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D 156844

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-117000A
    D-156844 hydrochloride

    		DNA/RNA Synthesis Dihydrofolate reductase (DHFR) Others
    D-156844 (Compound 11a) hydrochloride is a SMN2 promoter activator with an EC50 of 4 nM. D-156844 hydrochloride increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D-156844 hydrochloride overcomes DHFR inhibition. D-156844 hydrochloride can be used for SMA research .
    D-156844 hydrochloride

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