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CC-chemokine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CCR (15) Ligands for Target Protein for PROTAC (1) mRNA (1) Reference Standards (2)
By Research Areas:	Cancer (6) Endocrinology (6) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	mRNA (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: CCR CXCR CX3CR1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100183

GSK2239633A	CCR	Inflammation/Immunology Endocrinology
GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [ ¹²⁵I]-TARC to human CCR4 with a pIC₅₀ of 7.96.

HY-U00064

AZD2098 4 Publications Verification	CCR	Inflammation/Immunology Endocrinology
AZD2098 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC₅₀s of 7.8, 8.0, 8.0 and 7.6 for human, rat, mouse and dog respectively, used for asthma research .

HY-101038A

ZK756326 dihydrochloride 1 Publications Verification	CCR	Endocrinology Cancer
ZK756326 dihydrochloride is a nonpeptide chemokine receptor agonist for the CC chemokine receptor CCR8.

HY-133073

CCR7 Ligand 1 1 Publications Verification CCR7-Cmp2105	CCR Ligands for Target Protein for PROTAC	Cancer
CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a K_d of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC₅₀ of 7.3 μM .

HY-103364A

C-021 dihydrochloride 2 Publications Verification	CCR	Inflammation/Immunology
C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC₅₀s of 140 nM and 39 nM, respectively. C-021 dihydrochloride effectively prevents human CCL22-derived [ ³⁵S]GTPγS from binding to the receptor with an IC₅₀ of 18 nM .

HY-103364

C-021 2 Publications Verification	CCR	Inflammation/Immunology
C-021 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 potently inhibits functional chemotaxis in human and mouse with IC₅₀s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [ ³⁵S]GTPγS from binding to the receptor with an IC₅₀ of 18 nM .

HY-101038

ZK 756326	CCR	Endocrinology Cancer
ZK756326 is a nonpeptide chemokine receptor agonist for the CC chemokine receptor CCR8.

HY-163761

LT166	CCR	Others
LT166 is a fluorescent ligand for CC chemokine receptor 1 (CCR1) with a K_D of 1.90 μM .

HY-112874

BMS-681	CCR	Neurological Disease Inflammation/Immunology Cancer
BMS-681 is an orthosteric antagonist of CC chemokine receptor 2 (CCR2). BMS-681 restricts the movement of the extracellular end of TM6 by stabilizing TM7. TM7 and TM6 are the main components of the orthosteric binding site. BMS-681 can be used to study inflammatory neurodegenerative diseases and cancer .

HY-125836

CCR4 antagonist 2	CCR	Endocrinology Cancer
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits T_reg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC₅₀ values of Ca ²⁺flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively .

HY-157453

CCR4 antagonist 4 1 Publications Verification	CCR	Inflammation/Immunology
CCR4 antagonist 4 (compound 22) is a selective and potent antagonist of the CC chemokine receptor-4 (CCR4), with an IC₅₀ of 0.02 μM. CCR4 antagonist 4 also blocks MDC-mediated chemotaxis (IC₅₀: 0.007 μM) and Ca ²⁺ mobilization (IC₅₀: 0.003 μM). CCR4 antagonist 4 can be used for allergic inflammation research .

HY-103364AR

C-021 dihydrochloride (Standard)	Reference Standards CCR	Inflammation/Immunology
C-021 (dihydrochloride) (Standard) is the analytical standard of C-021 (dihydrochloride). This product is intended for research and analytical applications. C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 dihydrochloride effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM .

HY-103364R

C-021 (Standard)	Reference Standards CCR	Inflammation/Immunology
C-021 (Standard) is the analytical standard of C-021. This product is intended for research and analytical applications. C-021 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM .

HY-174744

Human CCR4 mRNA	mRNA	Inflammation/Immunology
Human CCR4 mRNA encodes the human C-C motif chemokine receptor 4 (CCR4) protein, a member of G protein-coupled receptors family. CCR4 is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

HY-121885

LMD-009 2 Publications Verification	CCR	Metabolic Disease Endocrinology
LMD-009 is a selective CCR8 nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC₅₀s from 11 to 87 nM .

HY-153670

IPG7236	CCR	Cancer
IPG7236 is a selective and orally active CC chemokine receptor 8 (CCR8) antagonist with an IC₅₀ of 24 nM in a Tango assay. IPG7236 effectively inhibits the downstream signaling of CCR8 induced by CCL1 (IC₅₀ = 8.44 nM), CCL1-induced downstream signaling in the CCR8-overexpressing cells (IC₅₀ = 24.3 nM), and CCL1-induced CCR8 ⁺ Treg cells’ migration (IC₅₀ = 33.8 nM) .IPG7236 demonstrates an anti-cancer effect via up-regulating T_reg and down-regulating cytotoxic T (CD8 ⁺ T) cells. IPG7236 can used for the study of breast cancer .

Species:	Human (8) Mouse (2)
Tag:	His (5) Tag Free (5) Myc (1)
Source:	HEK293 (3) E. coli Cell-free (1) P. pastoris (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P7759

	TARC/CCL17 Protein, Human (HEK293, His) 1 Publications Verification rHuCCL17, His; C-C motif chemokine 17; CC chemokine TARC; Small-inducible cytokine A17; Thymus and activation-regulated chemokine; CCL17; SCYA17; TARC	Human	HEK293
	TARC/CCL17 Protein, Human (HEK293, His) is the first CC chemokine identified to interact with T cells with high affinity and bind to the CCR4 receptor to mediate inflammation, cancer, and autoimmune related diseases. TARC/CCL17 Protein, Human (HEK293, His) is a recombinant human TARC/CCL17(A24-S94) protein expressed by HEK293 with a his tag at C end.

HY-P7767

	CTACK/CCL27 Protein, Human 1 Publications Verification rHuCCL27; C-C Motif chemokine 27; CC chemokine ILC; Cutaneous T-Cell-Attracting chemokine; CTACK; Eskine; IL-11 R-Alpha-Locus chemokine; Skinkine; Small-Inducible Cytokine A27; CCL27; ILC; SCYA27	Human	E. coli
	CTACK/CCL27 Protein, Human is a CC chemokine that binds to the chemokine receptor CCR10, attracts skin-associated memory T lymphocytes, mediates lymphocyte homing to skin sites, and plays a key role in skin inflammation. CTACK/CCL27 Protein, Human a recombinant human CTACK/CCL27 (F25-G112) protein expressed by E. coli.

HY-P71894

	CTACK/CCL27 Protein, Mouse CCl27; Ilc; Scya27C-C motif chemokine 27; CC chemokine ILC; Cutaneous T-cell-attracting chemokine; CTACK; ESkine; IL-11 R-alpha-locus chemokine; ALP; mILC; Skinkine; Small-inducible cytokine A27	Mouse	E. coli
	CTACK/CCL27 protein attracts skin-associated memory T-lymphocytes, mediating lymphocyte homing to the skin. It may also participate in embryonic cell migration. Nuclear forms of CCL27 induce cytoskeletal relaxation. The protein binds to CCR10, exists in monomeric, dimeric, and tetrameric forms, and heparin promotes oligomerization. Additionally, CCL27 interacts with TNFAIP6 through its Link domain. CTACK/CCL27 Protein, Mouse is the recombinant mouse-derived CTACK/CCL27 protein, expressed by E. coli , with tag free.

HY-P79264

	CTACK/CCL27 Protein, Mouse C-C motif chemokine 27; CC chemokine ILC; IL-11 R-alpha-locus chemokine; cutaneous T-cell-attracting chemokine; skinkine; skinskine; small inducible cytokine A27a; ALP; ILC; CTAK; CTACK; CCl27; PESKY; ESkine; Scya27; Scya27a; AW558992	Mouse	E. coli
	CTACK/CCL27 protein plays a crucial role in chemokine activity and cell chemotaxis. It regulates T cell chemotaxis and actin cytoskeletal reorganization, suggesting its involvement in immune responses and cell motility. CTACK/CCL27 Protein, Mouse is the recombinant mouse-derived CTACK/CCL27 protein, expressed by E. coli , with tag free.

HY-P702526

	MIP-3 beta/CCL19 Protein, Human beta chemokine exodus-3; Beta-chemokine exodus-3; CC chemokine ligand 19; C-C motif chemokine 19; CCL19; chemokine (C-C motif) ligand 19; CKb11; EBI1-ligand chemokine; ELC; ELCMIP-3-beta; Epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; Macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; MGC34433; MIP3 beta; MIP-3 beta; MIP-3b; MIP3BCK beta-11; SCYA19EBI1 ligand chemokine; small inducible cytokine subfamily A (Cys-Cys), member 19; Small-inducible cytokine A19	Human	E. coli
	The MIP-3 beta/CCL19 protein exhibits multifaceted effects affecting lymphocyte recycling, homing, and immune responses. It is involved in T cell trafficking in the thymus and guides T cells and B cells to secondary lymphoid organs by binding to CCR7. MIP-3 beta/CCL19 Protein, Human is the recombinant human-derived MIP-3 beta/CCL19 protein, expressed by E. coli , with tag free.

HY-P700400

	CCR8 Protein-VLP, Human (HEK293, His) CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; CCR-8; CKRL1; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973	Human	HEK293
	CCR8 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

HY-P700543

	CCR8 Protein, Human (P. pastoris, His, Myc) CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; CCR-8; CKRL1; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973	Human	P. pastoris
	CCR8 Protein-VLP, a receptor for CCL1/SCYA1/I-309, may regulate monocyte chemotaxis and thymic cell line apoptosis. It also acts as an alternative coreceptor with CD4 for HIV-1 infection, facilitating viral entry. The interaction with CCL1 highlights its role in mediating cellular responses to this chemokine, implying a regulatory function in immune and inflammatory processes. CCR8 Protein, Human (P. pastoris, His) is the recombinant human-derived CCR8 protein, expressed by P. pastoris , with C-Myc, C-6*His labeled tag.

HY-P7767A

	CTACK/CCL27 Protein, Human (His) rHuCCL27; C-C Motif chemokine 27; CC chemokine ILC; Cutaneous T-Cell-Attracting chemokine; CTACK; Eskine; IL-11 R-Alpha-Locus chemokine; Skinkine; Small-Inducible Cytokine A27; CCL27; ILC; SCYA27	Human	E. coli
	CTACK/CCL27 protein selectively attracts skin-associated memory T-lymphocytes, mediating their homing to cutaneous sites through CCR10 binding. Crucial for skin immunity regulation, CCL27 exists as a monomer, dimer, and tetramer, with heparin promoting its oligomerization. Interaction with TNFAIP6, particularly through its Link domain, implies regulatory roles in skin immune responses and inflammation within the skin microenvironment. CTACK/CCL27 Protein, Human (His) is the recombinant human-derived CTACK/CCL27 protein, expressed by E. coli , with N-His labeled tag.

HY-P700378

	ACKR2 Protein, Human (Cell-Free, His) ACKR2; atypical chemokine receptor 2; CCBP2; chemokine binding protein 2; CMKBR9; chemokine-binding protein 2; CCR9; CCR10; D6; chemokine receptor D6; chemokine receptor CCR-9; C-C chemokine receptor D6; chemokine receptor CCR-10; chemokine (C-C) receptor 9; chemokine-binding protein D6; chemokine (C-C motif) receptor 9; CC-chemokine-binding receptor JAB61; hD6; MGC126678; MGC138250	Human	E. coli Cell-free
	The ACKR2 protein is an atypical chemokine receptor that controls chemokine levels and localization through high-affinity binding. ACKR2 (also known as interceptor or decoy receptor) operates independently, interacts with multiple chemokines, and triggers β-arrestin 1-dependent signaling pathways. ACKR2 Protein, Human (Cell-Free, His) is the recombinant human-derived ACKR2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P704790

	MIP-3 beta/CCL19 Protein, Human (HEK293) beta chemokine exodus-3; Beta-chemokine exodus-3; CC chemokine ligand 19; C-C motif chemokine 19; CCL19; chemokine (C-C motif) ligand 19; CKb11; EBI1-ligand chemokine; ELC; ELCMIP-3-beta; Epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; Macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; MGC34433; MIP3 beta; MIP-3 beta; MIP-3b; MIP3BCK beta-11; SCYA19EBI1 ligand chemokine; small inducible cytokine subfamily A (Cys-Cys), member 19; Small-inducible cytokine A19	Human	HEK293
	The MIP-3 beta/CCL19 protein exhibits multifaceted effects affecting lymphocyte recycling, homing, and immune responses. It is involved in T cell trafficking in the thymus and guides T cells and B cells to secondary lymphoid organs by binding to CCR7. MIP-3 beta/CCL19 Protein, Human (HEK293) is the recombinant human-derived MIP-3 beta/CCL19 protein, expressed by HEK293, with tag free.

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HY-P81143

	CCR7 Antibody 1 Publications Verification CCR7_HUMAN; BLR 2; BLR2; C C chemokine receptor type 7; C C CKR 7; CC chemokine receptor 7; CC chemokine receptor type 7; CC CKR 7; CCCKR7; CCR 7; CD 197; CD197; CD197 antigen; CDW197; chemokine C C motif receptor 7; chemokine C C receptor 7; chemokine receptor 7-like protein; EBI 1; EBI1; Ebi1h; EBV Induced G Protein Coupled Receptor 1; Epstein Barr virus induced G protein coupled receptor; Epstein Barr virus induced gene 1; EVI 1; EVI1; Lymphocyte Specific G Protein Coupled Peptide Receptor; MGC108519; MIP 3 beta receptor; MIP3 Beta Receptor.	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	CCR7 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to CCR7.

HY-P80385

	CCR2 Antibody (YA548) 1 Publications Verification C C chemokine receptor type 2 antibody; C C CKR 2 antibody; C-C chemokine receptor type 2 antibody; C-C CKR-2 antibody; CC chemokine receptor type 2 antibody; CC CKR 2 antibody; CC-CKR-2 antibody; CCCKR2 antibody; CCR 2 antibody; CCR-2 antibody; CCR1L antibody; CCR2 antibody; CCR2_HUMAN antibody; CCR2A antibody; CCR2B antibody; CCR5L antibody; CD192 antibody; CD192 antigen antibody; chemokine C C motif receptor 2 antibody; chemokine CC Motif Receptor 2 antibody; CKR 2 antibody; CKR2 antibody; CKR2A antibody; CKR2B antibody; CMKBR2 antibody; MCP 1 R antibody; MCP-1-R antibody; MCP1 RECEPTOR antibody; MCP1R antibody; Monocyte chemoattractant protein 1 receptor antibody; Monocyte Chemotactic Protein 1 Receptor antibody; Monocyte Chemotactic Protein 1 Receptor antibody	WB, IHC-P, IP, FC	Human
	CCR2 Antibody (YA548) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CCR2.

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HY-174744

Human CCR4 mRNA		mRNA
Human CCR4 mRNA encodes the human C-C motif chemokine receptor 4 (CCR4) protein, a member of G protein-coupled receptors family. CCR4 is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

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