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Pathways Recommended:	Apoptosis

Results for "

Apoptosis assay

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (24) Amyloid-β (1) Androgen Receptor (3) Antibiotic (2) Aurora Kinase (4) Bacterial (3) Bcl-2 Family (3) Caspase (2) E1/E2/E3 Enzyme (1) EGFR (1) Endogenous Metabolite (1) FLAP (2) Fluorescent Dye (2) HDAC (1) Histone Methyltransferase (4) HSV (1) IAP (1) Interleukin Related (1) MDM-2/p53 (1) MMP (1) NADPH Oxidase (1) NF-κB (1) PARP (1) PDK-1 (1) Ras (1) Reactive Oxygen Species (1) Reference Standards (2) Ser/Thr Protease (1) TAM Receptor (1)
By Research Areas:	Cancer (26) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (4) Neurological Disease (1)

By Targets:

Apoptosis (24)

Amyloid-β (1)

Androgen Receptor (3)

Antibiotic (2)

Aurora Kinase (4)

Bacterial (3)

Bcl-2 Family (3)

Caspase (2)

E1/E2/E3 Enzyme (1)

EGFR (1)

Endogenous Metabolite (1)

FLAP (2)

Fluorescent Dye (2)

HDAC (1)

Histone Methyltransferase (4)

HSV (1)

IAP (1)

Interleukin Related (1)

MDM-2/p53 (1)

MMP (1)

NADPH Oxidase (1)

NF-κB (1)

PARP (1)

PDK-1 (1)

Ras (1)

Reactive Oxygen Species (1)

Reference Standards (2)

Ser/Thr Protease (1)

TAM Receptor (1)

By Research Areas:

Cancer (26)

Cardiovascular Disease (1)

Infection (2)

Inflammation/Immunology (4)

Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

MCE Kits

Natural
Products

Targets Recommended: Biochemical Assay Reagents Apoptosis SNIPERs ASK1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10126

Barasertib-HQPA 5+ Cited Publications AZD2811; INH-34; AZD1152-HQPA	Aurora Kinase Apoptosis	Cancer
Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor with an IC₅₀ of 0.37 nM in a cell-free assay. Barasertib-HQPA (AZD2811) induces growth arrest and apoptosis in cancer cells .

HY-10515

BX-320	PDK-1	Cancer
BX-320 is a selective, ATP-competitive, orally acitive, and direct PDK1 inhibitor with an IC₅₀ of 30 nM in a direct kinase assay format. BX-320 also induces *apoptosis*. Anticancer effect .

HY-10127

Barasertib 15+ Cited Publications AZD1152	Aurora Kinase Apoptosis	Cancer
Barasertib (AZD1152), a pro-drug of Barasertib-hQPA, is a highly selective Aurora B inhibitor with an IC₅₀ of 0.37 nM in a cell-free assay. Barasertib (AZD1152) induces growth arrest and apoptosis in cancer cells .

HY-16999

RO8994	MDM-2/p53 E1/E2/E3 Enzyme Apoptosis	Cancer
RO8994 (Compound 4) is an orally active, highly potent and selective spiroindolinone p53-MDM2 inhibitor with an IC₅₀ value of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). RO8994 induces up-regulation of p53 expression and *Apoptosis* in wild-type p53 cancer cells. RO8994 also inhibits tumor growth in the tumor xenograft model .

HY-W004520

Phenazine methylsulfate 1 Publications Verification 5-Methylphenazinium methylsulfate	Bacterial Antibiotic Apoptosis	Cancer
Phenazine methylsulfate is a free radical generator that can act as an electron transfer reactant in cell viability assays. It also has insecticidal properties. Furthermore, Phenazine methylsulfate induces oxidative DNA damage and cell *apoptosis*, showing antitumor activity .

HY-18950

GSK2795039 60+ Cited Publications	NADPH Oxidase Reactive Oxygen Species Apoptosis	Cancer
GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC₅₀ of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption . GSK2795039 reduces *apoptosis* .

HY-10127A

Barasertib dihydrochloride AZD1152 dihydrochloride	Aurora Kinase Apoptosis	Cancer
Barasertib (AZD1152 dihydrochloride), a pro-drug of Barasertib-hQPA, is a highly selective Aurora B inhibitor with an IC₅₀ of 0.37 nM in a cell-free assay. Barasertib (AZD1152 dihydrochloride) induces growth arrest and apoptosis in cancer cells .

HY-145499

XTT sodium hydrate	Fluorescent Dye	Others
XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator. It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.

HY-149005

PRMT5-IN-19	Histone Methyltransferase	Cancer
PRMT5-IN-19 (Compound 41) is an selective orally active non-nucleoside PRMT5 inhibitor with IC₅₀ values of 23.9 nM (radioactive biochemical assay) and 47 nM (AlphaLISA assay). PRMT5-IN-19 can occupy the SAM-binding pocket in PRMT5 and block methyltransferase activity, which displays good selectivity over other PRMTs and PKMTs. PRMT5-IN-19 inhibits cell proliferation by inducing cell *apoptosis*, and can be used for cancer-related research .

HY-10127R

Barasertib (Standard) AZD1152 (Standard)	Reference Standards Aurora Kinase Apoptosis	Cancer
Barasertib (Standard) is the analytical standard of Barasertib. This product is intended for research and analytical applications. Barasertib (AZD1152), a pro-drug of Barasertib-hQPA, is a highly selective Aurora B inhibitor with an IC50 of 0.37 nM in a cell-free assay. Barasertib (AZD1152) induces growth arrest and apoptosis in cancer cells .

HY-15924

Thiazolyl Blue Maximum Cited Publications 134 Publications Verification MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide	Fluorescent Dye	Others
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .

HY-13803

Tazemetostat 65+ Cited Publications EPZ-6438; E-7438	Histone Methyltransferase Apoptosis	Cancer
Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a K_i value of 2.5 nM. Tazemetostat inhibits EZH2 with IC₅₀s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC₅₀ of 4 nM. Tazemetostat also inhibits EZH1 with an IC₅₀ of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells .

HY-W004520R

Phenazine methylsulfate (Standard) 5-Methylphenazinium methylsulfate (Standard)	Bacterial Antibiotic Apoptosis	Cancer
Phenazine (methylsulfate) (Standard) is the analytical standard of Phenazine (methylsulfate). This product is intended for research and analytical applications. Phenazine methylsulfate is a free radical generator that can act as an electron transfer reactant in cell viability assays. It also has insecticidal properties. Furthermore, Phenazine methylsulfate induces oxidative DNA damage and cell apoptosis, showing antitumor activity[1][2][3].

HY-151968

KRAS G12C inhibitor 57	Ras	Cancer
KRAS G12C inhibitor 57 (Compound 50) is a potent, selective, covalent and orally active KRAS G12C inhibitor with an IC₅₀ of 0.21 μM in KRAS G12C/SOS1 binding assay. KRAS G12C inhibitor 57 induces cancer cell *apoptosis* .

HY-13208

Xevinapant hydrochloride 5+ Cited Publications AT-406 hydrochloride; Debio 1143 hydrochloride; SM-406 hydrochloride	IAP Apoptosis	Cancer
Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). Xevinapant hydrochloride binds to XIAP, cIAP1, and cIAP2 proteins with K_is of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizes XIAP BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines. Xevinapant hydrochloride is highly effective in induction of *apoptosis* in xenograft tumors .

HY-10037

Quiflapon 1 Publications Verification MK-591	FLAP Apoptosis	Inflammation/Immunology
Quiflapon (MK-591) is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.6 nM in a FLAP binding assay. Quiflapon is also a potent and orally active Leukotriene biosynthesis (LT) inhibitor, shows IC₅₀ values of 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively. Quiflapon induces cell *apoptosis* .

HY-13803R

Tazemetostat (Standard)	Histone Methyltransferase Apoptosis	Cancer
Tazemetostat (Standard) is the analytical standard of Tazemetostat. This product is intended for research and analytical applications. Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a K_i value of 2.5 nM. Tazemetostat inhibits EZH2 with IC₅₀s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC₅₀ of 4 nM. Tazemetostat also inhibits EZH1 with an IC₅₀ of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells .

HY-122611

CSRM617	Androgen Receptor Apoptosis	Cancer
CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a K_d of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces *apoptosis* by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

HY-122611A

CSRM617 hydrochloride 1 Publications Verification	Androgen Receptor Apoptosis	Cancer
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a K_d of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces *apoptosis* by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model

HY-138831

AES-350	HDAC Apoptosis	Cancer
AES-350 is a potent and orally active HDAC6 inhibitor with an IC₅₀ and a K_i of 0.0244 μM and 0.035 μM, respectively. AES-350 is also against HDAC3, HDAC8 in an enzymatic activity assay with IC₅₀ values of 0.187 μM and 0.245 μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research .

HY-168164

4-Methoxycinnamyl alcohol	Histone Methyltransferase	Cancer
4-Methoxycinnamyl alcohol is an anticancer compound with cytotoxic activity against MCF-7, HeLa, and DU145 cancer cell lines with IC50 values of 14.24, 7.82, and 22.10 μg/mL, respectively. 4-Methoxycinnamyl alcohol showed the ability to induce cell necrosis, rather than apoptosis, after a 48-hour DNA fragmentation assay. 4-Methoxycinnamyl alcohol was isolated from Foeniculum vulgare .

HY-122611R

CSRM617 (Standard)	Androgen Receptor Apoptosis	Cancer
CSRM617 (Standard) is the analytical standard of CSRM617. This product is intended for research and analytical applications. CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

HY-10037R

Quiflapon (Standard) MK-591 (Standard)	Reference Standards FLAP Apoptosis	Inflammation/Immunology
Quiflapon (Standard) is the analytical standard of Quiflapon. This product is intended for research and analytical applications. Quiflapon (MK-591) is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50?of 1.6 nM in a FLAP binding assay. Quiflapon is also a potent and orally active?Leukotriene biosynthesis (LT)?inhibitor, shows IC50?values of 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively. Quiflapon induces cell apoptosis .

HY-N1486R

Ursonic acid (Standard)	Apoptosis Endogenous Metabolite NF-κB	Inflammation/Immunology Cancer
CSRM617 (Standard) is the analytical standard of CSRM617. This product is intended for research and analytical applications. CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

HY-123244

YC137	Bcl-2 Family Apoptosis	Cancer
YC137 is a potent Bcl-2 antagonist with K_is of 1.3 μM and >100 μM for Bcl-2 and Bcl-xL when assayed in Bis-Tris buffer, respectively. YC137 inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. YC137 selectively induces *apoptosis* of Bcl-2-dependent cells. YC137 has the potential for breast cancer research .

HY-162103

Axl-IN-18	TAM Receptor Apoptosis	Cancer
Axl-IN-18 (compound 25c) is a potent and selective type II AXL inhibitor. Axl-IN-18 shows excellent AXL inhibitory activity (IC₅₀=1.1 nM) and 343-fold selectivity over the highly homologous kinase MET in biochemical assays (IC₅₀=377 nM). Axl-IN-18 significantly inhibits AXL-driven cell proliferation, dose-dependently suppresses 4T1 cell migration and invasion, and induces *apoptosis*. Axl-IN-18 shows noticeable antitumor efficacy in a BaF3/TEL-AXL xenograft model .

HY-143435

AG6033	Apoptosis	Cancer
AG6033 is a potential novel CRBN modulator. AG6033 suppresses various tumor cells by modulating the interactions between CRBN and various antitumor target proteins. AG6033 can cause GSPT1 and IKZF1 degradation. AG6033 induces CRBN-dependent cytotoxic effect .

HY-P5380

TNO211 Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2	MMP	Others
TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)

HY-N8501

Emestrin	Bacterial	Infection
Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities. It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC₅₀s=3.94, 0.6, 2.21, 4.55, and 2.21 μg/mL, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC₅₀=5.4 μM in a radioligand binding assay using isolated human monocytes).3 Emestrin (0.1 μg/mL) induces apoptosis in HL-60 cells. It induces heart, thymus, and liver tissue necrosis in mice when administered at doses ranging from 18 to 30 mg/kg.

HY-162360

EGFR-IN-109	Apoptosis EGFR Caspase Bcl-2 Family	Cancer
EGFR-IN-109 (compound 4) is an EGFR inhibitor, with the IC₅₀ values of 25.8 and 182.3 nM for EGFR ^WT and EGFR ^T790M, respectively. EGFR-IN-109 arrests the cancer cells’ growth at the G2/M phase and induces both early and late apoptosis. EGFR-IN-109 can be used in cancer research .

HY-147514

Anticancer agent 64	Apoptosis Caspase PARP Bcl-2 Family	Cancer
Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC₅₀ of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization .

HY-N2127

Pinostrobin 1 Publications Verification	Amyloid-β Apoptosis Ser/Thr Protease HSV Interleukin Related	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases .

Cat. No.	Product Name	Type

HY-15924

Thiazolyl Blue 130+ Cited Publications MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide	Chromogenic Substrates
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .

HY-145499

XTT sodium hydrate	Fluorescent Dyes/Probes
XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator. It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.

Cat. No.	Product Name	Target	Research Area

HY-P5380

TNO211 Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2	MMP	Others
TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)

Cat. No.	Product Name

HY-K1070

Apoptosis and Necrosis Assay Kit 2 Publications Verification
MCE Apoptosis and Necrosis Assay Kit provides a rapid and convenient method to detect cell apoptosis and necrosis.

Pinostrobin 1 Publications Verification	Structural Classification Monophenols Flavonoids other families Classification of Application Fields Flavonones Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Amyloid-β Apoptosis Ser/Thr Protease HSV Interleukin Related
Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases .

Ursonic acid (Standard)	Triterpenes Structural Classification Ziziphus jujuba Terpenoids Source classification Plants Endogenous metabolite Rhamnaceae	Apoptosis Endogenous Metabolite NF-κB
CSRM617 (Standard) is the analytical standard of CSRM617. This product is intended for research and analytical applications. CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

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