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Results for "

Amide derivatives

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (7) 5-HT Receptor (1) Acyltransferase (2) ADC Cytotoxin (2) ADC Linker (2) Angiotensin Receptor (1) Antibiotic (1) Apoptosis (13) Autophagy (1) Bacterial (5) Beta-lactamase (1) Biochemical Assay Reagents (9) DNA/RNA Synthesis (1) Drug Intermediate (2) Drug-Linker Conjugates for ADC (1) EBV (2) Endogenous Metabolite (3) Epoxide Hydrolase (2) ERK (11) Fluorescent Dye (2) Influenza Virus (1) Isotope-Labeled Compounds (3) MEK (11) NF-κB (12) NO Synthase (1) Opioid Receptor (1) P-glycoprotein (1) Parasite (1) Potassium Channel (1) Prostaglandin Receptor (6) Radionuclide-Drug Conjugates (RDCs) (1) Ras (1) Reference Standards (2) Sigma Receptor (1) Sodium Channel (11) Survivin (1) Topoisomerase (3) α-synuclein (4)
By Research Areas:	Cancer (21) Cardiovascular Disease (13) Endocrinology (1) Infection (6) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (13)
Click Chemistry:	Azide (2) Tetrazine (1)
Oligonucleotides:	Polymers (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Amino Acid Derivatives FAAH Drug Derivative

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139420

Tafluprost ethyl amide	Prostaglandin Receptor	Others
Tafluprost ethyl amide is a prostaglandin derivative. Tafluprost ethyl amide is capable of reducing intraocular pressure (IOP) and influencing eyelash growth. Tafluprost ethyl amide can be used in antiglaucoma ophthalmic compositions .

HY-W008559

L-Tyrosinamide	Endogenous Metabolite	Metabolic Disease
L-Tyrosinamide is a derivative of Tyrosine, is an amino acid amide .

HY-153600

GGFG-amide-glycol-amide-Exatecan	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
GGFG-amide-glycol-amide-Exatecan (Intermediate 2) is an Exatecan (HY-13631) derivative and can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-123934

VU6007477	P-glycoprotein	Neurological Disease
VU6007477 is a brain-penetrant, selective M1 positive allosteric modulator (PAM) with an EC₅₀ value of 230 nM. VU6007477 is also a human P-glycoprotein (P-gp) substrate with moderate permeability. VU6007477 displays improved central nervous system (CNS) penetration over the hydroxylated congeners. VU6007477 a pyranyl amide derivative, which is promising for research of robust cholinergic seizure activity .

HY-169479

Betulinic glycine amide	Drug Derivative	Infection Cancer
Betulinic glycine amide (compound 5a) is a pentacyclic triterpenoid and derivative of Betulinic acid (HY-10529). Betulinic glycine amide has been used as a precursor in the synthesis of betulinic acid derivatives with anticancer and antiviral activity .

HY-139272

Eicosapentaenoyl 1-propanol-2-amide	Drug Derivative	Cancer
Eicosapentaenoyl 1-propanol-2-amide is an amide derivative of Eicosapentaenoic Acid (HY-B0660). Eicosapentaenoyl 1-propanol-2-amide inhibits the 98.4% proliferation of cancer cell A549 at 3 μM. Eicosapentaenoyl 1-propanol-2-amide can be used in cancer research .

HY-147166

2-Carboxyanthracene MTSEA amide	Drug Derivative	Others
2-Carboxyanthracene MTSEA amide is an MTS derivative of anthracene. 2-Carboxyanthracene MTSEA Amide is a special spin-marker .

HY-P2212

(Asn1,Val5)-Angiotensin II	Angiotensin Receptor	Inflammation/Immunology
Angiotensin amide ((Asn1,Val5)-Angiotensin II) is a potent vasoconstrictor. Angiotensin amide is a derivative of angiotensin II. Angiotensin amide can be used as a cardiac activator .

HY-139420R

Tafluprost ethyl amide (Standard)	Prostaglandin Receptor	Others
Tafluprost ethyl amide (Standard) is the analytical standard of Tafluprost ethyl amide. This product is intended for research and analytical applications. Tafluprost ethyl amide is a prostaglandin derivative. Tafluprost ethyl amide is capable of intraocular pressure (IOP) reduction and influencing eyelash growth. Tafluprost ethyl amide can be used in antiglaucoma ophthalmic compositions or cosmetics .

HY-158936

Lumula Maxeyprost; Unoprostone N-ethyl Amide	Potassium Channel	Neurological Disease
Lumula (Maxeyprost) is an ethyl amide derivative of Unoprostone (HY-106916).

HY-W539916

Azido-mono-amide-DOTA	Biochemical Assay Reagents Radionuclide-Drug Conjugates (RDCs)	Others
Azido-mono-amide-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Azido-mono-amide-DOTA can be used for conjugation of peptides and radionuclides.

HY-158068

Maleimido-mono-amide-DTPA TFA	Biochemical Assay Reagents	Others
Maleimido-mono-amide-DTPA (TFA)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. Maleimido-mono-amide-DTPA (TFA) can be used for conjugation of peptides and radionuclides.

HY-176021

U-44069 serinol amide	Prostaglandin Receptor	Cardiovascular Disease
U-44069 serinol amide is a derivative of U-44069 (HY-121825). U-44069 serinol amide is a stable analog of the endoperoxide prostaglandin H2 (HY-136500). U-44069 serinol amide is a vasoconstrictor that can induce preglomerular Ca ²⁺ influx .

HY-101722

Melinamide AC 223; DL-N-(α-Methylbenzyl)linoleAmide	Acyltransferase	Metabolic Disease
Melinamide, an amide derivative of an unsaturated long-chain fatty acid, is an inhibitor of cholesterol absorption with an IC₅₀ of 20.9 μM.

HY-156101

Latanoprost amide	Prostaglandin Receptor	Cardiovascular Disease
Latanoprost amide is a derivative of the F-prostaglandin (FP) receptor agonist Latanoprost (HY-B0577) .

HY-149554

17-Phenyl trinor Prostaglandin F2α dimethyl amide Bimatoprost dimethyl Amide	Others	Neurological Disease
17-Phenyl trinor Prostaglandin F2α dimethyl amide (Bimatoprost dimethyl amide), a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivative, is a smooth muscle relaxant. 17-Phenyl trinor Prostaglandin F2α dimethyl amide has the potential for glaucoma research .

HY-W721596

Pentadecanoyl ethanolamide	Endogenous Metabolite	Neurological Disease
Pentadecanoyl ethanolamide is derivate of endougenous lipid amides, the N-acylethanolamines. Pentadecanoyl ethanolamide exhibits anticonvulsant efficacy in electroshocked mice without significant toxicity .

HY-112666

Farnesyl thiosalicylic acid amide FTS Amide; Salirasib Amide	Ras	Cancer
Farnesyl thiosalicylic acid amide (FTS-A) is an orally active derivative of farnesyl thiosalicylic acid (HY-14754). Farnesyl thiosalicylic acid amide reduces Ras-GTP levels and inhibits cell growth with IC₅₀s of 20 and 10 μM for Panc-1 and U87 cells, respectively. Farnesyl thiosalicylic acid amide can be used for the research of cancer .

HY-176022

U-46619 serinol amide	Prostaglandin Receptor	Cardiovascular Disease
U-46619 serinol amide is a derivative of U-46619 (HY-108566). U-46619 serinol amide is a stable analog of Thromboxane A2 (HY-113350) (TXA2). U-46619 serinol amide is a potent TXA2 agonist that can induce platelet shape change and aggregation .

HY-142021

Z-Leu-Arg-AMC	Parasite	Infection
Z-Leu-Arg-AMC is a 4-methylcoumarinyl-7-amide (Amc) leucine derivative with carboxybenzoyl (Z). Z-Leu-Arg-AMC is the active site of cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei .

HY-W250929

Maleimido-mono-amide-DOTA-tris(t-Bu ester)	Biochemical Assay Reagents	Others
Maleimido-mono-amide-DOTA-tris(t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Maleimido-mono-amide-DOTA-tris(t-Bu ester) can be used for conjugation of peptides and radionuclides.

HY-W749603

Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)	Biochemical Assay Reagents	Others
Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) can be used for conjugation of peptides and radionuclides.

HY-156882

Biotin-PEG3-amide-C2-CO-Halofuginone	Others	Cancer
Biotin-PEG3-amide-C2-CO-Halofuginone, a kind halofuginone derivative, can be used in the cancer study .

HY-W088413

DOTA-amide	Biochemical Assay Reagents	Others
DOTA-amideis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-amide can be used for conjugation of peptides and radionuclides.

HY-172633

15-Deoxy-Δ12,14-prostaglandin J2 serinol amide 15-Deoxy-Δ12,14-PGJ2 serinol Amide	Drug Derivative	Others
15-Deoxy-Δ12,14-prostaglandin J2 serinol amide (15-Deoxy-Δ12,14-PGJ2 serinol amide) is a derivative of 15-deoxy-Δ12,14-PGJ2-2-glyceryl ester .

HY-101722R

Melinamide (Standard) AC 223 (Standard); DL-N-(α-Methylbenzyl)linoleAmide (Standard)	Acyltransferase Reference Standards	Metabolic Disease
Melinamide (Standard) is the analytical standard of Melinamide. This product is intended for research and analytical applications. Melinamide, an amide derivative of an unsaturated long-chain fatty acid, is an inhibitor of cholesterol absorption with an IC50 of 20.9 μM.

HY-P3625

Dynorphin (2-17), amide (porcine)	Endogenous Metabolite Opioid Receptor	Neurological Disease
Dynorphin (2-17), amide (porcine) is a dynorphin derivative with some analgesic effects. Dynorphin is a class of opioid peptides produced by the precursor protein dynorphinogen and is involved in pain, addiction and mood regulation .

HY-160543

Exatecan-amide-CH2-O-CH2-CH2-OH	ADC Cytotoxin Topoisomerase	Cancer
Exatecan-amide-CH2-O-CH2-CH2-OH (Compound 4) is a derivative of Exatecan (HY-13631). Exatecan-amide-CH2-O-CH2-CH2-OH can be used for the research of cell proliferative diseases such as cancer .

HY-155070

SRE-II	DNA/RNA Synthesis Apoptosis	Cancer
SRE-II, an amide derivative, is an activatable photosensitizer for photodynamic cancer research with decreased fluorescence and photosensitizing capabilities. SRE-II can be further converted into the active photosensitizer SDU Red via carboxylesterase-catalyzed amide bond cleavage. SRE-II induces DNA damage and cell apoptosis in the presence of light. SRE-II can act as a promising theranostic agent for triple-negative breast cancer .

HY-160597

Exatecan-amide-bicyclo[1.1.1]pentan-1-ol	ADC Cytotoxin Topoisomerase	Cancer
Exatecan-amide-bicyclo[1.1.1]pentan-1-ol (Compound 79) is an exatecan (HY-13631) derivative that can be used as a payload in drug conjugates. Exatecan-amide-bicyclo[1.1.1]pentan-1-ol has significant inhibitory activity against a variety of tumor cell lines .

HY-163508

Antibacterial agent 210	Bacterial	Infection
Antibacterial agent 210 (compound A9), an amide derivative, is a Pseudomonas aeruginosa quorum sensing inhibitor (QSI). Antibacterial agent 210 inhibits the quorum sensing systems by binding with LasR and PqsR, especially PqsR .

HY-176014

17-Phenyl trinor prostaglandin F2α glycinamide 17-Phenyl trinor PGF2α glycinAmide	Drug Derivative	Others
17-phenyl trinor PGF2α glycinamide (17-Phenyl trinor PGF2α glycinamide) is a derivative of 17-phenyl trinor prostaglandin F2α ethyl amide .

HY-20128

Piperazin-2-one	Drug Intermediate	Others
Piperazin-2-one is a piperazine ring derivative containing amide and ester carbonyl groups. As an important intermediate, Piperazin-2-one can be used for the synthesis of various active compounds .

HY-155765

Anti-inflammatory agent 51	NF-κB	Inflammation/Immunology
Anti-inflammatory agent 51 (compound 11d) is an amide/sulfonamide derivative with anti-inflammatory activities. Anti-inflammatory agent 51 inhibits NF-κB activation, has the potential for acute lung injury and ulcerative colitis research .

HY-40421

(R)-3-Fluoropyrrolidine hydrochloride	Biochemical Assay Reagents	Others
(R)-3-Fluoropyrrolidine hydrochloride is a derivative of fluorinated pyrrolidines. The amide series of fluorinated pyrrolidines are inhibitors of dipeptidyl peptidase DP-IV. Novel α4β2 receptor ligands characterized by a 3-Fluoropyrrolidine core .

HY-D1085

AMCA-X SE	Fluorescent Dye	Others
AMCA-X-SE is a coumarin derivative that generates fixed blue fluorescence and an NHS-activated ester that forms stable amide bonds with primary amine groups. It is used as a reactive dye for labeling amino groups of peptides, proteins, and oligonucleotides. Maximum excitation/emission wavelength: 354/442 nm .

HY-B2117

Valpromide	Epoxide Hydrolase EBV	Infection Neurological Disease
Valpromide is an amide derivative of Valproic acid (HY-10585) and an orally active epoxide hydrolase inhibitor that can cross the blood-brain barrier. Valpromide has antiepileptic, anticonvulsant, and antipsychotic effects. Valpromide also exhibits antiviral activity and can inhibit the reactivation of the EBV lytic cycle .

HY-119001

BKM1644	Survivin	Cancer
BKM1644, an acyl-tyrosine bisphosphonate amide derivative, exhibits potent anti-cancer activity. BKM1644 effectively inhibits the proliferation of metastatic, castration-resistant prostate cance (mCRPC) cells. BKM1644 sensitizes mCRPC cells to Docetaxel (HY-B0011) and retards the bone metastatic growth of prostate cance .

HY-19469

Roluperidone 1 Publications Verification CYR-101; MIN-101; MT-210	5-HT Receptor Sigma Receptor	Neurological Disease
Roluperidone (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for 5-HT_2A and sigma-2 receptors (K_i of 7.53 nM and 8.19 nM for 5-HT_2A and sigma-2, respectively).

HY-147668

α-Synuclein inhibitor 6	α-synuclein	Neurological Disease
α-Synuclein inhibitor 6 (compound 3ge) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC₅₀ of 1.70 μM and inhibition ratio at 30 μM of 94.4% .

HY-147666

α-Synuclein inhibitor 4	α-synuclein	Neurological Disease
α-Synuclein inhibitor 4 (compound 3gh) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC₅₀ of 0.98 μM and inhibition ratio at 30 μM of 91.2% .

HY-147669

α-Synuclein inhibitor 7	α-synuclein	Neurological Disease
α-Synuclein inhibitor 7 (compound 3gf) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC₅₀ of 1.95 μM and inhibition ratio at 30 μM of 85.8% .

HY-147667

α-Synuclein inhibitor 5	α-synuclein	Neurological Disease
α-Synuclein inhibitor 5 (compound 4aa) is a potent and BBB-penetrated inhibitor of α-Synuclein (α-Syn) aggregation, with an IC₅₀ of 1.22 μM and inhibition ratio at 30 μM of 94.3% .

HY-D2427

Cy3-PEG-Amine	Fluorescent Dye	Others
Cy3-PEG-Amine is a derivative of the Cyanine 3 (Cy3) (HY-D0822) dye containing one PEG unit. Cy3-PEG-Amine bears an Amine group, which can react with various functional groups (such as carboxyl, aldehyde, or active esters) to form amide or imine bonds.

HY-B0185

Lidocaine Maximum Cited Publications 14 Publications Verification Lignocaine	Sodium Channel MEK ERK NF-κB Apoptosis	Cardiovascular Disease Cancer
Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-B0185B

Lidocaine hydrochloride hydrate 10+ Cited Publications Lignocaine hydrochloride hydrate	Sodium Channel MEK ERK NF-κB Apoptosis	Cardiovascular Disease Cancer
Lidocaine (Lignocaine) hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-B0185A

Lidocaine hydrochloride Maximum Cited Publications 14 Publications Verification Lignocaine hydrochloride	Sodium Channel MEK ERK NF-κB Apoptosis	Cardiovascular Disease Cancer
Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence . Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor .

HY-176008

Lauric acid leelamide	Drug Derivative	Inflammation/Immunology
Lauric acid leelamide is the lauric acid (C-12) amide analog of Leelamine (HY-W005629). Leelamine exhibits inhibitory activity against pyruvate dehydrogenase kinase (PDHK) with an IC₅₀ value of 9.5 µM. Leelamine derivatives possess anti-inflammatory effects and can inhibit phospholipase A2 activity from various sources .

HY-20128S

Piperazin-2-one-d6	Isotope-Labeled Compounds Drug Intermediate	Others
Piperazin-2-one-d₆ is the deuterium labeled Piperazin-2-one (HY-20128). Piperazin-2-one is a piperazine ring derivative containing amide and ester carbonyl groups. As an important intermediate, Piperazin-2-one can be used for the synthesis of various active compounds .

HY-108913

Nitrocefin 2 Publications Verification	Beta-lactamase Antibiotic Bacterial	Infection
Nitrocefin is a highly activated, chromogenic cephalosporin derivative. Nitrocefin is a chromogenic β-lactamase substrate. Nitrocefin undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics .

Cat. No.	Product Name	Type

HY-D1085

AMCA-X SE	Fluorescent Dyes/Probes
AMCA-X-SE is a coumarin derivative that generates fixed blue fluorescence and an NHS-activated ester that forms stable amide bonds with primary amine groups. It is used as a reactive dye for labeling amino groups of peptides, proteins, and oligonucleotides. Maximum excitation/emission wavelength: 354/442 nm .

HY-D2427

Cy3-PEG-Amine	Fluorescent Dyes/Probes
Cy3-PEG-Amine is a derivative of the Cyanine 3 (Cy3) (HY-D0822) dye containing one PEG unit. Cy3-PEG-Amine bears an Amine group, which can react with various functional groups (such as carboxyl, aldehyde, or active esters) to form amide or imine bonds.

HY-B0185G

Lidocaine (GMP)

Lignocaine (GMP)

Fluorescent Dye

Lidocaine (GMP) is Lidocaine (HY-B0185) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Lidocaine inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-D2772

5-TAMRA Cadaverine

Fluorescent Dyes/Probes

5-TAMRA cadaverine can used to modify carboxylic acid group in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond. It also can be reversibly coupled to aldehydes and ketones to form a Schiff base – which can be reduced to a generate stable amine derivative by sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3). Although the mixed isomers of 5(6)-TAMRA cadaverine is a preferred, routinely used orange-fluorescent dye for staining proteins, it is rearly used for labeling peptides and nucleotides. Purification of 5(6)-TAMRA labeled peptide and nucleotides might be troublesome due to significant signal broadening in HPLC purification. Peptides and nucleotides labeled with a single isomer TAMRA usually give better resolution in HPLC purification that is often required in the conjugation processes.

Cat. No.	Product Name	Type

HY-W539916

Azido-mono-amide-DOTA	Chelators
Azido-mono-amide-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Azido-mono-amide-DOTA can be used for conjugation of peptides and radionuclides.

HY-W088413

DOTA-amide	Chelators
DOTA-amideis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-amide can be used for conjugation of peptides and radionuclides.

HY-20128

Piperazin-2-one	Biochemical Assay Reagents
Piperazin-2-one is a piperazine ring derivative containing amide and ester carbonyl groups. As an important intermediate, Piperazin-2-one can be used for the synthesis of various active compounds .

HY-40421

(R)-3-Fluoropyrrolidine hydrochloride	Biochemical Assay Reagents
(R)-3-Fluoropyrrolidine hydrochloride is a derivative of fluorinated pyrrolidines. The amide series of fluorinated pyrrolidines are inhibitors of dipeptidyl peptidase DP-IV. Novel α4β2 receptor ligands characterized by a 3-Fluoropyrrolidine core .

HY-112624K

Dextran T5 (MW 5,000)

Dextran 5; Dextran D5; Dextran T5(MW 4500-5500)

Thickeners

Dextran T5 (MW 5,000) is a sulfated polysaccharide anti-apoptotic and autophagic agent. Dextran T5 (MW 5,000) has sulfated groups and interacts with cell membranes by mimicking endogenous glycosaminoglycans, inhibiting the mitochondrial apoptotic pathway and delaying DNA fragmentation to exert anti-apoptotic activity. Dextran T5 (MW 5,000) also promotes the conversion of LC3-I to LC3-II and the formation of autophagosomes to activate the autophagic pathway. Dextran T5 (MW 5,000) can prolong the survival cycle of CHO cells and increase the production of recombinant erythropoietin (EPO). The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong drug half-life, increase local concentration and reduce immune clearance activity. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .

HY-112624E

Dextran T0.8 (MW 800)

Dextran 0.8; Dextran D0.8; Dextran T0.8(MW 640-960)

Thickeners

Dextran T0.8 (Dextran 0.8; Dextran T0.8(MW 640-960)) is a food additive with a porous network structure that exhibits strong hydration capacity and low browning activity. Dextran T0.8 (MW 800) can improve the coagulation of dairy products and is used as a prebiotic in baked goods. Dextran T0.8 (MW 800) is non-toxic to HeLa cells at a concentration of ~500 μg/mL and has a low relative browning rate in the Maillard reaction. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .

HY-158068

Maleimido-mono-amide-DTPA TFA	Chelators
Maleimido-mono-amide-DTPA (TFA)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. Maleimido-mono-amide-DTPA (TFA) can be used for conjugation of peptides and radionuclides.

HY-W250929

Maleimido-mono-amide-DOTA-tris(t-Bu ester)	Chelators
Maleimido-mono-amide-DOTA-tris(t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Maleimido-mono-amide-DOTA-tris(t-Bu ester) can be used for conjugation of peptides and radionuclides.

HY-W749603

Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)	Chelators
Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) can be used for conjugation of peptides and radionuclides.

HY-B0185G

Lidocaine (GMP)

Lignocaine (GMP)

Biochemical Assay Reagents

HY-112624J

Dextran T4 (MW 4,000)

Dextran 4; Dextran D4; Dextran T4(MW 3200-4800)

Thickeners

Dextran 4,000 is a mucus rheology modifier. The dextran molecules in Dextran 4,000 can reduce the cross-link density of mucus through osmotic effects and hydrogen bond substitution, and reduce viscoelasticity and improve the mucociliary/cough clearance index by destroying the DNA-mucin network structure in mucus. Dextran 4,000 has the ability to improve the rheological properties and clearance ability of cystic fibrosis (CF) sputum, and can be used in the study of inhalation therapy or aerosol delivery of mucostatic respiratory diseases. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .

HY-112624B

Dextran T70 (MW 70,000)

Dextran 70; Dextran D70; Dextran T70(MW 64000-76000)

Drug Delivery Thickeners

Dextran 70,000 is a high molecular weight polysaccharide formed by glucose linked by α-(1→6) glycosidic bonds. Dextran 70,000 can expand blood volume through colloidal osmotic pressure effect and inhibit cell adhesion and platelet aggregation through steric hindrance. At the same time, Dextran 70,000 can be used as a drug carrier to achieve targeted delivery through endocytosis. Dextran 70,000 is biologically inert and has low immunogenicity. It can be used for clinical blood volume expansion, anti-thrombotic research, and evaluation of vascular permeability in in vitro experiments. It can also be combined with fluorescent dyes for cell tracking and drug delivery research. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.

HY-112624I

Dextran T3 (MW 3,000)

Dextran 3; Dextran D3; Dextran T3(MW 2400-3600)

Thickeners

Dextran T3 (Dextran 3; Dextran T3(MW 2400-3600)) is a neural tracer and intestinal permeability probe that can move anterogradely and retrogradely in neuronal axons by passive diffusion. Dextran T3 (MW 3,000) is able to permeate across the intestinal epithelial cell membrane in the presence of cholera toxin-induced cytoskeletal disturbance. Dextran T3 (MW 3,000) is used as a fluorescent marker to rapidly label developing neurons (such as Xenopus retinal ganglion cells) and to assess intestinal barrier function. It can be used to study axonal transport in neuroanatomy and permeability changes in intestinal pathophysiology. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance .

HY-112624H

Dextran T2 (MW 2,000)

Dextran 2; Dextran D2; Dextran T2(MW 1600-2400)

Thickeners

Dextran T2 (Dextran 2; Dextran T2(MW 1600-2400)) is a natural high molecular weight polysaccharide, the glycosidic bonds in its structure can be recognized by endo-dextranase and exo-dextranase. Dextran T2 (MW 2,000) breaks the glycosidic bonds in the enzymatic hydrolysis mechanism, releasing products such as D-glucose, Isomaltose (IM₂), and Isomaltotriose (IM₃). Dextran T2 (MW 2,000) can be used as a model substrate to characterize the catalytic properties of dextranase (such as optimal pH, temperature and product specificity), and to study enzymatic mechanism research and polysaccharide degradation pathways in glycobiology. The Dextran series of compounds are also a natural polysaccharide drug carrier, which can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong drug half-life, increase local concentration and reduce immune clearance activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1142

Lipoamide 5+ Cited Publications (±)-α-LipoAmide; DL-LipoAmide; DL-6,8-ThioctAmide	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	NO Synthase
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .

Cat. No.	Product Name	Chemical Structure

HY-B0185AS

Lidocaine-d10 hydrochloride

Lidocaine-d₁₀ (hydrochloride) is the deuterium labeled Lidocaine hydrochloride. Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence . Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride, an amide derivative, has the potential for the research of the ventricular arrhythmia .

HY-B0185S1

Lidocaine-d10

Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-B0185AS1

Lidocaine-d6 hydrochloride

Lidocaine-d₆ (hydrochloride) is deuterium labeled Lidocaine (hydrochloride). Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence . Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor .

HY-20128S

Piperazin-2-one-d6
Piperazin-2-one-d₆ is the deuterium labeled Piperazin-2-one (HY-20128). Piperazin-2-one is a piperazine ring derivative containing amide and ester carbonyl groups. As an important intermediate, Piperazin-2-one can be used for the synthesis of various active compounds .

HY-B0185S

Lidocaine-d10 N-Oxide

N-Oxide Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-B0185S2

Lidocaine-d6

Lidocaine-d₆ (Lignocaine-d₆) is deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

Cat. No.	Product Name		Classification

HY-W539916

Azido-mono-amide-DOTA		Azide
Azido-mono-amide-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Azido-mono-amide-DOTA can be used for conjugation of peptides and radionuclides.

HY-151833

Methyltetrazine-amido-N-bis(PEG4-acid)		Tetrazine
Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only . Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

HY-151738

Fmoc-Aeg(N3)-OH		Azide
Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-112624B

Dextran T70 (MW 70,000) Dextran 70; Dextran D70; Dextran T70(MW 64000-76000)		Polymers
Dextran 70,000 is a high molecular weight polysaccharide formed by glucose linked by α-(1→6) glycosidic bonds. Dextran 70,000 can expand blood volume through colloidal osmotic pressure effect and inhibit cell adhesion and platelet aggregation through steric hindrance. At the same time, Dextran 70,000 can be used as a drug carrier to achieve targeted delivery through endocytosis. Dextran 70,000 is biologically inert and has low immunogenicity. It can be used for clinical blood volume expansion, anti-thrombotic research, and evaluation of vascular permeability in in vitro experiments. It can also be combined with fluorescent dyes for cell tracking and drug delivery research. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance.

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