Search Result

Results for "

ErbB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	EGFR (111) Adrenergic Receptor (1) Akt (10) Amino Acid Derivatives (1) Apoptosis (16) Autophagy (21) Btk (4) c-Kit (1) c-Met/HGFR (6) CDK (2) ERK (3) FAK (1) Ferroptosis (14) FLT3 (1) HSP (2) IGF-1R (1) IKK (1) Insulin Receptor (1) Isotope-Labeled Compounds (9) Itk (1) JAK (1) Ligands for E3 Ligase (1) Mitosis (1) Orthopoxvirus (4) p38 MAPK (5) Paraptosis (1) PARP (1) PI3K (2) PI4K (1) PROTACs (1) Raf (1) Ras (1) Reference Standards (8) Small Interfering RNA (siRNA) (11) Src (3) Survivin (1) TNF Receptor (1) Trk Receptor (1)
By Research Areas:	Cancer (93) Cardiovascular Disease (2) Endocrinology (1) Infection (6) Inflammation/Immunology (10) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Aptamers (1) Rat Pre-designed siRNA Sets (3) Mouse Pre-designed siRNA Sets (4) Human Pre-designed siRNA Sets (4) siRNAs (11)

119

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

100

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: EGFR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-168438

ERBB agonist-1	EGFR Akt ERK	Cardiovascular Disease
ERBB agonist-1 (Compound EF-1) is an agonist for *ERBB4, that activates the ERBB4 signaling pathway by inducing dimerization of the ERBB4 receptor with an EC₅₀* of 10.5 μM. ERBB agonist-1 induces phosphorylation of Akt and ERK1/2, reduces the collagen expression in cardiac fibroblasts, inhibits H₂O₂-induced cardiomyocyte death and Ang II (HY-13948)-induced cardiomyocyte hypertrophy. ERBB agonist-1 prevents fibrosis and exhibits cardioprotective efficacy in mouse models .

HY-P4082

ErbB-2-binding peptide HER2-binding peptide	EGFR	Cancer
ErbB-2-binding peptide (HER2-binding peptide) is a tumor-binding peptide. ErbB-2-binding peptide has the potential for cancer research .

HY-P10981

ErbB2 peptide	PI3K Ligands for E3 Ligase	Cancer
ErbB2 peptide is a peptide ligand of E3 ubiquitin ligase targeting PI3K for peptide PROTACs .

HY-RS04469

ERBB3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) EGFR	Others
ERBB3 Human Pre-designed siRNA Set A contains three designed siRNAs for ERBB3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ERBB3 Human Pre-designed siRNA Set A ERBB3 Human Pre-designed siRNA Set A

HY-RS04466

ERBB2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) EGFR	Others
ERBB2 Human Pre-designed siRNA Set A contains three designed siRNAs for ERBB2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ERBB2 Human Pre-designed siRNA Set A ERBB2 Human Pre-designed siRNA Set A

HY-RS04474

Erbb4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) EGFR	Others
Erbb4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Erbb4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Erbb4 Rat Pre-designed siRNA Set A Erbb4 Rat Pre-designed siRNA Set A

HY-RS04468

ERBB2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ERBB2 Rat Pre-designed siRNA Set A contains three designed siRNAs for ERBB2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

ERBB2 Rat Pre-designed siRNA Set A ERBB2 Rat Pre-designed siRNA Set A

HY-RS04473

Erbb4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) EGFR	Others
Erbb4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Erbb4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Erbb4 Mouse Pre-designed siRNA Set A Erbb4 Mouse Pre-designed siRNA Set A

HY-RS04471

Erbb3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) EGFR	Others
Erbb3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Erbb3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Erbb3 Rat Pre-designed siRNA Set A Erbb3 Rat Pre-designed siRNA Set A

HY-RS04472

ERBB4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) EGFR	Others
ERBB4 Human Pre-designed siRNA Set A contains three designed siRNAs for ERBB4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ERBB4 Human Pre-designed siRNA Set A ERBB4 Human Pre-designed siRNA Set A

HY-RS04467

Erbb2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) EGFR	Others
Erbb2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Erbb2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Erbb2 Mouse Pre-designed siRNA Set A Erbb2 Mouse Pre-designed siRNA Set A

HY-RS04470

Erbb3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) EGFR	Others
Erbb3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Erbb3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Erbb3 Mouse Pre-designed siRNA Set A Erbb3 Mouse Pre-designed siRNA Set A

HY-P99268

Seribantumab SAR 256212; MM 121; Anti-Human ErbB3/ErbB 3 Recombinant Antibody	EGFR Apoptosis	Cancer
Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models .

HY-103440

*EGFR/ErbB-2/ErbB-4 inhibitor-3*	EGFR	Cancer
EGFR/ErbB-2/ErbB-4 inhibitor-3 (compound 29) is a potent tyrosine kinase inhibitor with IC₅₀s of 0.3, 1.1, 0.5, 2.5, 24 nM for erbB1, erbB2, erbB4, EGF, HER, respectively . EGFR/ErbB-2/ErbB-4 inhibitor-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-112420

*EGFR/ErbB-2/ErbB-4 inhibitor-2*	EGFR	Cancer
EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) is a EGFR and *ErbB* inhibitor with IC₅₀s of 0.017 μM, 0.08 μM, 1.91 μM .

HY-156639

*EGFR/ErbB-2 inhibitor-1*	EGFR	Cancer
EGFR/ErbB-2 inhibitor-1 is a ErbB2/HER2 inhibitor .

HY-43533

Tarlox-TKI 1 Publications Verification	EGFR	Cancer
Tarlox-TKI, the active metabolite of Tarloxotinib, is an irreversible pan-ErbB TKI (Tarlox-TKI) .

HY-P991241

*Anti-ERBB3/HER3 (29Z6)*	EGFR	Cancer
Anti-ERBB3/HER3 (29Z6) is an antibody inhibitor, targeting to human ERBB3/HER3.

HY-P991245

*Anti-ERBB3/HER3 (SGP1)*	EGFR	Cancer
Anti-ERBB3/HER3 (SGP1) is a human monoclonal antibody (mAb) targeting *ERBB3/HER3. Anti-ERBB3/HER3 (SGP1) inhibits Neuregulin stimulated growth of cultured breast cancer cells. Anti-ERBB*3/HER3 (SGP1) can be used in breast cancer research .

HY-P990408

*Anti-ERBB1/EGFR/HER1 Antibody*	EGFR	Inflammation/Immunology
The Anti-ERBB1/EGFR/HER1 Antibody is a CHO-expressed human antibody that targets *ERBB1/EGFR/HER1. The Anti-ERBB1/EGFR/HER1 Antibody consists of a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for the Anti-ERBB*1/EGFR/HER1 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99304

Lumretuzumab Anti-Human ErbB3 Recombinant Antibody	EGFR	Cancer
Lumretuzumab (Anti-Human ERBB3 Recombinant Antibody) is a humanized anti-HER3 (ERBB3) monoclonal antibody that can be used for the research of cancer .

HY-110039

BIBX 1382 dihydrochloride	EGFR	Infection
BIBX 1382 dihydrochloride is an ErbB kinase inhibitor with significant antiviral activity. BIBX 1382 affects the ability of viruses to enter host cells by inhibiting members of the ErbB kinase family. It can be used to study the interaction mechanism between virus and host and the broad spectrum intervention of highly pathogenic viruses .

HY-103441

JNJ28871063 hydrochloride	EGFR	Cancer
JNJ28871063 hydrochloride is an orally active, highly selective and ATP competitive *pan-ErbB* kinase inhibitor with IC₅₀** values of 22 nM, 38 nM, and 21 nM for ErbB1, ErbB2, and ErbB4, respectively. JNJ28871063 hydrochloride inhibits phosphorylation of functionally important tyrosine residues in both EGFR and ErbB2. JNJ28871063 hydrochloride crosses the blood-brain barrier and has antitumor activity in human tumor xenograft models that overexpress EGFR and ErbB2 .

HY-P99275

Patritumab 1 Publications Verification Human Anti-ErbB3 Recombinant Antibody	EGFR Akt ERK PARP Survivin	Cancer
Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to *ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell apoptosis* and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors .

HY-143874

HER2-IN-7	EGFR	Cancer
HER2-IN-7 is a potent inhibitor of HER2. Deregulation of ErbB family signalling modulates proliferation, invasion, metastasis, angiogenesis, and tumour cell survival. HER2-IN-7 has the potential for the research of diseases associated ErbBs (especially HER2), including cancer (extracted from patent WO2019214634A1, compound 23) .

HY-137028

2′-Thioadenosine PD157432	EGFR	Cancer
2'-Thioadenosine (PD157432) is a selective and irreversible inhibitor of *ErbB-1* and *ErbB-2, with an IC₅₀* of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site .

HY-153856

TAS2940	EGFR	Cancer
TAS2940 is a brain-penetrable, orally active, irreversible and selective *pan-ERBB* inhibitor. TAS2940 against wild-type HER2, HER2 V777L, and A775_G776insYVMA with IC₅₀ values of 5.6 nM, 2.1 nM, and 1.0 nM, respectively. TAS2940 can be used for the study of tumors with HER2 and EGFR aberrations .

HY-153856A

TAS2940 fumarate	EGFR	Cancer
TAS2940 fumarate is a brain-penetrable, orally active, irreversible and selective *pan-ERBB* inhibitor. TAS2940 fumarate against wild-type HER2, HER2 V777L, and A775_G776insYVMA with IC₅₀ values of 5.6 nM, 2.1 nM, and 1.0 nM, respectively. TAS2940 fumarate can be used for the study of tumors with HER2 and EGFR aberrations .

HY-P991524

MM-111	EGFR	Cancer
MM-111 is a bispecific antibody fusion protein targeting the *ErbB2/ErbB3* oncogenic unit. MM-111 blocks activation of the PI3K pro-survival pathway. MM-111 binds to the ErbB2 receptor, which localizes the bispecific molecule to ErbB2 over-expressing tumor cells and promotes binding of the anti-ErbB3 arm to the ErbB3 receptor. MM-111 binding to ErbB3 results in inhibition of ErbB3 signaling by blocking the binding of the ErbB3 physiological ligand heregulin. MM-111 can be used for the study of ErbB2 over-expressing breast tumors .

HY-50898

Lapatinib Maximum Cited Publications 81 Publications Verification GW572016; GW2016	EGFR Autophagy Ferroptosis	Cancer
Lapatinib (GW572016) is a potent inhibitor of the *ErbB-2* and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and *ErbB-2* of 10.2 and 9.8 nM, respectively .

HY-50898B

Lapatinib ditosylate monohydrate Maximum Cited Publications 81 Publications Verification GW572016 ditosylate monohydrate; GW2016 ditosylate monohydrate	EGFR Autophagy Ferroptosis	Cancer
Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent inhibitor of the *ErbB-2* and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and *ErbB-2* of 10.2 and 9.8 nM, respectively .

HY-50898C

Lapatinib tosylate GW572016 tosylate; GW2016 tosylate	EGFR Ferroptosis Autophagy	Cancer
Lapatinib (GW572016) tosylate is a potent, orally active inhibitor of the *ErbB-2* and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and *ErbB-2* of 10.2 and 9.8 nM, respectively .

HY-50898A

Lapatinib ditosylate Maximum Cited Publications 81 Publications Verification GW572016 ditosylate; GW2016 ditosylate	EGFR Autophagy Ferroptosis	Cancer
Lapatinib ditosylate (GW572016 ditosylate) is a potent inhibitor of the *ErbB-2* and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and *ErbB-2* of 10.2 and 9.8 nM, respectively .

HY-P991243

MP-RM-1	EGFR PI3K Akt	Cancer
MP-RM-1 is a selective murine monoclonal antibody inhibitor targeting human epidermal growth factor receptor 3 (ErbB-3). MP-RM-1 blocks the activation of ErbB-3 induced by neuregulin 1 (NRG-1β) and promotes the internalization and degradation of ErbB-3, inhibiting downstream signaling pathways such as PI3K-Akt. MP-RM-1 is promising for research of ErbB-3 highly expressed solid tumors such as breast cancer, melanoma, and prostate cancer .

HY-50898S2

Lapatinib-d5 GW572016-d₅; GW2016-d₅	Isotope-Labeled Compounds EGFR Autophagy Ferroptosis	Cancer
Lapatinib-d₅ is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-50898S1

Lapatinib-d7 dihydrochloride GW572016-dd₇ dihydrochloride; GW2016-dd₇ dihydrochloride	Isotope-Labeled Compounds EGFR Autophagy Ferroptosis	Cancer
Lapatinib-d₇ dihydrochloride is the deuterium labeled Lapatinib dihydrochloride. Lapatinib (GW572016) dihydrochloride is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-18609

PD158780 4 Publications Verification	EGFR	Cancer
PD158780 is a potent EGFR family inhibitor with IC₅₀s of 8 pM, 49, 52, 52 nM for EGFR, ErbB2, ErbB3, and ErbB4, respectively.

HY-50898S3

Lapatinib-d4-1 GW572016-d₄-1; GW2016-d₄-1	Isotope-Labeled Compounds EGFR Autophagy Ferroptosis	Cancer
Lapatinib-d₄-1 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-50898S

Lapatinib-d4 GW572016-d₄; GW2016-d₄	EGFR Autophagy Ferroptosis	Cancer
Lapatinib-d₄ is the deuterium labeled Lapatinib (HY-50898). Lapatinib is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-P991240

CDX-3379	EGFR	Cancer
CDX-3379 is a humanized monoclonal antibody inhibitor targeting *ErbB3. CDX-3379 binds to ErbB3, blocking the dimerization of ErbB3 with other receptors, thereby inhibiting the phosphorylation of ErbB3. CDX-3379 can inhibit the growth and proliferation of tumor cells. CDX-3379 is promising for research of tumors expressing ErbB*3 and NRG1, such as HNSCC .

HY-50898R

Lapatinib (Standard) GW572016 (Standard); GW2016 (Standard)	Reference Standards EGFR Autophagy Ferroptosis	Cancer
Lapatinib (Standard) is the analytical standard of Lapatinib. This product is intended for research and analytical applications. Lapatinib (GW572016) is a potent inhibitor of the *ErbB-2* and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and *ErbB-2* of 10.2 and 9.8 nM, respectively .

HY-13272

Dacomitinib 20+ Cited Publications PF-00299804; PF-299804	EGFR Apoptosis	Cancer
Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the *ERBB* family of kinases with IC₅₀s of 6 nM, 45.7 nM and 73.7 nM for EGFR, *ERBB2, and ERBB4*, respectively .

HY-50898S4

Lapatinib-d7 GW572016-d₇; GW2016-d₇	Isotope-Labeled Compounds Autophagy EGFR Ferroptosis	Cancer
Lapatinib-d₇ (GW572016-d₇) is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the *ErbB-2* and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and *ErbB-2* of 10.2 and 9.8 nM, respectively .

HY-50898BR

Lapatinib ditosylate monohydrate (Standard)	EGFR Autophagy Ferroptosis	Cancer
Lapatinib (ditosylate monohydrate) (Standard) is the analytical standard of Lapatinib (ditosylate monohydrate). This product is intended for research and analytical applications. Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-50898AR

Lapatinib ditosylate (Standard)	EGFR Autophagy Ferroptosis	Cancer
Lapatinib (ditosylate) (Standard) is the analytical standard of Lapatinib (ditosylate). This product is intended for research and analytical applications. Lapatinib ditosylate (GW572016 ditosylate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-W006886

Fmoc-(R)-2-(7-octenyl)Ala-OH	Amino Acid Derivatives	Others
Fmoc-(R)-2-(7-octenyl)Ala-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize inhibitor peptides that combinatorially inactivate ErbB1, ErbB2, and ErbB3 .

HY-50898CS

Lapatinib-d4 tosylate GW572016-d₄ tosylate; GW2016-d₄ tosylate	Isotope-Labeled Compounds EGFR Autophagy Ferroptosis	Cancer
Lapatinib-d₄ (GW572016-d₄) tosylate is deuterium labeled Lapatinib (tosylate). Lapatinib (GW572016) tosylate is a potent, orally active inhibitor of the *ErbB-2* and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and *ErbB-2* of 10.2 and 9.8 nM, respectively .

HY-W777297

Lapatinib-13C2,15N Ditosylate	Isotope-Labeled Compounds EGFR Autophagy Ferroptosis	Cancer
Lapatinib- ¹³C₂, ¹⁵N Ditosylate is the ¹³C- and ¹⁵N-labeled Lapatinib ditosylate (HY-50898A). Lapatinib ditosylate (GW572016 ditosylate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-13272S3

Dacomitinib-d10 PF-00299804-d₁₀; PF-299804-d₁₀	Isotope-Labeled Compounds EGFR Apoptosis	Cancer
Dacomitinib-d₁₀ is deuterium labeled Dacomitinib. Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC₅₀s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively .

HY-13272S2

Dacomitinib-d10 dihydrochloride PF-00299804-d₁₀ dihydrochloride; PF-299804-d₁₀ dihydrochloride	Isotope-Labeled Compounds EGFR Apoptosis	Cancer
Dacomitinib-d₁₀ dihydrochloride is the deuterium labeled Dacomitinib dihydrochloride. Dacomitinib (PF-00299804) dihydrochloride is a specific and irreversible inhibitor of the ERBB family of kinases with IC₅₀s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively .

Cat. No.	Product Name

HY-L074

Anti-Breast Cancer Compound Library

2,624 compounds

Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC).

Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer.

MCE supplies a unique collection of 2,624 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Cat. No.	Product Name	Target	Research Area

HY-P4082

ErbB-2-binding peptide HER2-binding peptide	EGFR	Cancer
ErbB-2-binding peptide (HER2-binding peptide) is a tumor-binding peptide. ErbB-2-binding peptide has the potential for cancer research .

HY-W006886

Fmoc-(R)-2-(7-octenyl)Ala-OH	Amino Acid Derivatives	Others
Fmoc-(R)-2-(7-octenyl)Ala-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize inhibitor peptides that combinatorially inactivate ErbB1, ErbB2, and ErbB3 .

HY-P5438

Srctide	Btk c-Kit FAK FLT3 Insulin Receptor	Others
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)

HY-P10981

ErbB2 peptide	PI3K Ligands for E3 Ligase	Cancer
ErbB2 peptide is a peptide ligand of E3 ubiquitin ligase targeting PI3K for peptide PROTACs .

HY-P5527F

FAM-CSKtide	Peptides	Others
FAM-CSKtide is a biological active peptide. (This is a FAM labeled peptide substrate (Abs/Em = 494/521 nm) for C-terminal Src kinase (Csk) and many other kinases such as Axl, cKit, ERBB4, Fes, Flt3, IGF-1 R, MET, MUSK, PYK2, Ret, TIE2, TrkA, VEGF-R1 and VEGF-R2.)

Cat. No.	Product Name	Target	Research Area

HY-P99268

Seribantumab SAR 256212; MM 121; Anti-Human ErbB3/ErbB 3 Recombinant Antibody	EGFR Apoptosis	Cancer
Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models .

HY-P99304

Lumretuzumab Anti-Human ErbB3 Recombinant Antibody	EGFR	Cancer
Lumretuzumab (Anti-Human ERBB3 Recombinant Antibody) is a humanized anti-HER3 (ERBB3) monoclonal antibody that can be used for the research of cancer .

HY-P99275

Patritumab 1 Publications Verification Human Anti-ErbB3 Recombinant Antibody	EGFR Akt ERK PARP Survivin	Cancer
Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to *ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell apoptosis* and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors .

HY-P991241

*Anti-ERBB3/HER3 (29Z6)*	EGFR	Cancer
Anti-ERBB3/HER3 (29Z6) is an antibody inhibitor, targeting to human ERBB3/HER3.

HY-P991245

*Anti-ERBB3/HER3 (SGP1)*	EGFR	Cancer
Anti-ERBB3/HER3 (SGP1) is a human monoclonal antibody (mAb) targeting *ERBB3/HER3. Anti-ERBB3/HER3 (SGP1) inhibits Neuregulin stimulated growth of cultured breast cancer cells. Anti-ERBB*3/HER3 (SGP1) can be used in breast cancer research .

HY-P990408

*Anti-ERBB1/EGFR/HER1 Antibody*	EGFR	Inflammation/Immunology
The Anti-ERBB1/EGFR/HER1 Antibody is a CHO-expressed human antibody that targets *ERBB1/EGFR/HER1. The Anti-ERBB1/EGFR/HER1 Antibody consists of a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for the Anti-ERBB*1/EGFR/HER1 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990409

*Anti-ERBB1/EGFR/HER1 Antibody (7A7)*	Inhibitory Antibodies	Inflammation/Immunology
Anti-ERBB1/EGFR/HER1 Antibody (7A7) is a human-derived antibody expressed in CHO cells, targeting *ERBB1/EGFR/HER1. Anti-ERBB1/EGFR/HER1 Antibody (7A7) has a muIgG1 heavy chain and an mκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-ERBB*1/EGFR/HER1 Antibody (7A7) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991524

MM-111	EGFR	Cancer
MM-111 is a bispecific antibody fusion protein targeting the *ErbB2/ErbB3* oncogenic unit. MM-111 blocks activation of the PI3K pro-survival pathway. MM-111 binds to the ErbB2 receptor, which localizes the bispecific molecule to ErbB2 over-expressing tumor cells and promotes binding of the anti-ErbB3 arm to the ErbB3 receptor. MM-111 binding to ErbB3 results in inhibition of ErbB3 signaling by blocking the binding of the ErbB3 physiological ligand heregulin. MM-111 can be used for the study of ErbB2 over-expressing breast tumors .

HY-P991243

MP-RM-1	EGFR PI3K Akt	Cancer
MP-RM-1 is a selective murine monoclonal antibody inhibitor targeting human epidermal growth factor receptor 3 (ErbB-3). MP-RM-1 blocks the activation of ErbB-3 induced by neuregulin 1 (NRG-1β) and promotes the internalization and degradation of ErbB-3, inhibiting downstream signaling pathways such as PI3K-Akt. MP-RM-1 is promising for research of ErbB-3 highly expressed solid tumors such as breast cancer, melanoma, and prostate cancer .

HY-P991240

CDX-3379	EGFR	Cancer
CDX-3379 is a humanized monoclonal antibody inhibitor targeting *ErbB3. CDX-3379 binds to ErbB3, blocking the dimerization of ErbB3 with other receptors, thereby inhibiting the phosphorylation of ErbB3. CDX-3379 can inhibit the growth and proliferation of tumor cells. CDX-3379 is promising for research of tumors expressing ErbB*3 and NRG1, such as HNSCC .

HY-P991149

Nesfrotamig	TNF Receptor	Cancer
Nesfrotamig is a humanized immunoglobulin (H-γ1-scFv-L-κ) dimer monoclonal antibody targeting human epidermal growth factor receptor 2 (ERBB2) and human tumor necrosis factor receptor superfamily member 9 (TNFRSF9). Nesfrotamig is promising for research of cancers, especially in ERBB2-positive related tumor diseases, such as breast cancer and gastric cancer .

HY-P990978

Caxmotabart	EGFR	Inflammation/Immunology
HY-P990978 is an *ERBB2*-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990909

Calotatug XMT-1519	EGFR	Inflammation/Immunology
HY-P990909 is an *ERBB2*-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P99672

Istiratumab MM 141; MM-005	IGF-1R EGFR	Cancer
Istiratumab (M-6495) is bispecific monoclonal antibody targeting IGF-1R and *ErbB3. Istiratumab induces IGF-1R and ErbB*3 receptor degradation through the proteasome pathway Istiratumab can be used for research of cancers .

HY-P990972

Azerutamig	EGFR	Inflammation/Immunology
HY-P990972 is an *KLRK1/ERBB2*-targeting (H-γ1_L-κ)_scFvkh-H-γ1(h-CH2-CH3) type bispecific antibody .

HY-P99558

Timigutuzumab GEXMab73; GT-MAb7.3-GEX; TrastuzuMab-GEX	EGFR	Cancer
Timigutuzumab (GEXMab73) is a humanized monoclonal antibody that targets *ErbB2*. Timigutuzumab can be used for the research of cancer .

HY-P991244

REGN-1400	EGFR	Cancer
REGN-1400 is a humanized monoclonal antibody inhibitor targeting *ErbB3. REGN-1400 reduces tumor cell proliferation by inhibiting ErbB*3 and blocking related signaling pathways. REGN-1400 is promising for research of solid tumors such as non-small cell lung cancer (NSCLC), colorectal cancer (CRC), and squamous cell carcinoma of the head and neck (SCCHN) .

HY-P990596

Hersintuzumab	Inhibitory Antibodies	Inflammation/Immunology
Hersintuzumab is a CHO-expressed humanized antibody targeting *ERBB2/HER2/CD340*. Hersintuzumab is equipped with a huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Hersintuzumab can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99866

Duligotuzumab MEHD-7945A; RG 7597	EGFR	Others
Duligotuzumab (MEHD-7945A; RG 7597) is a humanized IgG-κ monoclonal antibody that specifically targets Her3 (ErbB3) .

HY-P991159

Ruzaltatug	EGFR	Cancer
Ruzaltatug is a humanized IgG1 antibody targeting *ERBB3*. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P990695

Lunaxafusp	EGFR	Inflammation/Immunology
Lunaxafusp is an anti-ERBB2 scFv-heavy-κ monoclonal antibody composed of a single chain variable fragment, an antibody heavy chain, and a kappa antibody light chain .

HY-P990697

Anvatabart ARX-788	EGFR	Inflammation/Immunology
Anvatabart is an anti-ERBB2 human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99461

Barecetamab ISU-104	EGFR	Cancer
Barecetamab (ISU-104) is a fully human anti-ErbB3 monoclonal antibody. Barecetamab can be used for the research of recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1166

Tephrosin 2 Publications Verification Deguelinol I; Hydroxydeguelin	Structural Classification Flavonoids Ranunculus japonicus Thunb. Classification of Application Fields Isoflavanones Ranunculaceae Source classification Plants Disease Research Fields Cancer	EGFR
Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and *ErbB2* by inducing internalization of the receptors .

HY-W403933R

12-Ketochenodeoxycholic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Autophagy Reference Standards
Afatinib (Standard) is the analytical standard of Afatinib. This product is intended for research and analytical applications. Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .

Species:	Human (62) Rhesus Macaque (9) Mouse (11) Rat (9) Cynomolgus (7) Canine (2)
Tag:	His (64) Tag Free (4) Strep (2) Avi (24) Myc (1) GST (7) Fc (28)
Source:	HEK293 (86) CHO (1) Sf9 insect cells (11) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70608

	EGFR vIII Protein, Human (HEK293, Fc) 1 Publications Verification Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase ErbB-1; EGFR; ErbB; ErbB1; HER1	Human	HEK293
	The EGFR vIII protein is a transmembrane glycoprotein in the protein kinase superfamily that acts as a receptor for epidermal growth factor. It acts on the cell surface, binds to epidermal growth factor, triggers receptor dimerization and tyrosine autophosphorylation, and promotes cell proliferation. EGFR vIII Protein, Human (HEK293, Fc) is the recombinant human-derived EGFR vIII protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P70613

	EGFR Protein, Human (621a.a, HEK293, His) Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase ErbB-1; EGFR; ErbB; ErbB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (621a.a, HEK293, His) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72988

	EGFR Protein, Mouse (HEK293, Fc) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Mouse	HEK293
	The EGFR protein is a receptor tyrosine kinase that binds EGF family ligands and activates multiple signaling cascades. Ligand binding induces receptor homo- or heterodimerization, leading to autophosphorylation and recruitment of adapter proteins (such as GRB2). EGFR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived EGFR protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72989

	EGFR Protein, Mouse (HEK293, His) 1 Publications Verification Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Mouse	HEK293
	The EGFR protein is a receptor tyrosine kinase that binds EGF family ligands and activates multiple signaling cascades. Ligand binding induces receptor homo- or heterodimerization, leading to autophosphorylation and recruitment of adapter proteins (such as GRB2). EGFR Protein, Mouse (HEK293, His) is the recombinant mouse-derived EGFR protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P72990

	EGFR Protein, Rat (HEK293, His) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Rat	HEK293
	EGFR Protein is a receptor tyrosine kinase that binds to ligands of the EGF family.EGFR Protein is involved in the regulation of NF-kappa-B , RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs signaling pathways.EGFR Protein has calmodulin binding activity, epidermal growth factor binding activity and epidermal growth factor activating receptor activity.EGFR Protein, Rat (HEK293, His) is the recombinant rat-derived EGFR protein, expressed by HEK293 , with C-His labeled tag.

HY-P72987

	EGFR Protein, Human (sf9, His-GST) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Human	Sf9 insect cells
	EGFR is a transmembrane glycoprotein. EGFR binds to ligands, triggering receptor dimerization, inducing intracellular TK domain autophosphorylation, activating downstream Ras/MAPK, PI3K/Akt and other signaling pathways, and regulating cell proliferation, survival, migration and angiogenesis. EGFR Protein, Human (sf9, His-GST) is a recombinant EGFR protein expressed by Sf9 insect cells with N-His, N-GST tags.

HY-P74177

	EGFR Protein, Human (621a.a, HEK293, Fc) 1 Publications Verification Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (621a.a, HEK293, Fc) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73517

	EGFR Protein, Human (Biotinylated, 621a.a, HEK293, His) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (Biotinylated, 621a.a, HEK293, His) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-His labeled tag.

HY-P702752

	ERBB4 Protein, Human (sf9, GST) ErbB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); Her4; c-ErbB-4	Human	Sf9 insect cells
	HER4 is an important tyrosine protein kinase receptor for members of the neuregulin and EGF families that directs heart, central nervous system, and mammary gland development. It is critical for myocardial differentiation, postnatal cardiomyocyte proliferation, neural crest cell migration, axon guidance, and mammary gland function. ERBB4 Protein, Human (sf9, GST) is the recombinant human-derived ERBB4, expressed by Sf9 insect cells, with GST labeled tag. The total length of ERBB4 Protein, Human (sf9, GST) is 633 a.a..

HY-P72986

	EGFR Protein, Canine (sf9, His) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Canine	Sf9 insect cells
	EGFR Protein is a receptor tyrosine kinase that binds to ligands of the EGF family. The high expression of EGFR protein can be used as a diagnostic marker for canine transitional cell carcinoma (TCC). EGFR Protein participate in the NF-kappa-B signaling pathway. The high expression of EGFR protein can be used as a diagnostic marker for canine transitional cell carcinoma (TCC). EGFR Protein, Canine (sf9, His) is the recombinant canine-derived EGFR protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P78452

	HER3 Protein, Human (HEK293, His-Avi) ErbB3; ErbB-3; HER3; HER3c-ErbB-3; LCCS2; MDA-BF-1; MGC88033; p180-ErbB3; p45-sErbB3; p85-sErbB3; ErbB3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P7340

	EGFR Protein, Human (621a.a, CHO, His) rHuEGFR, His; ErbB; ErbB1; HER1	Human	CHO
	EGFR is a transmembrane glycoprotein. EGFR binds to ligands, triggering receptor dimerization, inducing intracellular TK domain autophosphorylation, activating downstream Ras/MAPK, PI3K/Akt and other signaling pathways, and regulating cell proliferation, survival, migration and angiogenesis. EGFR Protein, Human (621a.a, CHO, His) is a recombinant EGFR protein expressed by CHO, with a C-His tag and glycosylation modification.

HY-P70841

	HER4 Protein, Human (HEK293, His) Receptor tyrosine-protein kinase ErbB-4; Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4; p180ErbB4; ErbB4; HER4	Human	HEK293
	HER4 is an important tyrosine protein kinase receptor for members of the neuregulin and EGF families that directs heart, central nervous system, and mammary gland development. It is critical for myocardial differentiation, postnatal cardiomyocyte proliferation, neural crest cell migration, axon guidance, and mammary gland function. HER4 Protein, Human (HEK293, His) is the recombinant human-derived HER4 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7316

	EGFR Protein, Human (621a.a, sf9, His) rHuEGFR, His; ErbB1; HER1; ErbB	Human	Sf9 insect cells
	EGFR Protein, Human (sf9, His) is a glycosylated polypeptide chain with the C-termimal 6×His Tag produced in sf9 insect cells. EGFR, belongs to a family of tyrosine kinase receptors, plays important roles in cell growth and differentiation.

HY-P75259

	EGFR Protein, Cynomolgus (sf9, His) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Cynomolgus	Sf9 insect cells
	EGFR Protein is a receptor tyrosine kinase that binds to ligands of the EGF family. EGFR Protein is involved in the regulation of NF-kappa-B , RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs signaling pathways. EGFR Protein has calmodulin binding activity, epidermal growth factor binding activity and epidermal growth factor activating receptor activity. EGFR Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived EGFR protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P75260

	EGFR Protein, Cynomolgus (HEK293, His) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Cynomolgus	HEK293
	EGFR Protein is a receptor tyrosine kinase that binds to ligands of the EGF family. EGFR Protein is involved in the regulation of NF-kappa-B , RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs signaling pathways. EGFR Protein has calmodulin binding activity, epidermal growth factor binding activity and epidermal growth factor activating receptor activity. EGFR Protein, Cynomolgus (HEK293, His) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P702751

	EGFR Protein, Human (sf9, GST) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Human	Sf9 insect cells
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (sf9, GST) is the recombinant human-derived EGFR, expressed by Sf9 insect cells , with GST labeled tag.

HY-P72625

	HER3 Protein, Human (HEK293, His) Receptor tyrosine-protein kinase ErbB-3; ErbB3; HER3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (HEK293, His) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74891

	HER3 Protein, Rat (HEK293, His) Receptor tyrosine-protein kinase ErbB-3; ErbB3; HER3	Rat	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Rat (HEK293, His) is the recombinant rat-derived HER3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P74892

	HER3 Protein, Rat (HEK293, Fc) Receptor tyrosine-protein kinase ErbB-3; ErbB3; HER3	Rat	HEK293
	HER3 is a tyrosine-protein kinase that is a key cell surface receptor for neuregulin. ErbB2 and ErbB3 can form dimers and activate signaling pathways including MAPK, PI3K/Akt and PLC纬 to promote tumor development. HER3 Protein, Rat (HEK293, Fc) is the recombinant rat-derived HER3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75256

	EGFR Protein, Rhesus Macaque (sf9, His) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Rhesus Macaque	Sf9 insect cells
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Rhesus Macaque (sf9, His) is the recombinant Rhesus Macaque-derived EGFR protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P75257

	EGFR Protein, Rhesus Macaque (HEK293, His) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Rhesus Macaque	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived EGFR protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P75258

	EGFR Protein, Rhesus Macaque (HEK293, Fc) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Rhesus Macaque	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived EGFR protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76967

	HER3 Protein, Rhesus Macaque (HEK293) Receptor tyrosine-protein kinase ErbB-3; ErbB3; HER3	Rhesus Macaque	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Rhesus Macaque (HEK293) is the recombinant Rhesus Macaque-derived HER3 protein, expressed by HEK293 , with tag free.

HY-P701267

	FITC-labeled EGFR Protein, Human (HEK293, Fc) EGFR; ErbB; ErbB1; HER1; PIG61; mENA	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. FITC-labeled EGFR Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-labeled EGFR protein, expressed by HEK293 , with Fc labeled tag.

HY-P701281

	FITC-labeled HER3 Protein, Human (HEK293, His-Avi) ErbB3; HER3; LCCS2; MDA-BF-1; MGC88033; c-ErbB3; ErbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. FITC-labeled HER3 Protein, Human (HEK293, His) is the recombinant human-derived FITC-labeled HER3 protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

HY-P78435

	EGFR Protein, Human (HEK293, His-Avi) ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ErbB; ErbB1; HER1; PIG61; NISBD2	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (HEK293, His-Avi) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P74893

	HER3 Protein, Human (sf9, His-GST) Receptor tyrosine-protein kinase ErbB-3; ErbB3; HER3	Human	Sf9 insect cells
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (sf9, His-GST) is the recombinant human-derived HER3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P76968

	HER3 Protein, Rhesus Macaque (HEK293, Fc) Receptor tyrosine-protein kinase ErbB-3; ErbB3; HER3	Rhesus Macaque	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived HER3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76969

	HER3 Protein, Rhesus Macaque (HEK293, His) Receptor tyrosine-protein kinase ErbB-3; ErbB3; HER3	Rhesus Macaque	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived HER3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77554

	HER3 Protein, Human (Biotinylated, HEK293, His) Receptor tyrosine-protein kinase ErbB-3; ErbB3; HER3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72625A

	HER3 Protein, Human (HEK293, His, solution) Receptor tyrosine-protein kinase ErbB-3; ErbB3; HER3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (HEK293, His, solution) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P704578

	EGFR Protein, Human (621a.a, HEK293) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (621a.a, HEK293) is the recombinant human-derived EGFR protein, expressed by HEK293, with tag free.

HY-P705251

	EGFR Protein, Mouse (Biotinylated, HEK293, Fc-Avi) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Mouse	HEK293

HY-P705252

	EGFR Protein, Mouse (Biotinylated, HEK293, His-Avi) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Mouse	HEK293

HY-P78118

	EGFR Protein, Human (Biotinylated, HEK293, His-Avi) ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ErbB; ErbB1; HER1; PIG61; NISBD2	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78432

	EGFR vIII Protein, Human (HEK293, His-Avi) ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ErbB; ErbB1; HER1; PIG61; NISBD2	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR vIII Protein, Human (HEK293, His-Avi) is the recombinant human-derived EGFR vIII protein, expressed by HEK293 , with N-Avi, N-His labeled tag.

HY-P78117

	EGFR vIII Protein, Human (Biotinylated, HEK293, His-Avi) ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ErbB; ErbB1; HER1; PIG61; NISBD2	Human	HEK293
	The EGFRvIII protein is a transmembrane glycoprotein in the protein kinase superfamily that acts as a receptor for epidermal growth factor. It acts on the cell surface, binds to epidermal growth factor, triggers receptor dimerization and tyrosine autophosphorylation, and promotes cell proliferation. EGFR vIII Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived EGFR vIII protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78436

	FITC-Labeled EGFR Protein, Human (HEK293, His-Avi) ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ErbB; ErbB1; HER1; PIG61; NISBD2	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (FITC, HEK293, His-Avi) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78433

	FITC-Labeled EGFR vIII Protein, Human (HEK293, His-Avi) ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ErbB; ErbB1; HER1; PIG61; NISBD2	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR vIII Protein, Human (FITC, HEK293, His-Avi) is the recombinant human-derived EGFR vIII protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78434

	PE-Labeled EGFR vIII Protein, Human (HEK293, His-Avi) ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ErbB; ErbB1; HER1; PIG61; NISBD2	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. PE-Labeled EGFR vIII Protein, Human (HEK293, His-Avi) is the recombinant human-derived EGFR vIII protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P704197

	EGFR Protein, Human (L861Q, Active, sf9, GST) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Human	Sf9 insect cells
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (L861Q, Active, sf9, GST) is the recombinant human-derived EGFR protein, expressed by Sf9 insect cells, with N-GST labeled tag.

HY-P704576

	EGFR Protein, Human (621a.a, HEK293, Llama Fc) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (621a.a, HEK293, Llama Fc) is the recombinant human-derived EGFR protein, expressed by HEK293, with C-Llama Fc labeled tag.

HY-P72626

	HER2/CD340 Protein, Rat (His) Receptor tyrosine-protein kinase ErbB-2; p185neu; CD340; ErbB2; Neu	Rat	E. coli
	The HER2/CD340 protein is a key protein tyrosine kinase that is a component of multiple cell surface receptor complexes and requires coreceptors for ligand binding.Its interaction within the neuregulin-receptor complex depends on neuregulin, and GP30 emerges as a potential ligand.HER2/CD340 Protein, Rat (His) is the recombinant rat-derived HER2/CD340 protein, expressed by E.coli , with C-6*His labeled tag.

HY-P704574

	FITC-Labeled EGFR Protein, Human (621a.a, HEK293, His) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. FITC-Labeled EGFR Protein, Human (621a.a, HEK293, His) is the recombinant human-derived FITC-Labeled EGFR protein, expressed by HEK293, with C-His labeled tag.

HY-P705016

	EGFR Protein, Human (Biotinylated, 621a.a, HEK293, Fc-Avi) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Human	HEK293

HY-P70322

	HER3 Protein, Human (HEK293, Fc) 1 Publications Verification rHuReceptor tyrosine-protein kinase ErbB-3/HER3, Fc; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; ErbB3; HER3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (HEK293, Fc) is the recombinant human-derived HER3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P704661

	HER3 Protein, Human (HEK293, mFc) rHuReceptor tyrosine-protein kinase ErbB-3/HER3, Fc; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; ErbB3; HER3	Human	HEK293
	HER3, a pivotal tyrosine-protein kinase, acts as a crucial cell receptor for neuregulins. Neuregulin-1 (NRG1) activation boosts tyrosine phosphorylation and interaction with p85 subunit of phosphatidylinositol 3-kinase. CSPG5 may also activate HER3. Its involvement in myeloid cell differentiation underscores HER3's vital role in essential cellular processes for normal development and function. HER3 Protein, Human (HEK293, mFc) is the recombinant human-derived HER3 protein, expressed by HEK293, with C-mFc labeled tag.

HY-P700409

	EGFR Protein, Human (621a.a, HEK293, N-His, C-Myc) Epidermal growth factor receptor; EGFR; ErbB; ErbB1; HER1	Human	HEK293
	The EGFR protein is a receptor tyrosine kinase that can bind to a variety of ligands, such as EGF, TGFA, AREG, epigen, BTC, epiregulin, and HBEGF, to initiate signaling cascades that mediate cellular responses. This involves receptor dimerization, autophosphorylation and recruitment of adapter proteins such as GRB2, activating downstream pathways such as RAS-RAF-MEK-ERK, PI3-kinase-AKT, PLCgamma-PKC and STAT. EGFR Protein, Human (621a.a, HEK293, N-His, C-Myc) is the recombinant human-derived EGFR protein, expressed by HEK293 , with C-Myc, N-10*His labeled tag.

HY-P75805

	HER2/CD340 Protein, Cynomolgus (HEK293, His) Receptor tyrosine-protein kinase ErbB-2; p185neu; CD340; ErbB2; Neu	Cynomolgus	HEK293
	Erb-b2 receptor tyrosine kinase 2 is a member of EGFR family. Erb-b2 receptor tyrosine kinase 2 is over-expressed in the tumors of many types of cancers. Erb-b2 receptor tyrosine kinase 2 enables ATP binding and transmembrane receptor protein tyrosine kinase activity. HER2/CD340 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived HER2/CD340 protein, expressed by HEK293 , with C-His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-50898S

Lapatinib-d4
Lapatinib-d₄ is the deuterium labeled Lapatinib (HY-50898). Lapatinib is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-50898S2

Lapatinib-d5
Lapatinib-d₅ is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-50898S1

Lapatinib-d7 dihydrochloride
Lapatinib-d₇ dihydrochloride is the deuterium labeled Lapatinib dihydrochloride. Lapatinib (GW572016) dihydrochloride is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-50898S3

Lapatinib-d4-1
Lapatinib-d₄-1 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-50898S4

Lapatinib-d7
Lapatinib-d₇ (GW572016-d₇) is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the *ErbB-2* and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and *ErbB-2* of 10.2 and 9.8 nM, respectively .

HY-50898CS

Lapatinib-d4 tosylate
Lapatinib-d₄ (GW572016-d₄) tosylate is deuterium labeled Lapatinib (tosylate). Lapatinib (GW572016) tosylate is a potent, orally active inhibitor of the *ErbB-2* and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and *ErbB-2* of 10.2 and 9.8 nM, respectively .

HY-W777297

Lapatinib-13C2,15N Ditosylate
Lapatinib- ¹³C₂, ¹⁵N Ditosylate is the ¹³C- and ¹⁵N-labeled Lapatinib ditosylate (HY-50898A). Lapatinib ditosylate (GW572016 ditosylate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC₅₀ values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .

HY-13272S3

Dacomitinib-d10
Dacomitinib-d₁₀ is deuterium labeled Dacomitinib. Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC₅₀s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively .

HY-13272S2

Dacomitinib-d10 dihydrochloride
Dacomitinib-d₁₀ dihydrochloride is the deuterium labeled Dacomitinib dihydrochloride. Dacomitinib (PF-00299804) dihydrochloride is a specific and irreversible inhibitor of the ERBB family of kinases with IC₅₀s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively .

HY-32718S

Pelitinib-d6
Pelitinib-d₆ (EKB-569-d₆) is the deuterium labeled Pelitinib. Pelitinib (EKB-569) is an irreversible inhibitor of EGFR with an IC₅₀ of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC₅₀s of 282, 800, and 1255 nM, respectively .

HY-B0793S1

AZ-5104-d2
AZ-5104-d₂ is the deuterium labeled AZ-5104. AZ-5104 is an EGFR inhibitor with IC₅₀s of 1 nM, 6 nM, 1 nM, 25 nM and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80660

	ErbB 4 Antibody (YA456) ErbB4; HER4; Receptor tyrosine-protein kinase ErbB-4; Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4; p180ErbB4	WB	Human, Rat
	ErbB 4 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 147 kDa, targeting to ErbB 4. It can be used for WB assays with tag free, in the background of Human, Rat.

HY-P80648

	EGFR Antibody (YA775) EGFR; ErbB; ErbB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase ErbB-1	WB, ICC/IF, IP	Human, Monkey
	EGFR Antibody (YA775) is a non-conjugated and Mouse origined monoclonal antibody about 134 kDa, targeting to EGFR (6H11). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Monkey.

HY-P80808

	Phospho-EGFR (Tyr1068) Antibody (YA207) EGFR; ErbB; ErbB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase ErbB-1	WB, IHC-F, IHC-P, ICC/IF	Human
	Phospho-EGFR (Tyr1068) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 134 kDa, targeting to Phospho-EGFR (Tyr1068). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human.

HY-P80809

	Phospho-EGFR (Tyr1092) Antibody (YA206) EGFR; ErbB; ErbB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase ErbB-1	WB, IHC-P	Human, Mouse, Rat
	Phospho-EGFR (Tyr1092) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 134 kDa, targeting to Phospho-EGFR (Tyr1092). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P84183

	ERBB3 Antibody (YA3880) HER3; c-ErbB3	WB, ICC/IF, ELISA	Human
	ERBB3 Antibody (YA3880) is a mouse-derived and non-conjugated IgG1 antibody, targeting to ERBB3. It can be applicated for WB, ICC/IF, ELISA assays, in the background of human.

HY-P80659

	ErbB 3 Antibody (YA457) ErbB3; HER3; Receptor tyrosine-protein kinase ErbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3	WB	Human
	ErbB 3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 148 kDa, targeting to ErbB 3. It can be used for WB assays with tag free, in the background of Human.

HY-P86321

	ErbB-3 Antibody (YA6013) ErbB3; HER3; Receptor tyrosine-protein kinase ErbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ErbB-3 Antibody (YA6013) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ErbB-3. It can be applicated for WB, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

HY-P83946

	ERBB2 Antibody (YA3643) NEU; HER2; TKR1; CD340; HER-2	WB, IHC-P, FC, ELISA	Human
	ERBB2 Antibody (YA3643) is a mouse-derived and non-conjugated IgG1 antibody, targeting to ERBB2. It can be applicated for WB, IHC-P, FC, ELISA assays, in the background of human.

HY-P85843

	EGFR Antibody (YA5535) EGFR; ErbB; ErbB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase ErbB-1	IHC-P, WB, ICC/IF, ELISA	Human
	EGFR Antibody (YA5535) is a mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to EGFR. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human.

HY-P86375

	EGFR Antibody (YA6067) EGFR; ErbB; ErbB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase ErbB-1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	EGFR Antibody (YA6067) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EGFR. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

HY-P80810

	Phospho-EGFR (Tyr1173) Antibody (YA205) EGFR; ErbB; ErbB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase ErbB-1	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	Phospho-EGFR (Tyr1173) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 134 kDa, targeting to Phospho-EGFR (Tyr1173). It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human.

HY-P83891

	EGFR mutant Antibody (YA3588) ErbB; HER1; mENA; ErbB1; PIG61	WB, IHC-P, FC, ELISA	Human
	EGFR mutant Antibody (YA3588) is a mouse-derived and non-conjugated IgG1 antibody, targeting to EGFR mutant. It can be applicated for WB, IHC-P, FC, ELISA assays, in the background of human.

HY-P85600

	EGFR Antibody (YA5292) Avian erythroblastic leukemia viral; v erb b; oncogene homolog; Cell growth inhibiting protein 40; Cell proliferation inducing protein 61; EGF R; EGFR; EGFR_HUMAN; Epidermal growth factor receptor; avian erythroblastic leukemia viral; v erb b; oncogene homolog; Epidermal growth factor receptor; erythroblastic leukemia viral; v erb b; oncogene homolog avian; Epidermal growth factor receptor; ErbB 1; ErbB; ErbB1; ErbB1; Errp; HER1; mENA; Oncogene ErbB; PIG61; Proto-oncogene c-ErbB-1; Receptor tyrosine protein kinase ErbB 1; Receptor tyrosine-protein kinase ErbB-1; Urogastrone; wa2; Wa5.	WB, IHC-P, ICC/IF, IP	Human, Monkey
	EGFR Antibody (YA5292) is a mouse-derived and non-conjugated monoclonal antibody, targeting to EGFR. It can be applicated for WB, IHC-P, ICC/IF, IP assays, in the background of human, monkey.

HY-P80658

	HER2 Antibody (YA771) ErbB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase ErbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185ErbB2; CD antigen CD340	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	HER2 Antibody (YA771) is a non-conjugated and Mouse origined monoclonal antibody about 138 kDa, targeting to HER2. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P83761

	Phospho-HER2(Tyr1221/Tyr1222) Antibody ErbB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase ErbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185ErbB2; CD antigen CD340	WB, IHC-P, IP, ELISA	Human, Mouse
	Phospho-HER2(Tyr1221/Tyr1222) Antibody is a rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to phosphorylated HER2 (Tyr1221/Tyr1222). It can be applicated for WB, IHC-P, IP, ELISA assays, in the background of human, mouse.

HY-P86242

	HER2 Antibody (YA5934) Receptor tyrosine-protein kinase ErbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185ErbB2; CD antigen CD340;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	HER2 Antibody (YA5934) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HER2. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

HY-P86166

	Phospho-HER2(Tyr1221/1222) Antibody (YA5858) Receptor tyrosine-protein kinase ErbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185ErbB2; CD antigen CD340;	WB, ICC/IF, IP, ELISA	Human
	Phospho-HER2(Tyr1221/1222) Antibody (YA5858) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to phosphorylated HER2 (Tyr1221/1222). It can be applicated for WB, ICC/IF, IP, ELISA assays, in the background of human.

HY-P80116

	EGFR Antibody (YA468) 1 Publications Verification Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody; Cell growth inhibiting protein 40 antibody; Cell proliferation inducing protein 61 antibody; EGF R antibody; EGFR antibody; EGFR_HUMAN antibody; Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) antibody; Epidermal growth factor receptor antibody; erb-b2 receptor tyrosine kinase 1 antibody; ErbB antibody; ErbB1 antibody; Errp antibody; HER1 antibody; mENA antibody; NISBD2 antibody; Oncogen ErbB antibody; PIG61 antibody; Proto-oncogene c-ErbB-1 antibody; Receptor tyrosine protein kinase ErbB 1 antibody; Receptor tyrosine-protein kinase ErbB-1 antibody; SA7 antibody; Species antigen 7 antibody; Urogastrone antibody; v-erb-b Avian erythroblastic leukemia viral oncogen homolog antibody; wa2 antibody; Wa5 antibody	WB, ICC/IF, IP, FC, mIHC	Human, Mouse, Rat
	EGFR Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 134 kDa, targeting to EGFR. It can be used for WB,ICC/IF,mIHC,IP, FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P82764

	EBP1 Antibody (YA2509) PA2G4; EBP1; Proliferation-associated protein 2G4; Cell cycle protein p38-2G4 homolog; hG4-1; ErbB3-binding protein 1	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	EBP1 Antibody (YA2509) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2509), targeting EBP1, with a predicted molecular weight of 44 kDa (observed band size: 48 kDa). EBP1 Antibody (YA2509) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.