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Results for "

Bromine

" in MedChemExpress (MCE) Product Catalog:

32

Inhibitors & Agonists

4

Biochemical Assay Reagents

2

Natural
Products

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W032015
    1-Bromooctane

    n-Octyl Bromide

    		 Biochemical Assay Reagents Others
    1-Bromooctane (n-Octyl Bromide) posesses a terminal bromine. The bromine is a very good leaving group for nucleophilic substitution reactions.
    1-Bromooctane
  • HY-124284
    Hexamethylene bisacetamide

    HMBA

    		 Apoptosis p38 MAPK Akt NF-κB Notch Bcl-2 Family MDM-2/p53 Epigenetic Reader Domain Neurological Disease Metabolic Disease Cancer
    Hexamethylene bisacetamide (HMBA) is a differentiation inducer and selective bromine domain inhibitor that can differentiate across the blood-brain barrier. Hexamethylene bisacetamide can induce tumor cell differentiation and inhibit cell proliferation, showing antitumor activity. Hexamethylene bisacetamide induces apoptosis by Notch1, Bcl-2 and p53 signaling pathways. In addition, Hexamethylene bisacetamide improves the obesity phenotype of mice .
    Hexamethylene bisacetamide
  • HY-W016455
    6-Bromo-1-hexanol

    		Biochemical Assay Reagents Others
    6-Bromo-1-hexanol posesses a terminal bromine and hydroxylic group. The bromine is a very good leaving group for nucleophilic substitution reactions. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
    6-Bromo-1-hexanol
  • HY-163729
    I-BET787

    		Epigenetic Reader Domain Inflammation/Immunology
    I-BET787 is a pan-BET bromine domain inhibitor with oral activity. I-BET787 shows effectiveness in a mouse model of inflammation .
    I-BET787
  • HY-172117
    Boc-methylglycine-C2-bromine

    		PROTAC Linkers Cancer
    Boc-methylglycine-C2-bromine is a PROTAC linker.Boc-methylglycine-C2-bromine can be used to synthesize PROTAC molecules like PROTAC SMARCA2 degrader-24 (HY-169275) .
    Boc-methylglycine-C2-bromine
  • HY-169372
    (S,R,S)-AHPC-CO-C4-bromine

    		E3 Ligase Ligand-Linker Conjugates Cancer
    (S,R,S)-AHPC-CO-C4-bromine is an E3 Ligase Ligand-linker Conjugate for PROTAC synthesis. (S,R,S)-AHPC-CO-C4-bromine is composed of an E3 Ligase Ligand (HY-125845) and a linker
    (S,R,S)-AHPC-CO-C4-bromine
  • HY-169397
    Thalidomide-NH-CH2-CONH-C2-PEG-bromine

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-NH-CH2-CONH-C2-PEG-bromine is a conjugate of the E3 ligase ligand and the linker, that can be used for synthesis of PROTAC degrader SK-3-91 (HY-137341) .
    Thalidomide-NH-CH2-CONH-C2-PEG-bromine
  • HY-W800806
    Heptyl 8-bromooctanoate

    		Biochemical Assay Reagents Others
    Heptyl 8-bromooctanoate is an ester compound that has a terminal bromine. Heptyl 8-bromooctanoate is formed by coupling 8-Bromooctanoic acid to Heptanol. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions.
    Heptyl 8-bromooctanoate
  • HY-W008629
    (E, E)-Farnesyl bromide

    		Biochemical Assay Reagents Others
    (E,E)-Farnesyl bromine is a synthetic substrate that is used to study the enzyme guanine nucleotide-binding protein (G protein) in vitro.
    (E, E)-Farnesyl bromide
  • HY-W190881
    N3-PEG11-CH2CH2Br

    		Biochemical Assay Reagents Others
    N3-PEG11-CH2CH2Br is a PEG linker containing a bromine and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions.
    N3-PEG11-CH2CH2Br
  • HY-126965
    Lipid Y

    		Biochemical Assay Reagents Others
    Lipid Y is a potent monosaccharide which contains two bromines per chain. lipid Y binds to a tryptophan residue in a membrane protein and then quenches the fluorescence of the tryptophan residue .
    Lipid Y
  • HY-117690
    dBRD9

    		PROTACs Epigenetic Reader Domain Cancer
    dBRD9,a PROTAC, can selective degrades BRD9. dBRD9 improves the bromine domain binding profile and reduces the binding activity of the whole BET family .
    dBRD9
  • HY-148739
    dBRD 9-A

    		PROTACs Epigenetic Reader Domain Cancer
    dBRD 9-A is a PROTAC which can selective degrade BRD9. dBRD 9-A improves the bromine domain binding profile and reduces the binding activity of the whole BET family .
    dBRD 9-A
  • HY-W021597
    N-Boc-5-bromoindole

    		Drug Intermediate Others
    N-Boc-5-bromoindole is formed as an intermediate for the synthesis of di-Boc-protected 5-aminoindole via a Buchwald-Hartwig amination with tBu-carbamate followed by regioselective bromination .
    N-Boc-5-bromoindole
  • HY-W453715
    Thalidomide-4-F,5-Br

    		Ligands for E3 Ligase Cancer
    Thalidomide-4-F,5-Br is a Thalidomide analogue. Thalidomide recruits E3 ligase for the ubiquitinylation and subsequent proteolysis of a target protein. This molecule may be derivatized through substitution at fluorine or bromine.
    Thalidomide-4-F,5-Br
  • HY-59299
    3-Bromothiophene

    3-Bromothiophene

    		 Biochemical Assay Reagents Others
    3-Bromothiophene is a bromine atom-substituted 3-halogenated thiophene with electrochemical stability, small porosity, and high π-π* lowest transition energy. 3-Bromothiophene is often used as a conductive polymer monomer .
    3-Bromothiophene
  • HY-W011238
    Oleyl bromide

    (Z)-1-Bromooctadec-9-ene

    		 Biochemical Assay Reagents Others
    Oleyl bromide ((Z)-1-Bromooctadec-9-ene) is a hydrophobic compound that can carry out ring-opening reaction through a process called "encapsulation". Oleyl bromine can also be used as the starting material in the synthesis of oleylphosphonates.
    Oleyl bromide
  • HY-130398
    Aerophobin-2

    		α-synuclein Neurological Disease
    Aerophobin-2 is a bromine compound, which can be isolated from sponge Verongia aerophoba. Aerophobin-2 inhibits aggregation of α-synuclein (α-syn) and phosphorylated α-synuclein (pSyn), exhibits neuroprotective efficacy .
    Aerophobin-2
  • HY-161711
    CBP/p300 ligand 5

    		Ligands for Target Protein for PROTAC Cancer
    CBP/p300 ligand 5 is the target protein ligand of XYD129 (HY-161710). CBP/p300 ligand 5 can be used to study the acute myelogenous leukemia .
    CBP/p300 ligand 5
  • HY-160662
    BRD4-IN-5

    		Epigenetic Reader Domain Cancer
    BRD4-IN-5 (example 51) is a BRD4 inhibitor. The Ki values of the two BRD4 domains BDI_K57-E168 and BDII_E352-M457 are 9.7 nM and 16.1 nM, respectively. BRD4-IN-5 can be used in cancer research .
    BRD4-IN-5
  • HY-W458018
    Thalidomide-4-Br,7-F

    		Ligands for E3 Ligase Cancer
    Thalidomide-4-Br,7-F is an E3 ligase activator featuring a bromine and a fluorine. E3 ligase is a protein that marks other proteins for proteolytic destruction by labeling them with ubiquitin. Both halogens may be substituted for further derivitization.
    Thalidomide-4-Br,7-F
  • HY-W586320
    Thalidomide-5-Br,6-F

    		Ligands for E3 Ligase Cancer
    Thalidomide-5-Br,6-F is a Thalidomide analogue. Thalidomide-5-Br,6-F is an activator of E3 ligase, which ubiquitinylates proteins for proteolysis. The structure may be further derivatized via substitution at fluorine or bromine.
    Thalidomide-5-Br,6-F
  • HY-Y0678
    1,3,5-Trimethoxybenzene

    TRIMETHYL PHLOROGLUCINOL

    		 Biochemical Assay Reagents Others
    1,3,5-Trimethoxybenzene (TRIMETHYL PHLOROGLUCINOL) is an electrophilic substitution reaction substrate targeting free chlorine (Cl +) and free bromine (Br +). 1,3,5-Trimethoxybenzene has highly selective electrophilic addition characteristics. By capturing halogens, it undergoes specific substitution reactions to generate stable halogenated products. 1,3,5-Trimethoxybenzene can not only quench residual oxidants, but also quantify the halogen concentration by detecting the product without affecting the stability of redox-sensitive disinfection byproducts (DBPs). 1,3,5-Trimethoxybenzene is mainly used in water quality testing and quantitative analysis of free chlorine/bromine in water. At the same time, in phytochemistry, it is a key component of rose fragrance and participates in the study of pollination attraction mechanism .
    1,3,5-Trimethoxybenzene
  • HY-162281
    PROTAC SOS1 degrader-6

    		PROTACs SOS1 Ras Cancer
    PROTAC SOS1 degrader-6 (compound 23) is an effective SOS1 PROTACs degrader that synergizes with KRAS G12C inhibitors . PROTAC SOS1 degrader-6 consists of the target protein ligand (red part) SOS1 Ligand intermediate-7 (HY-169371), E3 ubiquitin ligase ligand (blue part) (S,R,S)-AHPC (HY-125845), and PROTAC linker (black part) 5-Bromopentanoic acid (HY-W016456). Among them, the E3 ubiquitin ligase ligand + linker can form (S,R,S)-AHPC-CO-C4-bromine (HY-169372).
    PROTAC SOS1 degrader-6
  • HY-W076740
    8-Bromoadenine

    8-Bromo-9H-purin-6-amine

    		 DNA/RNA Synthesis Biochemical Assay Reagents Others
    8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium .
    8-Bromoadenine
  • HY-150239
    BAY-364

    BAY-299N

    		 DNA/RNA Synthesis Cancer
    BAY-364 (BAY-299N) is an inhibitor of the second bromine domain in TAF1. BAY-364 inhibits the TAF1 of Kasumi-1 cells, CD34 + cells and K562 cells with IC50 values of 1.0 µM, 10.4 µM and 10.0 µM respectively .
    BAY-364
  • HY-W591402
    3,4-Dibromo-Mal-PEG4-Acid

    		ADC Linker Cancer
    3,4-Dibromo-Mal-PEG4-acid is a site specific ADC linker with a dibromomaleimide group and an acid group. The dibromomaleimide group allows for two points of substitution due to the two bromine atoms. The carboxylic acid can react with primary amines in the presence of EDC and HATU to form a stable amide bond. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.
    3,4-Dibromo-Mal-PEG4-Acid
  • HY-W011972
    Bromocholine bromide

    		Biochemical Assay Reagents Others
    2-Bromo-N,N,N-trimethylethanaminium bromide is a quaternary ammonium salt consisting of a positively charged 2-bromo-N,N,N-trimethylethylamine cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It can also be used as a halogenating agent, for example in the bromination of olefins.
    Bromocholine bromide
  • HY-W394551
    Methyl 3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate

    		Biochemical Assay Reagents Others
    Methyl 3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a small pyrrolidone molecule which features two bromine atoms and a methyl ester. The unsaturated dibromo motif is a covalent ligand for thiol groups, and may be used to label cysteine residues in proteins. The presence of two leaving groups on this molecule allows this linker to bind two thiols at a time. The methyl ester can be saponified to link this molecule to amines to form larger structures.
    Methyl 3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate
  • HY-15929
    TBHBA

    2,4,6-Tribromo-3-hydroxybenzoic acid

    		 Biochemical Assay Reagents Others
    TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) is a chemical colorimetric agent and nanomaterial surface modifier. TBHBA can react with some oxidants (such as H2O2) to generate high-absorbance quinoneimine dyes, which enhance the sensitivity of HDL cholesterol enzymatic determination. TBHBA can be used as a bromine-containing coupling agent to modify the surface of silica nanoparticles through esterification reaction. Thereby, organic flame retardant groups are introduced to improve the thermal stability and flame retardant properties of nanocomposites. TBHBA can be used in clinical biochemical testing (such as serum lipoprotein analysis) and the preparation of flame-retardant polymer nanocomposites .
    TBHBA
  • HY-136794
    SB-284851-BT

    		p38 MAPK Epigenetic Reader Domain Inflammation/Immunology Cancer
    SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC50=1.7 µM), p38α (Kd=0.47 nM), BRDT (1) (IC50=18 µM) and BRD4 (1)(IC50=3.7 µM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates c-Myc and NF-κB gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET) .
    SB-284851-BT
  • HY-161483
    CBP/p300 ligand 3

    		Epigenetic Reader Domain Histone Acetyltransferase Neurological Disease Cancer
    CBP/p300 ligand 3 is a target protein ligand of CBPD-268 (HY-161369). CBP and p300 are two proteins with histone acetyltransferase (HAT) activity, and CBP and p300 play key roles in regulating biological processes such as gene expression, cell proliferation, differentiation and DNA repair. Through its acetyltransferase activity, CBP/p300 can acetylate histones and other proteins, thereby regulating chromatin structure and gene expression. CBP/p300 ligand 3 regulates the function of CBP/p300 by binding to a specific domain of the CBP/p300 protein (the bromine domain or HAT domain), inhibiting its enzyme activity or altering its interactions with other proteins (transcription factors). CBP/p300 ligand 3 can be used in cancer, neurodegenerative diseases and other disease models associated with abnormal CBP/p300 function .
    CBP/p300 ligand 3

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