AF 1

By Targets:	Autophagy (2) Bacterial (2) Biochemical Assay Reagents (2) DNA/RNA Synthesis (2) Estrogen Receptor/ERR (1) FGFR (1) Fluorescent Dye (1) Fungal (1) Potassium Channel (1) Reference Standards (1) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Endocrinology (1) Infection (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136242

UT-34	Estrogen Receptor/ERR	Endocrinology Cancer
UT-34 is a potent, selective, orally bioactive second-generation pan-androgen receptor (AR) antagonist and degrader, with IC₅₀ values of 211.7 nM, 262.4 nM, and 215.7 nM for wild-type AR, F876L-AR, and W741L-AR, respectively. UT-34 binds to the ligand-binding domain (LBD) and functional 1 (AF-1) domain of AR and requires the ubiquitin-proteasome pathway for AR degradation. UT-34 has anti-prostate cancer effects.

HY-153736

NSC 194308	DNA/RNA Synthesis	Cancer
NSC 194308, a *U2AF2-RNA* complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations .

HY-W017241

1-Naphthalenemethanol 1-Hydroxymethylnaphthalene	Bacterial Biochemical Assay Reagents	Infection
1-Naphthalenemethanol is a hydroxyl-substituted naphthalene derivative. 1-Naphthalenemethanol can be extracted from the root of Annona senegalensis. 1-Naphthalenemethanol is a photolysis product of 1-napthaleneacetic acid. 1-Naphthalenemethanol, together with PAPS, provides some protection against the irreversible inactivation of AST IV caused by N-OH-2AF. 1-Naphthalenemethanol can be used in antibacterial research .

HY-D2977

*AF-1*	Fluorescent Dye Autophagy Fungal	Infection
AF-1 is a azole-based near-infrared fluorescence diagnostic probe with an emission wavelength of 632 nm. AF-1 selectively accumulates in fungal cell membranes at physiological pH. AF-1 targets and induces Autophagy. AF-1 exhibits antifungal activity and sensitivity to autophagy-related pH .

HY-RS10896

POU2AF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
POU2AF1 Human Pre-designed siRNA Set A contains three designed siRNAs for POU2AF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

POU2AF1 Human Pre-designed siRNA Set A POU2AF1 Human Pre-designed siRNA Set A

HY-RS15313

U2AF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
U2AF1 Human Pre-designed siRNA Set A contains three designed siRNAs for U2AF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

U2AF1 Human Pre-designed siRNA Set A U2AF1 Human Pre-designed siRNA Set A

HY-RS25173

U2af1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
U2af1 Rat Pre-designed siRNA Set A contains three designed siRNAs for U2af1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

U2af1 Rat Pre-designed siRNA Set A U2af1 Rat Pre-designed siRNA Set A

HY-RS18687

U2af1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
U2af1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for U2af1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

U2af1 Mouse Pre-designed siRNA Set A U2af1 Mouse Pre-designed siRNA Set A

HY-172923

FGFR-IN-20	FGFR	Cancer
Glu-IN-1 (compound AF1) is a covalent and selective FGFR2 inhibitor with an IC₅₀ of 1.6 μM. Glu-IN-1 covalently modifies Glu489 in FGFR2 .

HY-178155

AP232	DNA/RNA Synthesis Autophagy	Cancer
AP232 is a selective *U2AF1-UHM* Inhibitor with an IC₅₀ of 7.96 μM. AP232 exhibits 2.8-24-fold selectivity against other UHM-containing proteins. AP232 exerts anti-leukemia activity and shows higher activities in cell lines carrying splicing factor mutations. AP232 can induce leukemia cells G2/M and G1 arrest, impair lysosome acidification, and inhibit autophagy. AP232 can be used for the research of cancer, such as Leukemia .

HY-W017241R

1-Naphthalenemethanol (Standard) 1-Hydroxymethylnaphthalene (Standard)	Reference Standards Bacterial Biochemical Assay Reagents	Infection
1-Naphthalenemethanol (Standard) is the analytical standard of 1-Naphthalenemethanol (HY-W017241). This product is intended for research and analytical applications. 1-Naphthalenemethanol is a hydroxyl-substituted naphthalene derivative. 1-Naphthalenemethanol can be extracted from the root of Annona senegalensis. 1-Naphthalenemethanol is a photolysis product of 1-napthaleneacetic acid. 1-Naphthalenemethanol, together with PAPS, provides some protection against the irreversible inactivation of AST IV caused by N-OH-2AF. 1-Naphthalenemethanol can be used in antibacterial research .

HY-120355A

AP14145 hydrochloride	Potassium Channel	Cardiovascular Disease
AP14145 hydrochloride is a potent K_Ca2 (SK) channel negative allosteric modulator with an IC₅₀ of 1.1 μM for K_Ca2.2 (SK2) and K_Ca2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF) .

Cat. No.	Product Name	Type

HY-D2977

*AF-1*	Fluorescent Dye
AF-1 is a azole-based near-infrared fluorescence diagnostic probe with an emission wavelength of 632 nm. AF-1 selectively accumulates in fungal cell membranes at physiological pH. AF-1 targets and induces Autophagy. AF-1 exhibits antifungal activity and sensitivity to autophagy-related pH .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W017241

1-Naphthalenemethanol 1-Hydroxymethylnaphthalene	Natural Products Microorganisms other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Bacterial Biochemical Assay Reagents
1-Naphthalenemethanol is a hydroxyl-substituted naphthalene derivative. 1-Naphthalenemethanol can be extracted from the root of Annona senegalensis. 1-Naphthalenemethanol is a photolysis product of 1-napthaleneacetic acid. 1-Naphthalenemethanol, together with PAPS, provides some protection against the irreversible inactivation of AST IV caused by N-OH-2AF. 1-Naphthalenemethanol can be used in antibacterial research .

HY-W017241R

1-Naphthalenemethanol (Standard) 1-Hydroxymethylnaphthalene (Standard)	Natural Products Microorganisms other families Source classification Plants	Reference Standards Bacterial Biochemical Assay Reagents
1-Naphthalenemethanol (Standard) is the analytical standard of 1-Naphthalenemethanol (HY-W017241). This product is intended for research and analytical applications. 1-Naphthalenemethanol is a hydroxyl-substituted naphthalene derivative. 1-Naphthalenemethanol can be extracted from the root of Annona senegalensis. 1-Naphthalenemethanol is a photolysis product of 1-napthaleneacetic acid. 1-Naphthalenemethanol, together with PAPS, provides some protection against the irreversible inactivation of AST IV caused by N-OH-2AF. 1-Naphthalenemethanol can be used in antibacterial research .

Species:	Human (3)
Tag:	His (2) Fc (1)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P77396

	IGFLR1 Protein, Human (HEK293, Fc) IGF-like family receptor 1; Transmembrane protein 149; TMEM149; U2AF1L4	Human	HEK293
	IGFLR1 protein, a probable cell membrane receptor, exhibits specific affinity for IGF-like family proteins IGFL1 and IGFL3, with higher binding affinity compared to others. This selective interaction profile suggests a key role for IGFLR1 in mediating cellular responses to these ligands, emphasizing its significance in the intricate network of cellular signaling pathways. IGFLR1 Protein, Human (HEK293, Fc) is the recombinant human-derived IGFLR1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P700485

	EPS15 Protein, Human (His) Eps15 epidermal; growth factor receptor pathway substrate 15; 2410112D09Rik; epidermal growth factor receptor substrate 15; epidermal growth factor pathway substrate 15; protein AF-1p	Human	E. coli
	EPS15 is a multifunctional protein that regulates cell growth, controls mitotic signaling, and contributes to receptor tyrosine kinase (RTK) internalization, particularly affecting EGFR. As a clathrin adapter, EPS15 is critical for the assembly and maturation of clathrin-coated pits (CCP), affecting the endocytosis of molecules such as ITGB1 and transferrin receptor (TFR). EPS15 Protein, Human (His) is the recombinant human-derived EPS15 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P700454

	IGFLR1 Protein, Human (HEK293, C-His) IGFLR1; IGF-like family receptor 1; TMEM149, transmembrane protein 149 , U2(RNU2) small nuclear RNA auxiliary factor 1 like 4 , U2AF1L4; FLJ22573; transmembrane protein 149; U2 small nuclear RNA auxiliary factor 1-like 4; U2(RNU2) small nuclear RNA auxiliary factor 1-like 4; TMEM149; U2AF1L4	Human	HEK293
	IGFLR1 protein, a probable cell membrane receptor, exhibits specific affinity for IGF-like family proteins IGFL1 and IGFL3, with higher binding affinity compared to others. This selective interaction profile suggests a key role for IGFLR1 in mediating cellular responses to these ligands, emphasizing its significance in the intricate network of cellular signaling pathways. IGFLR1 Protein, Human (HEK293, C-His) is the recombinant human-derived IGFLR1 protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P88211

	IFNGR2 Antibody (YA7895) AF-1; IFGR2; IFNGT1; IMD28	IHC	Human
	IFNGR2 Antibody (YA7895) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targating to IFNGR2.

HY-P82370

	PSMD4 Antibody (YA2115) PSMD4; AF; AF-1; ASF; MCB1; Rpn10; S5A; pUB-R5	WB, IP, FC	Human, Mouse, Rat
	PSMD4 Antibody (YA2115) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSMD4.

HY-P82467

	BOB1 Antibody (YA2212) BOB 1; BOB-1; OBF 1; OBF1; OCA B; OCA-B; OCAB; OCT binding factor 1; Pou2AF1	WB, IHC-P, ICC/IF, FC	Human
	BOB1 Antibody (YA2212) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BOB1.

HY-P85829

	BOB1 Antibody (YA5521) B cell Oct binding protein 1; B cell specific coactivator OBF 1; B cell specific coactivator OBF1; B-cell-specific coactivator OBF-1; BOB 1; BOB-1; OBF 1; OBF1; OBF1_HUMAN; OCA B; OCA-B; OCAB; OCT binding factor 1; OCT-binding factor 1; POU class 2 associating factor 1; POU domain class 2 associating factor 1; POU domain class 2-associating factor 1; Pou2AF1	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,
	BOB1 Antibody (YA5521) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BOB1.

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Cat. No.	Product Name		Classification

HY-RS10896

POU2AF1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
POU2AF1 Human Pre-designed siRNA Set A contains three designed siRNAs for POU2AF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS15313

U2AF1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
U2AF1 Human Pre-designed siRNA Set A contains three designed siRNAs for U2AF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS25173

U2af1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
U2af1 Rat Pre-designed siRNA Set A contains three designed siRNAs for U2af1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18687

U2af1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
U2af1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for U2af1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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