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Results for "

(Z)-isomer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Isomer (3) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (1) CRM1 (1) Cytochrome P450 (2) Drug Derivative (1) Drug Metabolite (1) Endogenous Metabolite (3) Estrogen Receptor/ERR (5) Eukaryotic Initiation Factor (eIF) (1) FABP (1) HIV (1) HMG-CoA Reductase (HMGCR) (1) Isotope-Labeled Compounds (1) Lipoxygenase (1) NF-κB (2) Parasite (2) Phosphodiesterase (PDE) (1) Potassium Channel (2) PPAR (1) Reference Standards (1) Reverse Transcriptase (1) Sodium Channel (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (1)

By Targets:

Drug Isomer (3)

Apoptosis (1)

Bacterial (1)

Biochemical Assay Reagents (1)

CRM1 (1)

Cytochrome P450 (2)

Drug Derivative (1)

Drug Metabolite (1)

Endogenous Metabolite (3)

Estrogen Receptor/ERR (5)

Eukaryotic Initiation Factor (eIF) (1)

FABP (1)

HIV (1)

HMG-CoA Reductase (HMGCR) (1)

Isotope-Labeled Compounds (1)

Lipoxygenase (1)

NF-κB (2)

Parasite (2)

Phosphodiesterase (PDE) (1)

Potassium Channel (2)

PPAR (1)

Reference Standards (1)

Reverse Transcriptase (1)

Sodium Channel (1)

By Research Areas:

Cancer (11)

Cardiovascular Disease (1)

Infection (3)

Inflammation/Immunology (4)

Metabolic Disease (2)

Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Isomer

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100423A

Eltanexor Z-isomer 1 Publications Verification KPT-8602 (Z-isomer)	CRM1	Cancer
Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602.

HY-18719

*Endoxifen (Z-isomer)* 3 Publications Verification	Estrogen Receptor/ERR Potassium Channel	Cancer
Endoxifen Z-isomer is an oral active Tamoxifen (HY-13757A) metabolite, inducing an anti-estrogenic effect in breast cancer cells expressing ERα. Endoxifen Z-isomer inhibits hERG. This effect is concentration-dependent, with an IC₅₀ value of 1.6 μM .

HY-18719A

*Endoxifen Z-isomer* hydrochloride** 3 Publications Verification	Estrogen Receptor/ERR Potassium Channel	Cancer
Endoxifen Z-isomer hydrochloride is the most important Tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha (ERα).

HY-N2543

Damascenone 1 Publications Verification (E/Z)-Damascenone	NF-κB Endogenous Metabolite	Inflammation/Immunology
Damascenone ((E/Z)-Damascenone) is an active compound of Epipremnum pinnatum with anti-inflammatory activity . Damascenone is a mixture complex of E-isomer-Damascenone and Z-isomer Damascenone.

HY-18719D

*Endoxifen (E-isomer)* E-Endoxifen	Estrogen Receptor/ERR	Cancer
Endoxifen E-isomer (E-Endoxifen), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer exhibits antiestrogenic effects .

HY-18719S

*Endoxifen-d5 (Z-isomer)*	Isotope-Labeled Compounds Cytochrome P450 Estrogen Receptor/ERR Drug Metabolite Parasite	Cancer
Endoxifen-d₅ (Z-isomer) is the deuterium labeled Endoxifen (Z-isomer) (HY-18719). Endoxifen (Z-isomer) is an oral active Tamoxifen (HY-13757A) metabolite, inducing an anti-estrogenic effect in breast cancer cells expressing ERα. Endoxifen (Z-isomer) inhibits hERG. This effect is concentration-dependent, with an IC₅₀ value of 1.6 μM .

HY-166114A

(Z)-Heptaprenyl-MPDA diammonium (Z)-Heptaprenyl phosphate diammonium	Bacterial	Infection
(Z)-Heptaprenyl-MPDA ((Z)-Heptaprenyl phosphate) diammonium is the (Z)-isomer of Heptaprenyl-MPDA (HY-166114). Heptaprenyl-MPDA (Heptaprenyl phosphate) is a short-chain homolog of undecaprenyl phosphate, is an endogenous substrate of Phospho-MurNAc-pentapeptide translocase (MraY). Heptaprenyl-MPDA can be used for bacterial infections research .

HY-100615A

R 80123	Phosphodiesterase (PDE)	Cardiovascular Disease
R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor.

HY-134211

(Z)-2-Octenoic acid	Endogenous Metabolite	Others
Z-2-Octenoic acid is the Z-isomer of 2-Octenoic acid. trans-2-Octenoic acid is a metabolite of Mucor species.

HY-N16225

12(Z)-Octadecenoic acid cis-12-Octadecenoic acid	Biochemical Assay Reagents	Others
12(Z)-Octadecenoic acid (cis-12-Octadecenoic acid) is the 12(Z)-isomer of Octadecenoic acid. 12(Z)-Octadecenoic acid is an unsaturated fatty acid .

HY-18719C

*Endoxifen E-isomer* hydrochloride** E-Endoxifen hydrochloride	Estrogen Receptor/ERR	Cancer
Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride), an E-isomer of Endoxifen, is an impurity in Endoxifen Z-isomer agent substance. Endoxifen E-isomer hydrochloride exhibits antiestrogenic effects .

HY-W1004917

8,9-Z-Abamectin B1a	Drug Isomer Parasite	Infection
8,9-Z-Abamectin B1a is the 8,9-Z-isomer of Abamectin B1a (HY-15308). Avermectin B1a is an antiparasitic agent that paralyzes nematodes .

HY-135383B

(Z)-Pitavastatin calcium	HMG-CoA Reductase (HMGCR)	Metabolic Disease
(Z)-Pitavastatin calcium is the Z-Isomer of Pitavastatin hemicacium. Pitavastatin calcium is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin calcium inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells .

HY-N2543R

Damascenone (Standard) (E/Z)-Damascenone (Standard)	Reference Standards NF-κB Endogenous Metabolite	Inflammation/Immunology
Damascenone (Standard) is the analytical standard of Damascenone. This product is intended for research and analytical applications. Damascenone ((E/Z)-Damascenone) is an active compound of Epipremnum pinnatum with anti-inflammatory activity . Damascenone is a mixture complex of E-isomer-Damascenone and Z-isomer Damascenone.

HY-Z8176

(Z)-Flunarizine	Sodium Channel	Neurological Disease
(Z)-Flunarizine is the (Z)-isomer of Flunarizine (HY-B0358). Flunarizine is a potent dual Na ⁺/Ca ²⁺ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .

HY-N1516A

(Z)-Ganoderenic acid D	Apoptosis	Cancer
(Z)-Ganoderenic acid D is the z-isomer of Ganoderenic acid D (HY-N1516). (Z)-Ganoderenic acid D is the triterpene that can be isolated from Ganoderma, and contributes to the bitter taste of the basidiocarps and extracts of Ganoderma species. Ganoderenic acid D inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis .

HY-167642

(Z)-Rilpivirine (Z)-R278474; (Z)-TMC278; (Z)-DB08864	Drug Isomer HIV Reverse Transcriptase	Infection
(Z)-Rilpivirine ((Z)-R278474) is the (Z)-isomer of Rilpivirine (HY-10574). Rilpivirine is an effective and selective diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). It exhibits potent antiviral activity against both wild-type HIV (EC₅₀ = 0.4 nM) and mutant strains (EC₅₀ = 0.1-2.0 nM) .

HY-N0722A

(Z)-Neochlorogenic acid cis-5-O-Caffeoylquinic acid	Drug Derivative	Inflammation/Immunology Cancer
(Z)-Neochlorogenic acid is the z-isomer of Neochlorogenic acid (HY-N0722). Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation .

HY-19831A

(Z)-4EGI-1	Eukaryotic Initiation Factor (eIF)	Cancer
(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC₅₀ of 43.5 μM and a K_d value of 8.74 μM. (Z)-4EGI-1 has anticancer activity .

HY-107842

(Z)-JIB-04 NSC693627	Drug Isomer	Cancer
(Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis .

HY-126308

(E/Z)-DMU2139	Cytochrome P450	Cancer
(E/Z)-DMU2139 (Compound 180) is the E/Z isomer of DMU2139 (HY-101285). (E/Z)-DMU2139 is a potent and specific CYP1B1 inhibitor (IC₅₀: 4 nM) .

HY-113691

(E)-L-652343	Lipoxygenase	Others
(E)-L-652343 is a compound with potent cyclooxygenase and 5-lipoxygenase inhibitory activity. (E)-L-652343 can effectively inhibit the synthesis of products of these two pathways in vivo. (E)-L-652343 showed high sensitivity and specificity in the detection of geometric isomers in canine and human plasma. (E)-L-652343 showed selective metabolism in vivo, and the elimination rate of the E isomer was faster than that of the Z isomer .

HY-172883A

(E/Z)-ABP/PPAR modulator 1	FABP PPAR	Metabolic Disease Inflammation/Immunology
(E/Z)-ABP/PPAR modulator 1 is a mixture of the E and Z isomers of ABP/PPAR modulator 1 (HY-172883). ABP/PPAR modulator 1 is an orally active FABP and PPAR multiple modulator (IC₅₀s of 0.65  μM and 1.08  μM for FABP1 and FABP4, EC₅₀s of 9.19  μM, 2.20  μM and 1.58 μM for PPARα, PPARγ and PPARδ). ABP/PPAR modulator 1 has potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently ameliorates multiple pathological characteristics of fatty liver in WD + Carbon tetrachloride-induced MASH mice model .

Cat. No.	Product Name	Category	Target	Chemical Structure