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Results for "

CFTR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CFTR (92) Apoptosis (2) Aquaporin (2) Autophagy (26) Calcium Channel (1) Caspase (2) CDK (1) Chloride Channel (9) E1/E2/E3 Enzyme (2) Endogenous Metabolite (3) ERK (1) Fluorescent Dye (3) Glutathione Peroxidase (3) GSK-3 (1) GSNOR (1) Isotope-Labeled Compounds (7) JNK (1) Mitochondrial Metabolism (5) NO Synthase (3) P-glycoprotein (5) PARP (2) Phosphodiesterase (PDE) (1) Potassium Channel (6) PROTACs (1) SARS-CoV (1) Small Interfering RNA (siRNA) (3) TNF Receptor (3) TRP Channel (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (4) Endocrinology (15) Infection (2) Inflammation/Immunology (36) Metabolic Disease (15) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

107

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: CFTR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155742

CFTR corrector 12	CFTR	Others
CFTR corrector 12 (compound 17C) is a bithiazole derivative, serving as CFTR corrector. CFTR corrector 12 has the ability to correct some folding defective mutants of the channel responsible for the control of chloride transport across the plasma membrane. CFTR corrector 12 recovers the α-sarcoglycan (α-SG) content in mutant cells .

HY-147315

CFTR corrector 9	CFTR	Others
CFTR corrector 9 (compound 42) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator. CFTR corrector 9 can be used for researching cystic fibrosis (CF) and other CFTR associated disorders .

HY-W984122

CFTR corrector 17	CFTR	Inflammation/Immunology
CFTR corrector 17 (example 17) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator. CFTR corrector 17 can be used for the study of CFTR-mediated diseases .

HY-135279

CFTR corrector 4	CFTR	Inflammation/Immunology
CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis .

HY-16671

CFTR(inh)-172 10+ Cited Publications	CFTR Autophagy	Others
CFTR(inh)-172 is a potent and selective blocker of the *CFTR* chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a K_i of 300 nM.

HY-147249

CFTR corrector 8	CFTR	Inflammation/Immunology
CFTR corrector 8 is a potent *CFTR* modulator. CFTR can be used in the research of cystic fibrosis .

HY-136939

CFTR corrector 6	CFTR	Metabolic Disease Inflammation/Immunology
CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research .

HY-161753

CFTR potentiator 1	CFTR	Inflammation/Immunology
CFTR potentiator 1 (I1421) is a potent *CFTR* potentiator with an EC₅₀ value of 64 nM. CFTR potentiator 1 allosterically activates a wide range of CF-causing mutants, such as ΔF508 and G551D CFTR .

HY-172555

CFTR corrector 18	CFTR	Endocrinology
CFTR corrector 18 (Compound I-99) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 18 facilitates the processing and trafficking of CFTR, increasing the number of CFTR on the cell surface. CFTR corrector 18 is promising for research of cystic fibrosis (CF) .

HY-161894

CFTR corrector 13	CFTR	Inflammation/Immunology
CFTR corrector 13 (SVQ18) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector (EC₅₀=3.14 μM). CFTR corrector 13 enhances the function of *CFTR* channels, especially when used in combination with Lumacaftor (HY-13262), it can produce a dose-dependent increase in *CFTR* function. CFTR corrector 13 can be used in the study of cystic fibrosis (CF) and other *CFTR*-related diseases .

HY-161895

CFTR corrector 14	CFTR	Others
CFTR corrector 14 (Compound SVQ26) is a class 3 corrector for cystic fibrosis transmembrane conductance regulator (CFTR), that promotes the CFTR activity (EC₅₀ of 3.08 μM with presence of C1 class corrector VX-809). CFTR corrector 14 regulates the mutant-caused misfolding and impaired function of the CFTR protein. CFTR corrector 14 can be used in research about cystic fibrosis .

HY-153133

CFTR corrector 11	CFTR	Others
CFTR corrector 11 (compound 133) is a *CFTR* corrector .

HY-152264

CFTR activator 1	CFTR	Inflammation/Immunology
CFTR activator 1 is a potent and selective *CFTR* activator, with an EC₅₀ of 23 nM. CFTR activator 1 can be used to ameliorate dry eye disease .

HY-164000

CFTR corrector 15	CFTR	Others
CFTR corrector 15 (Compound 4172) is a corrector for cystic fibrosis transmembrane conductance regulator (CFTR), that repairs the F508del-CFTR folding defect when used with VX-809 (HY-13262). CFTR corrector 15 can be used in research of cystic fibrosis disease .

HY-14179

PPQ-102 4 Publications Verification CFTR Inhibitor	CFTR	Others
PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits *CFTR* chloride currents (IC₅₀ ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease .

HY-125381

CFTR corrector 2 1 Publications Verification	CFTR Autophagy	Inflammation/Immunology Cancer
CFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933 .

HY-169000

CFTR corrector 16	CFTR	Others
CFTR corrector 16 (Compound 39) is a corrector for cystic fibrosis transmembrane conductance regulator (CFTR), that can be used in research of cystic fibrosis disease .

HY-169536

CFTR activator 2 WAY-326769	CFTR	Inflammation/Immunology
CFTR activator 2 (WAY-326769) is an activator of mutant cystic fibrosis transmembrane conductance regulator (mutant-CFTR) .

HY-RS02572

CFTR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CFTR Human Pre-designed siRNA Set A contains three designed siRNAs for CFTR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CFTR Human Pre-designed siRNA Set A CFTR Human Pre-designed siRNA Set A

HY-RS02573

Cftr Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cftr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cftr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cftr Mouse Pre-designed siRNA Set A Cftr Mouse Pre-designed siRNA Set A

HY-RS02574

Cftr Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cftr Rat Pre-designed siRNA Set A contains three designed siRNAs for Cftr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cftr Rat Pre-designed siRNA Set A Cftr Rat Pre-designed siRNA Set A

HY-158002

IDOR-4	CFTR	Inflammation/Immunology
IDOR-4 is a type IV *CFTR* corrector. IDOR-4 restores F508del-CFTR trafficking to the cell surface .

HY-111680

Nesolicaftor 2 Publications Verification PTI-428	CFTR Autophagy	Endocrinology
Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier .

HY-15448

Tezacaftor 15+ Cited Publications VX-661	CFTR	Cancer
Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

HY-13017S

Ivacaftor-d9 VX-770-d₉	CFTR	Cancer
Ivacaftor-d₉ is a potent CFTR modulator and exhibits an EC₅₀ value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research .

HY-145603A

(R)-Vanzacaftor (R)-VX-121	CFTR	Others
(R)-Vanzacaftor ((R)-VX-121) is a regulator of cystic fibrosis transmembrane conduction regulator (CFTR) .

HY-158144

GLPG2737	CFTR	Others
GLPG2737 is a potent *CFTR* type 2 corrector, and GLPG2737 can be used in combination with a type 1 co-corrector in the study of cystic fibrosis .

HY-134385

6-PhEt-dATP	CFTR	Others
6-PhEt-dATP is an ATP analog that specifically enhances the function of certain *CFTR* mutants and is useful for studying cystic fibrosis .

HY-109177

Icenticaftor QBW251	CFTR	Inflammation/Immunology
Icenticaftor (QBW251) is an orally active *CFTR* channel potentiator, with EC₅₀s of 79 nM and 497 nM for F508del and G551D CFTR, respectively. Icenticaftor can be used for chronic obstructive pulmonary disease (COPD) and cystic fibrosis research .

HY-P10226

PGD97	Chloride Channel CFTR	Endocrinology
PGD97 is a selective cyclic peptide inhibitor against *CAL/CFTR* interactions, with a K_D value of 6 nM towards the CAL PDZ domain for its desulfide cyclized form. PGD97 (desulfide cyclized form) has selectivity ≥ 130-fold compared to NHERF1/2 PDZ domains. PGD97 is capable of stabilizing F508del-CFTR at the cell membrane and improving CFTR function required for proper fluid homeostasis in tne lung. PGD97 can be used for the research of cystic fibrosis .

HY-145603

Vanzacaftor VX-121	CFTR Chloride Channel	Neurological Disease
Vanzacaftor (VX-121) is an orally active noval corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves processing and trafficking of *CFTR* protein as well as increases chloride transport in triple combined with Tezacaftor (HY-15448) and Deutivacaftor. Vanzacaftor-Tezacaftor-Deutivacaftor is safe and well tolerated, improving lung function, respiratory symptoms, and *CFTR* function with cystic fibrosis, which is promising for research in the field of cystic fibrosis diseases .

HY-109027

Cavosonstat 1 Publications Verification N91115	GSNOR CFTR	Inflammation/Immunology
Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor. Cavosonstat is a CFTR stabilizer, and can be used for cystic fibrosis research .

HY-159706

S9-A13	Chloride Channel	Others
S9-A13 is a potent and selective inhibitor SLC26A9, with the IC₅₀ of 90.9 nM, without inhibiting other members of the SLC26 family such as SLC26A3, SLC26A4, and SLC26A6. S9-A13 can inhibits SLC26A9 Cl ^- currents in cells that lack expression of CFTR .

HY-13262

Lumacaftor 15+ Cited Publications VX-809; VRT 826809	CFTR Autophagy	Inflammation/Immunology
Lumacaftor (VX-809; VRT 826809) is a *CFTR* modulator that corrects the folding and trafficking of CFTR protein.

HY-N6818

5,7,4'-Trimethoxyflavone MTF	Apoptosis Caspase PARP Endogenous Metabolite CFTR	Cancer
5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a *CFTR* activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

HY-13017

Ivacaftor 10+ Cited Publications VX-770	CFTR Autophagy	Endocrinology
Ivacaftor (VX-770) is a potent and orally bioavailable *CFTR* potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively.

HY-111772

Elexacaftor Maximum Cited Publications 36 Publications Verification VX-445	CFTR Autophagy	Inflammation/Immunology
Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface .

HY-103369

PG01	CFTR	Endocrinology
PG01 is a potent *CFTR* Cl ^- channel potentiator. PG01 can correct gating defects of *CFTR* mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with K_d values of 0.22 μM, 0.45 μM and 1.94 μM, respectively. PG01 is also effective on ΔF508 (K_a of 0.3 μM). PG01 increases *ΔF508-CFTR* Cl ^- current after adding Forskolin .

HY-111099

GLPG1837 ABBV-974	CFTR Autophagy	Others
GLPG1837 is a potent and reversible *CFTR* potentiator, with EC₅₀s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.

HY-N6818R

5,7,4'-Trimethoxyflavone (Standard) MTF (Standard)	Apoptosis Caspase PARP Endogenous Metabolite CFTR	Cancer
5,?7,?4'-Trimethoxyflavone (Standard) is the analytical standard of 5,?7,?4'-Trimethoxyflavone. This product is intended for research and analytical applications. 5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a CFTR activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

HY-13017S2

Ivacaftor-d18 VX-770-d₁₈	Autophagy CFTR	Endocrinology
Ivacaftor-d₁₈ is the deuterium labeled Ivacaftor . Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively .

HY-145126

CP-628006	CFTR	Others
CP-628006, a small molecule *CFTR* potentiator, restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR.

HY-115878

NJH-2-057	CFTR	Others
NJH-2-057 is an EN523 OTUB1 recruiter linked to lumacaftor, a agent used to treat cystic fibrosis that binds *ΔF508-CFTR*.

HY-114725

VRT-532 CFpot-532	CFTR	Inflammation/Immunology
VRT-532 (CFpot-532) is a potent is a potent *CFTR* modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis .

HY-109187

Posenacaftor PTI-801	CFTR	Inflammation/Immunology
Posenacaftor (PTI-801) is a *cystic fibrosis transmembrane regulator (CFTR) protein* modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF) .

HY-109187A

Posenacaftor sodium 1 Publications Verification PTI-801 sodium	CFTR	Inflammation/Immunology
Posenacaftor (PTI-801) sodium is a *cystic fibrosis transmembrane regulator (CFTR) protein* modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF) .

HY-119936

GLPG2451	CFTR Autophagy	Inflammation/Immunology
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC₅₀ of 11.1 nM .

HY-15448S1

Tezacaftor-d6 VX-661-d₆	Isotope-Labeled Compounds CFTR	Cancer
Tezacaftor-d₆ (VX-661-d₆) is deuterium labeled Tezacaftor. Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

HY-13017S4

Ivacaftor-13C6 VX-770-¹³C₆	Isotope-Labeled Compounds CFTR Autophagy	Endocrinology
Ivacaftor- ¹³C₆ (VX-770- ¹³C₆) is ¹³C labeled Ivacaftor. Ivacaftor (VX-770) is a potent and orally bioavailable *CFTR* potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively.

HY-13017S3

Ivacaftor-d4 VX-770-d4	CFTR	Endocrinology
Ivacaftor-d4 (VX-770-d4) is the deuterium labeled-Ivacaftor (HY-13017). Ivacaftor is a potent and orally active *CFTR* potentiator, targeting *G551D-CFTR* and *F508del-CFTR* with EC₅₀s of 100 nM and 25 nM, respectively .

Cat. No.	Product Name

HY-L011

Membrane Transporter/Ion Channel Compound Library

1,788 compounds

Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development.

MCE designs a unique collection of 1,788 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Type

HY-D1297

ER-Tracker Green

1 Publications Verification

Fluorescent Dyes/Probes

ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206), highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K ⁺ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation .

HY-D1429

ER-Tracker Blue-White DPX

Fluorescent Dyes/Probes

HY-D1431

ER-Tracker Red

2 Publications Verification

Fluorescent Dyes/Probes

Cat. No.	Product Name	Target	Research Area

HY-P10226

PGD97	Chloride Channel CFTR	Endocrinology
PGD97 is a selective cyclic peptide inhibitor against *CAL/CFTR* interactions, with a K_D value of 6 nM towards the CAL PDZ domain for its desulfide cyclized form. PGD97 (desulfide cyclized form) has selectivity ≥ 130-fold compared to NHERF1/2 PDZ domains. PGD97 is capable of stabilizing F508del-CFTR at the cell membrane and improving CFTR function required for proper fluid homeostasis in tne lung. PGD97 can be used for the research of cystic fibrosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6818

5,7,4'-Trimethoxyflavone MTF	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Kaempferia parviflora Wall. ex Baker Plants Disease Research Fields Zingiberaceae Cancer	Apoptosis Caspase PARP Endogenous Metabolite CFTR
5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a *CFTR* activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

HY-N5101

Kobusin	Natural Products Source classification Magnoliaceae Magnolia biondii Pamp. Plants	CFTR Chloride Channel
Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel .

HY-N2057

Steviol	Other Terpenoids Structural Classification other families Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Disease Research Fields Sweeteners Food Research	Aquaporin
Steviol is a major metabolite of the sweetening compound stevioside. Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation .

HY-N6818R

5,7,4'-Trimethoxyflavone (Standard) MTF (Standard)	Structural Classification Flavonoids Flavones Source classification Kaempferia parviflora Wall. ex Baker Plants Zingiberaceae	Apoptosis Caspase PARP Endogenous Metabolite CFTR
5,?7,?4'-Trimethoxyflavone (Standard) is the analytical standard of 5,?7,?4'-Trimethoxyflavone. This product is intended for research and analytical applications. 5,7,4’-Trimethoxyflavone can be isolated from the medicinal plant Kaempferia parviflora (KP). 5,7,4’-Trimethoxyflavone is a CFTR activator and EC₅₀ is 64 μM. 5,7,4’-Trimethoxyflavone induces apoptosis, increases proteolytic activation of caspase-3, and degradation of ADP-ribose polymerase (PARP) protein. 5,7,4’-Trimethoxyflavone has antitumor activity. 5,7,4’-Trimethoxyflavone can be used to prevent skin aging and oxidative stress .

HY-N2057R

Steviol (Standard)	Other Terpenoids Structural Classification other families Terpenoids Source classification Plants	Aquaporin
Steviol (Standard) is the analytical standard of Steviol. This product is intended for research and analytical applications. Steviol is a major metabolite of the sweetening compound stevioside. Steviol slows renal cyst growth by reducing AQP2 expression and promoting AQP2 degradation .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P703101

	CFTR Protein, Human (HEK293) ABCC7	Human	HEK293
	CFTR Protein, Human (HEK293) is the recombinant human-derived CFTR, expressed by HEK293 , with tag Free labeled tag.

HY-P72069

	ABCC1 Protein, Human (His) ABC 29; ABC29; ABCC 1; ABCC; Abcc1; ATP binding cassette sub family C CFTR/MRP; member 1; ATP binding cassette sub-family C member 1; ATP binding cassette subfamily C member 1; ATP binding cassette transporter variant ABCC1delta ex13; ATP binding cassette transporter variant ABCC1delta ex13&14; ATP binding cassette transporter variant ABCC1delta ex25; ATP binding cassette transporter variant ABCC1delta ex25&26; ATP binding cassette, sub-family C CFTR/MRP; , member 1; ATP-binding cassette sub-family C member 1; DKFZp686N04233; DKFZp781G125; GS X; GSX; Leukotriene C4; transporter; LTC4 transporter; MRP 1; MRP; MRP1; MRP1_HUMAN; Multidrug resistance associated protein 1; Multidrug resistance protein; Multidrug resistance-associated protein 1; Multiple drug resistance associated protein; Multiple drug resistance protein 1	Human	E. coli
	ABCC1, Human (His) is a multitasking ATP-binding cassette (ABC) transporter. ABCC1, Human plays a part in inflammatory and other immunological diseases, age-related macular degeneration, cardiovascular disease, and certain neurological disorders as well as tumor progression.

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Cat. No.	Product Name	Chemical Structure

HY-13017S

Ivacaftor-d9
Ivacaftor-d₉ is a potent CFTR modulator and exhibits an EC₅₀ value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research .

HY-15448S

Tezacaftor-d4
Tezacaftor-d4 (VX-661-d4) is the deuterium-labeled Tezacaftor (HY-15448), a F508del CFTR corrector. Tezacaftor helps *CFTR* protein reach the cell surface .

HY-15206S1

Glyburide-d3

Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-13017S2

Ivacaftor-d18
Ivacaftor-d₁₈ is the deuterium labeled Ivacaftor . Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively .

HY-15448S1

Tezacaftor-d6

Tezacaftor-d₆ (VX-661-d₆) is deuterium labeled Tezacaftor. Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

HY-13017S4

Ivacaftor-13C6
Ivacaftor- ¹³C₆ (VX-770- ¹³C₆) is ¹³C labeled Ivacaftor. Ivacaftor (VX-770) is a potent and orally bioavailable *CFTR* potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively.

HY-13017S3

Ivacaftor-d4
Ivacaftor-d4 (VX-770-d4) is the deuterium labeled-Ivacaftor (HY-13017). Ivacaftor is a potent and orally active *CFTR* potentiator, targeting *G551D-CFTR* and *F508del-CFTR* with EC₅₀s of 100 nM and 25 nM, respectively .

HY-13017S1

Ivacaftor-d19
Ivacaftor-d₉ is a potent *CFTR* modulator and exhibits an EC₅₀ value of 255 nM for CFTR potentiation in G551D/F508del HBE Cells. Ivacaftor-D9 acts as an orally active and improved deuterated Ivacaftor analog for cystic fibrosis research .

HY-145603S

Vanzacaftor-d4

Vanzacaftor-d₄ (VX-121-d₄) is the deuterium labeled Vanzacaftor (HY-145603). Vanzacaftor is an orally active noval corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves processing and trafficking of CFTR protein as well as increases chloride transport in triple combined with Tezacaftor (HY-15448) and Deutivacaftor. Vanzacaftor-Tezacaftor-Deutivacaftor is safe and well tolerated, improving lung function, respiratory symptoms, and CFTR function with cystic fibrosis, which is promising for research in the field of cystic fibrosis diseases .

HY-B0679S

Lubiprostone-d7

Lubiprostone-d₇ (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .

HY-14832S1

Ataluren-13C6
Ataluren- ¹³C₆ (PTC124- ¹³C₆) is ¹³C labeled Ataluren. Ataluren (PTC124) is an orally available *CFTR-G542X* nonsense allele inhibitor.

HY-15206S

Glyburide-d11

Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .

HY-15206S2

Glibenclamide-13C6

Glibenclamide- ¹³C₆ (Glyburide- ¹³C₆) is ¹³C labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K ⁺ channel (K_ATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of K_ATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81118

	MRP2 Antibody (YA3526) ABC30 antibody; abcC2 antibody; ATP binding cassette sub family C (CFTR/MRP) member 2 antibody; ATP binding cassette subfamily C member 2 antibody; ATP-binding cassette sub-family C member 2 antibody; Canalicular multidrug resistance protein antibody; Canalicular multispecific organic anion transporter 1 antibody; CMOAT antibody; CMOAT1 antibody; cMRP antibody; DJS antibody; KIAA1010 antibody; MRP 2 antibody; MRP2_HUMAN antibody; Multidrug resistance associated protein 2 antibody; Multidrug resistance-associated protein 2 antibody;	WB, ICC/IF, FC	Human
	MRP2/ABCC2 Antibody is an unconjugated, approximately 174 kDa, rabbit-derived, anti-MRP2/ABCC2 monoclonal antibody. MRP2/ABCC2 Antibody can be used for: WB, ICC/IF, FC expriments in human background without labeling.

HY-P83773

	CFTR Antibody(YA3569) ABC 35 antibody ABC35 antibody ABCC 7 antibody ABCC7 antibody ATP binding cassette sub family C member 7 antibody; cAMP dependent chloride channel antibody; cAMP-dependent chloride channel antibody; CF antibody; CFTR antibody; CFTR/MRP antibody; CFTR_HUMAN antibody; Channel conductance controlling ATPase antibody; Channel conductance-controlling ATPase antibody; Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7) antibody; Cystic fibrosis transmembrane conductance regulator antibody; Cystic Fibrosis Transmembrane Regulator antibody; dJ760C5.1 antibody; MRP 7 antibody; MRP7 antibody; TNR CFTR antibody	WB, IP	Human

HY-P81902

	PIST Antibody (YA1647) GOPC; CAL; CFTR-associated ligand; GOPC1; FIG; PIST	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse
	PIST Antibody (YA1647) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1647), targeting PIST, with a predicted molecular weight of 51 kDa (observed band size: 51 kDa). PIST Antibody (YA1647) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse background.

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