GRK 2 Antibody (YA5226)

GRK 2 Antibody (YA5226) is a mouse-derived and non-conjugated monoclonal antibody, targeting to GRK 2. It can be applicated for WB assays, in the background of human.

GRK2 protein demonstrates a high degree of specificity as it selectively phosphorylates the agonist-occupied form of beta-adrenergic and closely related receptors, provoking their desensitization. This phosphorylation activity serves as a pivotal regulatory mechanism in receptor signaling. Additionally, GRK2 acts as a key modulator in LPAR1 signaling, engaging in competition with RALA for LPAR1 binding and influencing the receptor's signaling properties. Notably, GRK2 exhibits a phosphorylation-independent desensitization of LPAR1 and LPAR2. Beyond its role in G protein-coupled receptor desensitization, GRK2 plays a significant positive regulatory role in the ciliary Smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating SMO trafficking into the cilium and enhancing SMO activity. Furthermore, GRK2's involvement in the regulation of airway smooth muscle relaxation in response to blue light adds another layer to its diverse functional repertoire.

P25098

Observed band size: 80 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500

WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant human GRK2 protein fragments expressed in E.coli.