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Alphaviruses

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-19711
    STING agonist-1
    2 Publications Verification

    G10

    		 STING Virus Protease Infection
    STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM .
    STING agonist-1
  • HY-176268
    SGC-NSP2hel-1

    RA-0188293

    		 Virus Protease Infection
    SGC-NSP2hel-1 is a potent, specific and orally active inhibitor of the nsP2 helicase with a CC50 > 250 µM and Selectivity Index of > 4000. SGC-NSP2hel-1 has broad spectrum activity against multiple alphaviruses. SGC-NSP2hel-1 reduces virus replication and limited virus-induced pathology by forming a stable complex with nsP2 and ATP in a preclinical small animal model of CHIKV disease[1].
    SGC-NSP2hel-1

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