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Cedazuridine (E7727) (Compound 7a) is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine can be used for cancer research .
Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase(CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine .
CDA-IN-3 (NCDI) is an inhibitor of chitin deacetylase (CDA) with anti-parasitic activity. CDA-IN-3 disrupts the chitin metabolism of nematodes, leading to an increase in the level of ROS in nematodes and causing cell damage. CDA-IN-3 has a significant inhibitory effect on all developmental stages of Caenorhabditis elegans. CDA-IN-3 can be used in the research of the anti-infection field .
CDA-IN-4 (compound VS-24) is a chitin deacetylase (CDA) inhibitor. CDA-IN-4 shows a 61.2% protective effect against rice blast at a concentration of 100 μg/mL .
CDA-IN-1 (Compound vs#2-1) is an inhibitor of chitin deacetylase (CDA).CDA-IN-1 exhibits antifungal activity. It can inhibit fungal growth by suppressing the activity of fungal CDA, activating the plant immune response, and accumulating reactive oxygen species (ROS). At a concentration of 100 μM, CDA-IN-1 can achieve inhibition rates of 86.9% and 74.5% against PxCDA1 and PxCDA2 of P. xanthii, respectively. CDA-IN-1 can be applied to the research in the field of controlling plant fungal diseases, such as the research on diseases like cucurbit powdery mildew and tomato gray mold .
CDA-IN-2 (Compound VS#2-3) is a chitin deacetylase (Chitin Deacetylase, CDA) inhibitor with antifungal activity. At a concentration of 100 μM, it can inhibit the CDAPxCDA1 and PxCDA2 of P. xanthii by 83.7% and 74.5% respectively. CDA-IN-2 can be applied to the research in the field of controlling agricultural fungal diseases, such as dealing with resistant powdery mildew and Botrytis cinerea .
Cda Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cda gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cda Rat Pre-designed siRNA Set A contains three designed siRNAs for Cda gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
CDA Human Pre-designed siRNA Set A contains three designed siRNAs for CDA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cedazuridine (E7727) (Compound 7a) hydrochloride is an orally active cytidine deaminase (CDA) inhibitor with an IC50 value of 0.4 μM. Cedazuridine hydrochloride can be used for cancer research .
Tetrahydrouridine dihydrate (THU dihydrate) is potent inhibitor of cytidine deaminase(CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine.
Tetrahydrouridine-d3 is the deuterium labeled Tetrahydrouridine . Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine .
Benzohydroxamic acid (BHA) is a chitin deacetylase (CDA) inhibitor with significant antifungal activity. The Ki values of BHA against the CDAs of Verticillium dahliae and Puccinia striiformis f. sp. tritici are 8.31 μM and 9.83 μM, respectively. Benzohydroxamic acid can restore the defense responses of infected host plants, upregulate the expression of defense-related genes, and reduce the growth and reproduction of fungi in plants. Benzohydroxamic acid can be used in the research of the field of controlling agricultural fungal diseases, such as various plant fungal diseases caused by Verticillium dahliae, Puccinia striiformis and other fungi, like cotton wilt and wheat stripe rust .
Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis .
AnCDA-IN-1 (Compound J075-4187) is an inhibitor of chitin deacetylase (CDA) with antifungal activity. It has an IC50 of 4.24 μM against AnCDA of A. nidulans, a minimum inhibitory concentration (MIC) of 260 μg/mL against food spoilage fungi and plant pathogenic fungi, and a minimum fungicidal concentration (MFC) of 520 μg/mL. AnCDA-IN-1 can be used in the research of the antifungal field .
2’3’-c-di-AM(PS)2 (Rp,Rp) (ADU-S100), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity .
Cladribine-d4 (2-Chloro-2′-deoxyadenosine-d4) is deuterium labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis .
Cladribine- 15N (2-Chloro-2′-deoxyadenosine- 15N) is 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis .
2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt (ADU-S100 enantiomer ammonium salt) is the less active enantiomer of 2’3’-c-di-AM(PS)2 (Rp,Rp). 2’3’-c-di-AM(PS)2 (Rp,Rp) is an activator of stimulator of interferon genes (STING) .
2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt (ADU-S100 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity .
Cladribine- 13C5, 15N2 (2-Chloro-2′-deoxyadenosine- 13C5, 15N2) is 13C and 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis .
The NIP30 protein negatively regulates proteasomal protein catabolism and protein binding activity. It is located in the nucleus and is expressed in various tissues including the brain and testis. NIP30 Protein, Human (HEK293, His) is the recombinant human-derived NIP30 protein, expressed by HEK293 , with C-His labeled tag.
The HDAC8 protein is a histone deacetylase that has been shown to be critical for lysine deacetylation on core histones (H2A, H2B, H3, H4). This enzymatic activity initiates epigenetic repression that affects transcription, cell cycle, and developmental events. HDAC8 Protein, Human (sf9) is the recombinant human-derived HDAC8 protein, expressed by Sf9 insect cells , with no tag.
XTP3TPA protein crucially hydrolyzes deoxynucleoside triphosphates (dNTPs), particularly preferring dCTP and its analogs, like 5-iodo-dCTP and 5-methyl-dCTP. This selective hydrolysis, reflecting high efficiency, likely safeguards against the incorporation of genotoxic nucleotide analogs into DNA or RNA, contributing to genomic integrity and protecting cellular nucleotide pools. XTP3TPA Protein, Human (His) is the recombinant human-derived XTP3TPA protein, expressed by E. coli , with N-His labeled tag.
Cytosine deaminase (CodA) protein plays a key role in the pyrimidine salvage pathway by catalyzing the hydrolytic deamination of cytosine to uracil. This enzyme activity enables cells to efficiently utilize cytosine for pyrimidine nucleotide synthesis. Cytosine deaminase/CodA Protein, E.coli (His-SUMO) is the recombinant E. coli-derived Cytosine deaminase/CodA protein, expressed by E. coli , with N-His, N-SUMO labeled tag.
The HDAC8 protein is a histone deacetylase that removes acetyl groups from core histone lysine residues, contributing to epigenetic repression and affecting transcriptional regulation, cell cycle progression, and developmental events. It forms large multiprotein complexes and deacetylates SMC3, regulating the release of cohesin complexes. HDAC8 Protein, Mouse (sf9, His) is the recombinant mouse-derived HDAC8 protein, expressed by Sf9 insect cells , with C-His labeled tag.
Tetrahydrouridine-d3 is the deuterium labeled Tetrahydrouridine . Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine .
Cladribine-d4 (2-Chloro-2′-deoxyadenosine-d4) is deuterium labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis .
Cladribine- 15N (2-Chloro-2′-deoxyadenosine- 15N) is 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis .
Cladribine- 13C5, 15N2 (2-Chloro-2′-deoxyadenosine- 13C5, 15N2) is 13C and 15N labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis .
HDAC8 Antibody (YA2994) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2994), targeting HDAC8, with a predicted molecular weight of 42 kDa (observed band size: 42 kDa). HDAC8 Antibody (YA2994) can be used for WB, IP experiment in human background.
CDA Antibody (YA1148) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1148), targeting CDA. CDA Antibody (YA1148) can be used for IHC-P experiment in human background.
GRIM19 Antibody (YA1952) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1952), targeting GRIM19, with a predicted molecular weight of 17 kDa (observed band size: 17 kDa). GRIM19 Antibody (YA1952) can be used for WB, IHC-P, ICC/IF experiment in human background.
Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase(CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine .
Tetrahydrouridine dihydrate (THU dihydrate) is potent inhibitor of cytidine deaminase(CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine.
Cda Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cda gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cda Rat Pre-designed siRNA Set A contains three designed siRNAs for Cda gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
CDA Human Pre-designed siRNA Set A contains three designed siRNAs for CDA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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