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Results for "

Active scaffold

" in MedChemExpress (MCE) Product Catalog:

22

Inhibitors & Agonists

9

Biochemical Assay Reagents

1

Peptides

5

Natural
Products

9

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-112299
    Zipalertinib
    2 Publications Verification

    TAS6417; CLN-081

    		 EGFR Apoptosis Cancer
    Zipalertinib (TAS6417; CLN-081) is a highly effective, orally active and pan-mutation-selective EGFR tyrosine kinase inhibitor with a unique scaffold fitting into the ATP-binding site of the EGFR hinge region, with IC50 values ranging from 1.1-8.0 nM .
    Zipalertinib
  • HY-176774
    L07-2

    		Toll-like Receptor (TLR) Cancer
    L07-2 (Compound 6) is an active scaffold comprising a stimulator of TLR7/8. L07-2 can be used for synthesis of immune-stimulating antibody conjugates (ISACs) for cancers research .
    L07-2
  • HY-146079
    Antifungal agent 31

    		Fungal Infection
    Antifungal agent 31 (compound 12) is a potent and orally active triazole antifungal agents with a pyrrolotriazinone scaffold. Antifungal agent 31 shows antifungal activity against Candida spp. and filamentous fungi. Antifungal agent 31 significantly reduced mortality rates and kidney fungal burden in two murine models of lethal systemic infections .
    Antifungal agent 31
  • HY-155918
    mPEG-CHO (MW 1000)

    mPEG-Aldehyde (MW 1000)

    		 Biochemical Assay Reagents Others
    mPEG-CHO (MW 1000) participates in the formation of a three-dimensional porous scaffold that carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
    mPEG-CHO (MW 1000)
  • HY-155920
    mPEG-CHO (MW 3400)

    mPEG-Aldehyde (MW 3400)

    		 Biochemical Assay Reagents Others
    mPEG-CHO (MW 3400) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
    mPEG-CHO (MW 3400)
  • HY-155917
    mPEG-CHO (MW 750)

    mPEG-Aldehyde (MW 750)

    		 Biochemical Assay Reagents Others
    mPEG-CHO (MW 750) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
    mPEG-CHO (MW 750)
  • HY-155922
    mPEG-CHO (MW 10000)

    mPEG-Aldehyde (MW 10000)

    		 Biochemical Assay Reagents Others
    mPEG-CHO (MW 10000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
    mPEG-CHO (MW 10000)
  • HY-155916
    mPEG-CHO (MW 550)

    mPEG-Aldehyde (MW 550)

    		 Biochemical Assay Reagents Others
    mPEG-CHO (MW 550) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
    mPEG-CHO (MW 550)
  • HY-155923
    mPEG-CHO (MW 20000)

    mPEG-Aldehyde (MW 20000)

    		 Biochemical Assay Reagents Others
    mPEG-CHO (MW 20000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
    mPEG-CHO (MW 20000)
  • HY-155919
    mPEG-CHO (MW 2000)

    mPEG-Aldehyde (MW 2000)

    		 Biochemical Assay Reagents Others
    mPEG-CHO (MW 2000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
    mPEG-CHO (MW 2000)
  • HY-N6856
    4-Hydroxycoumarin

    		Bacterial Endogenous Metabolite Infection Cancer
    4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .
    4-Hydroxycoumarin
  • HY-155915
    mPEG-CHO (MW 350)

    mPEG-Aldehyde (MW 350)

    		 Biochemical Assay Reagents Others
    mPEG-CHO (MW 350) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
    mPEG-CHO (MW 350)
  • HY-155921
    mPEG-CHO (MW 5000)

    mPEG-Aldehyde (MW 5000)

    		 Biochemical Assay Reagents Others
    mPEG-CHO (MW 5000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.
    mPEG-CHO (MW 5000)
  • HY-N0126
    Xanthone
    1 Publications Verification

    		 Monoamine Oxidase Calcium Channel Cardiovascular Disease Neurological Disease
    Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K +-induced vasoconstriction with IC50 values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca 2+ channels. Xanthone is the scaffold of several pharmacologically active compounds .
    Xanthone
  • HY-160851
    GDC-3280

    AK3287; AKEX0011

    		 ASK1 p38 MAPK Inflammation/Immunology
    GDC-3280 (AK3287; AKEX0011) is an orally active compound based on Pirfenidone (HY-B0673)'s phenyl pyridone scaffold. GDC-3280 alleviates the inflammatory and fibrotic reaction of silicosis by inhibiting the ASK1-p38 MAPK pathway and regulating macrophage polarization. GDC-3280 exhibits anti-inflammatory and anti-fibrotic effects .
    GDC-3280
  • HY-147695
    c-Met-IN-12

    		c-Met/HGFR Cancer
    c-Met-IN-12 (compound 4r) is an orally active, potent and selective type II c-Met kinase inhibitor, with an IC50 of 10.6 nM. c-Met-IN-12 displays high inhibitory effects (inhibition rate > 80% in 1 μM) against AXL, Mer and TYRO3 kinases. c-Met-IN-12 can be used a scaffold for further kinase selectivity enhancement. c-Met-IN-12 shows antitumor efficacy .
    c-Met-IN-12
  • HY-N3373R
    Loganetin (Standard)

    		Reference Standards Bacterial Infection
    4-Hydroxycoumarin (Standard) is the analytical standard of 4-Hydroxycoumarin. This product is intended for research and analytical applications. 4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .
    Loganetin (Standard)
  • HY-N6856R
    4-Hydroxycoumarin (Standard)

    		Reference Standards Bacterial Endogenous Metabolite Infection Cancer
    4-Hydroxycoumarin (Standard) is the analytical standard of 4-Hydroxycoumarin. This product is intended for research and analytical applications. 4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .
    4-Hydroxycoumarin (Standard)
  • HY-N0126R
    Xanthone (Standard)
    1 Publications Verification

    		 Reference Standards Monoamine Oxidase Calcium Channel Cardiovascular Disease Neurological Disease
    Xanthone (Standard) is the analytical standard of Xanthone (HY-N0126). This product is intended for research and analytical applications. Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC50 of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K +-induced vasoconstriction with IC50 values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca 2+ channels. Xanthone is the scaffold of several pharmacologically active compounds .
    Xanthone (Standard)
  • HY-148346
    STING agonist-20-Ala-amide-PEG2-C2-NH2

    		Drug-Linker Conjugates for ADC STING Cancer
    STING agonist-20-Ala-amide-PEG2-C2-NH2 is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used for the research of cancer .
    STING agonist-20-Ala-amide-PEG2-C2-NH2
  • HY-148346A
    STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA

    		Drug-Linker Conjugates for ADC STING Cancer
    STING agonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used to synthesize immune-stimulating antibody conjugate (ISAC). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used for the research of cancer .
    STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA
  • HY-164445
    STAT3-IN-32

    		STAT Cancer
    STAT3-IN-32 (compound 2p) is an orally active, potent STAT3 dual phosphorylation inhibitor with an indole-containing tetra-aromatic heterocycle scaffold. STAT3-IN-32 exhibits STAT3 luciferase inhibition activity using HEK293T cells with an IC50 of 5.3 nM and ATP production inhibition activity using BxPC-3 cells with an IC50 of 4.2 nM. STAT3-IN-32 significantly blocks p-Tyr705 and p-Ser727 and causes the abrogation of the corresponding nuclear transcription and mitochondrial oxidative phosphorylation functions of STAT3 by targeting the STAT3 SH2 domain (KD=21.3 nM). STAT3-IN-32 exhibits significant suppressive effects in a pancreatic cancer xenograft model .
    STAT3-IN-32

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