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Results for "

Acyltransferase Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (99) Angiotensin Receptor (1) Apoptosis (3) Bacterial (2) BCRP (2) Biochemical Assay Reagents (1) Calcium Channel (1) Casein Kinase (1) DNA/RNA Synthesis (1) Drug Intermediate (1) Endogenous Metabolite (7) ERK (2) Ferroptosis (1) Fungal (1) GlyT (3) Hedgehog (5) Isotope-Labeled Compounds (4) NF-κB (1) OAT (2) Parasite (2) Phytohormone (1) PKC (3) Platelet-activating Factor Receptor (PAFR) (1) Porcupine (2) Reference Standards (2) STAT (1) Wnt (3)
By Research Areas:	Cancer (23) Cardiovascular Disease (17) Endocrinology (1) Infection (26) Inflammation/Immunology (16) Metabolic Disease (50) Neurological Disease (5)
Oligonucleotides:	Antisense Oligonucleotides (1)

120

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Acyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13009

PF-04620110 5 Publications Verification	Acyltransferase	Metabolic Disease
PF-04620110 is a potent, selective and orally bioavailable *diglyceride acyltransferase-1 (DGAT-1)* inhibitor with an IC₅₀ of 19 nM .

HY-112851

*Diacylglycerol acyltransferase* inhibitor-1**	Acyltransferase	Metabolic Disease
Diacylglycerol acyltransferase inhibitor-1 is a diacylglycerol acyltransferase (DGAT1) inhibitor.

HY-162854

*Diacylglycerol acyltransferase* inhibitor-2**	Acyltransferase	Metabolic Disease
Diacylglycerol acyltransferase inhibitor-2 (Example 8) is an inhibitor of Diacylglycerol Acyl Transferase 2 (DGAT2) with an IC₅₀ value of 3.7 nM .

HY-121762

NTE-122 dihydrochloride	Acyltransferase	Cardiovascular Disease
NTE-122 (dihydrochloride) is an inhibitor of acyl-CoA:cholesterol *acyltransferase* (ACAT), with the IC₅₀ in liver and aorta of cholesterol-fed rabbits of 7.6nM, 4.4nM and 9.6 nM, respectively, that plays an important role in atherosclerosis .

HY-121407

Lateritin	Acyltransferase	Infection Cancer
Lateritin is a potent inhibitor of **acyl-CoA:cholesterol acyltransferase (ACAT*), isolated from the mycelial cake of Gibberella lateritium* IFO 7188 . Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans .

HY-N14614

Pyripyropene B	Acyltransferase	Metabolic Disease
Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor found in the fungus Aspergillus fumigatus FO 1289. Pyripyropene B inhibits acyl-CoA: cholesterol acyltransferase with an IC₅₀ of 117 nM .

HY-N14573

Glisoprenin B	Acyltransferase	Infection
Glisoprenin B is a *cholesterol acyltransferase* (ACAT)** inhibitor .

HY-N14648

Purpactin B	Acyltransferase	Metabolic Disease
Purpactin B is a cholesterol acyltransferase (ACAT) inhibitor .

HY-N14649

Purpactin C	Acyltransferase	Metabolic Disease
Purpactin C is a cholesterol acyltransferase (ACAT) inhibitor .

HY-N14793

Amidepsin B	Acyltransferase	Metabolic Disease
Amidepsin B is a diacylglycerol acyltransferase (DGAT) inhibitor .

HY-N14794

Amidepsin C	Acyltransferase	Metabolic Disease
Amidepsin C is a diacylglycerol acyltransferase (DGAT) inhibitor .

HY-N10224

Terpendole C	Acyltransferase	Metabolic Disease
Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase (ACAT) .

HY-N14581

Roselipin 1A	Acyltransferase	Infection
Roselipin 1A inhibits *diacylglycerol acyltransferases* (DGAT)** of rat hepatic microcosm .

HY-N14580

Roselipin 2A	Acyltransferase	Infection
Roselipin 2A inhibits *diacylglycerol acyltransferases* (DGAT)** of rat hepatic microcosm .

HY-N14525

Glisoprenin A	Acyltransferase	Infection
Glisoprenin A is a *cholesterol acyltransferase* (ACAT)** inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14578

Roselipin 2B	Acyltransferase	Infection
Roselipin 2B inhibits *diacylglycerol acyltransferases* (DGAT)** of rat hepatic microcosm .

HY-N14584

Roselipin 1B	Acyltransferase	Infection
Roselipin 1B inhibits *diacylglycerol acyltransferases* (DGAT)** of rat hepatic microcosm .

HY-N14813

Glisoprenin D	Acyltransferase	Infection
Glisoprenin D is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14574

Glisoprenin C	Acyltransferase	Infection
Glisoprenin C is a *cholesterol acyltransferase* (ACAT)** inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14816

Glisoprenin E	Acyltransferase	Infection
Glisoprenin E is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N9552

Purpactin A	Acyltransferase	Infection
Purpactin A is a cholesterol acyltransferase (ACAT) inhibitor found in Pen. Purpurogenum FO-6 .

HY-112489

FSG67 2 Publications Verification	Acyltransferase	Metabolic Disease
FSG67 is a *glycerol 3-phosphate acyltransferase* (GPAT)** inhibitor with an IC₅₀ of 24 μM .

HY-119265

LDL-IN-4	Acyltransferase	Metabolic Disease
LDL-IN-4 (Compound 2) inhibits human acyl-CoA:cholesterol acyltransferase-1 and -2 activities. LDL-IN-4 inhibits copper-mediated low density lipoprotein (LDL) oxidation, with an IC₅₀ of 3 μM. LDL-IN-4 has anti-atherosclerotic biological activity .

HY-117832

Pyripyropene A 1 Publications Verification	Acyltransferase	Infection Cardiovascular Disease Inflammation/Immunology
Pyripyropene A is an orally active, potent and selective *sterol O-acyltransferase* 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)** inhibitor, with an IC₅₀ of 0.07 µM. Pyripyropene A attenuates hypercholesterolemia and atherosclerosis in vivo .

HY-111417

GSK2973980A	Acyltransferase	Metabolic Disease
GSK2973980A is a potent and selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor with an IC₅₀ of 3 nM.

HY-19183

E-5324	Acyltransferase	Metabolic Disease
E-5324 is potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC₅₀s of 44 to 190 nM.

HY-N10234

Phenylpyropene A	Acyltransferase	Infection
Phenylpyropene A, a fungal metabolite, is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ of 0.8 μM .

HY-16281

Lecimibide DuP 128	Acyltransferase	Metabolic Disease
Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research .

HY-108339

PF-06471553 1 Publications Verification	Acyltransferase	Metabolic Disease
PF-06471553 is a potent, selective and orally available *monoacylglycerol acyltransferase* 3 (MGAT3)** inhibitor, with an IC₅₀ of 92 nM.

HY-N10788

Pomonic acid	Acyltransferase	Inflammation/Immunology
Pomonic acid is a triterpenoid that significantly inhibits cholesterol ester accumulation and suppresses the acyl coenzyme A:cholesterol acyltransferase (ACAT) activity .

HY-101627

YM17E	Acyltransferase	Metabolic Disease
YM17E is an inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), with IC₅₀ of 44 nM in rabbit liver microsomes in vitro.

HY-16437

RP-64477	Acyltransferase	Cardiovascular Disease
RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).

HY-113671

Belfosdil	Calcium Channel Acyltransferase	Others
Belfosdil is an orally active and highly specific calcium channel blocker that also inhibits the activity of acyl coenzyme A cholesterol acyltransferase .

HY-N8331

Terpendole I	Acyltransferase Endogenous Metabolite	Cancer
Terpendole I, a fungal indoloditerpene, is a ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor (IC₅₀=145 µM) .

HY-139024

ACAT-IN-7	Acyltransferase	Inflammation/Immunology
ACAT-IN-7 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-7 inhibits NF-κB mediated transcription .

HY-139020

ACAT-IN-3	Acyltransferase	Inflammation/Immunology
ACAT-IN-3 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-3 inhibits NF-κB mediated transcription .

HY-161906

SD-066-4	Acyltransferase	Cancer
SD-066-4 is an orally active *acyltransferase* inhibitor. SD-066-4 can be used in cancer research .

HY-122078

FR-190809	Acyltransferase	Metabolic Disease
FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC₅₀ of 45 nM .

HY-N14968

Enniatin F	Parasite Fungal	Infection
Enniatin F has insecticidal and antifungal activity. Enniatin F also can inhibit acyl-CoA, cholesterol acyltransferase (ACAT) .

HY-105445

CP-113818 2 Publications Verification	Acyltransferase	Neurological Disease
CP-113818 is a potent cholesterol acyltransferase (ACAT) inhibitor. CP-113818 can be used for the research of Alzheimer's disease .

HY-19286

Eflucimibe F 12511	Acyltransferase	Cancer
Eflucimibe (F 12511) is a new acyl-coenzyme *A cholesterol O-acyltransferase* (ACAT)** inhibitor. Eflucimibe can be used in the research of atherosclerosis .

HY-112487

Sandoz 58-035	Acyltransferase	Endocrinology
Sandoz 58-035 is a competitive inhibitor of cholesterol acyltransferase (ACAT). Sandoz 58-035 effectively inhibits (>98%) hormonally stimulated cholesterol esterification in cells .

HY-107572

PD 128042 CI 976	Acyltransferase	Metabolic Disease
PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC₅₀s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC₅₀=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway .

HY-139025

ACAT-IN-8	Acyltransferase	Inflammation/Immunology
ACAT-IN-8 (example 206) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-8 inhibits NF-κB mediated transcription .

HY-139021A

ACAT-IN-4 hydrochloride	Acyltransferase	Inflammation/Immunology
ACAT-IN-4 hydrochloride (Example 208) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-4 hydrochloride inhibits NF-κB mediated transcription .

HY-139021

ACAT-IN-4	Acyltransferase	Inflammation/Immunology
ACAT-IN-4 (Example 208) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-4 inhibits NF-κB mediated transcription .

HY-139022

ACAT-IN-5	Acyltransferase	Inflammation/Immunology
ACAT-IN-5 (example 19) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-5 inhibits NF-κB mediated transcription .

HY-160804

Desmethyl nevanimibe	Drug Intermediate	Cancer
Desmethyl nevanimibe (Compound 5) is the demethyl precursor of the *sterol O-acyltransferase* 1 (SOAT1*) inhibitor* Nevanimibe (PD-132301) .

HY-U00430

MGAT2-IN-2	Acyltransferase	Metabolic Disease
MGAT2-IN-2 is a potent and selective acyl CoA:monoacylglycerol acyltransferase 2 (MGAT2) inhibitor with an IC₅₀ of 3.4 nM.

HY-125319

Amidepsine A	Acyltransferase	Metabolic Disease
Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity .

Cat. No.	Product Name	Type

HY-13912G

IWP-2 (GMP) 1 Publications Verification	Fluorescent Dye
IWP-2 (GMP) is IWP-2 (HY-13912) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWP-2 is an inhibitor of Wnt processing and secretion with an IC₅₀ of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and blocks Wnt ligand palmitoylation .

Cat. No.	Product Name	Type

HY-13912G

IWP-2 (GMP) 1 Publications Verification	Biochemical Assay Reagents
IWP-2 (GMP) is IWP-2 (HY-13912) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWP-2 is an inhibitor of Wnt processing and secretion with an IC₅₀ of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and blocks Wnt ligand palmitoylation .

HY-141572

1,2-Dioleoyl-sn-glycerol

sn-1,2-Dioleoylglycerol

Drug Delivery

ALN29882 is a glycerolipid located on the plasma membrane. It consists of two fatty acid chains covalently linked to a single glycerol molecule by means of an ester bond. 18:1 DG has been used as a source of diacylglycerol in the diacylglycerol O-acyltransferase 1 (DGAT1) assay. It is also used as a substrate in the DGAT-1 enzyme assay to evaluate compounds as potential inhibitors of DGAT-1. Suitable for lipoprotein overlay screening assays with the recombinant protein His-AtROP6.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N14614

Pyripyropene B	Structural Classification Natural Products Microorganisms Ketones, Aldehydes, Acids Source classification	Acyltransferase
Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor found in the fungus Aspergillus fumigatus FO 1289. Pyripyropene B inhibits acyl-CoA: cholesterol acyltransferase with an IC₅₀ of 117 nM .

HY-N14573

Glisoprenin B	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
Glisoprenin B is a *cholesterol acyltransferase* (ACAT)** inhibitor .

HY-N14648

Purpactin B	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Acyltransferase
Purpactin B is a cholesterol acyltransferase (ACAT) inhibitor .

HY-N14649

Purpactin C	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
Purpactin C is a cholesterol acyltransferase (ACAT) inhibitor .

HY-N14793

Amidepsin B	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Acyltransferase
Amidepsin B is a diacylglycerol acyltransferase (DGAT) inhibitor .

HY-N14794

Amidepsin C	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Acyltransferase
Amidepsin C is a diacylglycerol acyltransferase (DGAT) inhibitor .

HY-N10224

Terpendole C	Alkaloids Microorganisms Classification of Application Fields Source classification Metabolic Disease Disease Research Fields Indole Alkaloids	Acyltransferase
Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase (ACAT) .

HY-N14581

Roselipin 1A	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
Roselipin 1A inhibits *diacylglycerol acyltransferases* (DGAT)** of rat hepatic microcosm .

HY-N14580

Roselipin 2A	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
Roselipin 2A inhibits *diacylglycerol acyltransferases* (DGAT)** of rat hepatic microcosm .

HY-N14525

Glisoprenin A	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
Glisoprenin A is a *cholesterol acyltransferase* (ACAT)** inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14578

Roselipin 2B	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
Roselipin 2B inhibits *diacylglycerol acyltransferases* (DGAT)** of rat hepatic microcosm .

HY-N14584

Roselipin 1B	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
Roselipin 1B inhibits *diacylglycerol acyltransferases* (DGAT)** of rat hepatic microcosm .

HY-N14813

Glisoprenin D	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
Glisoprenin D is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14574

Glisoprenin C	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
Glisoprenin C is a *cholesterol acyltransferase* (ACAT)** inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14816

Glisoprenin E	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
Glisoprenin E is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N9552

Purpactin A	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
Purpactin A is a cholesterol acyltransferase (ACAT) inhibitor found in Pen. Purpurogenum FO-6 .

HY-117832

Pyripyropene A 1 Publications Verification	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Inflammation/Immunology Disease Research Fields	Acyltransferase
Pyripyropene A is an orally active, potent and selective *sterol O-acyltransferase* 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)** inhibitor, with an IC₅₀ of 0.07 µM. Pyripyropene A attenuates hypercholesterolemia and atherosclerosis in vivo .

HY-N10234

Phenylpyropene A	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Acyltransferase
Phenylpyropene A, a fungal metabolite, is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ of 0.8 μM .

HY-N10788

Pomonic acid	Triterpenes Structural Classification Terpenoids Verbenaceae Source classification Plants Lantana camaraLinn.	Acyltransferase
Pomonic acid is a triterpenoid that significantly inhibits cholesterol ester accumulation and suppresses the acyl coenzyme A:cholesterol acyltransferase (ACAT) activity .

HY-N8331

Terpendole I	Alkaloids Microorganisms Classification of Application Fields Terpenoids Source classification Diterpenoids Disease Research Fields Indole Alkaloids Cancer	Acyltransferase Endogenous Metabolite
Terpendole I, a fungal indoloditerpene, is a ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor (IC₅₀=145 µM) .

HY-N14968

Enniatin F	Structural Classification Natural Products Microorganisms Source classification	Parasite Fungal
Enniatin F has insecticidal and antifungal activity. Enniatin F also can inhibit acyl-CoA, cholesterol acyltransferase (ACAT) .

HY-125319

Amidepsine A	Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Disease Research Fields	Acyltransferase
Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity .

HY-N6702

Enniatin A	Cardiovascular Disease Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields	Acyltransferase
Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes .

HY-121254

GERI-BP002-A	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
GERI-BP002-A is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) produced by Aspergillus fumigatus F93, which can be used in cancer research .

HY-N6723

Fumonisin B2	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Endogenous metabolite Disease Research Fields Other Antibiotics	Acyltransferase
Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of *sphingosine N-acyltransferase* (ceramide synthase)** and disrupts de novo sphingolipid biosynthesis .

HY-16197

Epicochlioquinone A	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
Epicochlioquinone A can inhibit rat liver microsomal ACAT with IC₅₀ of 1.7 μM, inhibit plasma lecithin cholesterol acyltransferase (LCAT) with IC₅₀ of 15.8 μM, and inhibit cholesterol absorption in rats by 50% at 75 mg/kg .

HY-113054

DL-Glyceraldehyde 3-phosphate	Infection Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Acyltransferase Bacterial Endogenous Metabolite
DL-Glyceraldehyde 3-phosphate is an intermediate in several metabolic pathways, including glycolysis and gluconeogenesis. DL-Glyceraldehyde 3-phosphate is a potent inhibitor of the growth of *E. coli. DL-Glyceraldehyde 3-phosphate is a competitive inhibitor* of the *acyltransferase* .

HY-169813

Yakuchinone B	Structural Classification Monophenols Source classification Phenols Plants Alpinia oxyphylla Miq. Zingiberaceae	Acyltransferase
Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor with hypocholesterolemic activity, which is found in the seeds of Zingiberaceae. Yakuchinone B inhibits rat hepatic ACAT with an IC₅₀ value of 20.6 μM. Yakuchinone B is promising for research of hypercholesterolemia and atherosclerosis .

HY-N15411

Helminthosporol	Structural Classification Terpenoids Sesquiterpenes Source classification Artemisia desertorum Spreng. Plants Compositae	Acyltransferase Phytohormone
Helminthosporol is a natural plant growth-regulator that can promote the growth of rice and lettuce seedlings. Helminthosporol can also inhibit the activity of acyl-CoA: cholesterol acyltransferase (ACAT) in rat liver microsomes and the synthesis of cholesterol esters in macrophages .

HY-N14715

Gypsetin	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
Gypsetin can inhibit acylcoenzyme A, cholesterol acyltransferase (ACAT) activity, inhibit rat liver microbody ACAT with an IC₅₀ of 18 μM, and its action is competitive with oleoyl-COA substrate, K_i value is 5.5 μM. Gypsetin also inhibits Oleic acid from forming cholesterol esters with an IC₅₀ of 0.65 μM .

HY-N6719

Fumonisin B1 5 Publications Verification	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Endogenous metabolite Disease Research Fields Other Antibiotics	Acyltransferase
Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of *sphingosine N-acyltransferase* (ceramide synthase)** and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .

HY-N4193

Glabrol 2 Publications Verification	Cardiovascular Disease Structural Classification Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields	Acyltransferase
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ value of 24.6 μM for rat liver microsomal ACAT activity .

HY-N3806

Enniatin B	Infection Cardiovascular Disease Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields	Acyltransferase ERK
Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 113 μM in an enzyme assay using rat liver microsomes . Enniatins B decreases the activation of ERK (p44/p42) .

HY-129340

AS-183	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC₅₀=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC₅₀ values of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia .

HY-113202

Stearoylcarnitine 1 Publications Verification	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite PKC GlyT
Stearoylcarnitine, a fatty ester lipid molecule, is an endogenous metabolite. Stearoylcarnitine can be used as PKC inhibitor. Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoylcarnitine inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoylcarnitine acts as a metabolomics biomarker for Parkinson’s disease. Stearoylcarnitine is a less potent inhibitor of GlyT2 .

HY-N3807

Enniatin B1 1 Publications Verification	Infection Cardiovascular Disease Alkaloids Structural Classification Microorganisms Classification of Application Fields Other Alkaloids Source classification Disease Research Fields	Acyltransferase ERK NF-κB
Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 73 μM in an enzyme assay using rat liver microsomes . Enniatin B1 crosss the blood-brain barrier . Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation .

HY-N9530

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone	Cardiovascular Disease Alkaloids Classification of Application Fields Source classification Evodia rutaecarpa (Juss.) Benth. Rutaceae Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields	Acyltransferase Angiotensin Receptor Bacterial
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC₅₀s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL .

Cat. No.	Product Name	Chemical Structure

HY-N6723S

Fumonisin B2-13C34
Fumonisin B2- ¹³C₃₄ is the ¹³C labeled Fumonisin B2 (HY-N6723) . Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of *sphingosine N-acyltransferase* (ceramide synthase)** and disrupts de novo sphingolipid biosynthesis .

HY-N6719S

Fumonisin B1-13C34
Fumonisin B1- ¹³C₃₄ is the ¹³C labeled Fumonisin B1 (HY-N6719) . Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of *sphingosine N-acyltransferase* (ceramide synthase)** and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .

HY-113202S

Stearoyl-L-carnitine-d3

Stearoyl-L-carnitine-d₃ is the deuterium labeled Stearoylcarnitine. Stearoylcarnitine, a fatty ester lipid molecule, is an endogenous metabolite. Stearoylcarnitine can be used as PKC inhibitor. Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoylcarnitine inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoylcarnitine acts as a metabolomics biomarker for Parkinson’s disease. Stearoylcarnitine is a less potent inhibitor of GlyT2 .

HY-113202S1

Stearoyl-L-carnitine-d9 chloride

Stearoyl-L-carnitine-d9 chloride is the deuterium labeled Stearoyl-L-carnitine chloride. Stearoyl-L-carnitine chloride, a fatty ester lipid molecule, is an endogenous metabolite. Stearoyl-L-carnitine chloride can be used as PKC inhibitor. Stearoyl-L-carnitine chloride accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoyl-L-carnitine chloride inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoyl-L-carnitine chloride acts as a metabolomics biomarker for Parkinson’s disease. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2 .

Cat. No.	Product Name		Classification

HY-145624

Obeversen		Antisense Oligonucleotides
Obeversen is an antisense oligonucleotide that inhibits the synthesis of *diacylglycerol acyltransferase* 2 (DGAT-2)**. Obeversen can be used in the research of nonalcoholic fatty liver disease .

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