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Results for "

5α-reductase inhibition

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

3

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N7510
    12-O-Methylcarnosic acid

    12-Methoxycarnosic acid

    		 5 alpha Reductase Infection Cancer
    12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity .
    12-O-Methylcarnosic acid
  • HY-106951
    MK 386

    L-733692

    		 5 alpha Reductase Cancer
    MK 386 (L-733692) is a selective 5-α-reductase I inhibitor, used for prostate cancer inhibition .
    MK 386
  • HY-N7510R
    12-O-Methylcarnosic acid (Standard)

    12-Methoxycarnosic acid (Standard)

    		 Reference Standards 5 alpha Reductase Infection Cancer
    12-O-Methylcarnosic acid (Standard) is the analytical standard of 12-O-Methylcarnosic acid. This product is intended for research and analytical applications. 12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity .
    12-O-Methylcarnosic acid (Standard)
  • HY-N12248
    Eucalbanin B

    Cornusiin A

    		 5 alpha Reductase Interleukin Related TNF Receptor Apoptosis Cancer
    Eucalbanin B (Cornusiin A) is a dimeric tannic acid. Eucalbanin B inhibits 5α-reductase and reduces the production of dihydrotestosterone (DHT). Eucalbanin B has anti-inflammatory properties and can inhibit the production of key pro-inflammatory cytokines (IL-6, IL-8, IL-1β, TNF-α). Eucalbanin B has a strong inhibitory effect on the proliferation of benign prostatic hyperplasia (BPH) cell lines and can induce apoptosis in BPH cells. Eucalbanin B can be used for research on BPH .
    Eucalbanin B
  • HY-165478
    FCE 28260

    		5 alpha Reductase Endocrinology
    FCE 28260 is an orally active 4-azacyclic 5α-reductase (5αR) inhibitor. FCE 28260 exhibits IC₅₀ values for human 5αR type 1 and 5αR type 2 of 36 and 3.3 nM, respectively, and for human and rat prostates with IC₅₀ values of 16 and 15 nM, respectively. FCE 28260 simultaneously blocks the production of dihydrotestosterone (DHT) in the prostate and peripheral tissues. FCE 28260 can significantly inhibit the induction of prostatic and seminal vesicle hyperplasia by testosterone (T) in rat models, without inhibiting the growth of the prostate in DHT implantation models. FCE 28260 can be used for the studies DHT-dependent diseases such as benign prostatic hyperplasia (BPH) .
    FCE 28260

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