2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. L07-2

L07-2 (Compound 6) is an active scaffold comprising a stimulator of TLR7/8. L07-2 can be used for synthesis of immune-stimulating antibody conjugates (ISACs) for cancers research.

For research use only. We do not sell to patients.

L07-2

L07-2 Chemical Structure

CAS No. : 3093296-36-4

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Based on 1 publication(s) in Google Scholar

L07-2 Related Antibodies

Top Publications Citing Use of Products

View All Toll-like Receptor (TLR) Isoform Specific Products:

View All Isoforms
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • Biological Activity

  • Purity & Documentation

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Description

L07-2 (Compound 6) is an active scaffold comprising a stimulator of TLR7/8. L07-2 can be used for synthesis of immune-stimulating antibody conjugates (ISACs) for cancers research[1].

IC50 & Target[1]

TLR7

 

TLR8

 

Molecular Weight

1190.35

Formula

C56H83N15O14
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C=C1)N(CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N(C)CC(N[C@@H](CC(C)(C)C)C(NCCOC(C)(C)CN2C(COCC)=NC3=C2C4=C(C=CC=C4)N=C3N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (84.01 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8401 mL 4.2004 mL 8.4009 mL
5 mM 0.1680 mL 0.8401 mL 1.6802 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8401 mL 4.2004 mL 8.4009 mL 21.0022 mL
5 mM 0.1680 mL 0.8401 mL 1.6802 mL 4.2004 mL
10 mM 0.0840 mL 0.4200 mL 0.8401 mL 2.1002 mL
15 mM 0.0560 mL 0.2800 mL 0.5601 mL 1.4001 mL
20 mM 0.0420 mL 0.2100 mL 0.4200 mL 1.0501 mL
25 mM 0.0336 mL 0.1680 mL 0.3360 mL 0.8401 mL
30 mM 0.0280 mL 0.1400 mL 0.2800 mL 0.7001 mL
40 mM 0.0210 mL 0.1050 mL 0.2100 mL 0.5251 mL
50 mM 0.0168 mL 0.0840 mL 0.1680 mL 0.4200 mL
60 mM 0.0140 mL 0.0700 mL 0.1400 mL 0.3500 mL
80 mM 0.0105 mL 0.0525 mL 0.1050 mL 0.2625 mL
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L07-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L07-23093296-36-4Toll-like Receptor (TLR)Active scaffoldTLR7/8Immune-stimulating antibody conjugatesISACsCancersInhibitorinhibitorinhibit

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