ERG

By Targets:	Aminotransferases (Transaminases) (1) Calcium Channel (1) Cytochrome P450 (1) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) EGFR (1) Fungal (3) HDAC (1) HSP (2) iGluR (1) Potassium Channel (2) RPE65 (2) Ser/Thr Kinase (2) Small Interfering RNA (siRNA) (6)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (2) Metabolic Disease (4) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (4) siRNAs (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W193545A

ERG240 3 Publications Verification	Others	Inflammation/Immunology Cancer
ERG240 is an oral active branched-chain amino acid aminotransferase 1 (BCAT1) inhibitor. ERG240 can be used for the research of cancer, rheumatoid arthritis, and bone disease .

HY-159730

ERG245	Aminotransferases (Transaminases)	Cancer
ERG245 is a BCAT1 inhibitor that enhances oxidative phosphorylation (OXPHOS) in CD8 ⁺ T cells by specifically inhibiting BCAT1 activity, thereby increasing the cytotoxicity of CD8 ⁺ T cells. ERG245, in combination with Pembrolizumab (anti-PD-1, HY-P9902A), promotes tumor regression. ERG245 can be used in research related to immuno-oncology .

HY-139893

ERGi-USU-6 mesylate	Ser/Thr Kinase	Cancer
ERGi-USU-6 mesylate (Compound 7b) is an inhibitor of *ERG* and RIOK2 (IC₅₀ values: 0.17 and 0.13 μM in VCaP cells, respectively). ERGi-USU-6 mesylate exhibits anticancer activity against ERG-positive prostate cancer .

HY-RS23146

Erg Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Erg Rat Pre-designed siRNA Set A contains three designed siRNAs for Erg gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Erg Rat Pre-designed siRNA Set A Erg Rat Pre-designed siRNA Set A

HY-RS04491

ERG Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ERG Human Pre-designed siRNA Set A contains three designed siRNAs for ERG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ERG Human Pre-designed siRNA Set A ERG Human Pre-designed siRNA Set A

HY-RS16711

Erg Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Erg Mouse Pre-designed siRNA Set A contains three designed siRNAs for Erg gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Erg Mouse Pre-designed siRNA Set A Erg Mouse Pre-designed siRNA Set A

HY-RS04492

ERG28 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ERG28 Human Pre-designed siRNA Set A contains three designed siRNAs for ERG28 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ERG28 Human Pre-designed siRNA Set A ERG28 Human Pre-designed siRNA Set A

HY-RS04494

ERGIC3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ERGIC3 Human Pre-designed siRNA Set A contains three designed siRNAs for ERGIC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ERGIC3 Human Pre-designed siRNA Set A ERGIC3 Human Pre-designed siRNA Set A

HY-RS04493

ERGIC1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ERGIC1 Human Pre-designed siRNA Set A contains three designed siRNAs for ERGIC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ERGIC1 Human Pre-designed siRNA Set A ERGIC1 Human Pre-designed siRNA Set A

HY-P5806

Ergtoxin-1 ERGTx1	Potassium Channel	Neurological Disease
Ergtoxin-1 is a potassium channel blocker. Ergtoxin-1 is isolated from the venom of the Mexican scorpion Centruroides noxius. Ergtoxin 1 can block ERG-K ⁺ channels in nerve, heart and endocrine cells .

HY-112158

NSC139021 1 Publications Verification ERGi-USU	Ser/Thr Kinase	Cancer
NSC139021 (ERGi-USU) is a RIOK2 inhibitor with anticancer activity. RIOK2 can highly selectively inhibit the growth of ERG-positive cancer cells with IC₅₀s of 30-400 nM against cell lines. RIOK2 also causes cell cycle arrest and apoptosis in glioblastoma via induction of Skp2 and Skp2-p27/p21-Cyclin E/CDK2-pRb signaling .

HY-122234

VPC-18005	DNA/RNA Synthesis	Cancer
VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity .

HY-N7848

Linoleamide Linoleic acid amide	Calcium Channel	Metabolic Disease
Linoleamide is a linoleic acid amide. Linoleamide regulates Ca (II) ux and inhibits the erg current .

HY-121964

cis-Piperidine-2,3-dicarboxylic acid	iGluR	Neurological Disease
Cis-piperidine-2,3-dicarboxylic acid is a non-specific antagonist of NMDA, AMPA and kainate ionotropic receptors and a partial agonist for NMDA receptors. Cis-piperidine-2,3-dicarboxylic acid can be used in blocking general excitatory synaptic transmissions .

HY-W749520

Zymosterone	Dihydrofolate reductase (DHFR)	Metabolic Disease
Zymosterone is converted into zymosterol, an intermediate in cholesterol synthesis, through the action of the enzyme hydroxysteroid (17β) dehydrogenase 7 (HSD17B7), and this transformation, catalyzed by 3-keto sterol reductase (ERG27), plays a crucial role in the biosynthesis of ergosterol in yeast.

HY-116445

UNC9975	Dopamine Receptor	Neurological Disease
UNC9975 is a D₂R agonist that displays signaling bias via β-arrestin–ergic signaling and a simultaneously antagonist of Gi-regulated cAMP production and partial agonist for D₂R/β-arrestin-2 interactions. UNC9975 can be utilized in antipsychotic research .

HY-145814

HSP90-IN-9	HSP Fungal	Infection
HSP90-IN-9 is a potent and selective HSP90 inhibitor. HSP90-IN-9 displays a fungicidal effect in a dose-dependent manner. HSP90-IN-9 inhibits fungal biofilm formation and fungal morphological changes after being combined with FLC. HSP90-IN-9 recovers FLC resistance by down-regulating the expression of related genes (ERG11, CDR1 and CDR2) .

HY-117523

(Z)-RG-13022 (Z)-Tyrphostin RG13022	EGFR	Cancer
(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor, which inhibits preferentially the TK activity of the EGF receptor and inhibits EGF-stimulated growth of cultured cells. (Z)-RG-13022 exerts an IC₅₀ of 11 μM for DNA synthesis in the HN5 cells, which is 3 times more potent than (E)-RG-13022 (IC₅₀=38 μM). (Z)-RG-13022 can be used for research of breast cancer cells .

HY-144694

HDAC/HSP90-IN-3	HSP HDAC Fungal	Infection
HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC₅₀ values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1 .

HY-159585

CYP51-IN-20	Cytochrome P450 Fungal	Infection
CYP51-IN-20 (compound 5b) is an inhibitor of CYP51 and has antifungal activity. CYP51-IN-20 has a significant inhibitory effect on Candida albicans ATCC 10231, downregulates ERG11 (Cyp51) gene expression, and significantly reduces the yeast-to-hyphae morphological transition. CYP51-IN-20 can synergize with Voriconazole (HY-76200) to occupy the entire CYP51 binding site and exert a synergistic inhibitory effect in the Glechoma moth model .

HY-175663

EYE-002	RPE65	Metabolic Disease
EYE-002 is a RPE65 inhibitor with an IC₅₀ of 69 nM. EYE-002 promotes recovery of scotopic ERG a-/b-wave amplitudes. EYE-002 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-002 exerts protective effects against photic retinal damage in mice. EYE-002 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) .

HY-16915

RPR-260243 1 Publications Verification	Potassium Channel	Cardiovascular Disease
RPR-260243, a potent activator of human ether-a-go-go-related gene (hERG), slows deactivation and attenuates inactivation of hERG1 channels. RPR260243-modified HERG currents are inhibited by Dofetilide (IC₅₀=58 nM). RPR260243 displays no activator-like effects on other voltage-dependent ion channels, including the closely related ERG3 K+ channel . RPR-260243 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-175664

EYE-003	RPE65	Metabolic Disease
EYE-003 is an orally active RPE65 inhibitor with an IC₅₀ of 102 nM. EYE-003 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-003 suppresses scotopic ERG b-wave amplitude and exerts protective effects against retinal degeneration in Abca4 ^⁻/⁻ Rdh8 ^⁻/⁻ mice (a STGD1 model) by reducing retinal autofluorescent puncta and preserving outer nuclear layer (ONL) thickness in a dose-dependent manner. EYE-003 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1) .

Cat. No.	Product Name	Target	Research Area

HY-P5806

Ergtoxin-1 ERGTx1	Potassium Channel	Neurological Disease
Ergtoxin-1 is a potassium channel blocker. Ergtoxin-1 is isolated from the venom of the Mexican scorpion Centruroides noxius. Ergtoxin 1 can block ERG-K ⁺ channels in nerve, heart and endocrine cells .

Cat. No.	Product Name	Target	Research Area

HY-P990410

*Anti-ERG* Antibody**	Inhibitory Antibodies	Inflammation/Immunology
Anti-ERG Antibody is a humanized antibody expressed in CHO, targeting *ERG. The Anti-ERG* Antibody is composed of a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-ERG Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7848

Linoleamide Linoleic acid amide	Microorganisms Source classification	Calcium Channel
Linoleamide is a linoleic acid amide. Linoleamide regulates Ca (II) ux and inhibits the erg current .

Species:	Human (5)
Tag:	GFP (1) His (3) GST (2)
Source:	HEK293 (2) P. pastoris (1) Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P71733

	ERG Protein, Human (P.pastoris, His) ERG3; included; ets related; ETS-related gene; KCNH2; Oncogene TMPRSS2/ERG fusion	Human	P. pastoris
	ERG Protein, a transcriptional regulator, recruits SETDB1 histone methyltransferase to modify local chromatin. It interacts with SETDB1 and is identified in an IGF2BP1-dependent mRNP granule complex with untranslated mRNAs. ERG Protein, Human (P.pastoris, His) is the recombinant human-derived ERG protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P72165

	ERG11 Protein, Saccharomyces cerevisiae (GST) ERG11; CYP51; YHR007CLanosterol 14-alpha demethylase; EC 1.14.14.154; CYPLI; Cytochrome P450 51; Cytochrome P450-14DM; Cytochrome P450-LIA1; Sterol 14-alpha demethylase	Others	E. coli
	ERG11 Proteinas is a sterol 14α-demethylase, a key enzyme in the ergosterol biosynthetic pathway, particularly in the late pathway that occurs in the endoplasmic reticulum membrane. ERG11 catalyzes the three-step removal of the 14α-methyl group from lanosterol, releasing it as a formate, resulting in the conversion of the sterol into a key intermediate in ergosterol biosynthesis. ERG11 Protein, Saccharomyces cerevisiae (GST) is the recombinant ERG11 protein, expressed by E. coli , with N-GST labeled tag.

HY-P72193

	FDFT1 Protein, Human (His) DGPT; ERG9; Farnesyl diphosphate farnesyltransferase; Farnesyl-diphosphate farnesyltransferase; FDFT_HUMAN; FDFT1; FPP:FPP farnesyltransferase; SQS; Squalene synthase; Squalene synthetase; SS	Human	E. coli
	FDFT1 is a key enzyme in cellular metabolism responsible for coordinating the condensation of two farnesyl pyrophosphate (FPP) molecules, a key step in sterol biosynthesis. The process proceeds in two distinct steps: First, two FPP molecules react to form the stable squalene diphosphate intermediate (PSQPP), releasing protons and inorganic diphosphate. FDFT1 Protein, Human (His) is the recombinant human-derived FDFT1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701834

	hERG Protein, Human (HEK293, GFP, His) KCNH2; Potassium voltage-gated channel subfamily H member 2; Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; Voltage-gated potassium channel subunit Kv11.1	Human	HEK293
	The hERG protein is the α subunit of voltage-gated potassium channels and is critical for mediating cardiac delayed rectifier potassium current (IKr). It lacks individual channel activity but dynamically affects properties by forming heterotetramers with other isoforms. hERG Protein, Human (HEK293, GFP, His) is the recombinant human-derived hERG protein, expressed by HEK293 , with C-10*His, C-GFP labeled tag.

HY-P703937

	hERG Protein, Human (HEK293) Voltage-gated inwardly rectifying potassium channel KCNH2; Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; Potassium voltage-gated channel subfamily H member 2; Voltage-gated potassium channel subunit Kv11.1	Human	HEK293
	The hERG protein is the α subunit of voltage-gated potassium channels and is critical for mediating cardiac delayed rectifier potassium current (IKr). It lacks individual channel activity but dynamically affects properties by forming heterotetramers with other isoforms. hERG Protein, Human (HEK293) is the recombinant human-derived hERG protein, expressed by HEK293, with tag free.

HY-P703071

	SETDB1 Protein, Human (sf9, GST) KMT1E; Histone-lysine N-methyltransferase SETDB1; ERG-associated protein with SET domain (ESET); Histone H3-K9 methyltransferase 4 (H3-K9-HMTase 4); Lysine N-methyltransferase 1E; SET domain bifurcated 1; SETDB1; ESET	Human	Sf9 insect cells
	SETDB1 Protein, Human (sf9, GST) is the recombinant human-derived SETDB1, expressed by Sf9 insect cells , with GST labeled tag. ,

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83097

	ERG Antibody (YA2842) ERG; ERG-3; p55; KCNH2	WB, IHC-P, ICC/IF, ChIP	Human, Mouse, Rat
	ERG Antibody (YA2842) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERG.

HY-P81002

	FDFT1 Antibody (YA3512) DGPT; ERG9; FDFT1; SQS; Squalene synthase; SS	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	FDFT1 Antibody (YA3512) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FDFT1.

HY-P82181

	EGR2 Antibody (YA1926) EGR2; KROX20; E3 SUMO-protein ligase EGR2; AT591; E3 SUMO-protein transferase ERG2 Curated; Early growth response protein 2 (EGR-2); Zinc finger protein Krox-20;	WB	Human, Mouse, Rat
	EGR2 Antibody (YA1926) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EGR2.

HY-P85855

	ERG Antibody (YA5547)	WB, ICC/IF, ELISA	Human
	ERG Antibody (YA5547) is a Mouse-derived and non-conjugated IgG3 monoclonal antibody, targeting to ERG.

HY-P86237

	ERG Antibody (YA5929)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ERG Antibody (YA5929) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ERG.

HY-P85154

	SETDB1/ESET Antibody (YA4846) SETDB1; KIAA0067; KMT1E; Histone-lysine N-methyltransferase SETDB1; ERG-associated protein with SET domain; ESET; Histone H3-K9 methyltransferase 4; H3-K9-HMTase 4; Lysine N-methyltransferase 1E; SET domain bifurcated 1	WB, ICC/IF, ELISA	Human, Mouse, Monkey
	SETDB1/ESET Antibody (YA4846) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SETDB1/ESET.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS23146

Erg Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Erg Rat Pre-designed siRNA Set A contains three designed siRNAs for Erg gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS04491

ERG Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ERG Human Pre-designed siRNA Set A contains three designed siRNAs for ERG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16711

Erg Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Erg Mouse Pre-designed siRNA Set A contains three designed siRNAs for Erg gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS04492

ERG28 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ERG28 Human Pre-designed siRNA Set A contains three designed siRNAs for ERG28 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS04494

ERGIC3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ERGIC3 Human Pre-designed siRNA Set A contains three designed siRNAs for ERGIC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS04493

ERGIC1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ERGIC1 Human Pre-designed siRNA Set A contains three designed siRNAs for ERGIC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides