CD221

By Targets:	IGF-1R (4) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (3) Inflammation/Immunology (2)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990084

Veligrotug	IGF-1R	Cancer
Veligrotug is an IgG1-kappa, anti-IGF1R (insulin-like growth factor 1 receptor, CD221) chimeric monoclonal antibody .

HY-P991253

BIIB022	IGF-1R	Cancer
BIIB022 is a human IgG4 monoclonal antibody (mAb) targeting *IGF1R/CD221*. BIIB022 blocks IGF-1 and IGF-2-induced phosphorylation of IGF-1R and downstream substrates. BIIB022 can be used in lung, pancreatic, and colon cancer research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .

HY-P991457

AVE1642	IGF-1R	Cancer
AVE1642 is a human IgG monoclonal antibody (mAb) targeting *CD221/IGF1R*. AVE1642 delays growth of tumour xenografts and prolongs the survival of tumour-bearing nude mice. AVE1642 can be used in advanced solid tumours research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991255

VRDN-002	IGF-1R	Inflammation/Immunology
VRDN-002 is a human monoclonal antibody (mAb) targeting *IGF1R/CD221*. VRDN-002 reduces inflammation and proptosis in thyroid eye disease (TED). VPI-2690B can be used in Graves ophthalmopathy research .

HY-RS06615

IGF1R Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IGF1R Human Pre-designed siRNA Set A contains three designed siRNAs for IGF1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IGF1R Human Pre-designed siRNA Set A IGF1R Human Pre-designed siRNA Set A

HY-RS06616

Igf1r Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Igf1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igf1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Igf1r Mouse Pre-designed siRNA Set A Igf1r Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P990084

Veligrotug	IGF-1R	Cancer
Veligrotug is an IgG1-kappa, anti-IGF1R (insulin-like growth factor 1 receptor, CD221) chimeric monoclonal antibody .

HY-P990440

*Anti-IGF1R/CD221* Antibody**	Inhibitory Antibodies	Inflammation/Immunology
Anti-IGF1R/CD221 Antibody is a CHO-expressed human antibody that targets *IGF1R/CD221. Anti-IGF1R/CD221* Antibody contains huIgG1 heavy chains and huκ light chains, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-IGF1R/CD221 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991253

BIIB022	IGF-1R	Cancer
BIIB022 is a human IgG4 monoclonal antibody (mAb) targeting *IGF1R/CD221*. BIIB022 blocks IGF-1 and IGF-2-induced phosphorylation of IGF-1R and downstream substrates. BIIB022 can be used in lung, pancreatic, and colon cancer research. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .

HY-P991457

AVE1642	IGF-1R	Cancer
AVE1642 is a human IgG monoclonal antibody (mAb) targeting *CD221/IGF1R*. AVE1642 delays growth of tumour xenografts and prolongs the survival of tumour-bearing nude mice. AVE1642 can be used in advanced solid tumours research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991255

VRDN-002	IGF-1R	Inflammation/Immunology
VRDN-002 is a human monoclonal antibody (mAb) targeting *IGF1R/CD221*. VRDN-002 reduces inflammation and proptosis in thyroid eye disease (TED). VPI-2690B can be used in Graves ophthalmopathy research .

Species:	Human (7) Mouse (1) Rat (1) Cynomolgus (1)
Tag:	His (9) Avi (2) GST (1) Fc (1)
Source:	HEK293 (8) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72606

	IGF-I R Protein, Human (HEK293, His) Insulin-like growth factor 1 receptor; IGF-I receptor; IGF1R; CD221	Human	HEK293
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (HEK293, His) is the recombinant human-derived IGF-I R protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74442

	IGF-I R Protein, Human (HEK293, His, solution) Insulin-like growth factor 1 receptor; IGF-I receptor; CD221; IGF1R	Human	HEK293
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (HEK293, His, solution) is the recombinant human-derived IGF-I R protein, expressed by HEK293 , with C-His labeled tag.

HY-P78723

	IGF-I R Protein, Mouse (HEK293, His) 1 Publications Verification IGF1R; IGFR; JTK13; CD221; MGC142170; MGC142172; MGC18216	Mouse	HEK293
	The IGF-I R protein is a receptor tyrosine kinase that mediates the effects of insulin-like growth factor 1 (IGF1) and has high affinity for IGF1. Upon ligand binding, IGF1R is activated, leading to autophosphorylation and tyrosine phosphorylation of substrates, including IRS1/2, Shc, and 14-3-3 proteins. IGF-I R Protein, Mouse (HEK293, His) is the recombinant mouse-derived IGF-I R protein, expressed by HEK293 , with C-His labeled tag.

HY-P78724

	IGF-I R Protein, Rat (HEK293, His) IGF1R; IGFR; JTK13; CD221; MGC142170; MGC142172; MGC18216	Rat	HEK293
	Igf1r Protein, a cell surface receptor, is involved in growth regulation and development. Dysregulation of Igf1r Protein has been linked to diseases like cancer and growth disorders. Targeting Igf1r Protein may offer potential therapeutic interventions in these conditions by modulating cell growth, inhibiting tumor progression, and managing growth-related disorders. IGF-I R Protein, Rat (HEK293, His) is the recombinant rat-derived IGF-I R protein, expressed by HEK293 , with C-His labeled tag.

HY-P72256

	IGF-I R Protein, Human (His) CD221; CD221 antigen ; IGF 1 receptor; IGF 1R; IGF I receptor; IGF-I receptor; Igf1r; IGF1R_HUMAN; IGFIR; IGFIRC; IGFR; Insulin like growth factor 1 receptor; Insulin like growth factor 1 receptor precursor; Insulin-like growth factor 1 receptor beta chain; Insulin-like growth factor I receptor; JTK13; MGC142170; MGC142172; MGC18216; Soluble IGF1R variant 1; Soluble IGF1R variant 2	Human	E. coli
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (His) is the recombinant human-derived IGF-I R protein, expressed by E. coli , with N-6*His labeled tag.

HY-P78458

	IGF-I R Protein, Human (HEK293, His-Avi) CD221; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216	Human	HEK293
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (HEK293, His-Avi) is the recombinant human-derived IGF-I R protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78142

	IGF-I R Protein, Human (Biotinylated, HEK293, His-Avi) CD221; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGFR; JTK13; MGC142170; MGC142172; MGC18216	Human	HEK293
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IGF-I R protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P73137

	IGF-I R Protein, Human (sf9, His-GST) Insulin-like growth factor 1 receptor; IGF-I receptor; CD221; IGF1R	Human	Sf9 insect cells
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (sf9, His-GST) is the recombinant human-derived IGF-I R protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P78586

	IGF-I R Protein, Cynomolgus (HEK293, His) IGF1R; IGFR; JTK13; CD221; MGC142170; MGC142172; MGC18216	Cynomolgus	HEK293
	The IGF-I R protein is a receptor tyrosine kinase that mediates the effects of insulin-like growth factor 1 (IGF1) and has high affinity for IGF1. Upon ligand binding, IGF1R is activated, leading to autophosphorylation and tyrosine phosphorylation of substrates, including IRS1/2, Shc, and 14-3-3 proteins. IGF-I R Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IGF-I R protein, expressed by HEK293 , with C-His labeled tag.

HY-P704676

	IGF-I R Protein, Human (HEK293, Fc) Insulin-like growth factor 1 receptor; IGF-I receptor; IGF1R; CD221	Human	HEK293
	IGF-I receptor (IGF1R) mediates insulin-like growth factor effects, binding strongly to IGF1. Activation triggers PI3K-AKT/PKB and Ras-MAPK pathways, influencing cell survival, protein synthesis, and proliferation. IGF1R also signals through JAK/STAT, inhibiting JNK activation. Hybrid receptors show variable binding to IGF1 and insulin. IGF-I R Protein, Human (HEK293, Fc) is the recombinant human-derived IGF-I R protein, expressed by HEK293, with C-hFc labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80717

	IGF1 Receptor Antibody (YA351) IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221	WB, IHC-P	Human
	IGF1 Receptor Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 155 kDa, targeting to IGF1 Receptor. It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P80825

	Phospho-IGF1 Receptor (Tyr1166) Antibody (YA186) IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221	WB, IP	Human, Mouse, Rat
	Phospho-IGF1 Receptor (Tyr1166) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 155 kDa, targeting to Phospho-IGF1 Receptor (Tyr1166). It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P85213

	IGF-1R Antibody (YA4905) IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221	WB, IHC-P, ICC/IF, ELISA	Human
	IGF-1R Antibody (YA4905) is a mouse-derived and non-conjugated monoclonal antibody, targeting to IGF-1R. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

HY-P85214

	IGF-1R Antibody (YA4906) IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221	WB, IHC-P, ICC/IF, ELISA	Human
	IGF-1R Antibody (YA4906) is a mouse-derived and non-conjugated monoclonal antibody, targeting to IGF-1R. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

HY-P86629

	IGF-1R Antibody (YA6321) IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221	WB, IHC-P, ICC/IF, IP, ELISA	Human
	IGF-1R Antibody (YA6321) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGF-1R. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human.

HY-P86076

	Phospho-IGF1R(Tyr1135/1136)/Insulin Receptor β(Tyr1150/1151) Antibody (YA5768) IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221; INSR; Insulin receptor; IR; CD antigen CD220	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-IGF1R(Tyr1135/1136)/Insulin Receptor β(Tyr1150/1151) Antibody (YA5768) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to phosphorylated IGF1R (Tyr1135/1136)/Insulin Receptor β (Tyr1150/1151). It can be applicated for WB, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS06615

IGF1R Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IGF1R Human Pre-designed siRNA Set A contains three designed siRNAs for IGF1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06616

Igf1r Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Igf1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igf1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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