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15-lipoxygenase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Lipoxygenase (14) Akt (1) Apoptosis (2) Autophagy (2) Bcl-2 Family (1) COX (1) Drug Metabolite (2) Endogenous Metabolite (3) Ferroptosis (3) Fungal (1) LOX-1 (1) Mitochondrial Metabolism (1) NO Synthase (1) PPAR (1) Reference Standards (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (6) Infection (1) Inflammation/Immunology (11) Metabolic Disease (3) Neurological Disease (1)

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Targets Recommended: Lipoxygenase 15-PGDH Enteropeptidase FLAP EHD Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101051

2-TEDC	Lipoxygenase	Cardiovascular Disease Metabolic Disease
2-TEDC is a potent inhibitor of 5-, 12-, and 15-lipoxygenase with IC₅₀ values of 0.09 μM, 0.013 μM and 0.5 μM, respectively. 2-TEDC can be used for the research of atheroscrelosi .

HY-118480

4-MMPB	Lipoxygenase Apoptosis	Cancer
4-MMPB is a selective inhibitor of *15-lipoxygenase, with an IC₅₀* of 18 μM. 4-MMPB has IC₅₀s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer .

HY-130675A

15(S)-HEPE 15(S)-hydroxy-Eicosapentaenoic acid; 15(S)-hydroxy EPA	Lipoxygenase	Inflammation/Immunology
15(S)-HEPE is a monohydroxy fatty acid. 15(S)-HEPE is biosynthesized from eicosapentaenoic acid by 15-lipoxygenase (15-LO). Serum levels of 15(S)-HEPE are elevated in patients with asthma.

HY-158843

15(S)-Hete-biotin 15(S)-Hydroxyeicosatetraenoic acid-biotin	Endogenous Metabolite	Others
15(S)-Hete-biotin (15(S)-Hydroxyeicosatetraenoic acid-biotin) can be used to detect 15(S)-HETE binding proteins and/or receptors. 15(S)-HETE is an arachidonic acid metabolite produced by the 15-lipoxygenase pathway .

HY-113884B

(S)-Coriolic acid 13(S)-HODE	PPAR Mitochondrial Metabolism	Inflammation/Immunology Cancer
(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury .

HY-150548

COX-2/15-LOX-IN-1	COX Lipoxygenase	Inflammation/Immunology
COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and **15-lipoxygenase enzyme (15-LOX) inhibitor with IC₅₀ values of 10.65, 0.075 and 2.98 μM against COX-1**, COX-2 and 15-LOX, respectively. COX-2/15-LOX-IN-1 shows anti-inflammatory activity .

HY-N12987

Caffeoylcalleryanin	Lipoxygenase	Others
Caffeoylcalleryanin is a potent *15-lipoxygenase* inhibitor with an IC₅₀ value of 1.59 µM. Caffeoylcalleryanin shows no cytotoxic .

HY-120109

13-HODE methyl ester	Endogenous Metabolite	Cancer
13-HODE methyl ester, a racemic mixture of 13(R)-HODE methyl ester and 13(S)-HODE methyl ester, is a 15-lipoxygenase metabolite of Linoleic acid .

HY-168774

17(S)-HDoTE	Drug Metabolite	Others
17(S)-HDoTE is a metabolite of Adrenic acid (HY-W013215). 17(S)-HDoTE is formed by the catalysis of Adrenic acid through 15-lipoxygenase (15-LO) .

HY-138154

BLX-3887	Lipoxygenase	Metabolic Disease
BLX-3887 is a selective 15-lipoxygenase type 1 (15-LO-1) inhibitor with an IC₅₀ of 32 nM. BLX-3887 can be utilized in research related to the 15-LO pathways .

HY-N15453

Asperenone	Lipoxygenase Fungal	Infection Cardiovascular Disease
Asperenone is an inhibitor of 15-lipoxygenase (15-LOX) with an IC₅₀ value of 0.3 mM. It is also an inhibitor of platelet aggregation, with an IC₅₀ value of 0.23 mM. Additionally, Asperenone has antifungal activity and can inhibit the growth of pathogenic fungi Ophiostoma crassivaginatum and O. piliferum. Asperenone can be used in the research of cardiovascular diseases and anti-infection fields .

HY-103157

PD146176 5 Publications Verification NSC168807	Autophagy Ferroptosis	Cardiovascular Disease
PD146176 (NSC168807), a **15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (K_i**=197 nM, IC₅₀=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice .

HY-116124

17(S)-HpDHA	Lipoxygenase	Others
17(S)-HpDHA is the main 15-Lipoxygenase (LOX) isoenzyme: h15-LOX-1 and h15-LOX-2 and docosahexaenoic acid (DHA). product. 17(S)-HpDHA negatively regulates epoxide synthesis via allosteric regulation. 17(S)-HpDHA also inhibits platelet aggregation with an EC₅₀ of approximately 1 μM .

HY-103157R

PD146176 (Standard) NSC168807 (Standard)	Reference Standards Autophagy Ferroptosis	Cardiovascular Disease
PD146176 (Standard) is the analytical standard of PD146176. This product is intended for research and analytical applications. PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice .

HY-113438

15(S)-HPETE	Drug Metabolite Bcl-2 Family Akt Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
15(S)-HPETE is a precursor of 15(S)-HETE (HY-113336). 15(S)-HPETE is a product of Arachidonic acid (HY-109590) in the 15-lipoxygenase pathway. 15(S)-HPETE reduces Bcl-2, Akt, and phosphorylated Akt protein levels. 15(S)-HPETE induces Apoptosis. 15(S)-HPETE antagonizes the angiogenic effects of 15(S)-HETE. 15(S)-HPETE exhibits antitumor effects against chronic myeloid leukemia. 15(S)-HPETE can be used in adipose tissue explant studies .

HY-115701

1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine; 15(S)-HpETE-SAPE; 15(S)-hydroperoxyeicostetraenoic acid-SAPE	Ferroptosis	Inflammation/Immunology
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-Pe (SAPE) by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.

HY-139196

ThioLox	Lipoxygenase	Neurological Disease Inflammation/Immunology
ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with a K_i of 3.30 μM. ThioLox shows anti-inflammatory and neuroprotective properties .

HY-137493

14,15-Leukotriene D4 14,15-LTD4; Eoxin D4	Endogenous Metabolite	Inflammation/Immunology
14,15-Leukotriene D4 (14,15-LTD4) is a leukotriene that producted by eosinophils with Arachidonic acid (HY-109590), and through the 15-lipoxygenase-1 pathway .

HY-N11058

Damnacanthol	Lipoxygenase NO Synthase	Inflammation/Immunology
Damnacanthol is a natural product that can be isolated from Damnacanthus major . Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells .

HY-153930

h15-LOX-2 inhibitor 1	Lipoxygenase	Inflammation/Immunology
h15-LOX-2 inhibitor 1 (Comp 105) is a human epithelial 15-lipoxygenase-2 (h15-LOX-2) inhibitor with IC₅₀ of 0.34 μM .

HY-138989

15-LOX-1 inhibitor 1	Lipoxygenase	Inflammation/Immunology
15-LOX-1 inhibitor 1 is a potent inhibitor of *15-LOX-1* (15-lipoxygenase-1) with an IC₅₀ value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation .

HY-116919

MLS000536924	Lipoxygenase	Cardiovascular Disease
MLS000536924 is a potent and selective inhibitor of human epithelial 15-lipoxygenase-2 with competitive activity. MLS000536924 exhibits more than 50-fold selectivity in inhibiting h15-LOX-2 and can be effectively applied to study its role in atherosclerosis, cystic fibrosis, and ferroptosis. The binding mode of MLS000536924 shows stronger restriction of protein movement than other inhibitors, further verifying its higher biological activity .

HY-173332

15-LOX-1 inhibitor 2	LOX-1	Inflammation/Immunology
15-LOX-1 inhibitor 2 (Compound 5i) is an inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC₅₀ of 1.7 μM. 15-LOX-1 inhibitor 2 inhibits the activity of *15-LOX-1* enzyme, reduces the production of lipid peroxides, thereby inhibiting lipid peroxidation and protecting cells from cell death induced by RSL3 (HY-100218A). 15-LOX-1 inhibitor 2 can be used in research on cell death mechanisms, oxidative stress-related diseases and other fields .

HY-138688

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate CDC	Lipoxygenase	Metabolic Disease Cancer
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent *12/15-Lipoxygenases* (LO)** inhibitor. Cinnamyl-3,4-dihydroxy-α-cyanocinnamate has the potential for the research of type 1 diabetes mellitus .

(S)-Coriolic acid 13(S)-HODE	Other disease Disease markers Endogenous metabolite	PPAR Mitochondrial Metabolism
(S)-Coriolic acid (13(S)-HODE), the product of 15-lipoxygenase (15-LOX) metabolism of linoleic acid, functions as the endogenous ligand to activate PPARγ. (S)-Coriolic acid is an important intracellular signal agent and is involved in cell proliferation and differentiation in various biological systems. (S)-Coriolic acid induces mitochondrial dysfunction and airway epithelial injury .

Damnacanthol	Quinones Structural Classification Monophenols Anthraquinones Source classification Rubiaceae Phenols Plants Damnacanthus major Sieb. et Zucc.	Lipoxygenase NO Synthase
Damnacanthol is a natural product that can be isolated from Damnacanthus major . Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells .

Caffeoylcalleryanin	Structural Classification Source classification Phenols Polyphenols Cuspidaria pulchra (Cham.) L.G.Lohmann Bignoniaceae Plants	Lipoxygenase
Caffeoylcalleryanin is a potent *15-lipoxygenase* inhibitor with an IC₅₀ value of 1.59 µM. Caffeoylcalleryanin shows no cytotoxic .

13-HODE methyl ester	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
13-HODE methyl ester, a racemic mixture of 13(R)-HODE methyl ester and 13(S)-HODE methyl ester, is a 15-lipoxygenase metabolite of Linoleic acid .

Asperenone	Structural Classification Natural Products Microorganisms Source classification	Lipoxygenase Fungal
Asperenone is an inhibitor of 15-lipoxygenase (15-LOX) with an IC₅₀ value of 0.3 mM. It is also an inhibitor of platelet aggregation, with an IC₅₀ value of 0.23 mM. Additionally, Asperenone has antifungal activity and can inhibit the growth of pathogenic fungi Ophiostoma crassivaginatum and O. piliferum. Asperenone can be used in the research of cardiovascular diseases and anti-infection fields .

Species:	Human (2)
Tag:	His (1) Tag Free (1) GST (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P74437

	15 Lipoxygenase 2 Protein, Human (sf9) Polyunsaturated fatty acid lipoxygenase ALOX15B; 15-LOX-2; ALOX15B	Human	Sf9 insect cells
	15-lipoxygenase 2 (15-LOX2) is a nonheme iron-containing dioxygenase essential for the peroxidation of polyunsaturated fatty acids (PUFA). It exhibits peroxidase activity towards arachidonic acid and linoleic acid, producing bioactive lipid mediators. 15 Lipoxygenase 2 Protein, Human (sf9) is the recombinant human-derived 15 Lipoxygenase 2 protein, expressed by Sf9 insect cells, with tag free and additional two amino acids (Gly & Pro) at the N-terminus.

HY-P74436

	15 Lipoxygenase 2 Protein, Human (sf9, His-GST) Polyunsaturated fatty acid lipoxygenase ALOX15B; 15-LOX-2; ALOX15B	Human	Sf9 insect cells
	15-lipoxygenase 2 (15-LOX2) is a nonheme iron-containing dioxygenase essential for the peroxidation of polyunsaturated fatty acids (PUFA). It exhibits peroxidase activity towards arachidonic acid and linoleic acid, producing bioactive lipid mediators. 15 Lipoxygenase 2 Protein, Human (sf9, His-GST) is the recombinant human-derived 15 Lipoxygenase 2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

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HY-P81564

	15 Lipoxygenase 1/ALOX15 Atibody (YA1309) LOG15	IHC-P, ICC/IF, FC	Human
	15 Lipoxygenase 1/ALOX15 Atibody (YA1309) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1309), targeting ALOX15. 15 Lipoxygenase 1/ALOX15 Atibody (YA1309) can be used for IHC-P, ICC/IF, FC experiment in human background.

HY-P81346

	15 Lipoxygenase 1/ALOX15 Atibody (YA1091) LOG15; LOG15; Polyunsaturated fatty acid lipoxygenase ALOX15; Polyunsaturated fatty acid lipoxygenase ALOX15	IHC-P	Human
	15 Lipoxygenase 1/ALOX15 Atibody (YA1091) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1091), targeting 15 Lipoxygenase 1. 15 Lipoxygenase 1/ALOX15 Atibody (YA1091) can be used for IHC-P experiment in human background.

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15-lipoxygenase

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

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Natural
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