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Results for "

14-3-3 protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Biochemical Assay Reagents (1) Estrogen Receptor/ERR (1) Hippo (MST) (1) MMP (1) Molecular Glues (2) NF-κB (1) YAP (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (1) Metabolic Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-146302

14-3-3η Protein inhibitor 1 2 Publications Verification	Apoptosis	Cancer
14-3-3η Protein inhibitor 1 (Compound C11) is a *14-3-3η* protein inhibitor with a K_D of 35 µM. 14-3-3η Protein inhibitor 1 shows inhibitory activities against several typical human liver cancer cell lines. 14-3-3η Protein inhibitor 1 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability .

HY-122815

Fusicoccin Fusicoccin A	Apoptosis	Cancer
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific *14-3-3* protein-protein interactions. Fusicoccin sabilizes H ⁺-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .

HY-P1380A

Difopein TFA	Apoptosis	Cancer
Difopein TFA, a specific and competitive inhibitor of **14-3-3 protein** (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein TFA is not cell permeable. Difopein TFA leads to induction of apoptosis and enhances the ability of Cisplatin (HY-17394) to kill cells .

HY-177590

14-3-3-IN-2	MMP	Others
14-3-3-IN-2 is a 14-3-3 protein inhibitor with an IC₅₀ of 15 nM. 14-3-3-IN-2 can disrupt the interaction of 14-3-3α with aminopeptidase N and down-regulate 14-3-3α increased MMP-1 mRNA levels .

HY-161611

14-3-3-IN-1	YAP	Others
14-3-3-IN-1 (Compound 2) is an inhibitor for 14-3-3 proteins in Arabidopsis thaliana, with an IC₅₀ of 1.21 μM. 14-3-3-IN-1 exhibits different inhibitory activities against different 14-3-3 isomers. 14-3-3-IN-1 promotes the closure of stomata on leaves .

HY-170593

ChREBPα/14-3-3 regulator-1	Molecular Glues	Metabolic Disease
ChREBPα/14-3-3 regulator-1 (Compound 43) is a selective molecular gel that can stabilize the interaction of carbohydrate response element binding protein (ChREBP) with *14-3-3* proteins (EC₅₀: 3.8 μM). ChREBPα/14-3-3 regulator-1 effectively protects β cells from glucolipotoxicity and maintains cell function, and can be used in the study of type 2 diabetes .

HY-W1005067

EN171	Molecular Glues Hippo (MST) Estrogen Receptor/ERR	Others
EN171 is a covalent ligand that covalently targets both C38 and C96 on *14-3-3* to enhance *14-3-3* interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent *14-3-3* recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol .

HY-N13798

ADHPE	NF-κB Biochemical Assay Reagents	Inflammation/Immunology
ADHPE is a stabilizer of 14-3-3σ and p65 protein complex. ADHPE inhibits NF-κB (p65) signaling pathway and reduces the inflammatory response. ADHPE can be used for pediatric pneumonia-related acute lung injury and acute respiratory distress syndrome study .

Cat. No.	Product Name	Target	Research Area

HY-P1380A

Difopein TFA	Apoptosis	Cancer
Difopein TFA, a specific and competitive inhibitor of **14-3-3 protein** (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein TFA is not cell permeable. Difopein TFA leads to induction of apoptosis and enhances the ability of Cisplatin (HY-17394) to kill cells .

Fusicoccin Fusicoccin A	Microorganisms Classification of Application Fields Terpenoids Source classification Diterpenoids Disease Research Fields Cancer	Apoptosis
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific *14-3-3* protein-protein interactions. Fusicoccin sabilizes H ⁺-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .

ADHPE	Zingiber officinale Roscoe Source classification Phenols Polyphenols Plants Zingiberaceae	NF-κB Biochemical Assay Reagents
ADHPE is a stabilizer of 14-3-3σ and p65 protein complex. ADHPE inhibits NF-κB (p65) signaling pathway and reduces the inflammatory response. ADHPE can be used for pediatric pneumonia-related acute lung injury and acute respiratory distress syndrome study .

Species:	Human (13) Mouse (6) Cynomolgus (1)
Tag:	His (10) SUMO (1) Tag Free (5) Myc (1) GST (5)
Source:	Sf9 insect cells (3) P. pastoris (2) E. coli (15)

Cat. No.	Compare	Product Name	Species	Source

HY-P75548A

	14-3-3 theta Protein, Human (His) 14-3-3 protein theta	Human	E. coli
	14-3-3 theta proteins are adapters in multiple signaling pathways that recognize phosphoserine or phosphothreonine motifs and modulate chaperone activity upon binding. It negatively regulates PDPK1 kinase activity, forms homodimers, and interacts with CDK16, phosphorylated RGS7, SSH1, phosphorylated CDKN1B, GAB2, phosphorylated PDPK1, and phosphorylated DAPK2. 14-3-3 theta Protein, Human (His) is the recombinant human-derived 14-3-3 theta protein, expressed by E. coli , with N-6His labeled tag.

HY-P74438

	14-3-3 sigma Protein, Mouse 14-3-3 protein sigma; HME1; SFN; Stratifin; Mkrn3	Mouse	E. coli
	14-3-3 sigma proteins are adapter proteins in various signaling pathways that bind to phosphoserine or phosphothreonine motifs to regulate chaperone activity. When bound to KRT17, it stimulates the regulation of protein synthesis and cell growth through the Akt/mTOR pathway. 14-3-3 sigma Protein, Mouse is the recombinant mouse-derived 14-3-3 sigma protein, expressed by E. coli , with tag free.

HY-P75549

	14-3-3 epsilon Protein, Mouse (His) 14-3-3 protein epsilon, N-GST; YWHAE; 14-3-3E	Mouse	E. coli
	14-3-3 epsilon proteins are adapter proteins in various signaling pathways that bind to phosphoserine or phosphothreonine motifs to regulate chaperone activity.It positively regulates HSF1 nuclear export to the cytoplasm, forming homo- and heterodimers with YWHAZ.14-3-3 epsilon Protein, Mouse (His) is the recombinant mouse-derived 14-3-3 epsilon protein, expressed by E.coli , with N-6*His labeled tag.

HY-P71682

	14-3-3 eta Protein, Human (GST) 14-3-3 protein eta; Brain protein 14-3-3; eta isoform; HGNC:12853; protein AS1; YWHA 1; YWHA1; Ywhah	Human	E. coli
	YWHAH proteins are adapter proteins in multiple signaling pathways that recognize phosphoserine or phosphothreonine motifs and regulate chaperone activity upon binding. It negatively regulates PDPK1 kinase activity and interacts with nuclear hormone receptors (AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP, THRA) and cofactors. 14-3-3 eta Protein, Human (GST) is the recombinant human-derived YWHAH protein, expressed by E. coli , with N-GST labeled tag.

HY-P74440

	14-3-3 beta Protein, Human KCIP-1; 14-3-3 protein beta/alpha; GW128; protein 1054; YWHAB	Human	E. coli
	14-3-3 beta proteins serve as adapter proteins that regulate multiple signaling pathways by recognizing phosphoserine or phosphothreonine motifs and regulating chaperone activity. It acts as a negative regulator during osteogenesis, inhibiting nuclear translocation of SRPK2 and preventing neuronal apoptosis. 14-3-3 beta Protein, Human is the recombinant human-derived 14-3-3 beta protein, expressed by E. coli , with tag free.

HY-P75550

	14-3-3 beta Protein, Cynomolgus KCIP-1; 14-3-3 protein beta/alpha; GW128; protein 1054; YWHAB	Cynomolgus	E. coli
	14-3-3 beta proteins act as adapters, binding to phosphoserine or phosphothreonine motifs in different signaling pathways, regulating chaperone activity. It negatively regulates osteogenesis by blocking the nuclear translocation of phosphorylated SRPK2 and counteracting the pro-apoptotic effect of SRPK2 through cyclin D1 expression. 14-3-3 beta Protein, Cynomolgus is the recombinant cynomolgus-derived 14-3-3 beta protein, expressed by E. coli , with tag free.

HY-P703012

	14-3-3 theta Protein, Mouse (sf9, His) 14-3-3 protein theta; 14-3-3 protein tau; Ywhaq	Mouse	Sf9 insect cells
	14-3-3 theta Protein, Mouse (sf9, His) is the recombinant mouse-derived 14-3-3 theta protein, expressed by Sf9 insect cells, with His tag.

HY-P75548

	14-3-3 theta Protein, Human (GST) 14-3-3 protein theta; 14-3-3 protein tau; protein HS1; YWHAQ	Human	E. coli
	14-3-3 theta proteins are adapters in multiple signaling pathways that recognize phosphoserine or phosphothreonine motifs and modulate chaperone activity upon binding. It negatively regulates PDPK1 kinase activity, forms homodimers, and interacts with CDK16, phosphorylated RGS7, SSH1, phosphorylated CDKN1B, GAB2, phosphorylated PDPK1, and phosphorylated DAPK2. 14-3-3 theta Protein, Human (GST) is the recombinant human-derived 14-3-3 theta protein, expressed by E. coli , with N-GST labeled tag.

HY-P702997

	14-3-3 zeta Protein, Human 14-3-3 zeta; YWHAZ; KCIP-1; MGC111427; MGC126532; MGC138156	Human	E. coli
	14-3-3 zeta Protein, Human is the recombinant human-derived 14-3-3 zeta, expressed by E. coli, with tag free labeled tag.

HY-P74439

	14-3-3 beta Protein, Human (GST) KCIP-1; 14-3-3 protein beta/alpha; GW128; protein 1054; YWHAB	Human	E. coli
	14-3-3 beta proteins serve as adapter proteins that regulate multiple signaling pathways by recognizing phosphoserine or phosphothreonine motifs and regulating chaperone activity. It acts as a negative regulator during osteogenesis, inhibiting nuclear translocation of SRPK2 and preventing neuronal apoptosis. 14-3-3 beta Protein, Human (GST) is the recombinant human-derived 14-3-3 beta protein, expressed by E. coli , with N-GST labeled tag.

HY-P700304

	14-3-3 beta Protein, Human (His) KCIP-1; 14-3-3 protein beta/alpha; GW128; protein 1054; YWHAB	Human	E. coli
	14-3-3 beta proteins serve as adapter proteins that regulate multiple signaling pathways by recognizing phosphoserine or phosphothreonine motifs and regulating chaperone activity. It acts as a negative regulator during osteogenesis, inhibiting nuclear translocation of SRPK2 and preventing neuronal apoptosis. 14-3-3 beta Protein, Human (His) is the recombinant human-derived 14-3-3 beta protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702996

	14-3-3 zeta Protein, Human (sf9, His) 14-3-3 zeta; YWHAZ; KCIP-1; MGC111427; MGC126532; MGC138156	Human	Sf9 insect cells
	14-3-3 zeta Protein, Human (sf9, His) is the recombinant human-derived 14-3-3 zeta, expressed by Sf9 insect cells, with His labeled tag.

HY-P703013

	14-3-3 zeta Protein, Mouse (sf9, His) 14-3-3 protein zeta/delta; protein kinase C inhibitor protein 1 (KCIP-1); SEZ-2; Ywhaz	Mouse	Sf9 insect cells
	14-3-3 zeta Protein, Mouse (sf9, His) is the recombinant mouse-derived 14-3-3 zeta, expressed by Sf9 insect cells, with His labeled tag.

HY-P7445

	14-3-3 epsilon Protein, Human (GST) rHu14-3-3 protein epsilon, N-GST; YWHAE	Human	E. coli
	14-3-3 epsilon Protein, Human (GST) is a mediator that guides chondrocytes toward an inflammatory phenotype with GST tag.

HY-P702995

	14-3-3 zeta Protein, Human (GST) Proto-oncogene vav; VAV1; VAV	Human	E. coli
	14-3-3 zeta Protein, Human (GST) is the recombinant human-derived 14-3-3 zeta, expressed by E. coli, with GST labeled tag.

HY-P71339

	Stratifin Protein, Human 1 Publications Verification 14-3-3 protein Sigma; Epithelial Cell Marker protein 1; Stratifin; SFN; HME1	Human	E. coli
	Stratifin (14-3-3 sigma), encoded by SFN, functions as a multifaceted adapter protein that binds to partners through phosphoserine or phosphothreonine motifs and participates in a variety of cellular processes. It regulates epithelial cell growth and protein synthesis through keratin 17 (KRT17), and may affect MDM2 autoubiquitination and activate p53. Stratifin Protein, Human is the recombinant mouse-derived Stratifin protein, expressed by E. coli , with tag free.

HY-P700308

	Stratifin Protein, Human (N-His, C-Myc) 14-3-3 protein Sigma; Epithelial Cell Marker protein 1; Stratifin; SFN; HME1	Human	E. coli
	Stratifin (14-3-3 sigma), encoded by SFN, functions as a multifaceted adapter protein that binds to partners through phosphoserine or phosphothreonine motifs and participates in a variety of cellular processes. It regulates epithelial cell growth and protein synthesis through keratin 17 (KRT17), and may affect MDM2 autoubiquitination and activate p53. Stratifin Protein, Human (N-His, C-Myc) is the recombinant human-derived Stratifin protein, expressed by E. coli , with N-10*His, C-Myc labeled tag.

HY-P71850

	KCIP-1 Protein, Mouse (P.pastoris, His) Ywhab; 14-3-3 protein beta/alpha; protein kinase C inhibitor protein 1; KCIP-1	Mouse	P. pastoris
	KCIP-1 protein serves as the linker of TNFRSF1A/TNFR1 and mediates its interaction with FADD. Overexpression induces TNF-induced responses: apoptosis and NF-κ-B activation. KCIP-1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived KCIP-1 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P71850Y

	KCIP-1 Protein, Mouse (P.pastoris, His, solution) Ywhab; 14-3-3 protein beta/alpha; protein kinase C inhibitor protein 1; KCIP-1	Mouse	P. pastoris
	KCIP-1 protein serves as the linker of TNFRSF1A/TNFR1 and mediates its interaction with FADD. Overexpression induces TNF-induced responses: apoptosis and NF-κ-B activation. KCIP-1 Protein, Mouse (P.pastoris, His, solution) is the recombinant mouse-derived KCIP-1 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P72226

	HJURP Protein, Human (His-SUMO) HJURP; FAKTS; FLEG1; URLC9; Holliday junction recognition protein; 14-3-3-associated AKT substrate; Fetal liver-expressing gene 1 protein; Up-regulated in lung cancer 9	Human	E. coli
	The HJURP protein is a centromeric factor that plays a critical role in centromeric integration and maintenance of CENPA. As a chaperone, it ensures the integration of newly synthesized CENPA into nucleosomes at replicating centromeres. HJURP Protein, Human (His-SUMO) is the recombinant human-derived HJURP protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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HY-P82210

	14-3-3 theta Antibody (YA1955) YWHAQ; 14-3-3 protein theta; 14-3-3 protein T-cell; 14-3-3 protein tau; protein HS1	WB	Human, Mouse, Rat
	14-3-3 theta Antibody (YA1955) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 theta.

HY-P82909

	14-3-3 sigma Antibody (YA2654) SFN; HME1; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin	WB, IHC-P	Human, Rat
	14-3-3 sigma Antibody (YA2654) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 sigma.

HY-P82884

	14-3-3 epsilon Antibody (YA2629) 14-3-3 epsilon; 14-3-3E; 143E; KCIP-1; MDCR; protein kinase C inhibitor protein-1; YWHAE	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	14-3-3 epsilon Antibody (YA2629) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 epsilon.

HY-P80525

	14-3-3 eta Antibody (YA838) 14-3-3 protein eta; 1433F_HUMAN; Brain protein 14-3-3; eta isoform; HGNC:12853; protein AS1; Tyrosine 3/tryptophan 5 monooxygenase activation protein eta polypeptide; YWHA 1; YWHA1; Ywhah.	WB	Human, Mouse, Rat
	14-3-3 eta Antibody (YA838) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 eta.

HY-P85780

	14-3-3 eta Antibody (YA5472) 14-3-3 protein eta; protein AS1;	WB, IHC-P	Human, Mouse, Rat
	14-3-3 eta Antibody (YA5472) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to 14-3-3 eta.

HY-P82923

	14-3-3 gamma Antibody (YA2668) YWHAG; 14-3-3 protein gamma; protein kinase C inhibitor protein 1; KCIP-1	WB	Human, Mouse, Rat
	14-3-3 gamma Antibody (YA2668) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 gamma.

HY-P82204

	14-3-3 beta Antibody (YA1949) YWHAB; 14-3-3 protein beta/alpha; protein 1054; protein kinase C inhibitor protein 1; KCIP-1	WB	Human, Rat
	14-3-3 beta Antibody (YA1949) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 14-3-3 beta.

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14-3-3 protein

Inhibitors & Agonists

Peptides

NaturalProducts

Recombinant Proteins

Antibodies

Natural
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