Search Result
Results for "
1-A-N
" in MedChemExpress (MCE) Product Catalog:
17
Biochemical Assay Reagents
42
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W011291S
-
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Isotope-Labeled Compounds
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Others
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N,N,N-Trimethylhexadecan-1-aminium-d42 (chloride) is the deuterium labeled N,N,N-Trimethylhexadecan-1-aminium chloride [1].
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-
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- HY-W008630S
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-
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- HY-D0222
-
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Fluorescent Dye
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Others
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N,N-Dimethyl-1-naphthylamine is an aromatic amine and a dye. N,N-Dimethyl-1-naphthylamine can be used in nitrate reduction test [1] .
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-
-
- HY-150235
-
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Galectin
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Inflammation/Immunology
|
Galectin-8N-IN-1 (compound 19a) is a potent and selective galectin-8N inhibitor with a Kd value of 1.8 μM. Galectin-8N-IN-1 is a galectin-8N ligand. Galectin-8N-IN-1 can be used in research of immune system [1].
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-
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- HY-159675
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Liposome
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Inflammation/Immunology
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1-A-N is a lipid nanoparticle (LNP) used for in vivo delivery of siRNA. 1-A-N can regulate immune response by delivering siCD45 (siRNA targeting CD45) to T cells and silencing the CD45 gene [1].
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-
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- HY-146923S
-
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Isotope-Labeled Compounds
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Others
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D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d7 is deuterium labeled D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine.
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-
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- HY-146922S
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Isotope-Labeled Compounds
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Others
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D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d7 is deuterium labeled D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine.
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-
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- HY-146766S
-
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Isotope-Labeled Compounds
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Others
|
D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine-d7 is deuterium labeled D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine.
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-
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- HY-146764S
-
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Isotope-Labeled Compounds
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Others
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D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine-d7 is deuterium labeled D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine.
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-
-
- HY-W335735
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Benzyldimethyltetradecylammonium Bromide
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Isotope-Labeled Compounds
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Others
|
N,N-dimethyl-N-((phenyl-dd5)methyl)tetradecan-1-aminium bromide is the deuterium labeled N,N-dimethyl-N-((phenyl)methyl)tetradecan-1-aminium bromide [1].
|
-
-
- HY-E70139
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EC:2.4.1.313; B3GALNT2; β-1,3-N-acetylgalactosaminyltransferase II
|
Glucosylceramide Synthase (GCS)
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Others
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UDP-GalNAc:β-1,3-N-acetylgalactosaminyltransferase 2 ( EC:2.4.1.313; B3GALNT2; β-1,3-N-acetylgalactosaminyltransferase II) is a glycosyltransferase
[1].
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-
-
- HY-N9147
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-
-
- HY-13541
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ADH-1
Maximum Cited Publications
8 Publications Verification
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Cadherin
|
Cancer
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ADH-1, an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion.
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-
-
- HY-146761S
-
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Isotope-Labeled Compounds
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Others
|
3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d7 is deuterium labeled 3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine.
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-
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- HY-146921S
-
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Isotope-Labeled Compounds
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Others
|
3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine-d7 (ammonium) is deuterium labeled 3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine (ammonium).
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-
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- HY-34713
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-
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- HY-N10636
-
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Others
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Others
|
D-lactosyl-β-1,1′ N-stearoyl-D-erythro-sphingosine is a neutral glycolipid [1].
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-
-
- HY-Y1078
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N-Dimethoxymethyl-N,N-dimethylamine
|
Biochemical Assay Reagents
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Others
|
1,1-Dimethoxy-N,N-dimethylmethanamine (N-Dimethoxymethyl-N,N-dimethylamine) is a biological molecule.
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-
-
- HY-169250
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-
-
- HY-W717623
-
-
-
- HY-111845
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-
-
- HY-157429
-
|
5-HT Receptor
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Neurological Disease
|
25N-N1-Nap (compound 16) is a β-arrestin-biased 5-HT2A agonist. 25N-N1-Nap antagonizes phencyclidine induced hyperactivity in Male C57BL/6 J mice [1].
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-
-
- HY-W032015
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n-Octyl Bromide
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Biochemical Assay Reagents
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Others
|
1-Bromooctane (n-Octyl Bromide) posesses a terminal bromine. The bromine is a very good leaving group for nucleophilic substitution reactions.
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-
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- HY-158088S
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-
-
- HY-158086S
-
-
-
- HY-158087S
-
-
-
- HY-E70048
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Gb4 synthetase
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Others
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Others
|
beta-1,3-N-Acetylgalactosaminyltransferase (LgtD) (Gb4 synthetase) expressed by mature/activated B cells [1].
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-
-
- HY-140569
-
|
PROTAC Linkers
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Cancer
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N-(PEG1-OH)-N-Boc-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. N-(PEG1-OH)-N-Boc-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-W010348
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Biochemical Assay Reagents
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Others
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1-Carboxy-N,N,N-trimethylmethanaminium hydroxide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
-
- HY-139733
-
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Others
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Others
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β-N-Acetyl-D-hexosaminidase-IN-1 is a novel β-N-acetyl-d-hexosaminidase inhibitor with a Ki value of 3.72 μM.
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-
-
- HY-N12302
-
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Others
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Others
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N1-Dihydrocaffeoyl, N10-caffeoyl spermidine is a natural product that can be isolated from Lycium ruthenicum Murr. [1].
|
-
-
- HY-Y1818
-
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Biochemical Assay Reagents
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Others
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N,N,N-trimethyl-1-phenylmethanaminium chloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
-
- HY-113136
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N1-Methylguanosine
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Endogenous Metabolite
|
Cancer
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1-Methylguanosine (N1-Methylguanosine) is a methylated nucleoside originating from RNA degradation. 1-Methylguanosine is a tumour marker [1].
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-
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- HY-128113
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-
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- HY-Y0120
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Methyltributylammonium chloride
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Biochemical Assay Reagents
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Others
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N,N-Dibutyl-N-methylbutan-1-aminium chloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
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- HY-W008630
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Biochemical Assay Reagents
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Others
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N,N,N-Trimethyldecan-1-aminium bromide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
-
- HY-W099930
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Trimethylpropylammonium bromide
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Biochemical Assay Reagents
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Others
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N,N,N-Trimethylpropan-1-aminium bromide is a quaternary ammonium compound belonging to the class of alkylammonium salts. This compound is widely used as a phase transfer catalyst in organic synthesis, facilitating the transfer of reactants between immiscible phases. It can also be used as a surfactant, corrosion inhibitor or antimicrobial. Due to its unique chemical properties, N,N,N-Trimethylpropan-1-aminium bromide has applications in various industries such as pharmaceuticals, agrochemicals, and materials science.
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- HY-E70049
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GM2/GD2 synthase
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Others
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Neurological Disease
|
beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) (GM2/GD2 synthase) is a key enzyme which catalyzes the conversion of GM3, GD3 and lactosylceramide (LacCer) to GM2, GD2 and asialo-GM2 (GA2), respectively. beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) is a key enzyme to control the synthesis of brain-enriched complex gangliosides [1].
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- HY-E70033
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Endogenous Metabolite
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Metabolic Disease
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D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP) is a member of CAZy glycoside hydrolase GH112 family, is often used in biochemical studies. D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP) catalyses the phosphorolysis of lacto-n-biose and galacto-n-biose, to produce Gal-1-P and the corresponding N-acetyl-D-hexosamine [1].
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- HY-143839S
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-
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- HY-W042416S2
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DMAc-d3
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Isotope-Labeled Compounds
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Others
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N,N-Dimethylacetamide-d3 is the deuterium labeled N,N-Dimethylacetamide [1]. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent .
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- HY-W042416S1
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DMAc-d6
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Isotope-Labeled Compounds
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Others
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N,N-Dimethylacetamide-d6 is the deuterium labeled N,N-Dimethylacetamide [1]. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent .
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-
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- HY-147083
-
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AAK1
|
Cancer
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SGC-AAK1-1N is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor, with an IC50 of 1.8 μM [1].
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-
-
- HY-W042416S
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DMAc-d9
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Isotope-Labeled Compounds
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Others
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N,N-Dimethylacetamide-d9 is the deuterium labeled N,N-Dimethylacetamide [1]. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent .
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-
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- HY-N10634S
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N-ω-CD3-Hexadecaoyl-glucopsychosie; GluCe(d18:1/16:0-d3); Glucosylceamide-d3 (d18:1/16:0-d3)
|
Isotope-Labeled Compounds
Others
|
Inflammation/Immunology
|
D-Glucosyl-β-N-palmitoylsphingosine-d3 (N-ω-CD3-Hexadecaoyl-glucopsychosie) is deuterium labeled D-Glucosyl-β-1,1′-N-palmitoylsphingosine (HY-N10634). D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity [1] [1] .
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-
-
- HY-W014536
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Trimethyl-n-octylammonium Chloride
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Biochemical Assay Reagents
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Others
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N,N,N-Trimethyloctan-1-aminium chloride is a quaternary ammonium salt consisting of a positively charged N,N,N-trimethyloctan-1-aminium cation and a negatively charged chloride anion. The compound is commonly used as a surfactant and emulsifier in a variety of applications including detergents, fabric softeners and personal care products. It can also be used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. Additionally, it has antimicrobial properties and is used as a disinfectant or antiseptic in some products.
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-
-
- HY-23149S
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TRIMETHYLPROPANEDIAMINE-d6
|
Isotope-Labeled Compounds
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Others
|
N,N,N-Trimethyl-1,3-propanediamine-d6 is the deuterium labeled N,N,N-Trimethyl-1,3-propanediamine[1].
|
-
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- HY-141580S1
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N-octadecaoyl-D-eytho-Dihydosphigosie-d3; Ce(d18:0/18:0)-d3; Ceamide-d3 (d18:0/18:0-d3)
|
Isotope-Labeled Compounds
Others
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Metabolic Disease
|
C18 Dihydroceramide-d3-1 (N-octadecaoyl-D-eytho-Dihydosphigosie-d3) is deuterium labeled C18 Dihydroceramide. C18 Dihydroceramide is an ester product [1].
|
-
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- HY-124891
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N-Phenylpyrrole
|
Fluorescent Dye
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Others
|
1-Phenylpyrrole (N-Phenylpyrrole) has dual fluorescent properties. 1-Phenylpyrrole displays a single band in nonpolar solvents and a second red-shifted fluorescent band in polar solvents [1].
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-
-
- HY-176472
-
|
Biochemical Assay Reagents
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Others
|
N,N'-Di-3-butyn-1-ylurea (Compound m7N) is a linker. N,N'-Di-3-butyn-1-ylurea is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity [1] .
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- HY-W008608S1
-
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Isotope-Labeled Compounds
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Others
|
N-Dodecyl-N,N-dimethyldodecan-1-aminium-d5 (bromide) is the deuterium labeled N-Dodecyl-N,N-dimethyldodecan-1-aminium bromide [1].
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- HY-150658S
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-
- HY-W653822
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(2S)-Nicotine 1-N-oxide
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Drug Metabolite
|
Others
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(2'S)-Nicotine 1-oxide ((2S)-Nicotine 1-N-oxide) is an alkaloid N-oxide, which is found in leaves, stems and roots of Nicotiana tabacum [1].
|
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- HY-139006
-
|
TRP Channel
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Neurological Disease
|
N-oleoyl-glutamine is a PM20D1-regulated N-acyl amino acids (NAAs). N-oleoyl-glutamine is a transient receptor potential (TRP) antagonist [1].
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- HY-W008608S
-
|
Isotope-Labeled Compounds
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Others
|
N-Dodecyl-N,N-dimethyldodecan-1-aminium-d25 (bromide) is the deuterium labeled N-Dodecyl-N,N-dimethyldodecan-1-aminium bromide [1].
|
-
- HY-N10634
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C16 Glucosyl(β) Ceramide (d18:1/16:0)
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Others
|
Inflammation/Immunology
|
D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity [1].
|
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- HY-100617A
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(RS)-4-Carboxyphenylglycine
|
mGluR
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Others
|
(RS)-4CPG ((RS)-4-Carboxyphenylglycine) is a type I metabotropic glutamate receptor antagonist with activity in blocking LTP induction. In mice lacking IP3R1, (RS)-4CPG (500μM) nearly blocked long-term potentiation (LTP) induced by type I metabotropic glutamate receptor activation, with LTP of 117.6±1.7% (n = 8) in IP3R1(-/-) mice and 116.9±1.8% (n = 5) in IP3R1(+/+) mice.
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- HY-E70051
-
EC 2.4.1.40(Pm1138)
|
Endogenous Metabolite
|
Others
|
alpha-1,3-N-Acetylgalactosaminyltransferase (Pm1138) (EC 2.4.1.40(Pm1138)), also namely the ABO system transferase with glycosyl transferase activity [1].
|
-
- HY-W002736
-
|
Biochemical Assay Reagents
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Others
|
N,N'-Di-Boc-1H-pyrazole-1-carboximidamide (Compound 1) is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1].
|
-
- HY-W800631
-
|
Biochemical Assay Reagents
|
Others
|
Benzyl N1-(PEG1-acid)-N6-(t-Boc)-L-lysinate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-12726S1
-
|
Isotope-Labeled Compounds
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Cancer
|
Liproxstatin-1- 15N is the 15N labled Liproxstatin-1 (HY-12726). Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM) [1].
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- HY-Y0252S4
-
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Endogenous Metabolite
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Others
|
L-Proline- 13C5,1- 15N is the 13C- and 15N-labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
|
-
- HY-122426
-
n-Undecyl bromide
|
Biochemical Assay Reagents
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Others
|
1-Bromoundecane (n-Undecyl bromide) is a chemical reagent featuring a bromide along a saturated C11 chain. Bromide is easily displaced by nucleophiles such as alcohols or amines. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles.
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-
- HY-115754
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PEITC-Cys
|
DNA/RNA Synthesis
Cytochrome P450
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Cancer
|
S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells [1]. S-(N-PhenethylthiocarbaMoyl)-L-cysteine is a P450 inhibitor .
|
-
- HY-149777
-
|
Others
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Others
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B3GNT2-IN-1 (compound 8j) is a β-1,3-N-Acetylglucosaminyltransferase 2 (B3GNT2) inhibitor, with an IC50 of 9 nM [1].
|
-
- HY-110273
-
|
Calcium Channel
E1/E2/E3 Enzyme
|
Cardiovascular Disease
|
N106 is a first-in-class sarcoplasmic reticulum calcium ATPase (SERCA2a) SUMOylation activator. N106 directly activates the SUMO-activating enzyme, E1 ligase. N106 can be used for heart failure research [1].
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- HY-E70136
-
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Others
|
Metabolic Disease
|
Endo-β-Galactosidase catalyzes the hydrolysis of internal β1-4 galactose linkages in unbranched, repeating poly-N-acetyllactosamine ([GlcNAc- (1-3)Gal- (1-4)]n) structures [1].
|
-
- HY-E70140
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EC 2.4.1; A4GNT
|
Antibiotic
|
Infection
|
α-1,4-N-Acetylglucosaminyltransferase 4 (EC 2.4.1, A4GNT) catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans and suppresses H. pylori growth [1].
|
-
- HY-E70141
-
EC:2.4.1.149; B3GNT4
|
Glycosyltransferase
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Others
|
β-1,3-N-Acetylglucosaminyltransferase 4 (EC:2.4.1.149, B3GNT4) is involved in the synthesis of poly-N-acetyllactosamine and has activity for type 2 oligosaccharides [1].
|
-
- HY-P2776
-
|
Endogenous Metabolite
|
Metabolic Disease
|
Hexokinase (ScHEX1) (EC 2.7.1.1) is a glycolytic enzyme hexokinase that is inhibited by n-acetylglucosamine. Inhibition of Hexokinase (ScHEX1) by n-acetylglucosamine leads to its separation from the mitochondrial outer membrane, resulting in activation of NLRP3 inflammasome [1].
|
-
- HY-E70061
-
|
Others
|
Others
|
alpha-1,3-N-Acetylgalactosaminyltransferase (BgtA) is an acetylgalactose aminotransferase, which can be isolated from Helicobacter mustelae, and can specifically recognize Fucα1,2-Gal epitopes [1].
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- HY-P1242B
-
|
Drug Derivative
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Inflammation/Immunology
|
NEP(1-40), N-terminal uncapped is a NEP(1-40) (HY-P1242) analog without the acetylation modification at the N-terminal. NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide [1].
|
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- HY-E70060
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EB4GALT1 (LgtE)
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Others
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Others
|
beta-1,4-Galactosyltransferase (LgtE) (EB4GALT1 (LgtE)) catalyzes the reaction involving UDP-galactose and N-acetylglucosamine for the production of galactose beta-1,4-N-acetylglucosamine [1].
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- HY-100644
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Trimethoprim 1-N-oxide
|
Drug Metabolite
|
Infection
|
Trimethoprim N-oxide (Trimethoprim 1-N-oxide) belongs to human urinary metabolites. Trimethoprim N-oxide is generated by oxidation of nitrogen atoms in the pyrimidine ring. Trimethoprim N-oxide is formed predominantly by CYP1A2 in human liver microsomes [1].
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- HY-152325
-
|
Nucleoside Antimetabolite/Analog
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Others
|
N1-(N,N-Dimethylaminocarbonyl)-pseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
|
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- HY-W140566S
-
-
- HY-112582S
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1-Methylpseudouridine-d3; N1-methyl-pseudouridine-d3
|
Nucleoside Antimetabolite/Analog
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Cancer
|
N1-Methylpseudouridine-d3 is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
|
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- HY-W009512S
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RS-94287-d8
|
Isotope-Labeled Compounds
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Others
|
N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide-d8 is the deuterium labeled N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide [1].
|
-
- HY-B1449S10
-
β-Uridine-13C5
|
Isotope-Labeled Compounds
|
Cancer
|
Uridine- 13C5 (β-Uridine- 13C5) is a 13C labeled Uridine (HY-B1449). Uridine (β-Uridine) is a nucleoside compound consisting of uracil and a ribose ring, which are linked by a β-N1- glycosyl bond.
|
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- HY-171493
-
|
Biochemical Assay Reagents
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Others
|
mCherry mRNA(N1-Me-Pseudo UTP) is a reporter mRNA encoding a red fluorescent protein, suitable for gene expression analysis, cell viability assays, and in vivo imaging. mCherry, derived from mushroom coral, is a widely used red fluorescent protein tracer in biotechnology applications.
|
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- HY-113136S
-
N1-Methylguanosine-d3
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
1-Methylguanosine-d3 (N1-Methylguanosine-d3) is deuterium labeled 1-Methylguanosine (HY-113136). 1-Methylguanosine is a methylated nucleoside originating from RNA degradation. 1-Methylguanosine is a tumour marker [1] .
|
-
- HY-144364S
-
|
Isotope-Labeled Compounds
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Others
|
N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine-d3 is the deuterium labeled N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine [1].
|
-
- HY-W014728
-
|
Dopamine Receptor
|
Cardiovascular Disease
Neurological Disease
|
N-Methyldopamine hydrochloride is a precursor of adrenaline in the adrenal medulla. N-Methyldopamine hydrochloride is a modification of the dopamine (DA), and retains agonist activity at the DA1 receptor. N-Methyldopamine hydrochloride remains capable of universal surface coating and secondary reactions using the surface catechols. N-Methyldopamine hydrochloride can be used for heart failure research [1] .
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-
- HY-144364S1
-
|
Isotope-Labeled Compounds
|
Others
|
cis-N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine-d3 is the deuterium labeled cis-N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine.
|
-
- HY-143989S
-
|
Isotope-Labeled Compounds
|
Others
|
N,N-Didesmethyl Mifepristone-d4 is the deuterium labeled N,N-Didesmethyl Mifepristone [1]. N,N-Didesmethyl Mifepristone-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W702068
-
Metabolite D hydrochloride
|
Biochemical Assay Reagents
|
Others
|
7-Hydroxy-1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide (Metabolite D) hydrochloride is a biological molecule.
|
-
- HY-W721117
-
Methyl N-acetyl-S-(3-hydroxypropyl)-L-cysteinate-d3
|
Isotope-Labeled Compounds
|
Others
|
N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine-d3 (Methyl N-acetyl-S-(3-hydroxypropyl)-L-cysteinate-d3) is the deuterium labeled N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine.
|
-
- HY-172290
-
|
ADC Linker
|
Cancer
|
Benzyl N1-[PEG1-NHS] -N6-(t-Boc)-L-lysinate is a multifunctional ADC linker consisting of a terminal benzyl group, one PEG unit, an NHS ester, and a t-Boc-protected L-lysine, often used for bioconjugation and chemical modifications in R&D.
|
-
- HY-120726
-
|
HSP
|
Others
|
BF844 mitigate hearing loss associated with USH3 (usher syndrome type III) mutation CLRN1 (clarin-1) N48K. BF844 induces CLRN1 N48K transportes to the plasma membrane. BF844 shows significantly preserves hearing in vivo [1].
|
-
- HY-138540
-
N-Dodecylimidazole
|
Fungal
|
Cancer
|
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity [1] .
|
-
- HY-168610
-
|
Epigenetic Reader Domain
YTHDF
|
Cancer
|
YTH-IN-1 (compound N-7) is a pan-YTH domain inhibitor with the IC50 values of 39 μM, 34 μM, 35 μM, 48 μM and 30 μM for human YTH YTHDF1, YTH YTHDF2, YTH YTHDF3, YTH YTHDC1, and YTH YTHDC2, respectively [1].
|
-
- HY-116285S1
-
|
Isotope-Labeled Compounds
|
Others
|
1-O-n-Octyl-β-D-glucopyranoside-d17 is the deuterium labeled n-Octyl β-D-glucopyranoside [1]. n-Octyl-β-d-glucopyranoside is a non-ionic detergent, it can be widely used in the research of biotechnical, biochemical applications, solubilization and crystallization of membrane proteins .
|
-
- HY-E70143
-
EC:2.4.1.15; N-Acetylglucosaminyltransferase
|
Biochemical Assay Reagents
|
Cancer
|
Glucosaminyl (N-acetyl) Transferase 2 (EC:2.4.1.150, GCNT2, GCNT5, NACGT1, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, N-acetylglucosaminyltransferase, IGNT) is responsible for formation of the blood group I antigen and plays an important role in cancer [1].
|
-
- HY-136433S
-
1,4-Dinitrosopiperazine-d8; DNP-d8
|
Isotope-Labeled Compounds
|
Cancer
|
N,N'-Dinitrosopiperazine-d8 is the deuterium labeled N,N'-Dinitrosopiperazine [1]. N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568 .
|
-
- HY-112582
-
1-Methylpseudouridine; N1-methyl-pseudouridine
|
Nucleoside Antimetabolite/Analog
DNA/RNA Synthesis
|
Inflammation/Immunology
|
N1-methyl-pseudouridine (1-Methylpseudouridine), a methylpseudouridine, outperforms 5 mC and 5 mC/N1-methyl-pseudouridine in translation. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density [1].
|
-
- HY-124891S
-
N-Phenylpyrrole-d9
|
Isotope-Labeled Compounds
|
Others
|
1-Phenylpyrrole-d9 (N-Phenylpyrrole-d9) is the deuterium labeled 1-Phenylpyrrole (HY-124891). 1-Phenylpyrrole (N-Phenylpyrrole) has dual fluorescent properties. 1-Phenylpyrrole displays a single band in nonpolar solvents and a second red-shifted fluorescent band in polar solvents [1].
|
-
- HY-P99777
-
TTI-621
|
CD47
|
Cancer
|
Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a CD47-blocking checkpoint inhibitor with antitumor activity [1].
|
-
- HY-103332
-
NA-Gly
|
GlyT
Endogenous Metabolite
|
Inflammation/Immunology
|
N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration [1] .
|
-
- HY-W042181S
-
Didecyldimethylammonium-d6 chloride; DDAC-d6
|
Isotope-Labeled Compounds
Bacterial
Fungal
|
Infection
|
N-Decyl-N,N-dimethyldecan-1-aminium-d6 (chloride) is a deuterated labeled N-Decyl-N,N-dimethyldecan-1-aminium (chloride) [1]. N-Decyl-N,N-dimethyldecan-1-aminium chloride (Didecyldimethylammonium chloride) is a dialkyl-quaternary ammonium compound that is used in numerous products for its bactericidal, virucidal and fungicidal properties .
|
-
- HY-W551412
-
|
Biochemical Assay Reagents
|
Others
|
β-D-Galactosyl-(1→3)-N-acetyl-D-galactosamine is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
|
-
- HY-152657
-
|
Nucleoside Antimetabolite/Analog
|
Others
|
N1-Methyl-N3-[(2S)-2-(t-butoxycarbonyl)amino-3-(t-butoxycarbonyl)] propylpseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
|
-
- HY-P991158
-
|
TGF-β Receptor
|
Neurological Disease
|
Rinvatercept, a fusion protein, is a glycyl (1)-chimeric N-terminal (1-108)-peptide (2-109) combined from the sequences of the extracellular domains of the human ACVR2A/B, and is fused via a G3 peptide linker (110-112) to an immunoglobulin G1 (IgG1) Fc fragment. Rinvatercept can be used for research of neuromuscular disease [1].
|
-
- HY-19012
-
|
Adrenergic Receptor
|
Cardiovascular Disease
|
N-1518 is an α and β adrenergic receptor blocker that has competitive antagonism against β1 and α1 receptors, but does not show selectivity for β1 receptors, but shows about 20-fold selectivity for α1 receptors. N-1518 has vasodilatory effects and can be used in the research field of hypertension treatment [1].
|
-
- HY-D1601
-
|
Fluorescent Dye
|
Others
|
N-Aminofluorescein is a fluorescein hydrazide with spiro form, a highly selective and sensitive fluorescence probe for Cu 2+. N-Aminofluorescein has no selective fluorescence response to other common metal ions, can be used for direct detection of Cu 2+ in biological systems with λex/em=495/516 nm [1] . N-Aminofluorescein can be used to measure the concentration of copper ions in cells .
|
-
- HY-162428
-
|
Phosphatase
|
Cancer
|
PTPN2/1-IN-3 (compound 4) is a modified, orally active PTPN2/N1 inhibitor based on ABBV-CLS-484 (HY-145923). PTPN2/1-IN-3 has anti-tumor effects, inhibiting PTPN2 with an IC50 of 9.3 nM and having an oral bioavailability of 93% in mice [1].
|
-
- HY-E70046
-
|
Endogenous Metabolite
|
Metabolic Disease
|
beta-1,4-Galactosyltransferase (LgtB) (EC 2.4.1.90) (B4GALT1 (LgtB)) is often used in biochemical studies. beta-1,4-Galactosyltransferase (LgtB) catalyzes the reaction involving UDP-galactose and N-acetylglucosamine for the production of galactose beta-1,4-N-acetylglucosamine [1].
|
-
- HY-W012167
-
|
Biochemical Assay Reagents
|
Others
|
N,N,N-Trimethyldecan-1-aminium chloride is a compound belonging to the class of quaternary ammonium compounds. It is a salt with cationic properties and thus useful in various industrial and biomedical applications. Decyltrimethylammonium chloride is commonly used as a surfactant, emulsifier and disinfectant in personal care products, detergents, textiles and pharmaceutical formulations. It is also used as a phase transfer catalyst in organic synthesis reactions, which involves facilitating the movement of reactants between immiscible phases.
|
-
- HY-W009512S1
-
RS-94287-d6
|
Isotope-Labeled Compounds
|
Others
|
N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide-d6 (N-[(2-chlorophenyl)carbamoyl]phenylalanine-d6) is deuterium-labeled CVT-2738 (HY-W009512). CVT-2738 is a Ranolazine (HY-B0280) Metabolite, and shows anti-myocardial ischemia activities [1].
|
-
- HY-I0678S
-
|
PDGFR
Drug Metabolite
|
Cancer
|
Regorafénib N-oxyde-d3(M2) is the deuterium labeled Regorafénib N-oxyde M2 [1]. Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively .
|
-
- HY-103332S
-
NA-Gly-d8
|
Isotope-Labeled Compounds
Endogenous Metabolite
GlyT
|
Inflammation/Immunology
|
N-Arachidonylglycine-d8 is a deuterated labeled N-Arachidonylglycine [1]. N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .
|
-
- HY-101982
-
Lys-Nε-MCC-DM1
|
Drug-Linker Conjugates for ADC
|
Cancer
|
Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a agent-linker conjugates for ADC that can inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is a HER2-targeting ADC with a tubulin polymerization inhibitor DM1. Lys-SMCC-DM1 can be used in the research of breast cancer [1] .
|
-
- HY-139014
-
H-L-Lys(Poc)-OH
|
Fluorescent Dye
|
Cancer
|
N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals [1] . N-ε-propargyloxycarbonyl-L-lysine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-171764
-
|
Fluorescent Dye
|
Others
|
β-Ethoxy-α-ketobutyraldehyde is a chemical probe. β-Ethoxy-α-ketobutyraldehyde specifically modifies the N1 and N2 positions of guanine. β-Ethoxy-α-ketobutyraldehyde is mainly used to study the steric protection of single-stranded/double-stranded regions of nucleic acids and protein binding sites. β-Ethoxy-α-ketobutyraldehyde can be used for nucleic acid structure analysis and footprint studies of protein-nucleic acid complexes [1].
|
-
- HY-113056AS
-
|
Endogenous Metabolite
|
Cancer
|
N1-Acetylspermidine-d6 (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA [1] .
|
-
- HY-151637
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-N-propargyl-MPBA is a propargyl-substituted MPBA linker derived from 4-hydroxy-3-methoxybenzaldehyde. Fmoc-N-propargyl-MPBA can be elongated using standard Fmoc-based solid phase chemistry and linked to supports by standard coupling procedures [1]. Fmoc-N-propargyl-MPBA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-128676
-
H-L-Lys(Poc)-OH hydrochloride
|
Amino Acid Derivatives
|
Cancer
|
N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) hydrochloride is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals [1] . N-ε-propargyloxycarbonyl-L-lysine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-170774
-
|
Apoptosis
Reactive Oxygen Species
|
Cardiovascular Disease
|
Hypoxia inducer-1 (Compound N6) is an orally active hypoxia activated nitric oxide (NO) donor compound. Hypoxia inducer-1 exhibits highly selective NO release under hypoxic conditions and inhibits hypoxia-induced apoptosis, necrosis, and the increase in ROS levels. Hypoxia inducer-1 regulates vascular dilation and has a protective effect in a mouse model of myocardial hypoxia injury. Hypoxia inducer-1 can be used in the research of coronary heart disease [1].
|
-
- HY-126525
-
|
ADC Linker
|
Cancer
|
4-N3Pfp-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. 4-N3Pfp-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-Z0922
-
|
Biochemical Assay Reagents
|
Others
|
6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-((R)-1-(((R)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide is a biological molecule.
|
-
- HY-W011978
-
|
Endogenous Metabolite
Mitochondrial Metabolism
Neurokinin Receptor
Caspase
Interleukin Related
|
Neurological Disease
Inflammation/Immunology
|
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases [1] .
|
-
- HY-158456
-
FA2[3]BG1 & FA2[6]BG1 glycan N-linked oligosaccharide, 2-AB labelled; G1F with bisecting GlcNAc, 2-AB labelled
|
Biochemical Assay Reagents
|
Others
|
FA2[3]BG1 & FA2[6]BG1 glycan (G1B), 2-AB labelled (FA2[3]BG1 & FA2[6]BG1 glycan N-linked oligosaccharide, 2-AB labelled; G1F with bisecting GlcNAc, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
|
-
- HY-158455
-
FA2[3]BG1 & FA2[6]BG1 glycan N-linked oligosaccharide, 2-AA labelled; G1F with bisecting GlcNAc, 2-AA labelled
|
Biochemical Assay Reagents
|
Others
|
FA2[3]BG1 & FA2[6]BG1 glycan (G1B), 2-AA labelled (FA2[3]BG1 & FA2[6]BG1 glycan N-linked oligosaccharide, 2-AA labelled; G1F with bisecting GlcNAc, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
|
-
- HY-170651
-
|
CDK
HDAC
Apoptosis
|
Cancer
|
CDK4/6/HDAC-IN-1 (Compound N14) is a dual-targeting inhibitor of CDK4/6 and HDAC (IC50: CDK4 = 7.23 nM, CDK6 = 13.20 nM, HDAC1 = 55.66 nM, HDAC6 = 48.38 nM). CDK4/6/HDAC-IN-1 induces cell Apoptosis and G0/G1 phase arrest through HDAC-p21-CDK signaling pathway. CDK4/6/HDAC-IN-1 inhibits hepatocellular carcinoma [1].
|
-
- HY-W127407
-
|
Biochemical Assay Reagents
|
Others
|
Glycerophospho-N-Arachidonoyl Ethanolamine is a N-acylated ethanolamines (NAEs). Most NAEs are naturally occurring lipids with diverse biological activities. Different types of NAE can be derived from glycerophosphate-linked precursors through the activity of glycerophosphodiesterase 1 (GDE1). Glycerophosphate-N-Arachidonoyl Ethanolamine is the precursor of Anandamide (AEA), also known as Anandamide. AEA is an endocannabinoid neurotransmitter that binds to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM compared to 46 nM for δ9-THC.
|
-
- HY-N6866
-
|
Apoptosis
AMPK
Akt
PERK
Keap1-Nrf2
Caspase
PARP
GSK-3
NO Synthase
Interleukin Related
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Endocrinology
Cancer
|
Gomisin N is an orally active lignan compound. Gomisin N can be isolated from Schisandra chinensis. Gomisin N induces Apoptosis in a variety of cells. Gomisin N activates AMPK, Akt, MAPK/ERK, Nrf2, caspase-3 and PARP-1. Gomisin N inhibits GSK3β, nitric oxide (NO), and proinflammatory cytokines (IL-1β, IL-6, TNF-α). Gomisin N has anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, and anti-melanogenesis activities. Gomisin N has anti-tumor activity against cervical cancer and liver cancer. Gomisin N improves Alzheimer's disease [1] .
|
-
- HY-129934
-
Lat-NEt
|
Prostaglandin Receptor
|
Endocrinology
|
Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.
|
-
- HY-112056
-
|
Nuclear Hormone Receptor 4A/NR4A
Apoptosis
DAPK
Isocitrate Dehydrogenase (IDH)
PERK
|
Cancer
|
DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhCO2Me induces Apoptosis. DIM-C-pPhCO2Me decreases PAX3-FOXO1A, N-Myc, Rassf4, MyoD1, Grem1, and DAPK1 proteins. DIM-C-pPhCO2Me decreases expression of TXNDC5 and IDH1, induces markers of ER stress (CHOP, ATF4 and p-PERK). DIM-C-pPhCO2Me inhibits renal cell carcinoma, breast cancer. DIM-C-pPhCO2Me can also be used in rhabdomyosarcoma research [1] .
|
-
- HY-163985
-
|
PROTACs
FGFR
Apoptosis
|
Cancer
|
PROTAC FGFR2 degrader 1 (compound N5) is a PROTAC that effectively targets FGFR2 with DC50 of 6.46 nM, the FGFR2 IC50 is 0.08 nM. PROTAC FGFR2 degrader 1 has anti-proliferative activity and highly selective, induces G0/G1 arrest of KATOIII and SNU16 cell cycle and inhibits apoptosis by reducing the activation of p-ERK and p-PLCγ, the downstream proteins of FGFR2.
PROTAC FGFR2 degrader 1 inhibits gastric cancer cells remained above 50% at a concentration of 0.17 nM.
PROTAC FGFR2 degrader 1 potently inhibits the growth of SNU16 xenograft tumors in mouse model (Structure Note: Pink, FGFR2 activator: HY-18708; Blue, E3 ligase ligand: HY--10984; Black, linker: HY-163989; E3 ligase ligand + linker:HY-163986) [1].
|
-
- HY-129934S
-
Lat-NEt-d4
|
Isotope-Labeled Compounds
Prostaglandin Receptor
|
Endocrinology
|
Latanoprost ethyl amide-d4 (Lat-NEt-d4) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides [1].
|
-
- HY-116161A
-
|
Prostaglandin Receptor
|
Endocrinology
|
17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.1 The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost.2 This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.3 In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF2α isopropyl ester derivative is examined for IOP-lowering activity during the development of latanoprost.4 At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF2α isopropyl ester is the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative is also significantly more irritating to the eye than latanoprost.
|
-
Cat. No. |
Product Name |
Type |
-
- HY-D0222
-
|
Dyes
|
N,N-Dimethyl-1-naphthylamine is an aromatic amine and a dye. N,N-Dimethyl-1-naphthylamine can be used in nitrate reduction test [1] .
|
-
- HY-D1601
-
|
Fluorescent Dyes/Probes
|
N-Aminofluorescein is a fluorescein hydrazide with spiro form, a highly selective and sensitive fluorescence probe for Cu 2+. N-Aminofluorescein has no selective fluorescence response to other common metal ions, can be used for direct detection of Cu 2+ in biological systems with λex/em=495/516 nm [1] . N-Aminofluorescein can be used to measure the concentration of copper ions in cells .
|
Cat. No. |
Product Name |
Type |
-
- HY-W010348
-
|
Cell Assay Reagents
|
1-Carboxy-N,N,N-trimethylmethanaminium hydroxide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-Y1818
-
|
Surfactants
|
N,N,N-trimethyl-1-phenylmethanaminium chloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W008630
-
|
Biochemical Assay Reagents
|
N,N,N-Trimethyldecan-1-aminium bromide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W099930
-
Trimethylpropylammonium bromide
|
Biochemical Assay Reagents
|
N,N,N-Trimethylpropan-1-aminium bromide is a quaternary ammonium compound belonging to the class of alkylammonium salts. This compound is widely used as a phase transfer catalyst in organic synthesis, facilitating the transfer of reactants between immiscible phases. It can also be used as a surfactant, corrosion inhibitor or antimicrobial. Due to its unique chemical properties, N,N,N-Trimethylpropan-1-aminium bromide has applications in various industries such as pharmaceuticals, agrochemicals, and materials science.
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-
- HY-W014536
-
Trimethyl-n-octylammonium Chloride
|
Biochemical Assay Reagents
|
N,N,N-Trimethyloctan-1-aminium chloride is a quaternary ammonium salt consisting of a positively charged N,N,N-trimethyloctan-1-aminium cation and a negatively charged chloride anion. The compound is commonly used as a surfactant and emulsifier in a variety of applications including detergents, fabric softeners and personal care products. It can also be used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. Additionally, it has antimicrobial properties and is used as a disinfectant or antiseptic in some products.
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-
- HY-W002736
-
|
Biochemical Assay Reagents
|
N,N'-Di-Boc-1H-pyrazole-1-carboximidamide (Compound 1) is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1].
|
-
- HY-E70139
-
EC:2.4.1.313; B3GALNT2; β-1,3-N-acetylgalactosaminyltransferase II
|
Enzyme Substrates
|
UDP-GalNAc:β-1,3-N-acetylgalactosaminyltransferase 2 ( EC:2.4.1.313; B3GALNT2; β-1,3-N-acetylgalactosaminyltransferase II) is a glycosyltransferase
[1].
|
-
- HY-Y0120
-
Methyltributylammonium chloride
|
Biochemical Assay Reagents
|
N,N-Dibutyl-N-methylbutan-1-aminium chloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-E70140
-
EC 2.4.1; A4GNT
|
Enzyme Substrates
|
α-1,4-N-Acetylglucosaminyltransferase 4 (EC 2.4.1, A4GNT) catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans and suppresses H. pylori growth [1].
|
-
- HY-E70141
-
EC:2.4.1.149; B3GNT4
|
Enzyme Substrates
|
β-1,3-N-Acetylglucosaminyltransferase 4 (EC:2.4.1.149, B3GNT4) is involved in the synthesis of poly-N-acetyllactosamine and has activity for type 2 oligosaccharides [1].
|
-
- HY-138540
-
N-Dodecylimidazole
|
Cell Assay Reagents
|
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity [1] .
|
-
- HY-E70143
-
EC:2.4.1.15; N-Acetylglucosaminyltransferase
|
Enzyme Substrates
|
Glucosaminyl (N-acetyl) Transferase 2 (EC:2.4.1.150, GCNT2, GCNT5, NACGT1, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, N-acetylglucosaminyltransferase, IGNT) is responsible for formation of the blood group I antigen and plays an important role in cancer [1].
|
-
- HY-W551412
-
|
Carbohydrates
|
β-D-Galactosyl-(1→3)-N-acetyl-D-galactosamine is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology [1].
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-
- HY-W012167
-
|
Biochemical Assay Reagents
|
N,N,N-Trimethyldecan-1-aminium chloride is a compound belonging to the class of quaternary ammonium compounds. It is a salt with cationic properties and thus useful in various industrial and biomedical applications. Decyltrimethylammonium chloride is commonly used as a surfactant, emulsifier and disinfectant in personal care products, detergents, textiles and pharmaceutical formulations. It is also used as a phase transfer catalyst in organic synthesis reactions, which involves facilitating the movement of reactants between immiscible phases.
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-
- HY-158456
-
FA2[3]BG1 & FA2[6]BG1 glycan N-linked oligosaccharide, 2-AB labelled; G1F with bisecting GlcNAc, 2-AB labelled
|
Carbohydrates
|
FA2[3]BG1 & FA2[6]BG1 glycan (G1B), 2-AB labelled (FA2[3]BG1 & FA2[6]BG1 glycan N-linked oligosaccharide, 2-AB labelled; G1F with bisecting GlcNAc, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
|
-
- HY-158455
-
FA2[3]BG1 & FA2[6]BG1 glycan N-linked oligosaccharide, 2-AA labelled; G1F with bisecting GlcNAc, 2-AA labelled
|
Carbohydrates
|
FA2[3]BG1 & FA2[6]BG1 glycan (G1B), 2-AA labelled (FA2[3]BG1 & FA2[6]BG1 glycan N-linked oligosaccharide, 2-AA labelled; G1F with bisecting GlcNAc, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans [1].
|
-
- HY-W127407
-
|
Drug Delivery
|
Glycerophospho-N-Arachidonoyl Ethanolamine is a N-acylated ethanolamines (NAEs). Most NAEs are naturally occurring lipids with diverse biological activities. Different types of NAE can be derived from glycerophosphate-linked precursors through the activity of glycerophosphodiesterase 1 (GDE1). Glycerophosphate-N-Arachidonoyl Ethanolamine is the precursor of Anandamide (AEA), also known as Anandamide. AEA is an endocannabinoid neurotransmitter that binds to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM compared to 46 nM for δ9-THC.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-13541
-
|
Cadherin
|
Cancer
|
ADH-1, an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion.
|
-
- HY-P5349
-
|
Peptides
|
Others
|
4N1K peptide is a biological active peptide. (4N1K-peptide (KRFYVVMWKK), which is derived from thrombospondins has anti-cancer activities in several cancers)
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-
- HY-P1242B
-
|
Drug Derivative
|
Inflammation/Immunology
|
NEP(1-40), N-terminal uncapped is a NEP(1-40) (HY-P1242) analog without the acetylation modification at the N-terminal. NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide [1].
|
-
- HY-139006
-
|
TRP Channel
|
Neurological Disease
|
N-oleoyl-glutamine is a PM20D1-regulated N-acyl amino acids (NAAs). N-oleoyl-glutamine is a transient receptor potential (TRP) antagonist [1].
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P99777
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TTI-621
|
CD47
|
Cancer
|
Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a CD47-blocking checkpoint inhibitor with antitumor activity [1].
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-
- HY-P991158
-
|
TGF-β Receptor
|
Neurological Disease
|
Rinvatercept, a fusion protein, is a glycyl (1)-chimeric N-terminal (1-108)-peptide (2-109) combined from the sequences of the extracellular domains of the human ACVR2A/B, and is fused via a G3 peptide linker (110-112) to an immunoglobulin G1 (IgG1) Fc fragment. Rinvatercept can be used for research of neuromuscular disease [1].
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-113136
-
-
-
- HY-N10634
-
-
-
- HY-103332
-
-
-
- HY-W011978
-
-
-
- HY-N6866
-
|
Structural Classification
Neurological Disease
Classification of Application Fields
Source classification
Lignans
Phenylpropanoids
Plants
Schisandraceae
Schisandra chinensis (Turcz.) Baill.
Inflammation/Immunology
Disease Research Fields
Cancer
|
Apoptosis
AMPK
Akt
PERK
Keap1-Nrf2
Caspase
PARP
GSK-3
NO Synthase
Interleukin Related
|
Gomisin N is an orally active lignan compound. Gomisin N can be isolated from Schisandra chinensis. Gomisin N induces Apoptosis in a variety of cells. Gomisin N activates AMPK, Akt, MAPK/ERK, Nrf2, caspase-3 and PARP-1. Gomisin N inhibits GSK3β, nitric oxide (NO), and proinflammatory cytokines (IL-1β, IL-6, TNF-α). Gomisin N has anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, and anti-melanogenesis activities. Gomisin N has anti-tumor activity against cervical cancer and liver cancer. Gomisin N improves Alzheimer's disease [1] .
|
-
-
- HY-N9147
-
-
-
- HY-N12302
-
-
-
- HY-N11454
-
LNnDFH II
|
Structural Classification
Polysaccharides
Microorganisms
Source classification
Saccharides
|
Others
|
Lacto-N-neodifucohexaose II (Compd 9) is a derivative of key human milk tetrasaccharide [1]. Lacto-N-neodifucohexaose II is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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-
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W011291S
-
|
N,N,N-Trimethylhexadecan-1-aminium-d42 (chloride) is the deuterium labeled N,N,N-Trimethylhexadecan-1-aminium chloride [1].
|
-
-
- HY-W008630S
-
|
N,N,N-Trimethyldecan-1-aminium-d21 bromide is the deuterium labeled N,N,N-Trimethyldecan-1-aminium bromide [1].
|
-
-
- HY-158088S
-
|
N-(1-Oxoheptadecyl)glycine-d2 is the deuterated labeled N-(1-Oxoheptadecyl)glycine [1].
|
-
-
- HY-146923S
-
|
D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d7 is deuterium labeled D-Lactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine.
|
-
-
- HY-146922S
-
|
D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine-d7 is deuterium labeled D-Galactosyl-ß-1,1' N-nervonoyl-D-erythro-sphingosine.
|
-
-
- HY-146766S
-
|
D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine-d7 is deuterium labeled D-Galactosyl-β-1,1'-N-tridecanoyl-D-erythro-sphingosine.
|
-
-
- HY-146764S
-
|
D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine-d7 is deuterium labeled D-Lactosyl-β-1,1'-N-pentadecanoyl-D-erythro-sphingosine.
|
-
-
- HY-W335735
-
|
N,N-dimethyl-N-((phenyl-dd5)methyl)tetradecan-1-aminium bromide is the deuterium labeled N,N-dimethyl-N-((phenyl)methyl)tetradecan-1-aminium bromide [1].
|
-
-
- HY-146761S
-
|
3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine-d7 is deuterium labeled 3-O-Sulfo-D-galactosyl-β1-1'-N-tridecanoyl-D-erythro-sphingosine.
|
-
-
- HY-146921S
-
|
3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine-d7 (ammonium) is deuterium labeled 3-O-Sulfo-D-galactosyl-ß1-1’-N-nervonoyl-D-erythro-sphingosine (ammonium).
|
-
-
- HY-158086S
-
|
N-(1-Oxotridecyl)glycine-d2 is the deuterated labeled N-(1-Oxotridecyl)glycine [1].
|
-
-
- HY-158087S
-
|
N-(1-Oxopentadecyl)glycine-d2 is the deuterated labeled N-(1-Oxopentadecyl)glycine [1].
|
-
-
- HY-143839S
-
|
N-Ethyl-N-nitroso-1-propanamine-d4 is the deuterium labeled N-Ethyl-N-nitroso-1-propanamine [1].
|
-
-
- HY-W042416S2
-
|
N,N-Dimethylacetamide-d3 is the deuterium labeled N,N-Dimethylacetamide [1]. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent .
|
-
-
- HY-W042416S1
-
|
N,N-Dimethylacetamide-d6 is the deuterium labeled N,N-Dimethylacetamide [1]. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent .
|
-
-
- HY-W042416S
-
|
N,N-Dimethylacetamide-d9 is the deuterium labeled N,N-Dimethylacetamide [1]. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent .
|
-
-
- HY-N10634S
-
|
D-Glucosyl-β-N-palmitoylsphingosine-d3 (N-ω-CD3-Hexadecaoyl-glucopsychosie) is deuterium labeled D-Glucosyl-β-1,1′-N-palmitoylsphingosine (HY-N10634). D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) is an endogenous Mincle ligand possessing immunostimulatory activity [1] [1] .
|
-
-
- HY-23149S
-
|
N,N,N-Trimethyl-1,3-propanediamine-d6 is the deuterium labeled N,N,N-Trimethyl-1,3-propanediamine[1].
|
-
-
- HY-141580S1
-
|
C18 Dihydroceramide-d3-1 (N-octadecaoyl-D-eytho-Dihydosphigosie-d3) is deuterium labeled C18 Dihydroceramide. C18 Dihydroceramide is an ester product [1].
|
-
-
- HY-W008608S1
-
|
N-Dodecyl-N,N-dimethyldodecan-1-aminium-d5 (bromide) is the deuterium labeled N-Dodecyl-N,N-dimethyldodecan-1-aminium bromide [1].
|
-
-
- HY-150658S
-
|
DMT-2′O-TBDMS-rA(ac)-1- 15N phosphoramidite is the 15N labeled DMT-2′O-TBDMS-rA(ac) phosphoramidite [1].
|
-
-
- HY-W008608S
-
|
N-Dodecyl-N,N-dimethyldodecan-1-aminium-d25 (bromide) is the deuterium labeled N-Dodecyl-N,N-dimethyldodecan-1-aminium bromide [1].
|
-
-
- HY-12726S1
-
|
Liproxstatin-1- 15N is the 15N labled Liproxstatin-1 (HY-12726). Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM) [1].
|
-
-
- HY-Y0252S4
-
|
L-Proline- 13C5,1- 15N is the 13C- and 15N-labeled L-Proline. L-Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
|
-
-
- HY-W140566S
-
|
N-(2-Aminoethyl)-2-(naphthalen-1-yl)acetamide-d4 is deuterium labeled N-(2-Aminoethyl)-2-(naphthalen-1-yl)acetamide.
|
-
-
- HY-112582S
-
|
N1-Methylpseudouridine-d3 is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
|
-
-
- HY-W009512S
-
|
N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide-d8 is the deuterium labeled N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide [1].
|
-
-
- HY-B1449S10
-
1 Publications Verification
|
Uridine- 13C5 (β-Uridine- 13C5) is a 13C labeled Uridine (HY-B1449). Uridine (β-Uridine) is a nucleoside compound consisting of uracil and a ribose ring, which are linked by a β-N1- glycosyl bond.
|
-
-
- HY-113136S
-
|
1-Methylguanosine-d3 (N1-Methylguanosine-d3) is deuterium labeled 1-Methylguanosine (HY-113136). 1-Methylguanosine is a methylated nucleoside originating from RNA degradation. 1-Methylguanosine is a tumour marker [1] .
|
-
-
- HY-144364S
-
|
N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine-d3 is the deuterium labeled N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine [1].
|
-
-
- HY-144364S1
-
|
cis-N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine-d3 is the deuterium labeled cis-N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine.
|
-
-
- HY-143989S
-
|
N,N-Didesmethyl Mifepristone-d4 is the deuterium labeled N,N-Didesmethyl Mifepristone [1]. N,N-Didesmethyl Mifepristone-d4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
-
- HY-W721117
-
|
N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine-d3 (Methyl N-acetyl-S-(3-hydroxypropyl)-L-cysteinate-d3) is the deuterium labeled N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine.
|
-
-
- HY-116285S1
-
|
1-O-n-Octyl-β-D-glucopyranoside-d17 is the deuterium labeled n-Octyl β-D-glucopyranoside [1]. n-Octyl-β-d-glucopyranoside is a non-ionic detergent, it can be widely used in the research of biotechnical, biochemical applications, solubilization and crystallization of membrane proteins .
|
-
-
- HY-136433S
-
|
N,N'-Dinitrosopiperazine-d8 is the deuterium labeled N,N'-Dinitrosopiperazine [1]. N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568 .
|
-
-
- HY-124891S
-
|
1-Phenylpyrrole-d9 (N-Phenylpyrrole-d9) is the deuterium labeled 1-Phenylpyrrole (HY-124891). 1-Phenylpyrrole (N-Phenylpyrrole) has dual fluorescent properties. 1-Phenylpyrrole displays a single band in nonpolar solvents and a second red-shifted fluorescent band in polar solvents [1].
|
-
-
- HY-W042181S
-
|
N-Decyl-N,N-dimethyldecan-1-aminium-d6 (chloride) is a deuterated labeled N-Decyl-N,N-dimethyldecan-1-aminium (chloride) [1]. N-Decyl-N,N-dimethyldecan-1-aminium chloride (Didecyldimethylammonium chloride) is a dialkyl-quaternary ammonium compound that is used in numerous products for its bactericidal, virucidal and fungicidal properties .
|
-
-
- HY-W009512S1
-
|
N-(2,6-Dimethylphenyl)-2-(piperazin-1-yl)acetamide-d6 (N-[(2-chlorophenyl)carbamoyl]phenylalanine-d6) is deuterium-labeled CVT-2738 (HY-W009512). CVT-2738 is a Ranolazine (HY-B0280) Metabolite, and shows anti-myocardial ischemia activities [1].
|
-
-
- HY-I0678S
-
|
Regorafénib N-oxyde-d3(M2) is the deuterium labeled Regorafénib N-oxyde M2 [1]. Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively .
|
-
-
- HY-103332S
-
|
N-Arachidonylglycine-d8 is a deuterated labeled N-Arachidonylglycine [1]. N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .
|
-
-
- HY-113056AS
-
|
N1-Acetylspermidine-d6 (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA [1] .
|
-
-
- HY-129934S
-
|
Latanoprost ethyl amide-d4 (Lat-NEt-d4) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides [1].
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-
Cat. No. |
Product Name |
|
Classification |
-
- HY-139014
-
H-L-Lys(Poc)-OH
|
|
Alkynes
Labeling and Fluorescence Imaging
|
N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals [1] . N-ε-propargyloxycarbonyl-L-lysine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-128676
-
H-L-Lys(Poc)-OH hydrochloride
|
|
Labeling and Fluorescence Imaging
Alkynes
|
N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) hydrochloride is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals [1] . N-ε-propargyloxycarbonyl-L-lysine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-140569
-
|
|
Alkynes
PROTAC Synthesis
|
N-(PEG1-OH)-N-Boc-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. N-(PEG1-OH)-N-Boc-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-176472
-
|
|
Alkynes
|
N,N'-Di-3-butyn-1-ylurea (Compound m7N) is a linker. N,N'-Di-3-butyn-1-ylurea is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity [1] .
|
-
- HY-N11454
-
LNnDFH II
|
|
Azide
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Lacto-N-neodifucohexaose II (Compd 9) is a derivative of key human milk tetrasaccharide [1]. Lacto-N-neodifucohexaose II is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-151637
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Alkynes
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Fmoc-N-propargyl-MPBA is a propargyl-substituted MPBA linker derived from 4-hydroxy-3-methoxybenzaldehyde. Fmoc-N-propargyl-MPBA can be elongated using standard Fmoc-based solid phase chemistry and linked to supports by standard coupling procedures [1]. Fmoc-N-propargyl-MPBA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-126525
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ADC Synthesis
Azide
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4-N3Pfp-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. 4-N3Pfp-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Cat. No. |
Product Name |
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Classification |
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- HY-112582
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1-Methylpseudouridine; N1-methyl-pseudouridine
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Nucleosides and their Analogs
U
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N1-methyl-pseudouridine (1-Methylpseudouridine), a methylpseudouridine, outperforms 5 mC and 5 mC/N1-methyl-pseudouridine in translation. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density [1].
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- HY-159675
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Cationic Lipids
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1-A-N is a lipid nanoparticle (LNP) used for in vivo delivery of siRNA. 1-A-N can regulate immune response by delivering siCD45 (siRNA targeting CD45) to T cells and silencing the CD45 gene [1].
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- HY-152325
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Nucleosides and their Analogs
U
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N1-(N,N-Dimethylaminocarbonyl)-pseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
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- HY-152657
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Nucleosides and their Analogs
U
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N1-Methyl-N3-[(2S)-2-(t-butoxycarbonyl)amino-3-(t-butoxycarbonyl)] propylpseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
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