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Results for "

ATP synthase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ATP Synthase (17) GSK-3 (3) Adenosine Kinase (2) Antibiotic (10) Apoptosis (3) Autophagy (1) Bacterial (14) Biochemical Assay Reagents (1) CDK (1) Drug Intermediate (1) Endogenous Metabolite (5) Fungal (2) HDAC (1) Isotope-Labeled Compounds (2) Keap1-Nrf2 (1) Mitochondrial Metabolism (2) mTOR (3) Oxidative Phosphorylation (2) Reactive Oxygen Species (ROS) (5) Reference Standards (4) Succinate Dehydrogenase (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (4) Infection (15) Inflammation/Immunology (4) Metabolic Disease (5) Neurological Disease (9)

By Targets:

ATP Synthase (17)

GSK-3 (3)

Adenosine Kinase (2)

Antibiotic (10)

Apoptosis (3)

Autophagy (1)

Bacterial (14)

Biochemical Assay Reagents (1)

CDK (1)

Drug Intermediate (1)

Endogenous Metabolite (5)

Fungal (2)

HDAC (1)

Isotope-Labeled Compounds (2)

Keap1-Nrf2 (1)

Mitochondrial Metabolism (2)

mTOR (3)

Oxidative Phosphorylation (2)

Reactive Oxygen Species (ROS) (5)

Reference Standards (4)

Succinate Dehydrogenase (1)

By Research Areas:

Cancer (11)

Cardiovascular Disease (4)

Infection (15)

Inflammation/Immunology (4)

Metabolic Disease (5)

Neurological Disease (9)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: ATP Synthase PGE synthase ATP Citrate Lyase Thymidylate Synthase Acetolactate Synthase (ALS) ATP-binding cassette (ABC) transporters Glucosylceramide Synthase (GCS) NO Synthase Fatty Acid Synthase (FASN) Cyclic GMP-AMP Synthase GSK-3 P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150983

ATP synthase inhibitor 2	ATP Synthase Bacterial	Infection
ATP synthase inhibitor 2 is a Pseudomonas aeruginosa (PA) **ATP synthase inhibitor (IC₅₀*=10 μg/mL). ATP* synthase inhibitor 2 can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL .

HY-112715

ATP synthase inhibitor 1	ATP Synthase	Cardiovascular Disease
ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F₁/F_O-ATP synthase complex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels .

HY-146388

*Mtb ATP* synthase-IN-1**	Bacterial ATP Synthase	Infection
Mtb ATP synthase-IN-1 (compound 6ab) is a potent **Mycobacterium tuberculosis (Mtb) ATP synthase** inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC₅₀ > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium .

HY-N125722

Venturicidin A Aabomycin A1	ATP Synthase Antibiotic	Infection
Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC50 of 31 μg/mL.

HY-14881A

Bedaquiline fumarate 45+ Cited Publications R403323; TMC207 fumarate; R207910 fumarate	Bacterial Antibiotic	Infection
Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.

HY-162804

ATP synthase inhibitor 3	Bacterial ATP Synthase	Infection
ATP synthase inhibitor 3 (compound PT6) is an orally active inhibitor of mycobacterial F-ATP synthase (IC₅₀=0.788 μM). ATP synthase inhibitor 3 inhibits the growth of Mycobacterium tuberculosis H37Rv strain (ATCC-27294) in vitro and depletes intracellular ATP levels at an IC₅₀ value of 30μM .

HY-150983A

ATP synthase inhibitor 2 TFA	ATP Synthase Bacterial	Infection
ATP synthase inhibitor 2 (Compound 22) TFA is a Pseudomonas aeruginosa (PA) **ATP synthase inhibitor (IC₅₀*=10 μg/mL). ATP* synthase inhibitor 2 TFA can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL .

HY-125637

Venturicidin B Aabomycin A2	Antibiotic Fungal ATP Synthase	Infection
Venturicidin B (Aabomycin A2) is a macrolide antibiotic isolated from Streptomyces sp., used as an antifungal agent, a potent inhibitor of the mitochondrial F0-ATP *synthase* complex .

HY-175412

DDTAC Dodecylmercapto-S-(poly(tris(hydroxymethyl)acrylamidomethane); H12-TAC	Biochemical Assay Reagents	Others
DDTAC (H12-TAC) is a detergent that can extract and solubilize membrane proteins. DDTAC has a thio dodecanoyl chain linked to a polar group made of Tris polyalcoholic moieties and can be utilized in extracting yeast ATP synthase from mitochondrial membranes .

HY-155754

3′-Acetate-ATP	ATP Synthase	Others
3’-Acetate-ATP, an ATP analogue, is ATP acetylation product with an maxima uv absorption at 259 nm in water at neutral pH. 3’-Acetate-ATP exerts a blocking effect on nucleic acid polymerization .

HY-N12486

Isofalcarintriol	Keap1-Nrf2 ATP Synthase	Metabolic Disease
Isofalcarintriol is a NRF2 activator and selective inhibitor of the mitochondrial ATP synthase. Isofalcarintriol can be used for aging study .

HY-134141

5-Octyl hydrogen L-glutamate	Drug Intermediate	Metabolic Disease
5-Octyl hydrogen L-glutamate is cell-permeable molecule and can be used for synthesizing 5-octyl ester derivatives (5-octyl α-ketoglutarate) .

HY-N6784

Oligomycin B	ATP Synthase Bacterial Apoptosis Antibiotic	Neurological Disease
Oligomycin B is an antibiotic isolated from marine Streptomyces, used as an eukaryotic **ATP synthase inhibitor, induces apoptosis** .

HY-111651

Gboxin 4 Publications Verification	Oxidative Phosphorylation ATP Synthase Mitochondrial Metabolism	Cancer
Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F₀F₁ ATP synthase. Antitumour activity .

HY-14881AR

Bedaquiline fumarate (Standard) R403323 (Standard); TMC207 fumarate (Standard); R207910 fumarate (Standard)	Reference Standards Bacterial Antibiotic	Infection
Bedaquiline (fumarate) (Standard) is the analytical standard of Bedaquiline (fumarate). This product is intended for research and analytical applications. Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.

HY-118960A

BMS-199264	ATP Synthase	Cardiovascular Disease
BMS-199264 is an inhibitor of *F1F0 ATP* hydrolase (IC₅₀*=0.5 μM) without inhibitory effect on F1F0 ATP* synthase. BMS-199264 selectively inhibits ATP decline during ischemia to reduces cardiac necrosis. BMS-199264 also enhances the recovery of contractile function following reperfusion .

HY-118960

BMS-199264 hydrochloride	ATP Synthase	Cardiovascular Disease
BMS-199264 hydrochloride is an inhibitor of *F1F0 ATP* hydrolase (IC₅₀*=0.5 μM) without inhibitory effect on F1F0 ATP* synthase. BMS-199264 hydrochloride selectively inhibits ATP decline during ischemia to reduces cardiac necrosis. BMS-199264 hydrochloride also enhances the recovery of contractile function following reperfusion .

HY-162028

GaMF1.39	Bacterial	Infection
GaMF1.39 is an antimycobacterial compound, targeting the F-ATP synthase subunit γ. GaMF1.39 displays enhanced anti-tuberculosis activity in combination with ETC inhibitors .

HY-59090

1-Azakenpaullone 3 Publications Verification 1-Akp	GSK-3	Neurological Disease Metabolic Disease
1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of *glycogen synthase* kinase-3 β (GSK-3β), with an IC₅₀** value of 18 nM .

HY-N6782

Oligomycin Maximum Cited Publications 74 Publications Verification	Oxidative Phosphorylation ATP Synthase Fungal Antibiotic	Infection Cancer
Oligomycin, an antifungal antibiotic, is an inhibitor of H ⁺-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells .

HY-14881

Bedaquiline 45+ Cited Publications TMC207; R207910	Bacterial Antibiotic	Infection
Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-11001

PHA-793887 5 Publications Verification	CDK Apoptosis	Cancer
PHA-793887 is a potent, ATP-competitive CDK inhibitor, can inhibit Cdk2, Cdk1, Cdk4, and Cdk9 with IC₅₀s of 8 nM, 60 nM, 62 nM and 138 nM, respectively, and also inhibits glycogen synthase kinase 3β with an IC₅₀ of 79 nM.

HY-172959

mPTP-IN-1	Mitochondrial Metabolism	Cardiovascular Disease
mPTP-IN-1 (Compound 14e) is a mitochondrial permeability transition pore (mPTP) inhibitor. mPTP-IN-1 blocks calcium-induced mPTP opening by targeting the C subunit of ATP synthase. mPTP-IN-1 can be used to study myocardial ischemia/reperfusion injury (IRI) .

HY-W010918R

Adenosine 5'-diphosphate (Standard) Adenosine diphosphate (Standard); ADP (Standard)	Reference Standards Endogenous Metabolite	Others
Adenosine 5'-diphosphate (Standard) is the analytical standard of Adenosine 5'-diphosphate. This product is intended for research and analytical applications. Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors. In Vitro: Adenosine 5'-diphosphate consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases. ATP is an important energy transfer molecule in cells. Adenosine 5'-diphosphate is utilized in a wide number of cellular processes, including respiration, biosynthetic reactions, motility, and cell division.

HY-14881B

(Rac)-Bedaquiline (Rac)-TMC207; (Rac)-R207910	Bacterial	Infection
(Rac)-Bedaquiline is the racemate of Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting both the c- and the ε-subunit. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-W587827

Thiamine triphosphoric acid ester Thiamine triphosphate	Endogenous Metabolite	Neurological Disease Metabolic Disease
Thiamine triphosphoric acid ester (TTP), a neuroactive compound, is a triphosphate derivative of the vitamin thiamine. Thiamine triphosphoric acid ester exists in microorganisms, animal organs and plants. Thiamine triphosphoric acid ester is transiently produced in response to amino acid starvation in E. coli, while constitutively producing at a low rate in mammalian cells. Thiamine triphosphoric acid ester can be synthesized by two different enzymes (AK1 in the cytosol and FoF1-ATP synthase in brain mitochondria). Thiamine triphosphoric acid ester has a basic role in cell metabolism or cell signaling .

HY-14881R

Bedaquiline (Standard) TMC207 (Standard); R207910 (Standard)	Reference Standards Bacterial Antibiotic	Infection
Bedaquiline (Standard) is the analytical standard of Bedaquiline. This product is intended for research and analytical applications. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-14881S2

Bedaquiline impurity 2-d6	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Bedaquiline impurity 2-d₆ is deuterium labeled Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-14881S1

(Rac)-Bedaquiline-d6	Isotope-Labeled Compounds Bacterial Antibiotic	Others
(Rac)-Bedaquiline-d₆ is the deuterium labeled Bedaquiline (HY-14881) . Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-15424

5-Iodotubercidin 5+ Cited Publications NSC 113939; 5-ITu	Adenosine Kinase	Cancer
5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC₅₀ of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .

HY-113038

D-α-Hydroxyglutaric acid 3 Publications Verification (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid	Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits **ATP synthase and inhibits mTOR** signaling .

HY-113914

9-ING-41 4 Publications Verification Elraglusib	GSK-3 Apoptosis Autophagy	Cancer
9-ING-41 (Elraglusib) is a maleimide-based ATP-competitive and selective *glycogen synthase* kinase-3β (GSK-3β) inhibitor with an IC₅₀ of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis** in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic agents .

HY-15424R

5-Iodotubercidin (Standard)	Adenosine Kinase	Cancer
5-Iodotubercidin (Standard) is the analytical standard of 5-Iodotubercidin. This product is intended for research and analytical applications. 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .

HY-100542

D-α-Hydroxyglutaric acid disodium 3 Publications Verification Disodium (R)-2-hydroxyglutarate	Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits **ATP synthase and inhibits mTOR** signaling .

HY-161667

GSK-3β/HDAC-IN-1	GSK-3 HDAC	Neurological Disease
GSK-3β/HDAC-IN-1 (Compd 4) is a brain-penetrant and first in class dual non-ATP-competitive Glycogen Synthase Kinase 3β/Histone Deacetylases (GSK-3β/HDACs) Inhibitor with IC₅₀s of 0.142, 0.03 and 0.045 μM against GSK-3β, HDAC2 and HDAC6, respectively. GSK-3β/HDAC-IN-1 can be used for Alzheimer’s disease research .

HY-162142

BB2-50F	Bacterial Succinate Dehydrogenase Reactive Oxygen Species (ROS)	Infection
BB2-50F, a potent *M. tuberculosis* inhibitor, is a succinate dehydrogenase and F1Fo-ATP synthase inhibitor. BB2-50F rapidly sterilizes both replicating and non-replicating cultures of M. tuberculosis. BB2-50F inhibits succinate oxidation, decreases the activity of the tricarboxylic acid (TCA) cycle, and results in succinate secretion from M. tuberculosis. BB2-50F induces reactive oxygen species (ROS) in M. tuberculosis .

HY-100542R

D-α-Hydroxyglutaric acid disodium (Standard) Disodium (R)-2-hydroxyglutarate (Standard)	Reference Standards Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
D-α-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of D-α-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .

HY-N12486A

(3S,8R,9R)-Isofalcarintriol	Others	Neurological Disease Metabolic Disease Cancer
(3S,8R,9R)-Isofalcarintriol is a natural polyacetylene compound found in carrot root parts. (3S,8R,9R)-Isofalcarintriol is a potent longevity promoter that improves glucose metabolism and has anti-tumor activity. (3S,8R,9R)-Isofalcarintriol can affect cellular respiration, interact with the α subunit of mitochondrial ATP synthase, and promote mitochondrial biogenesis. (3S,8R,9R)-Isofalcarintriol can be used in the study of neurodegenerative diseases, metabolic diseases, and aging .

HY-W654003

D-α-Hydroxyglutaric acid-d5 disodium Disodium (R)-2-hydroxyglutarate-d₅	Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
D-α-Hydroxyglutaric acid-d₅ disodium (Disodium (R)-2-hydroxyglutarate-d₅) is the deuterium labeled D-α-Hydroxyglutaric acid disodium (HY-100542). D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .

Cat. No.	Product Name

HY-L089

Mitochondria-Targeted Compound Library	891 compounds
Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation. MCE supplies a unique collection of 891 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

Mitochondria-Targeted Compound Library

891 compounds

Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

MCE supplies a unique collection of 891 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

5-Octyl hydrogen L-glutamate	Drug Intermediate	Metabolic Disease
5-Octyl hydrogen L-glutamate is cell-permeable molecule and can be used for synthesizing 5-octyl ester derivatives (5-octyl α-ketoglutarate) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N125722

Venturicidin A Aabomycin A1	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields	ATP Synthase Antibiotic
Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC50 of 31 μg/mL.

HY-N6784

Oligomycin B	Structural Classification Microorganisms Antifungal Macrolide Antibiotics Antibiotics Source classification Disease Research	ATP Synthase Bacterial Apoptosis Antibiotic
Oligomycin B is an antibiotic isolated from marine Streptomyces, used as an eukaryotic **ATP synthase inhibitor, induces apoptosis** .

HY-N6782

Oligomycin Maximum Cited Publications 74 Publications Verification	Infection Structural Classification Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields	Oxidative Phosphorylation ATP Synthase Fungal Antibiotic
Oligomycin, an antifungal antibiotic, is an inhibitor of H ⁺-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells .

HY-W010918R

Adenosine 5'-diphosphate (Standard) Adenosine diphosphate (Standard); ADP (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder	Reference Standards Endogenous Metabolite
Adenosine 5'-diphosphate (Standard) is the analytical standard of Adenosine 5'-diphosphate. This product is intended for research and analytical applications. Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors. In Vitro: Adenosine 5'-diphosphate consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases. ATP is an important energy transfer molecule in cells. Adenosine 5'-diphosphate is utilized in a wide number of cellular processes, including respiration, biosynthetic reactions, motility, and cell division.

HY-113038

D-α-Hydroxyglutaric acid 3 Publications Verification (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid	Classification of Application Fields Neurological Disease Anti-aging Source classification Endocrine diseases Endogenous metabolite Immune System Disorder Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Inflammation/Immunology Cancer	Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits **ATP synthase and inhibits mTOR** signaling .

HY-100542

D-α-Hydroxyglutaric acid disodium 3 Publications Verification Disodium (R)-2-hydroxyglutarate	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits **ATP synthase and inhibits mTOR** signaling .

HY-N12486

Isofalcarintriol	Structural Classification Natural Products Source classification Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Plants Umbelliferae	Keap1-Nrf2 ATP Synthase
Isofalcarintriol is a NRF2 activator and selective inhibitor of the mitochondrial ATP synthase. Isofalcarintriol can be used for aging study .

HY-100542R

D-α-Hydroxyglutaric acid disodium (Standard) Disodium (R)-2-hydroxyglutarate (Standard)	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of D-α-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .

HY-N12486A

(3S,8R,9R)-Isofalcarintriol	Structural Classification Natural Products Source classification Umbelliferae Plants Mentha suaveolens Ehrh.	Others
(3S,8R,9R)-Isofalcarintriol is a natural polyacetylene compound found in carrot root parts. (3S,8R,9R)-Isofalcarintriol is a potent longevity promoter that improves glucose metabolism and has anti-tumor activity. (3S,8R,9R)-Isofalcarintriol can affect cellular respiration, interact with the α subunit of mitochondrial ATP synthase, and promote mitochondrial biogenesis. (3S,8R,9R)-Isofalcarintriol can be used in the study of neurodegenerative diseases, metabolic diseases, and aging .

Species:	Human (8) Bovine (1)
Tag:	His (9) SUMO (3) Myc (1)
Source:	E. coli Cell-free (1) P. pastoris (1) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P72098

	ATP5D Protein, Human (His) ATP synthase subunit delta; mitochondrial ; ATP synthase subunit delta; mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; delta subunit; ATP5D; ATPD_HUMAN; F ATPase delta subunit ; F-ATPase delta subunit; Mitochondrial ATP synthase complex delta subunit precusor ; Mitochondrial ATP synthase delta subunit	Human	E. coli
	ATP5D Protein, a vital component of mitochondrial membrane ATP synthase (Complex V), facilitates ATP generation from ADP using the proton gradient established by respiratory chain electron transport complexes. As part of the F(1) domain and central stalk, ATP5D contributes to ATP hydrolysis through a rotary mechanism. The ATP synthase complex, involving ATP5D, is pivotal for cellular energy production via ATP synthesis. ATP5D Protein, Human (His) is the recombinant human-derived ATP5D protein, expressed by E. coli , with N-10*His labeled tag.

HY-P72070

	ACLY Protein, Human (His-SUMO) ACL; Acly; ACLY_HUMAN; ATP citrate pro-S; lyase; ATP citrate lyase; ATP citrate synthase; ATP-citrate pro-S-; -lyase; ATP-citrate synthase; ATPcitrate synthase; ATPCL; Citrate cleavage enzyme; CLATP; OTTHUMP00000164773	Human	E. coli
	ACLY Protein, Human (His-SUMO) is an important enzyme in the cholesterol biosynthetic pathway. ACLY produces acetyl-CoA (AcCoA) from mitochondrial citrate for cholesterol and fatty acid biosynthesis.

HY-P72095

	ATP5F1A Protein, Human (His) ATP synthase alpha chain; ATP synthase alpha chain; mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit 1; cardiac muscle; ; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 2; alpha subunit; ATP5A; ATP5a1; ATP5AL2; ATPA_HUMAN; ATPM; hATP1; HEL-S-123m; MC5DN4; mitochondrial;	Human	E. coli
	ATP5F1A is an important component of mitochondrial ATP synthase (complex V) that coordinates ATP production from ADP by utilizing the transmembrane proton gradient. As part of the F-type ATPase, the α and β subunits of ATP5F1A form the catalytic core to achieve ATP hydrolysis. ATP5F1A Protein, Human (His) is the recombinant human-derived ATP5F1A protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71716

	ATP5F1B Protein, Human (P.pastoris, His) ATP 5B; ATP synthase H+ transporting mitochondrial F1 complex beta polypeptide; ATPB; ATPB_HUMAN; ATPMB; ATPSB	Human	P. pastoris
	ATP5F1B protein is an important component of mitochondrial membrane ATP synthase (complex V). ATP5F1B Protein, Human (P.pastoris, His) is the recombinant human-derived ATP5F1B protein, expressed by P. pastoris , with N-His labeled tag.

HY-P72097

	ATP5D Protein, Human (His-SUMO) ATP synthase subunit delta; mitochondrial ; ATP synthase subunit delta; mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; delta subunit; ATP5D; ATPD_HUMAN; F ATPase delta subunit ; F-ATPase delta subunit; Mitochondrial ATP synthase complex delta subunit precusor ; Mitochondrial ATP synthase delta subunit	Human	E. coli
	ATP5D Protein, a vital component of mitochondrial membrane ATP synthase (Complex V), facilitates ATP generation from ADP using the proton gradient established by respiratory chain electron transport complexes. As part of the F(1) domain and central stalk, ATP5D contributes to ATP hydrolysis through a rotary mechanism. The ATP synthase complex, involving ATP5D, is pivotal for cellular energy production via ATP synthesis. ATP5D Protein, Human (His-SUMO) is the recombinant human-derived ATP5D protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P702220

	ATP5J2 Protein, Human (Cell-Free, His) ATP synthase subunit f, mitochondrial; ATP synthase membrane subunit f	Human	E. coli Cell-free
	ATP5J2 protein is a component of mitochondrial membrane ATP synthase (complex V), which uses the proton gradient established by the respiratory chain electron transport complex to help ADP synthesize ATP. ATP5J2 is located in the F(0) domain as a small subunit and cooperates with subunit a in the membrane. ATP5J2 Protein, Human (Cell-Free, His) is the recombinant human-derived ATP5J2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P71550

	ATP5MG Protein, Bovine (Myc, His) ATP5MG; ATP5LATP synthase subunit g; mitochondrial; ATPase subunit g; ATP synthase membrane subunit g	Bovine	E. coli
	ATP5MG Protein, an essential part of mitochondrial membrane ATP synthase (Complex V), facilitates ATP generation from ADP using the proton gradient established by respiratory chain electron transport complexes. Positioned within the F(0) domain as a minor subunit alongside subunit a, ATP5MG collaborates with various subunits in the overall F-type ATPase complex, including CF(1) and CF(0), to ensure efficient ATP synthesis. ATP5MG Protein, Bovine (Myc, His) is the recombinant bovine-derived ATP5MG protein, expressed by E. coli , with N-His, C-Myc labeled tag.

HY-P704166

	ATP6 Protein, Human (His) MT-ATP6; ATP6; ATPASE6; MTATP6; ATP synthase subunit a; F-ATPase protein 6	Human	E. coli
	ATP6 Protein, Human (His) is the recombinant human-derived ATP6 protein, expressed by E. coli, with N-10*His tag.

HY-P72096

	ATP5F1A Protein, Human (His-SUMO) ATP synthase alpha chain; ATP synthase alpha chain; mitochondrial; ATP synthase subunit alpha; ATP synthase subunit alpha mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit 1; cardiac muscle; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; 1; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 1; cardiac muscle; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 2; non-cardiac muscle-like 2; ATP sythase F1 ATPase; alpha subunit; ATP5A; ATP5a1; ATP5AL2; ATPA_HUMAN; ATPM; Epididymis secretory sperm binding protein Li 123m; hATP1; HEL-S-123m; MC5DN4; mitochondrial; Mitochondrial ATP synthetase; Mitochondrial ATP synthetase oligomycin resistant; Modifier of Min 2; Modifier of Min 2 mouse homolog; Modifier of Min 2; mouse; homolog of; MOM2; OMR; ORM; OTTHUMP00000163475	Human	E. coli
	ATP5F1A is an important component of mitochondrial ATP synthase (complex V) that coordinates ATP production from ADP by utilizing the transmembrane proton gradient. As part of the F-type ATPase, the α and β subunits of ATP5F1A form the catalytic core to achieve ATP hydrolysis. ATP5F1A Protein, Human (His-SUMO) is the recombinant human-derived ATP5F1A protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-14881S1

(Rac)-Bedaquiline-d6
(Rac)-Bedaquiline-d₆ is the deuterium labeled Bedaquiline (HY-14881) . Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-W654003

D-α-Hydroxyglutaric acid-d5 disodium

D-α-Hydroxyglutaric acid-d₅ disodium (Disodium (R)-2-hydroxyglutarate-d₅) is the deuterium labeled D-α-Hydroxyglutaric acid disodium (HY-100542). D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .

HY-14881S2

Bedaquiline impurity 2-d6
Bedaquiline impurity 2-d₆ is deuterium labeled Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P86778

	ATP5F1 Antibody (YA6471) ATP synthase F(0) complex subunit B1, mitochondrial Curated ATP synthase peripheral stalk-membrane subunit b Curated ATP synthase proton-transporting mitochondrial F(0) complex subunit B1 ATP synthase subunit b (ATPase subunit b) ATP5PB ATP5F1	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	ATP5F1 Antibody (YA6471) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATP5F1.

HY-P86400

	ATP5A Antibody (YA6092) ATP5A1; ATP5A; ATP5AL2; ATPM; ATP synthase subunit alpha; mitochondrial	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ATP5A Antibody (YA6092) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATP5A.

HY-P80560

	ATP Citrate Lyase Antibody (YA829) ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme	WB, ICC/IF, FC	Human, Mouse, Monkey
	ATP Citrate Lyase Antibody (YA829) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ATP Citrate Lyase.

HY-P83293

	LIG1 Antibody (YA3038) LIG1; DNA ligase 1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	LIG1 Antibody (YA3038) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LIG1.

HY-P82954

	DNA Ligase IV Antibody (YA2699) LIG4; DNA ligase 4; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4	WB	Human
	DNA Ligase IV Antibody (YA2699) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DNA Ligase IV.

HY-P81888

	ATP Synthase C Antibody (YA1633) ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 1	WB, ICC/IF	Human
	ATP Synthase C Antibody (YA1633) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATP Synthase C.

HY-P82460

	ATP Synthase C Antibody (YA2205) ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 1	WB, IHC-P, IP	Human, Rat
	ATP Synthase C Antibody (YA2205) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATP Synthase C.

HY-P82045

	LIG1 Antibody (YA1790) LIG1; DNA ligase 1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1	WB, IHC-P, ICC/IF	Human, Rat
	LIG1 Antibody (YA1790) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LIG1.