CD32b

By Targets:	CD20 (1) Fc Receptor (FcR) (3) Interleukin Related (1) Small Interfering RNA (siRNA) (1) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (2)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99395

Talacotuzumab 1 Publications Verification JNJ 56022473; CSL 362	Interleukin Related	Cancer
Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has K_Ds of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models .

HY-P991527

*Anti-CD32b Antibody (HuMax-CD32b)*	Transmembrane Glycoprotein	Others
Anti-CD32b Antibody (HuMax-CD32b) is a humanized antibody against *CD32b*.

HY-P991086

MGD010 PRV-3279	Fc Receptor (FcR)	Inflammation/Immunology
MGD010 is a bispecific CD32B (FcγRIIb) and CD79B antibody. MGD010 inhibits activated B-cells by delivering a negative signal via simultaneous co-ligation of CD32B (FcγRIIb), with the BCR component, CD79B. MGD010 has the potential for the study of autoimmune disorders .

HY-P991582

BI-1607	Fc Receptor (FcR)	Cancer
BI-1607 is a humanized monoclonal antibody targeting CD32b/FcγRIIB. BI-1607 has an antagonistic function capable of blocking the inhibitory function of FcγRIIB on immune effector cells. BI-1607 has a significant cytolytic activity against malignant B cells and antitumor activity against HER2-positive solid tumors including advanced gastric cancer (GC) with combination with Trastuzumab (HY-P9907) .

HY-P991225

BI-1206	Fc Receptor (FcR) CD20	Inflammation/Immunology Cancer
BI-1206 is a recombinant and antagonistic human monoclonal antibody targeting FcγRIIB (CD32B). BI-1206 can block CD20 internalization induced by Rituximab (HY-P9913) itself or combined with others including Ibrutinib (HY-10997), Venetoclax (HY-15531), and CHOP. BI-1206 can enhance or recover the activity of Rituximab or other anti-CD20 monoclonal antibodies. BI-1206 has cytolytic activity against malignant B cells. BI-1206 can be studied for cancer research such as mantle cell lymphoma (MCL) .

HY-RS04829

FCGR2B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FCGR2B Human Pre-designed siRNA Set A contains three designed siRNAs for FCGR2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FCGR2B Human Pre-designed siRNA Set A FCGR2B Human Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P99395

Talacotuzumab 1 Publications Verification JNJ 56022473; CSL 362	Interleukin Related	Cancer
Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has K_Ds of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models .

HY-P991527

*Anti-CD32b Antibody (HuMax-CD32b)*	Transmembrane Glycoprotein	Others
Anti-CD32b Antibody (HuMax-CD32b) is a humanized antibody against *CD32b*.

HY-P991086

MGD010 PRV-3279	Fc Receptor (FcR)	Inflammation/Immunology
MGD010 is a bispecific CD32B (FcγRIIb) and CD79B antibody. MGD010 inhibits activated B-cells by delivering a negative signal via simultaneous co-ligation of CD32B (FcγRIIb), with the BCR component, CD79B. MGD010 has the potential for the study of autoimmune disorders .

HY-P991582

BI-1607	Fc Receptor (FcR)	Cancer
BI-1607 is a humanized monoclonal antibody targeting CD32b/FcγRIIB. BI-1607 has an antagonistic function capable of blocking the inhibitory function of FcγRIIB on immune effector cells. BI-1607 has a significant cytolytic activity against malignant B cells and antitumor activity against HER2-positive solid tumors including advanced gastric cancer (GC) with combination with Trastuzumab (HY-P9907) .

HY-P991225

BI-1206	Fc Receptor (FcR) CD20	Inflammation/Immunology Cancer
BI-1206 is a recombinant and antagonistic human monoclonal antibody targeting FcγRIIB (CD32B). BI-1206 can block CD20 internalization induced by Rituximab (HY-P9913) itself or combined with others including Ibrutinib (HY-10997), Venetoclax (HY-15531), and CHOP. BI-1206 can enhance or recover the activity of Rituximab or other anti-CD20 monoclonal antibodies. BI-1206 has cytolytic activity against malignant B cells. BI-1206 can be studied for cancer research such as mantle cell lymphoma (MCL) .

Species:	Human (6) Mouse (2) Rat (1) Cynomolgus (3)
Tag:	His (11) SUMO (1) Strep (1) Avi (4) HSA (1)
Source:	HEK293 (12)

Cat. No.	Compare	Product Name	Species	Source

HY-P72735

	*Fc gamma RIIB/CD32b Protein, Mouse (HEK293, His)* Low affinity immunoglobulin gamma Fc region receptor II; Fc-gamma-RIIB; Ly-17; CD32; Fcgr2	Mouse	HEK293
	Fc gamma RIIB/CD32b protein is a low-affinity receptor for immunoglobulin gamma and is involved in a variety of effector and regulatory functions. When co-aggregated with BCR, TCR and Fc receptors, it promotes endocytosis of soluble immune complexes (IIB2), modulates antibody production, and downregulates B-cell, T-cell and mast cell activation. Fc gamma RIIB/CD32b Protein, Mouse (HEK293, His) is the recombinant mouse-derived Fc gamma RIIB/CD32b protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76235

	*Fc gamma RIIB/CD32b Protein, Rat (HEK293, His)* Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b; IgG Fc Receptor II-b; CDw32; FcRII-b; CD32; FCGR2B; FCG2; IGFR2	Rat	HEK293
	Fc gamma RIIB/CD32b Protein plays a crucial role, specifically binding to the Fc region of immunoglobulins gamma as a low-affinity receptor. Binding to IgG, it initiates cellular responses against pathogens, highlighting its immune system modulation. Interactions with FGR and LYN underscore its role in signaling pathways, emphasizing its significance in mediating cellular responses and contributing to immune defense against diverse antigens. Fc gamma RIIB/CD32b Protein, Rat (HEK293, His) is the recombinant rat-derived Fc gamma RIIB/CD32b protein, expressed by HEK293 , with C-His labeled tag.

HY-P70491

	*Fc gamma RIIB/CD32b Protein, Human (HEK293, His)* Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b; IgG Fc Receptor II-b; CDw32; Fc-Gamma RII-b; Fc-Gamma-RIIb; FcRII-b; CD32; FCGR2B; FCG2; IGFR2	Human	HEK293
	Fc gamma RIIB/CD32b protein is a low-affinity receptor for immunoglobulin gamma and plays a key role in immune responses. It mediates phagocytosis of immune complexes and regulates antibody production by B cells. Fc gamma RIIB/CD32b Protein, Human (HEK293, His) is the recombinant human-derived Fc gamma RIIB/CD32b protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76800

	*Fc gamma RIIB/CD32b Protein, Cynomolgus (HEK293, His)* Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b; IgG Fc Receptor II-b; CDw32; Fc-Gamma RII-b; Fc-Gamma-RIIb; FcRII-b; CD32; FCGR2B; FCG2; IGFR2	Cynomolgus	HEK293
	Fc γ RIIB/CD32b proteins exhibit low affinity as complexes or receptors that aggregate the immunoglobulin γFc region. ITIM phosphorylated by Fc γ RIIB/CD32b recruits inositol phosphatases SHIP1 and SHIP2, inhibits Ras activation, down-regulates MAPK activity, reduces PLC-γ function, and results in PKC activation. Inhibition of MAP kinase pathway and anti-apoptotic kinase Akt inhibit cell proliferation and survival. Fc gamma RIIB/CD32b Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Fc gamma RIIB/CD32b protein, expressed by HEK293 , with C-His labeled tag.

HY-P78424

	*Fc gamma RIIB/CD32b Protein, Human (HEK293, His-Avi)* Fc gamma Receptor IIB/C; CD32; CD32b; CDw32; FCGR2B/C; CD32b/c; FcRII-b/c; FCG2; IGFR2; CD32A; Fc gamma RII; Fc gamma RIIB; FCG2 ; FcGR; FCGR2; FCGR21; FCGR2A	Human	HEK293
	Fc gamma RIIB/CD32b protein is a low-affinity receptor for immunoglobulin gamma and plays a key role in immune responses. It mediates phagocytosis of immune complexes and regulates antibody production by B cells. Fc gamma RIIB/CD32b Protein, Human (HEK293, His-Avi) is the recombinant human-derived Fc gamma RIIB/CD32b protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P75211

	*Fc gamma RIIB/CD32b Protein, Human (Biotinylated, HEK293, His-Avi)* Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b; IgG Fc Receptor II-b; CDw32; FcRII-b; CD32; FCGR2B; FCG2; IGFR2	Human	HEK293
	Fc gamma RIIB/CD32b protein is a low-affinity receptor for immunoglobulin gamma and plays a key role in immune responses. It mediates phagocytosis of immune complexes and regulates antibody production by B cells. Fc gamma RIIB/CD32b Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Fc gamma RIIB/CD32b protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P75649

	*Fc gamma RIIB/CD32b Protein, Mouse (Biotinylated, HEK293, His-Avi)* Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b; IgG Fc Receptor II-b; CDw32; FcRII-b; CD32; FCGR2B; FCG2; IGFR2	Mouse	HEK293
	Fc gamma RIIB/CD32b protein is essential for IgG binding activity and participates in immune responses and various processes. It plays a role in antigen processing and presentation, negative regulation of immune processes, and phagocytosis. Fc gamma RIIB/CD32b Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived Fc gamma RIIB/CD32b protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P76799

	*Fc gamma RIIB/CD32b Protein, Cynomolgus (Biotinylated, HEK293, His-Avi)* Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b; IgG Fc Receptor II-b; CDw32; Fc-Gamma RII-b; Fc-Gamma-RIIb; FcRII-b; CD32; FCGR2B; FCG2; IGFR2	Cynomolgus	HEK293
	Fc γ RIIB/CD32b proteins exhibit low affinity as complexes or receptors that aggregate the immunoglobulin γFc region. ITIM phosphorylated by Fc γ RIIB/CD32b recruits inositol phosphatases SHIP1 and SHIP2, inhibits Ras activation, down-regulates MAPK activity, reduces PLC-γ function, and results in PKC activation. Inhibition of MAP kinase pathway and anti-apoptotic kinase Akt inhibit cell proliferation and survival. Fc gamma RIIB/CD32b Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) is the recombinant cynomolgus-derived Fc gamma RIIB/CD32b protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P704598

	*Fc gamma RIIB/CD32b Protein, Human (HEK293, HSA-His)* Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b; IgG Fc Receptor II-b; CDw32; Fc-Gamma RII-b; Fc-Gamma-RIIb; FcRII-b; CD32; FCGR2B; FCG2; IGFR2	Human	HEK293
	Fc gamma RIIB/CD32b protein is a low-affinity receptor for immunoglobulin gamma and plays a key role in immune responses. It mediates phagocytosis of immune complexes and regulates antibody production by B cells. Fc gamma RIIB/CD32b Protein, Human (HEK293, HSA-His) is the recombinant human-derived Fc gamma RIIB/CD32b protein, expressed by HEK293, with C-HSA and C-His labeled tag.

HY-P704599

	*Fc gamma RIIB/CD32b Protein, Human (HEK293, SUMO, His)* Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b; IgG Fc Receptor II-b; CDw32; Fc-Gamma RII-b; Fc-Gamma-RIIb; FcRII-b; CD32; FCGR2B; FCG2; IGFR2	Human	HEK293
	Fc gamma RIIB/CD32b protein is a low-affinity receptor for immunoglobulin gamma and plays a key role in immune responses. It mediates phagocytosis of immune complexes and regulates antibody production by B cells. Fc gamma RIIB/CD32b Protein, Human (HEK293, SUMO, His) is the recombinant human-derived Fc gamma RIIB/CD32b protein, expressed by HEK293, with N-SUMO and C-His labeled tag.

HY-P704600

	*Fc gamma RIIB/CD32b Protein, Human (HEK293, Twin Strep)* Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b; IgG Fc Receptor II-b; CDw32; Fc-Gamma RII-b; Fc-Gamma-RIIb; FcRII-b; CD32; FCGR2B; FCG2; IGFR2	Human	HEK293
	Fc gamma RIIB/CD32b protein is a low-affinity receptor for immunoglobulin gamma and plays a key role in immune responses. It mediates phagocytosis of immune complexes and regulates antibody production by B cells. Fc gamma RIIB/CD32b Protein, Human (HEK293, Twin Strep) is the recombinant human-derived Fc gamma RIIB/CD32b protein, expressed by HEK293, with C-Twin-Strep labeled tag.

HY-P704959

	*Fc gamma RIIB/CD32b Protein, Cynomolgus (179a.a, HEK293, C-His)* Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b; IgG Fc Receptor II-b; CDw32; Fc-Gamma RII-b; Fc-Gamma-RIIb; FcRII-b; CD32; FCGR2B; FCG2; IGFR2	Cynomolgus	HEK293

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81870

	CD32B Antibody (YA1615) Fc fragment of IgG; low affinity IIb; receptor (CD32); CD32; FCG2; CD32b; FCGR2; IGFR2	WB, IHC-P	Human, Rat
	CD32B Antibody (YA1615) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1615), targeting CD32B, with a predicted molecular weight of 34 kDa (observed band size: 44 kDa). CD32B Antibody (YA1615) can be used for WB, IHC-P experiment in human, rat background.

HY-P84987

	CD32B Antibody (YA4679) CD32 antibody; CD32 antigen antibody; CD32b antibody; CDw32 antibody; Fc fragment of IgG; low affinity II; receptor for; CD32; antibody; Fc fragment of IgG; low affinity IIb; receptor antibody; Fc fragment of IgG; low affinity IIb; receptor; CD32; antibody; Fc fragment of IgG; low affinity IIb; receptor for; CD32; antibody; Fc fragment of IgG; low affinity IIb; receptor for antibody; Fc gamma receptor IIB antibody; Fc gamma RII antibody; Fc gamma RIIB antibody; Fc-gamma RII antibody; Fc-gamma RII-b antibody; Fc-gamma-RIIb antibody; FCG2 antibody; FCG2B_HUMAN antibody; Fcgr2 antibody; FCGR2B antibody; FCRII antibody; FcRII-b antibody; IGFR2 antibody; IgG Fc receptor II beta antibody; IgG Fc receptor II-b antibody; Low affinity immunoglobulin gamma Fc region receptor II antibody; Low affinity immunoglobulin gamma Fc region receptor II-b antibody; Ly-17 antibody; Lym 1 antibody; Lymphocyte antigen 17 antibody; CD32 nanobody;	ELISA, FC	Human
	CD32B Antibody (YA4679) is a mouse-derived and non-conjugated monoclonal antibody, targeting to CD32. It can be applicated for ELISA, FC assays, in the background of human.

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Cat. No.	Product Name		Classification

HY-RS04829

FCGR2B Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FCGR2B Human Pre-designed siRNA Set A contains three designed siRNAs for FCGR2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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