MCP-2/CCL8 Protein, Human (His)

MCP-2/CCL8 Protein, Human (His) is the recombinant human-derived MCP-2/CCL8 protein, expressed by E. coli, with N-His tag.

MCP-2/CCL8 is a chemotactic factor that attracts monocytes, lymphocytes, basophils, and eosinophils. It may play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not exhibit monocyte chemotactic activity but inhibits the chemotactic effect most predominantly of CCL7, as well as CCL2, CCL5, and CCL8. by similar: The protein shares functional similarities with other members of the chemokine family, but its processed form exhibits unique inhibitory effects.

Human

E. coli

N-His

P80075 (Q24-P99)

6355

Approximately 10-11 kDa, based on SDS-PAGE under reducing conditions.

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from 0.22 μm filtered solution of PBS, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.