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Results for "

Affinity probe

" in MedChemExpress (MCE) Product Catalog:

69

Inhibitors & Agonists

19

Fluorescent Dye

1

Biochemical Assay Reagents

5

Peptides

6

Click Chemistry

1

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-152231
    BODIPY FL thalidomide

    		Fluorescent Dye Ligands for E3 Ligase Others
    BODIPY FL thalidomide is a high-affinity fluorescent probe for human cereblon protein with a Kd value of 3.6 nM .
    BODIPY FL thalidomide
  • HY-113553
    4-Aminophenylphosphorylcholine

    (p-Aminophenyl)phosphocholine; p-Aminophenylphosphorylcholine; 4-APPC

    		 Endogenous Metabolite Metabolic Disease
    4-Aminophenylphosphorylcholine ((p-Aminophenyl)phosphocholine) is a probe that can be conjugated to agarose gels to generate adsorbents for affinity precipitation experiments.
    4-Aminophenylphosphorylcholine
  • HY-136219
    Protein kinase affinity probe 1

    		Fluorescent Dye Others
    Protein kinase affinity probe 1 is a novel protein kinase affinity probe for the functional identification of protein kinases (PKs). Protein kinase affinity probe 1 is a modified Purvalanol B (HY-18299) probe with 50% beads loading (Compound S3) .
    Protein kinase affinity probe 1
  • HY-D1684
    DCDAPH

    		Amyloid-β Neurological Disease
    DCDAPH (Compound 2c) is a novel smart NIRF probe for detection of β-amyloid (Aβ) plaques (λex/λem=597/665 nm in PBS). DCDAPH shows high affinity for Aβ aggregates (Ki=37 nM, Kd=27 nM). DCDAPH shows good blood brain barrier permeation and can meet most of the requirements for the detection of Aβ plaques both in vitro and in vivo .
    DCDAPH
  • HY-P11307
    Biotin-epoxomicin

    		Proteasome Others
    Biotin-epoxomicin is a biotin labeled Epoxomicin (HY-13821). Biotin-epoxomicin is a high affinity probe targeting Proteasome. Biotin-epoxomicin covalently binds to multiple proteasome catalytic subunits (such as LMP7, Z and MECL1) .
    Biotin-epoxomicin
  • HY-P11306
    Biotin-(Oaa)3-epoxomicin

    		Proteasome Others
    Biotin-(Oaa)3-epoxomicin (Compound 13) is a biotinylated active form of Epoxomicin (HY-13821). Biotin-(Oaa)3-epoxomicin is a high affinity probe targeting Proteasome. Biotin-(Oaa)3-epoxomicin covalently binds to multiple proteasome catalytic subunits (such as LMP7, Z and MECL1) .
    Biotin-(Oaa)3-epoxomicin
  • HY-145837
    Y1R probe-1

    		Neuropeptide Y Receptor Cancer
    Y1R probe-1 (Compound 39) is a high-affinity fluorescence probe for the Neuropeptide Y Y1 Receptor. Y1R probe-1 has the potential for the research of cancer disease .
    Y1R probe-1
  • HY-121637
    IDFP

    iso-Prdodecylfluorophosphonate

    		 Cannabinoid Receptor Neurological Disease
    IDFP (iso-Prdodecylfluorophosphonate) is a chemical affinity probe for the cannabinoid CB1 receptor .
    IDFP
  • HY-169295
    RAP 1

    		Biochemical Assay Reagents Others
    RAP 1 is a reactive affinity probe (RAP) that selectively labels SLC6A8 in the presence of guanine alanine (GPA). RAP 1 can be used as a chemical probe for identifying and studying potential drug binding sites on SLC6A8 .
    RAP 1
  • HY-172666F
    C6 Biotin dihydro ceramide (d18:0/6:0)

    Biotin ceramide (d18:0/6:0)

    		 Fluorescent Dye Neurological Disease
    C6 Biotin dihydro ceramide is an affinity probe that allows C6 dihydro ceramide to be detected or immobilized through interaction with the biotin ligand.
    C6 Biotin dihydro ceramide (d18:0/6:0)
  • HY-126829
    Coumarin-SAHA

    		HDAC Cancer
    Coumarin-SAHA is a fluorescent probe for determining the binding affinities (kd) and the dissociation off-rates (koff) of the HDAC8-inhibitor complexes .
    Coumarin-SAHA
  • HY-D2327
    DPP-8/9 probe-1

    		Dipeptidyl Peptidase Others
    DPP-8/9 probe-1 (compound 20) is a fluorescent probe targeting Dipeptidyl Peptidase DPP8/9, which can be selectively labeled and visualized in vitro by fluorescence microscopy Active DPP8/9. DPP-8/9 probe-1 contains a nitrobenzoxadiazole (NBD) tag and has high affinity and selectivity for DPP8/9 over related S9 family members (IC50 of 210 nM and 15 nM, respectively) .
    DPP-8/9 probe-1
  • HY-155698
    Mz438

    		Fluorescent Dye CXCR Others
    Mz438 is high-affinity and selective fluorescent CXCR2 ligand. Mz438 is a small-molecule-based fluorescent probe targeting the IABS of CXCR2 .
    Mz438
  • HY-148116
    DN02

    		Epigenetic Reader Domain Cancer
    DN02 is a potent, selective BRD8 bromodomain probe. DN02 has exhibits high affinity for the BRD8(1) (Ki=32 nM), which is 30-fold more affinity than BRD8 (2) (Ki＞1000 nM) .
    DN02
  • HY-172137
    FAPI-FUSCC-07

    		FAP Cancer
    FAPI-FUSCC-07 is a targeted probe for fibroblast activation protein (FAP), exhibiting high affinity binding to FAP for applications in molecular imaging, tumor diagnosis, and radiotherapy .
    FAPI-FUSCC-07
  • HY-P5287
    cRGDfK-thioacetyl ester

    		Integrin Cancer
    cRGDfK-thioacetyl ester is a bioactive polypeptide molecule. cRGDfK peptide has a selective affinity for integrins. cRGDfK peptide can modify NIR fluorescent probes for cancer targeting imaging .
    cRGDfK-thioacetyl ester
  • HY-P5287A
    cRGDfK-thioacetyl ester TFA

    		Integrin Cancer
    cRGDfK-thioacetyl ester TFA is a bioactive polypeptide molecule. cRGDfK peptide has a selective affinity for integrins. cRGDfK peptide can modify NIR fluorescent probes for cancer targeting imaging .
    cRGDfK-thioacetyl ester TFA
  • HY-129953F
    Prostaglandin F2α-biotin

    PGF2α-biotin

    		 Biochemical Assay Reagents Prostaglandin Receptor Others
    Prostaglandin F2α-biotin (PGF2α-biotin) is a biotinylated form of Prostaglandin F2α (HY-12956). Prostaglandin F2α-biotin can be used in the study of the mechanism of action of prostaglandins. In addition, Prostaglandin F2α-biotin can be detected in the ethanolic extract of Hawm Gra Dang Ngah rice .
    Prostaglandin F2α-biotin
  • HY-119581
    MBED

    9-Methyl-7-bromoeudistomin D

    		 Fluorescent Dye Neurological Disease
    MBED (9-Methyl-7-bromoeudistomin D) is a RyR agonist. MBED is a high-affinity caffeine-like probe, helps identify the caffeine-binding site in RyRs .
    MBED
  • HY-103242
    CRANAD-2

    		Amyloid-β Neurological Disease
    CRANAD-2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM .
    CRANAD-2
  • HY-D2380
    H2S probe 1

    		G-quadruplex Cancer
    H2S probe 1 (compound 1NND) is a derivative of nitrobenzoxadiazole (NBD) with antitumor activity. H2S probe 1 is cytotoxic to human pancreatic cancer cell MIA PaCa-2 (IC50=77.9 nM) and has a high affinity for human telomeric G-quadruplex (G4) (Kd=1.72 μM). H2S probe 1 can be used in cancer research .
    H2S probe 1
  • HY-101140A
    KI696 isomer

    		Keap1-Nrf2 Metabolic Disease Inflammation/Immunology
    KI696 isomer is the less active isomer of KI696 (HY-101140). KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction .
    KI696 isomer
  • HY-101181
    THK-5105

    		Microtubule/Tubulin Neurological Disease
    THK-5105, an arylquinoline derivative, displays high binding affinity to tau fibrils. THK-5105 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD)  brain homogenates. 18F-THK-5105 has the potential to act as a tau imaging PET probe .
    THK-5105
  • HY-W010936
    Nitrobenzylthioinosine
    1 Publications Verification

    NBMPR

    		 Adenosine Receptor Neurological Disease
    Nitrobenzylthioinosine is an ENT1 transporter inhibitor that binds to ENT1 transporter with high affinity. Nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Nitrobenzylthioinosine can cross the blood-brain barrier .
    Nitrobenzylthioinosine
  • HY-D0157
    ZnAF-2

    		Biochemical Assay Reagents Others
    ZnAF-2, 6-iso- is a cell-impermeable compound that acts as a high-affinity Zn2 -specific fluorescent probe (Kd = 2.7 nM). It exhibits low basal fluorescence with an approximately 51-fold increase in fluorescence intensity upon stoichiometric (1:1) binding to Zn2 . Little affinity for Ca2 , Mg2 , Na or K .
    ZnAF-2
  • HY-101182
    THK-5117

    		Microtubule/Tubulin Neurological Disease
    THK-5117, an arylquinoline derivative, displays high binding affinity to tau fibrils with a Ki of 10.5 nM. THK-5117 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD)  brain homogenates. 18F-THK-5117 has the potential to act as a tau imaging PET probe .
    THK-5117
  • HY-101140
    KI696
    15+ Cited Publications

    		 Keap1-Nrf2 Metabolic Disease Inflammation/Immunology
    KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of the KEAP1/NRF2 interaction .
    KI696
  • HY-111188
    A55453

    		Adrenergic Receptor Others
    A55453 is a prazosin analogue and a potent α1-adrenergic antagonist. 125I-A55453 is a high-affinity alpha 1-adrenergic receptor probe .
    A55453
  • HY-156842
    MCAAD-3

    		Amyloid-β Neurological Disease
    MCAAD-3 is a near-infrared Aβ imaging probe with blood-brain barrier penetrability. MCAAD-3 has a strong affinity for Aβ polymers (Ki >106 nM) and can label Aβ plaques in the brains of transgenic mice .
    MCAAD-3
  • HY-P2510
    Parathyroid Hormone (1-34), human, biotinylated

    		Thyroid Hormone Receptor Metabolic Disease
    Parathyroid Hormone (1-34), human, biotinylated is a probe for the parathyroid hormone receptor, can be used for analyzing the interaction between parathyroid hormone and parathyroid hormone receptors in living cells and for purifying hormone-receptor complexes with affinity columns .
    Parathyroid Hormone (1-34), human, biotinylated
  • HY-107725
    BIBO3304
    3 Publications Verification

    		 Neuropeptide Y Receptor Metabolic Disease
    BIBO3304, a chemical probe, is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively) .
    BIBO3304
  • HY-157556
    BPP-2

    		GHSR Others
    BPP-2 is a GHSR ligand with an F element. Using 18F isotope labeling BPP-2, a PET probe targeting GHSR can be obtained. The binding affinity Ki of 18F-BPP-2 for GHSR is 274 nM .
    BPP-2
  • HY-116222
    A 53693

    		Fluorescent Dye Endocrinology
    A 53693 is a rigid catecholamine with selective adrenergic agonist activity. A 53693 has affinity for certain rat alpha-2 receptor subtypes. A 53693 shows high selectivity for alpha-2 receptors and, in contrast, has low affinity for alpha-1 receptors. A 53693 is used as a probe in biological studies to explore the molecular interactions of alpha agonist compounds .
    A 53693
  • HY-D2345
    GZ22-4

    		Fluorescent Dye Carbonic Anhydrase Cancer
    GZ22-4 is a near-infrared (NIR) fluorescent probe. GZ22-4 shows high affinity for carbonic anhydrase IX (CAIX), with a Kd of 0.2 nM. GZ22-4 can be used for the research of visualize CAIX-positive tumors .
    GZ22-4
  • HY-155772
    LUF7690

    		Adenosine Receptor Fluorescent Dye Inflammation/Immunology
    LUF7690 (Compound 9) is a clickable and covalent affinity-based probe (AfBP) that targets the human A3AR (hA3AR). LUF7690 can be used in the detection and characterization of the hA3AR in different types of granulocytes, among other cell types .
    LUF7690
  • HY-113331F
    Thromboxane B2-biotin

    		Biochemical Assay Reagents Others
    Thromboxane B2-biotin is an affinity probe that allows detection of thromboxane B2 through an interaction with the biotin ligand. Thromboxane B2-biotin is designed to allow thromboxane B2 to be detected in complexes with protein binding partners .
    Thromboxane B2-biotin
  • HY-122653
    CCT367766

    		PROTACs Cancer
    CCT367766 is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein .
    CCT367766
  • HY-153748
    ML162-yne

    		Glutathione Peroxidase Cancer
    ML162-yne is a potent GPX4-inhibitor affinity probe . ML162-yne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    ML162-yne
  • HY-122653A
    CCT367766 formic

    		PROTACs Cancer
    CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein .
    CCT367766 formic
  • HY-160063
    SW1 aptamer sodium

    		Fluorescent Dye DNA Alkylator/Crosslinker Cancer
    SW1 aptamer sodium is a high-affinity DNA aptamer (Kd: 123.62 nM) that targets liver cancer SMMC-7721 cells and targets intracellular components within the nucleus. SW1 aptamer sodium can also identify various other types of cancer cells and tissues, serving as an effective molecular probe for clinical cancer diagnosis .
    SW1 aptamer sodium
  • HY-175086
    PtdIns-(3,4,5)-P3-fluorescein triethylammonium

    DOPI-3,4,5-P3-fluorescein triethylammonium; PI(3,4,5)P3-fluorescein triethylammonium; PIP3[3',4',5']-fluorescein triethylammonium

    		 Fluorescent Dye Others
    PtdIns-(3,4,5)-P3 is a second messenger. PtdIns-(3,4,5)-P3-fluorescein triethylammonium is a fluorescent probe that can detect any protein that has a high-affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids .
    PtdIns-(3,4,5)-P3-fluorescein triethylammonium
  • HY-136214
    R-BC154 acetate

    		Integrin Inflammation/Immunology Cancer
    R-BC154 acetate is a selective fluorescent α9β1 integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity .
    R-BC154 acetate
  • HY-101418
    JNJ-47965567
    5 Publications Verification

    		 P2X Receptor Neurological Disease
    JNJ-47965567 is a centrally permeable, high-affinity, selective P2X7 antagonist, with pKis of 7.9 and 8.7 for human and rat P2X7, respectively. JNJ-47965567 can be used to probe the role of central P2X7 in rodent models of CNS pathophysiology .
    JNJ-47965567
  • HY-D2268
    QM-FN-SO3

    		Fluorescent Dye Amyloid-β Neurological Disease
    QM-FN-SO3 is a BBB-penetrable near-infrared (NIR) aggregation-induced emission (AIE)-active probe for Aβ plaques. QM-FN-SO3 can be used for in vivo detection of Aβ plaques. QM-FN-SO3 has ultra-high S/N ratio, binding affinity, and high-performance NIR emission .
    QM-FN-SO3
  • HY-172534
    BPN-01

    		Fluorescent Dye EGFR TSPO Cancer
    BPN-01 is a fluorescent probe targeting translocator protein (TSPO) and human epidermal growth factor receptor 2 (HER2) with binding affinities of -10.7 kcal/mol for TSPO and -11.3 kcal/mol for HER2. BPN-01 is promising for research of solid tumor imaging during fluorescence image-guided surgery (FIGS) (Ex/Em = 475/510 nm) .
    BPN-01
  • HY-147115
    4-Azidophlorizin

    		Fluorescent Dye Others
    4-Azidophlorizin is a high affinity probe and photoaffinity label for the glucose transporter in brush border membranes . 4-Azidophlorizin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    4-Azidophlorizin
  • HY-D2268A
    QM-FN-SO3 ammonium

    		Amyloid-β Fluorescent Dye Neurological Disease
    QM-FN-SO3 ammonium is a BBB-penetrable near-infrared (NIR) aggregation-induced emission (AIE)-active probe for Aβ plaques. QM-FN-SO3 ammonium can be used for in vivo detection of Aβ plaques. QM-FN-SO3 ammonium has ultra-high S/N ratio, binding affinity, and high-performance NIR emission .
    QM-FN-SO3 ammonium
  • HY-101189
    JNJ-39758979

    		Histamine Receptor Neurological Disease Endocrinology
    JNJ-39758979, a chemical probe, is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity .
    JNJ-39758979
  • HY-141511
    Coppersensor 1
    20+ Cited Publications

    		 Fluorescent Dye Neurological Disease Cancer
    Coppersensor-1 (CS1) is a membrane-permeable fluorescent dye. Coppersensor-1 has a picomolar affinity for Cu + with high selectivity over competing cellular metalions. Coppersensor-1 as a probe, can selective and sensitive detection of copper(I) ions (Cu +) in biological samples, including live cells. Coppersensor-1 can be used for the research of imaging of severe diseases such as cancer, cardiovascular disorders and neurogenerative diseases .
    Coppersensor 1
  • HY-176548
    PY-PAP

    		YAP Annexin A Inflammation/Immunology
    PY-PAP is a photoactivatable affinity probe and a derivative of PY-60 (HY-141644). PY-PAP retains the cellular function of activating YAP transcriptional activity. In 293A cells, PY-PAP can label cathepsin D (CTSD) and annexin A2 (ANXA2) through ultraviolet crosslinking and click reactions. PY-PAP plays a key role in identifying ANXA2 as the specific target of PY-60 .
    PY-PAP

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