2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. DNA/RNA Synthesis Dihydrofolate reductase (DHFR)
  4. D156844

D156844 (Compound 11a) is a SMN2 promoter activator with an EC50 of 4 nM. D156844 increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D156844 overcomes DHFR inhibition. D156844 can be used for SMA research.

For research use only. We do not sell to patients.

D156844

D156844 Chemical Structure

CAS No. : 1005501-84-7

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Description

D156844 (Compound 11a) is a SMN2 promoter activator with an EC50 of 4 nM. D156844 increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D156844 overcomes DHFR inhibition. D156844 can be used for SMA research[1].

Molecular Weight

381.45

Formula

C21H24FN5O
CAS No.
SMILES

NC1=NC(N)=C2C(OCC3CCN(CC4=CC=CC=C4F)CC3)=CC=CC2=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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D156844 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D1568441005501-84-7D 156844D-156844DNA/RNA SynthesisDihydrofolate reductase (DHFR)SMN2 promoterNSC-34 cellsFibroblastsDHFR inhibitionSpinal muscular atrophySMAInhibitorinhibitorinhibit

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