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Results for "

Benzodiazepines

" in MedChemExpress (MCE) Product Catalog:

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Click Chemistry:	Azide (1) Alkynes (1)

183

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B2120

2-Amino-5-nitrobenzophenone Ro-7-19990	Biochemical Assay Reagents	Neurological Disease
2-Amino-5-nitrobenzophenone (Ro-7-19990) is a degradation of benzodiazepines. 2-Amino-5-nitrobenzophenone can be used for research and forensic applications .

HY-137994

Deschloroetizolam	Drug Derivative	Neurological Disease
Deschloroetizolam is a designer Benzodiazepine. Deschloroetizolam is a psychoactive substance, with physical and cognitive effects .

HY-124467

Difludiazepam Ro 07-4065	GABA Receptor	Neurological Disease
Difludiazepam (Ro 07-4065), a benzodiazepine, has binding affinity (0.613) to GABA_A receptors .

HY-133773

Desoxochlordiazepoxide	Biochemical Assay Reagents	Neurological Disease
Desoxochlordiazepoxide is a kind of benzodiazepine compound. Desoxochlordiazepoxide has anticonvulsant effect .

HY-114876

Desmethylflunitrazepam Norflunitrazepam; Ro 05-4435	Drug Metabolite	Neurological Disease
Desmethylflunitrazepam (Norflunitrazepam) is a compound from the benzodiazepine family and is an active metabolite of Flunitrazepam .

HY-111194

Ro 22-8515	GABA Receptor	Others
Ro 22-8515 is a ligand of Benzodiazepine receptor .

HY-137152

8-Aminoclonazolam	Drug Metabolite	Neurological Disease
8-Aminoclonazolam is a benzodiazepine and clonazolam metabolite .

HY-167658

Tuclazepam KC 1956	GABA Receptor	Neurological Disease
Tuclazepam (KC 1956) is a derivative of benzodiazepines that has anti-anxiety and sedative effects .

HY-103499

ZK 93426 hydrochloride	GABA Receptor	Neurological Disease
ZK 93426 (hydrochloride) is a benzodiazepine antagonist. ZK 93426 (hydrochloride) can be used for the research of neurological disease .

HY-106635

Suriclone RP31264	GABA Receptor	Neurological Disease
Suriclone (RP31264) is a GABA receptor agonist. Suriclone is an anxiolytic agent with a high affinity for the benzodiazepine receptors. Suriclone has oral activity .

HY-136471

Anticonvulsant agent 6	Drug Derivative	Neurological Disease
Anticonvulsant agent 6 (Compound V) is a benzodiazepine compound with anticonvulsant and central depressant effects .

HY-105056

Bretazenil Ro 16-6028	GABA Receptor	Neurological Disease
Bretazenil (Ro 16-6028) is a partial agonist at the gamma-aminobutyric acid A (GABA_A) receptor-linked benzodiazepine site. Bretazenil is potent benzodiazepine examined, exhibiting an IC₅₀ (concentration at which half-maximal inhibition of specific [35S]TBPS binding occurs) of 6.1 nM. Bretazenil shows an EC₅₀ of 10 nM for recombinant α1β1γ2. Anticonvulsant effects .

HY-167650

Fletazepam	GABA Receptor	Neurological Disease
Fletazepam is a benzodiazepine derivative with sedative, anxiolytic and muscle relaxant effects. Fletazepam can be utilized in neurological research .

HY-118259

L-663581 FG-8205	GABA Receptor	Neurological Disease
L-663581 (FG-8205) is an agonist of benzodiazepine receptor, acting as a partial agonist at GABA A receptor .

HY-135154

epi-Aszonalenin A	GABA Receptor	Neurological Disease
epi-Aszonalenin A is a benzodiazepine fungal metabolite originally isolated from Aspergillus novofumigatus. epi-Aszonalenin A can be used as a psychoactive agent .

HY-119605

DAA-1097	GABA Receptor	Neurological Disease
DAA-1097 is an orally active and selective agonist for the *peripheral benzodiazepine* receptor (PBR)**. DAA-1097 has anxiolytic effects .

HY-168363

Ciclotizolam WE-973	GABA Receptor	Neurological Disease
Ciclotizolam (WE-973) is a thienotriazolodiazepine with anticonvulsant and anti-aggressive activities. Ciclotizolam binds to benzodiazepine receptors in the central nervous system. Ciclotizolam decreases total sleep time in cats .

HY-106454

N-Desalkylflurazepam Norfludiazepam	Calcium Channel	Neurological Disease
N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC₅₀ values of 55 μM and 37 μM for Ca_v1.2 and Ca_v1.3, respectively .

HY-138014

Cinazepam	GABA Receptor	Neurological Disease
Cinazepam is a partial GABA_A receptor agonist and a benzodiazepine derivative with anxiolytic and sedative properties. Cinazepam can be utilized in research related to sleep disorders .

HY-103500

Ro19-4603	GABA Receptor	Neurological Disease
Ro19-4603 is a benzodiazepine inverse agonist. Ro19-4603 antagonizes ethanol (EtOH) intake in alcohol-preferring rats .

HY-106454R

N-Desalkylflurazepam (Standard) Norfludiazepam (Standard)	Reference Standards Calcium Channel	Neurological Disease
N-Desalkylflurazepam (Standard) is the analytical standard of N-Desalkylflurazepam. This product is intended for research and analytical applications. N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 values of 55 μM and 37 μM for Cav1.2 and Cav1.3, respectively .

HY-W274194

Antioxidant agent-7	Reactive Oxygen Species (ROS)	Others
Antioxidant agent-7 (SD-7) is a benzodiazepine derivative with antioxidant activity with an IC₅₀ value of 470 nM to scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical .

HY-U00199A

(S)-Norzopiclone (S)-N-Desmethyl zopiclone; SEP-174559	GABA Receptor nAChR iGluR	Neurological Disease
(S)-Norzopiclone ((S)-N-Desmethyl zopiclone; SEP-174559) is a metabolite of Zopiclone with anxiolytic and anticonvulsant effects. (S)-Norzopiclone has benzodiazepine-like actions at γ2-bearing subtypes of the GABA_A receptor and inhibits nACh and NMDA receptors .

HY-105791

Sulazepam	GABA Receptor	Inflammation/Immunology
Sulazepam, a benzodiazepine, is a selective ovarian cancer G protein-coupled receptor (OGR1) agonist. Sulazepam has anticonvulsive action and has the potential for airway hyperresponsiveness (AHR) research .

HY-101725

Meclonazepam Ro 11-3128; Ro 11-3128/002	Parasite	Infection Neurological Disease
Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect . Meclonazepam is active against immature S. mansoni. Meclonazepam (30 μM) eliminates 100% of immature parasites. Meclonazepam has a anti-schistosomal effect .

HY-103512

TP003	GABA Receptor	Neurological Disease
TP003 is a non-selective benzodiazepine site agonist with EC₅₀s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABA_A receptors .

HY-100369A

DMCM hydrochloride	GABA Receptor	Neurological Disease
DMCM hydrochloride is a nonselective full inverse agonist of *benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor* subtypes with K_is of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 receptors, respectively .

HY-101059

FGIN 1-27	GABA Receptor	Neurological Disease
FGIN 1-27, an indoleacetamide, is a specific *peripheral benzodiazepine* receptor (PBR) ligand with a K_i** of 5.0 nM. FGIN 1-27 can penetrate the blood brain barrier (BBB). FGIN 1-27 inhibits the onset of Isoniazid-induced convulsions .

HY-100369AR

DMCM hydrochloride (Standard)	Reference Standards GABA Receptor	Neurological Disease
DMCM (hydrochloride) (Standard) is the analytical standard of DMCM (hydrochloride). This product is intended for research and analytical applications. DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 ?receptors, respectively .

HY-101059R

FGIN 1-27 (Standard)	GABA Receptor Reference Standards	Neurological Disease
FGIN 1-27 (Standard) is the analytical standard of FGIN 1-27. This product is intended for research and analytical applications. FGIN 1-27, an indoleacetamide, is a specific peripheral benzodiazepine receptor (PBR) ligand with a Ki of 5.0 nM. FGIN 1-27 can penetrate the blood brain barrier (BBB). FGIN 1-27 inhibits the onset of Isoniazid-induced convulsions .

HY-W098756

Thionordiazepam Demethylsulazepam	Biochemical Assay Reagents	Neurological Disease
Thionordiazepam is a benzodiazepine compound and serves as an analytical reference standard for benzodiazepine-related psychoactive substances .

HY-101596

Ethyl dirazepate	GABA Receptor	Neurological Disease
Ethyl dirazepate is a agent which is a *benzodiazepine* derivative. It has anxiolytic and possibly other characteristic benzodiazepine properties.

HY-B0353

Chlormezanone	GABA Receptor	Neurological Disease
Chlormezanone resembles *benzodiazepine. The action of Chlormezanone is similar to benzodiazepine*-type agents. Chlormezanone is used as an anxiolytic and a muscle relaxant.

HY-U00192

CGP11952	GABA Receptor	Neurological Disease
CGP11952 is a triazolyl-Benzaphenon resembling the benzodiazepines in its pharmacological action. CGP11952 is an experimental *benzodiazepine* derivative.

HY-19945

DAA-1106 1 Publications Verification	GABA Receptor	Neurological Disease
DAA1106 is a potent and selective ligand for peripheral benzodiazepine receptor (PBR), as a potent and selective agonist at the peripheral benzodiazepine receptor.

HY-103476

Ro15-4513	GABA Receptor	Neurological Disease
Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR) . Ro15-4513 is a potent ethanol antagonist . Ro15-4513 has anti-anxiety effect . Ro15-4513 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-139264

Cloniprazepam	Drug Derivative	Neurological Disease
Cloniprazepam is a benzodiazepine .

HY-W749797

Nitrazolam	GABA Receptor	Neurological Disease
Nitrazolam is a benzodiazepine compound, that may exhibit CNS depressant properties as traditional benzodiazepines, including sedation, hypnosis, anxiolysis, and anticonvulsant effects, by acting on GABA receptors .

HY-13108

Bz 423 1 Publications Verification BZ48	Bcl-2 Family	Inflammation/Immunology
Bz 423 is a pro-apoptotic 1,4-benzodiazepine with therapeutic properties in murine models of lupus demonstrating selectivity for autoreactive lymphocytes, and activates Bax and Bak.

HY-U00241

Carburazepam RGH 3331; Uxepam	GABA Receptor	Neurological Disease
Carburazepam is a agent which derives from benzodiazepine. Benzodiazepines (BZD, BZs) are a class of psychoactive agents whose core chemical structure is the fusion of a benzene ring and a diazepine ring.

HY-A0164

Cinolazepam Gerodorm; OX 373	Drug Derivative	Neurological Disease
Cinolazepam (Gerodorm) is a benzodiazepine .

HY-100248

Sarmazenil Ro 15-3505	GABA Receptor	Neurological Disease
Sarmazenil is a benzodiazepine receptor antagonist.

HY-168358

4'-Fluoro diazepam	Drug Derivative	Others
4'-Fluoro diazepam is a 1,4-benzodiazepine compound. 4'-Fluoro diazepam is structurally similar to Diazepam, but its has only minimal biological activity .

HY-129901

1-Demethyl phenazolam	Drug Derivative	Neurological Disease
1-Demethyl phenazolam is a benzodiazepine.

HY-139367

α-Hydroxy flubromazolam	Drug Derivative	Neurological Disease
α-Hydroxy flubromazolam is a benzodiazepine.

HY-150343

(±)-3-Methyl nimetazepam	Drug Derivative	Neurological Disease
(±)-3-Methyl nimetazepam is a benzodiazepine.

HY-150349

(±)-3-Methyl nitrazepam	Drug Derivative	Neurological Disease
(±)-3-Methyl nitrazepam is a benzodiazepine.

HY-W753325

α-Hydroxy flualprazolam	Drug Metabolite	Neurological Disease
α-Hydroxy flualprazolam is a benzodiazepine.

HY-B0353R

Chlormezanone (Standard)	Reference Standards GABA Receptor	Neurological Disease
Chlormezanone (Standard) is the analytical standard of Chlormezanone. This product is intended for research and analytical applications. Chlormezanone resembles *benzodiazepine. The action of Chlormezanone is similar to benzodiazepine*-type agents. Chlormezanone is used as an anxiolytic and a muscle relaxant.

HY-121332

Cyclopeptine	Drug Intermediate	Infection
Cyclopeptine is an intermediate in the synthesis of benzodiazepine alkaloids in Penicillium.

Cat. No.	Product Name	Type

HY-163555

BZO/BSA

Biochemical Assay Reagents

BZO/BSA is an antigen-adjuvant conjugate formed by the coupling of BZO (benzodiazepine) with bovine serum albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the production of antigen-specific T cells.

Cat. No.	Product Name	Target	Research Area

HY-P2602

α-Casozepine	GABA Receptor	Neurological Disease
α-Casozepine is a bioactive peptide derived from the α protein S1 casein in milk and has an affinity for γ-aminobutyric acid (GABA) receptors in the brain. α-Casozepine has anti-anxiety effects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6648

Cirsimaritin	Structural Classification Flavonoids Flavones Leguminosae Source classification Phenols Polyphenols Abrus precatorius Linn. Plants	GABA Receptor
Cirsimaritin binds weakly to the benzodiazepine site on GABA_A receptors, with antidepressant, anxiolytic and antinociceptive activities.

HY-110399

Cirsiliol	Structural Classification Flavonoids Flavones Leguminosae Source classification Phenols Polyphenols Abrus precatorius Linn. Plants	Lipoxygenase
Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.

HY-Y0265

Isatin Indoline-2,3-dione	Cardiovascular Disease Alkaloids Structural Classification other families Neurological Disease Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids	Monoamine Oxidase Apoptosis
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

HY-N1951

Miltirone 1 Publications Verification Rosmariquinone	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Source classification Diterpenoids Plants	GABA Receptor Apoptosis Carboxylesterase (CES) SARS-CoV
Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC₅₀ of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; K_i = 0.04 μM) and SARS-CoV main protease (Mpro) .

HY-135154

epi-Aszonalenin A	Alkaloids Microorganisms Source classification	GABA Receptor
epi-Aszonalenin A is a benzodiazepine fungal metabolite originally isolated from Aspergillus novofumigatus. epi-Aszonalenin A can be used as a psychoactive agent .

HY-126788

Antibiotic DC 102 DC 102	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic
Antibiotic DC 102 is a new glycosidic pyrrole(1,4)benzodiazepine antibiotic with a MIC value of 42 μg/mL target Bacillus subtilis No. 10707. Antibiotic DC 102 has an LD₅₀ value of 1.5mg/mL(i.p) in mouse .

HY-116812

Sclerotigenin	Structural Classification Natural Products Microorganisms Source classification	Insecticide
Sclerotigenin is an anti-insect benzodiazepine compound identified in Penicillium sclerotigenum (NRRL 3461). Sclerotigenin exhibits significant anti-insect activity against crop pest Helicoverpa zea .

HY-110399R

Cirsiliol (Standard)	Structural Classification Flavonoids Flavones Leguminosae Source classification Phenols Polyphenols Abrus precatorius Linn. Plants	Lipoxygenase
Cirsiliol (Standard) is the analytical standard of Cirsiliol. This product is intended for research and analytical applications. Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.

HY-N6687R

Calcimycin (Standard) A-23187 (Standard); Antibiotic A-23187 (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Polyether Antibiotics	Oxidative Phosphorylation Reference Standards Bacterial Fungal Apoptosis Autophagy Antibiotic
N-Desalkylflurazepam (Standard) is the analytical standard of N-Desalkylflurazepam. This product is intended for research and analytical applications. N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 values of 55 μM and 37 μM for Cav1.2 and Cav1.3, respectively .

HY-Y0265R

Isatin (Standard) Indoline-2,3-dione (Standard)	Alkaloids Structural Classification other families Source classification Plants Indole Alkaloids	Reference Standards Monoamine Oxidase Apoptosis
Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

HY-101392

Harmane 1 Publications Verification	Alkaloids Structural Classification other families Source classification Pyridine Alkaloids Plants Indole Alkaloids	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-N7110

6-Hydroxyflavone 1 Publications Verification	Structural Classification Monophenols Flavonoids Classification of Application Fields Flavones Labiatae Source classification Phenols Plants Medicago truncatula Gaertn. Inflammation/Immunology Disease Research Fields	Akt ERK JNK GABA Receptor
6-Hydroxyflavone is an orally effective flavonoid compound. 6-Hydroxyflavone can inhibit LPS (HY-D1056) -induced NO production and has anti-inflammatory effects. 6-Hydroxyflavone promotes osteoblast differentiation by activating AKT, ERK 1/2 and JNK signaling pathways. 6-Hydroxyflavone has an inhibitory effect on bovine hemoglobin (BHb) glycosylation. 6-Hydroxyflavone has a kidney protective effect. In addition, 6-Hydroxyflavone enhances GABA-induced current through the Benzodiazepine sites of γ-aminobutyric acid (GABA_A) receptors. 6-Hydroxyflavone shows a clear preference for α2 - and α3 - subtypes, which play an anti-anxiety role .

HY-101392A

Harmane hydrochloride	Apocynaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants Rauwolfia canescens	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane hydrochloride is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

Cat. No.	Product Name	Chemical Structure

HY-B0548AS1

Hydroxyzine-d4' dihydrochloride
Hydroxyzine-d₄ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine?H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder .

HY-W740707

Midazolam 2,5-Dioxide-d6
Midazolam 2,5-Dioxide-d₆ is the deuterium labeled 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 2,5-DioxideMidazolam 2,5-Dioxide (HY-W776994).

HY-121877S

Valnoctamide-d5
Valnoctamide-d₅ is the deuterium labeled Valnoctamide. Valnoctamide (Valmethamide), a derivative of valproate, suppresses benzodiazepine-refractory status epilepticus. Valnoctamide (Valmethamide) acts directly on GABAA receptors .

HY-W740139

4-Hydroxy midazolam methanoate-d5
4-Hydroxy midazolam methanoate-d₅ is the deuterium labeled 4-Hydroxymidazolam (HY-100050). 4-Hydroxymidazolam is a major metabolite of Midazolam. Midazolam is a potent benzodiazepine with anxiolytic properties.

HY-139145S

Etbicyphat-13C3
Etbicyphat- ¹³C₃ is the ¹³C labeled Etbicyphat (HY-139145). Etbicyphat is a potent GABA(A) receptors competitive antagonist. Etbicyphat induces epileptiform activities in hippocampal CA1 neurons, and binds to the GABA(A)-benzodiazepine receptors .

HY-W740297

Methyl Clonazepam-d3
Methyl Clonazepam-d₃ is the deuterium labeled Methylclonazepam (HY-W399186). Methylclonazepam is a benzodiazepine with anxiolytic activity. Methylclonazepam inhibits the absorption of 5-hydroxytryptamine by Schistosoma mansoni. Methylclonazepam derivatives have anti-Schistosoma mansoni activity .

HY-B0548AS2

Hydroxyzine-d8 dihydrochloride
Hydroxyzine-d₈ (dihydrochloride) is the deuterium labeled Hydroxyzine dihydrochloride. Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine?H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder .

HY-A0198S

Adinazolam-d5
Adinazolam-d₅ (U 41123-d₅) is a deuterium labeled Adinazolam (HY-A0198). Adinazolam is a triazolobenzodiazepine. Adinazolam binds to peripheral-type benzodiazepine receptors which interact allosterically with GABA receptors. Adinazolam has dual anxiolytic and antidepressant activities .

HY-16579AS2

Etifoxine-d5
Etifoxine-d₅ is the deuterium labeled Etifoxine. Etifoxine, a non-benzodiazepine GABAergic compound, is a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. Etifoxine reveals anxiolytic and anticonvulsant properties in rodents .

HY-W701464

N-Desalkylflurazepam-d4
N-Desalkylflurazepam-d₄ is a deuterated labeled N-Desalkylflurazepam (HY-106454). N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC₅₀ values of 55 μM and 37 μM for Ca_v1.2 and Ca_v1.3, respectively .

HY-W700834

Harman-d3

Harman-d₃ is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-W777360

Harman-13C2,15N

Harman- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

Cat. No.	Product Name		Classification

HY-103476

Ro15-4513		Azide
Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR) . Ro15-4513 is a potent ethanol antagonist . Ro15-4513 has anti-anxiety effect . Ro15-4513 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-123249

HZ166		Alkynes
HZ166 is a GABAA receptor subtype-selective benzodiazepine site agonist with preferential activity at α2- and α3-GABAA receptors. HZ166 shows anti-hyperalgesic effects . HZ166 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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