2 Antibody (YA4885)

GRK2 Antibody (YA4885) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to GRK2.

GRK2 protein demonstrates a high degree of specificity as it selectively phosphorylates the agonist-occupied form of beta-adrenergic and closely related receptors, provoking their desensitization. This phosphorylation activity serves as a pivotal regulatory mechanism in receptor signaling. Additionally, GRK2 acts as a key modulator in LPAR1 signaling, engaging in competition with RALA for LPAR1 binding and influencing the receptor's signaling properties. Notably, GRK2 exhibits a phosphorylation-independent desensitization of LPAR1 and LPAR2. Beyond its role in G protein-coupled receptor desensitization, GRK2 plays a significant positive regulatory role in the ciliary Smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating SMO trafficking into the cilium and enhancing SMO activity. Furthermore, GRK2's involvement in the regulation of airway smooth muscle relaxation in response to blue light adds another layer to its diverse functional repertoire.

P25098

Predicted band size: 80 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal, Recombinant

Rabbit

Human, Mouse, Rat

WB: 1:500-1:2000; IHC-P: 1:100-1:500; FC: 1:50-100

WB, IHC-P, FC

Liquid

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.