Ror2 - receptor tyrosine kinase-like orphan receptor 2 Gene

Mus musculus

Also known as Ntrkr2

Gene ID: 26564 | Gene type: protein coding

About Ror2

Summary

Enables Wnt-protein binding activity; Frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in positive regulation of canonical Wnt signaling pathway and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including cartilage condensation; cell surface receptor signaling pathway; and embryonic morphogenesis. Predicted to be located in several cellular components, including dendrite; microtubule; and neuronal cell body. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; neural ectoderm; and sensory organ. Used to study autosomal recessive Robinow syndrome. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like Orphan Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ror2 Products(1)

mRNA	Protein	Name
NM_013846.4	NP_038874.3	tyrosine-protein kinase transmembrane receptor ROR2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	18606138	MGI
enables frizzled binding	IPI IPI: Inferred from physical interaction	12839624	MGI
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	18762249	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12839624	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	20660756	MGI
acts upstream of or within JNK cascade	IDA IDA: Inferred from direct assay	12839624	MGI
acts upstream of or within SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	20660756	MGI
acts upstream of or within Wnt signaling pathway, calcium modulating pathway	IPI IPI: Inferred from physical interaction	12839624	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IMP IMP: Inferred from mutant phenotype	18606138	MGI
acts upstream of or within cartilage condensation	IMP IMP: Inferred from mutant phenotype	14745966	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	20660756	MGI
acts upstream of or within chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	14745966	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	20660756	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	20660756	MGI
acts upstream of or within embryonic genitalia morphogenesis	IMP IMP: Inferred from mutant phenotype	14745966	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	18606138	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16602827	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18215320	MGI
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	18215320	MGI
acts upstream of or within regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20660756	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	10700181	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	20660756	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	14745966	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein kinase transmembrane receptor ROR2

neurotrophic tyrosine kinase, receptor-related 2

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145626	Ozuriftamab		99.73%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12125	ROR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17495	Ror2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23952	Ror2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145627	Ozuriftamab vedotin	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ror2	NCBI	NCBI:4920
Macaca fascicularis	Ror2	NCBI	NCBI:102118636

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