2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Glutathione Reductase (GR)

Glutathione Reductase (GR)

Glutathione Reductase

Glutathione reductase (GR) is a flavoenzyme whose main function is to catalyze the reduction of oxidized glutathione (GSSG) to reduced glutathione (GSH), playing a crucial role in the redox balance of cells. Glutathione reductase maintains the dynamic equilibrium between the two forms of glutathione within the cell, indirectly participates in antioxidant processes such as the elimination of reactive oxygen species in the cell, and protects cells from oxidative damage. In addition, it is also involved in the detoxification processes of organs such as the liver. Abnormal activity of glutathione reductase can lead to cellular redox imbalance and plays an important role in the occurrence and development of cardiovascular diseases, neurodegenerative diseases, hemolytic anemia, liver diseases, etc[1].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0910
    Notoginsenoside Ft1
    		Activator ≥98.0%
    NotoginsenosideFt1 is a saponin found in Panax notoginseng. Notoginsenoside Ft1 inhibits the PI3K/AKT/mTOR signaling pathway, activates the p38 MAPK and ERK1/2 signaling pathways, and increases the proportion of CD8+ T cells, thereby inducing apoptosis and lysosomal cell death in various cancer cells, and promoting angiogenesis. Notoginsenoside Ft1 causes vasodilation by activating glucocorticoid receptors (GR) and estrogen receptor beta (ERβ) in endothelial cells. Notoginsenoside Ft1 increases intracellular Ca2+ accumulation, reduces cAMP levels by activating a signaling network mediated through P2Y12 receptors, and promotes platelet aggregation, thereby exerting a procoagulant effect. Notoginsenoside Ft1 inhibits ferroptosis (ferroptosis) in renal tubular epithelial cells by activating the TGR5 receptor, thereby demonstrating a renal protective effect. Notoginsenoside Ft1 acts as a TGR5 agonist and an FXR antagonist to combat obesity and insulin resistance.
    Notoginsenoside Ft1
  • HY-12542S
    Dantrolene-13C3
    		Inhibitor ≥99.0%
    Dantrolene-13C3 is the 13C3 labeled Dantrolene. Dantrolene (F368), a muscle relaxant, non-competitively inhibits human erythrocyte glutathione reductase. Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. Dantrolene is a ryanodine receptor antagonist and Ca2+ signaling stabilizer. Dantrolene can be used for the research of muscle spasticity, malignant hyperthermia, Huntington's disease and other neuroleptic malignant syndrome.
    Dantrolene-<sup>13</sup>C<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity