ROR2 Protein, Mouse (HEK293, Fc)

The ROR2 protein is a tyrosine protein kinase receptor that plays a critical role in early chondrocyte formation and is essential for cartilage and growth plate development. Despite minimal tyrosine kinase activity, ROR2 phosphorylates YWHAB, which is associated with osteogenic induction and bone formation. ROR2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived ROR2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ROR2 Protein, Mouse (HEK293, Fc) is 370 a.a., with molecular weight of 70-100 kDa.

ROR2 protein, a tyrosine-protein kinase receptor, emerges as a key player in the early stages of chondrocyte formation and is indispensable for cartilage and growth plate development. This receptor demonstrates the capability to phosphorylate YWHAB, an event associated with the induction of osteogenesis and bone formation. Intriguingly, although it exhibits minimal tyrosine kinase activity in vitro, ROR2 is proposed to act as a receptor for the WNT ligand WNT5A, potentially exerting inhibitory effects on WNT3A-mediated signaling. The nuanced role of ROR2 underscores its involvement in intricate cellular processes during skeletal development.

Mouse

HEK293

C-hFc

Q9Z138 (E34-G403)

26564  [NCBI]

70-100 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.