ESR1

By Targets:	Apoptosis (2) ASK1 (2) Autophagy (2) COX (2) Estrogen Receptor/ERR (3) JNK (2) MMP (2) NF-κB (2) PROTACs (1) Reference Standards (1) Small Interfering RNA (siRNA) (3) SOD (2) TNF Receptor (2) Toll-like Receptor (TLR) (2) YAP (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (2) Endocrinology (2) Inflammation/Immunology (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149480

ERD-3111	PROTACs Estrogen Receptor/ERR	Cancer
ERD-3111 (Compound 44) is an orally active PROTAC ERα degrader (DC₅₀: 0.5 nM). ERD-3111 inhibits tumor growth in the parental MCF-7 xenograft model with wild-type ER and two clinically relevant ESR1 mutated mice model. ERD-3111 can be used in the research of ER+ breast cancer ^[1].

HY-147165

VT02956	YAP	Cancer
VT02956 is a LATS inhibitor (IC₅₀: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids ^[1]. VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N1508

Ecliptasaponin A	MMP Apoptosis Autophagy NF-κB TNF Receptor COX Toll-like Receptor (TLR) SOD ASK1 JNK	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Ecliptasaponin A is an orally active pentacyclic triterpenoid saponin. Ecliptasaponin A exerts anti-tumor activity by activating *ASK1/JNK* pathway, inducing apoptosis and autophagy in lung cancer cells. Ecliptasaponin A exerts anti-inflammatory/anti-fibrotic effects and protects the cardiovascular system by inhibiting the *HMGB1/TLR4/NF-κB* pathway, and the expression of COX-2 and MMP-9. Ecliptasaponin A can enhance SOD activity, reduce MDA levels, and alleviate oxidative stress damage. Ecliptasaponin A exerts chondroprotective effects by inhibiting the expression of MMP13 and regulating inflammatory factors. Ecliptasaponin A improves ovarian function and regulates sex hormones by upregulating the expression of *ESR1* receptors ^[1] .

HY-136255

Camizestrant 5 Publications Verification AZD-9833	Estrogen Receptor/ERR	Cancer
Camizestrant (AZD-9833) is a potent and orally active estrogen receptor (ER) antagonist. Camizestrant is used for the study of ER ⁺ HER2-advanced breast cancer ^[1].

HY-RS04529

ESR1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ESR1 Human Pre-designed siRNA Set A contains three designed siRNAs for ESR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ESR1 Human Pre-designed siRNA Set A ESR1 Human Pre-designed siRNA Set A

HY-RS04530

Esr1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Esr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Esr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Esr1 Mouse Pre-designed siRNA Set A Esr1 Mouse Pre-designed siRNA Set A

HY-RS04531

Esr1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Esr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Esr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Esr1 Rat Pre-designed siRNA Set A Esr1 Rat Pre-designed siRNA Set A

HY-147165A

VT02956 hydrochloride	YAP	Cancer
VT02956 is a LATS inhibitor (IC₅₀: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids ^[1]. VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N1508R

Ecliptasaponin A (Standard)	Reference Standards MMP Apoptosis Autophagy NF-κB TNF Receptor COX Toll-like Receptor (TLR) SOD ASK1 JNK	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Ecliptasaponin A (Standard) is the analytical standard for Ecliptasaponin A (HY-N1508). Ecliptasaponin A is an orally active pentacyclic triterpenoid saponin. Ecliptasaponin A exerts anti-tumor activity by activating *ASK1/JNK* pathway, inducing apoptosis and autophagy in lung cancer cells. Ecliptasaponin A exerts anti-inflammatory/anti-fibrotic effects and protects the cardiovascular system by inhibiting the *HMGB1/TLR4/NF-κB* pathway, and the expression of COX-2 and MMP-9. Ecliptasaponin A can enhance SOD activity, reduce MDA levels, and alleviate oxidative stress damage. Ecliptasaponin A exerts chondroprotective effects by inhibiting the expression of MMP13 and regulating inflammatory factors. Ecliptasaponin A improves ovarian function and regulates sex hormones by upregulating the expression of *ESR1* receptors.

HY-101119

GLL398	Estrogen Receptor/ERR	Cancer
GLL398 is a potent, orally bioavailable selective estrogen receptor degrader (SERD) with an IC₅₀ value of 1.14 nM. GLL398 shows a strong dose-dependent binding to ER with a mutation at Y537S (IC₅₀=29.5 nM). GLL398 blocks tumor growth in xenograft models of breast cancer.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1508

Ecliptasaponin A	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields	MMP Apoptosis Autophagy NF-κB TNF Receptor COX Toll-like Receptor (TLR) SOD ASK1 JNK
Ecliptasaponin A is an orally active pentacyclic triterpenoid saponin. Ecliptasaponin A exerts anti-tumor activity by activating *ASK1/JNK* pathway, inducing apoptosis and autophagy in lung cancer cells. Ecliptasaponin A exerts anti-inflammatory/anti-fibrotic effects and protects the cardiovascular system by inhibiting the *HMGB1/TLR4/NF-κB* pathway, and the expression of COX-2 and MMP-9. Ecliptasaponin A can enhance SOD activity, reduce MDA levels, and alleviate oxidative stress damage. Ecliptasaponin A exerts chondroprotective effects by inhibiting the expression of MMP13 and regulating inflammatory factors. Ecliptasaponin A improves ovarian function and regulates sex hormones by upregulating the expression of *ESR1* receptors ^[1] .

HY-N1508R

Ecliptasaponin A (Standard)	Triterpenes Structural Classification other families Terpenoids Source classification Plants	Reference Standards MMP Apoptosis Autophagy NF-κB TNF Receptor COX Toll-like Receptor (TLR) SOD ASK1 JNK
Ecliptasaponin A (Standard) is the analytical standard for Ecliptasaponin A (HY-N1508). Ecliptasaponin A is an orally active pentacyclic triterpenoid saponin. Ecliptasaponin A exerts anti-tumor activity by activating *ASK1/JNK* pathway, inducing apoptosis and autophagy in lung cancer cells. Ecliptasaponin A exerts anti-inflammatory/anti-fibrotic effects and protects the cardiovascular system by inhibiting the *HMGB1/TLR4/NF-κB* pathway, and the expression of COX-2 and MMP-9. Ecliptasaponin A can enhance SOD activity, reduce MDA levels, and alleviate oxidative stress damage. Ecliptasaponin A exerts chondroprotective effects by inhibiting the expression of MMP13 and regulating inflammatory factors. Ecliptasaponin A improves ovarian function and regulates sex hormones by upregulating the expression of *ESR1* receptors.

Species:	Human (2)
Tag:	His (2)
Source:	P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70248

	*ER alpha/ESR1* Protein, Human (His)** 1 Publications Verification rHuEstrogen receptor/ER alpha, His; Estrogen Receptor; ER; ER-Alpha; Estradiol Receptor; Nuclear Receptor Subfamily 3 Group A Member 1; ESR1; ESR; NR3A1	Human	E. coli
	The ER α/ESR1 protein is a nuclear receptor that plays a critical regulatory role in gene expression, affecting cell proliferation and differentiation. Ligand-dependent transactivation involves binding of homodimers to estrogen response elements or association with transcription factors. ER alpha/ESR1 Protein, Human (His) is the recombinant human-derived ER alpha/ESR1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701106

	*ER alpha/ESR1* Protein, Human (P. pastoris, N-His)** rHuEstrogen receptor/ER alpha, His; Estrogen Receptor; ER; ER-Alpha; Estradiol Receptor; Nuclear Receptor Subfamily 3 Group A Member 1; ESR1; ESR; NR3A1	Human	P. pastoris
	The ER α/ESR1 protein is a nuclear receptor that plays a critical regulatory role in gene expression, affecting cell proliferation and differentiation. Ligand-dependent transactivation involves binding of homodimers to estrogen response elements or association with transcription factors. ER alpha/ESR1 Protein, Human (P. pastoris, N-His) is the recombinant human-derived ER alpha/ESR1 protein, expressed by P. pastoris , with N-6*His labeled tag.

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HY-P80662

	Estrogen Receptor alpha Antibody (YA768) ESR1; Era; Eralpha; Estrogen receptor; Estradiol receptor; ER-alpha; Estrogen receptor 1; NR3A1; ER; ESR; ESRA; Estrogen receptor alpha	WB	Human, Mouse, Rat
	Estrogen Receptor alpha Antibody (YA768) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Estrogen Receptor alpha.

HY-P80663

	Estrogen Receptor alpha Antibody (YA450) 1 Publications Verification ESR1; Era; Eralpha; Estrogen receptor; Estradiol receptor; ER-alpha; Estrogen receptor 1; NR3A1; ER; ESR; ESRA; Estrogen receptor alpha	WB, IHC-F, IHC-P, ICC/IF, IP, ChIP	Human
	Estrogen Receptor alpha Antibody (YA450) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Estrogen Receptor alpha.

HY-P86246

	Estrogen Receptor alpha Antibody (YA5938) ESR1 ESR NR3A1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Estrogen Receptor alpha Antibody (YA5938) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Estrogen Receptor alpha.

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Cat. No.	Product Name		Classification

HY-RS04529

ESR1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ESR1 Human Pre-designed siRNA Set A contains three designed siRNAs for ESR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS04530

Esr1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Esr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Esr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS04531

Esr1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Esr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Esr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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