2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CC Chemokines

CC Chemokines

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CC chemokines, a class of soluble proteins with low molecular weight (8-15 kDa) and an N-terminal CC structural domain, were originally identified as mediators of inflammatory processes and regulators of leukocyte transport. All chemokines share the same overall structure: at least three β-folded sheets, an α-helix in the C-terminal domain, and a disulfide bond connecting conserved cysteine residues. Depending on the arrangement of the first two N-terminal cysteine residues in their amino acid sequence, chemokines can be divided into four families: the CXC (or α) family, the CC (or β) family, the CX3C (or δ) family, and the C (or γ) family. Most chemokines exert their biological effects through the activation of G protein-coupled seven transmembrane receptors (GPCR). Chemokines are a class of soluble cytokines that act as chemoattractants to direct the migration of cells (especially immune cells) and are also involved in cell proliferation, differentiation and survival and are associated with a variety of human diseases, including chronic inflammation, immune dysfunction, cancer and metastasis[1][2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P7237
    MCP-1/CCL2 Protein, Human

    rHuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2

    		Human E. coli
    MCP-1/CCL2 Protein, Human is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human is a recombinant human MCP-1/CCL2(Q24-T99) expressed by E.coil.
  • HY-P7160
    Eotaxin/CCL11 Protein, Mouse

    rMuEotaxin/CCL11; C-C motif chemokine 11; Eosinophil chemotactic protein; SCYA11

    		Mouse E. coli
    Eotaxin/CCL11 Protein, Mouse is a potent chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia.
  • HY-P70450
    RANTES/CCL5 Protein, Human

    C-C Motif Chemokine 5; EoCP; Eosinophil Chemotactic Cytokine; SIS-Delta; Small-Inducible Cytokine A5; T Cell-Specific Protein P228; TCP228; T-Cell-Specific Protein RANTES; CCL5; D17S136E; SCYA5

    		Human E. coli
    RANTES/CCL5 Protein is a secreted protein located outside the cell membrane and is a key pro-inflammatory chemokine and immune regulatory molecule in the CC chemokine family. RANTES/CCL5 Protein sends signals through its specific G protein-coupled receptors (GPCR) CCR1, CCR3, and CCR5, mediating inflammatory immune responses, viral infections, and tumor development. RANTES/CCL5 Protein can promote endothelial cell migration, proliferation, and angiogenesis in rats. RANTES/CCL5 Protein is useful for research into tumors, autoimmune diseases, and atherosclerosis. RANTES/CCL5 Protein, Human is a recombinant human CCL5 (S24-S91) protein expressed by E. coli.
  • HY-P7282
    RANTES/CCL5 Protein, Human (HEK293)

    rHuRANTES/CCL5; C-C motif chemokine 5; SCYA5

    		Human HEK293
    RANTES/CCL5 Protein, Human (HEK293) is a key pro-inflammatory chemokine in the CC chemokine family that interacts with CCR1, CCR3, CCR4, and CCR5 to mediate inflammatory immune responses, viral infections, and tumorigenesis. RANTES/CCL5 Protein, Human ( HEK293) is a recombinant human RANTES/CCL5(S24-S91) protein expressed by HEK293.
  • HY-P72756
    6Ckine/CCL21A Protein, Mouse

    C-C motif chemokine 21a; 6Ckine; TCA4; Ccl21a; Scya21; Scya21a

    		Mouse E. coli
    6Ckine/CCL21A Protein, Mouse is a homeostatic lymphoid chemokine that contributes to the entry of T cells and dendritic cells into the lymphoid T-zone. It acts through chemokine receptors CCR7 and CXCR3 to promote fibrogenic and inflammatory cytokine production. 6Ckine/CCL21 Protein, Mouse is a recombinant mouse 6Ckine/CCL21A (S24-G133) expressed by E. coli.
  • HY-P7764
    MCP-1/CCL2 Protein, Mouse

    rMuCCL2; C-C motif chemokine 2; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; MCP-1; Ccl2; Scya2

    		Mouse E. coli
    MCP-1/CCL2 Protein, Mouse is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse is a mouse MCP-1/CCL2 (Q24-R96) expressed by E.coil.
  • HY-P7263
    MIP-3 alpha/CCL20 Protein, Mouse

    rMuMIP-3α/CCL20; C-C motif chemokine 20; MIP3A; SCYA20

    		Mouse E. coli
    MIP-3 alpha/CCL20 Protein, Mouse is a CC chemokine that attracts lymphocytes and mild neutrophils by binding to and acting on the chemokine receptor CCR6. It induces intracellular calcium mobilization and mediates cancer, various autoimmune diseases, and antimicrobial effects. MIP-3 alpha/CCL20 Protein, Mouse  is a recombinant mouse CCL20 (A28-M97) expressed by E. coli.
  • HY-P72786
    MPIF-1/CCL23 Protein, Human (99a.a)

    C-C motif chemokine 23; CCL23; CKB-8; MIP-3; MPIF-1; SCYA23

    		Human E. coli
    MPIF-1/CCL23 protein, Human (99a.a), a CC chemokine, is highly chemotactic for resting T cells and monocytes, mediates inflammatory and immune responses by binding to the chemokine receptor CCR1, inhibits myeloid progenitor cell formation, and has some pro-cancer effects. MPIF-1/CCL23 Protein, Human (99a.a) is a recombinant human MPIF-1/CCL23 (R22-N120) protein expressed by E. coli.
  • HY-P7257
    CCL4 Protein, Human

    rHuMIP-1β/CCL4; C-C motif chemokine 4; LAG-1; Macrophage inflammatory protein 1-beta; SCYA4

    		Human E. coli
    CCL4 Protein, Human is a small cytokine of the CC chemokine subfamily that binds to the CCR5 chemokine receptor on the cell surface, promotes leukocyte aggregation under various inflammatory conditions, and contributes to immune protection against human immunodeficiency virus type 1. CCL4 Protein, Human is a recombinant human CCL4 (A24-N92) expressed by E. coli.
  • HY-P7236
    MCP-1/CCL2 Protein, Rat (HEK293, C-His)

    rRtMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2

    		Rat HEK293
    MCP-1/CCL2 Protein, Rat (HEK293, His) is a small cytokine that belongs to the CC chemokine family.
  • HY-P7239
    MCP-2/CCL8 Protein, Mouse

    rMuMCP-2/CCL8; C-C motif chemokine 8; MCP-2; SCYA10; SCYA8

    		Mouse E. coli
    MCP-2/CCL8 Protein, Mouse is a CC chemokine that interacts with CCR1, CCR2B, CCR3, and CCR5 to mediate host inflammatory immune responses, tumorigenesis, and antiviral infections. MCP-2/CCL8 Protein, Mouse is a recombinant mouse MCP-2/CCL8 (G24-P97) protein expressed by E. coli.
  • HY-P78173
    MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi)

    C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2

    		Human HEK293
    MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human MCP-1/CCL2 (Q24-T99) expressed by HEK293 with His and Avi tags at the C-terminus.
  • HY-P71890
    RANTES/CCL5 Protein, Mouse

    Ccl5; Scya5C-C motif chemokine 5; MuRantes; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES

    		Mouse E. coli
    RANTES/CCL5 Protein, Mouse is a key pro-inflammatory chemokine in the CC chemokine family that interacts with CCR1, CCR3, CCR4, and CCR5 to mediate inflammatory immune responses, viral infections, and tumorigenesis. RANTES/CCL5 Protein, Mouse is a recombinant mouse CCL5(S24-S91) protein expressed by E. coli.
  • HY-P7243
    MCP-3/CCL7 Protein, Mouse

    rMuMCP-3/CCL7; C-C motif chemokine 7; MCP3; SCYA7

    		Mouse E. coli
    MCP-3/CCL7 Protein, Mouse is a CC chemokine and elicitor that binds to CCR1, CCR2 and CCR3 to mediate antiviral, antibacterial, antitumor and other immune responses. MCP-3/CCL7 Protein, Mouse is a recombinant mouse MCP-3/CCL7 protein expressed by E.coilMCP-3/CCL7(Q24-P97).
  • HY-P7238
    MCP-2/CCL8 Protein, Human

    rHuMCP-2/CCL8; C-C motif chemokine 8; MCP-2; SCYA10; SCYA8

    		Human E. coli
    MCP-2/CCL8 Protein, Human is a CC chemokine that interacts with CCR1, CCR2B, CCR3, and CCR5 to mediate host inflammatory immune responses, tumorigenesis, and antiviral infections. MCP-2/CCL8 Protein, Human is a recombinant human MCP-2/CCL8 (Q24-P99) protein expressed by E. coli.
  • HY-P7248
    MDC/CCL22 Protein, Mouse (His)

    rMuMDC/CCL22; C-C motif chemokine 22; Abcd1; SCYA22

    		Mouse E. coli
    CCL22/MDC Protein,Mouse (His) is a CC chemokine that acts as a ligand for the CCR4 receptor and is a chemoattractant for CCR4-expressing cells such as Th2 cells, playing an important role in homeostatic and inflammatory responses. CCL22/MDC Protein, Mouse (His) is a recombinant mouse CCL22/MDC (G25-S92) protein expressed by E. coli with a his tag.
  • HY-P7260
    MIP-3 alpha/CCL20 Protein, Human (CHO)

    rHuMIP-3α/CCL20; C-C motif chemokine 20; MIP3A; SCYA20

    		Human CHO
    MIP-3 alpha/CCL20 Protein, Human (CHO) is a CC chemokine that attracts lymphocytes and mild neutrophils by binding to and acting on the chemokine receptor CCR6. It induces intracellular calcium mobilization and mediates cancer, various autoimmune diseases, and antimicrobial effects. MIP-3 alpha/CCL20 Protein, Human (CHO) is a recombinant human CCL20 (A27-M96) expressed by CHO cells.
  • HY-P7264
    MIP-3 beta/CCL19 Protein, Mouse

    rMuMIP-3β/CCL19; C-C motif chemokine 19; SCYA19

    		Mouse E. coli
    MIP-3 beta/CCL19 Protein, Mouse is a CC chemokine that is strongly chemotactic for CD4 T cells and CD8 T cells and acts as a ligand that binds specifically to the chemokine receptor CCR7 to mediate tissue immunity, inflammatory responses, and antiviral infections. MIP-3 beta/CCL19 Protein, Mouse is a recombinant mouse MIP-3 beta/CCL19 (G26-S108) protein expressed by E. coli.
  • HY-P72790
    MDC/CCL22 Protein, Human

    C-C motif chemokine 22; CCL22; MDC; SCYA22

    		Human E. coli
    MDC/CCL22 Protein, Human is a CC chemokine that acts as a ligand for the CCR4 receptor and is a chemoattractant for CCR4-expressing cells such as Th2 cells, playing an important role in homeostatic and inflammatory responses. MDC/CCL22 Protein, Human is a recombinant human MDC/CCL22 (G25-Q93) protein expressed by E. coli.
  • HY-P7768
    MIP-1 alpha/CCL3 Protein, Mouse (His)

    rMuCCL3, His; C-C motif chemokine 3; Heparin-binding chemotaxis protein; LD78 alpha; MIP-1 alpha; SCYA3; CCL3

    		Mouse E. coli
    MIP-1 alpha/CCL3 Protein, Mouse (His), an important chemokine, is a key regulator of immune microenvironment and primarily mediates the trafficking of immune cells in both inflammation and cancer. MIP-1 alpha/CCL3 Protein, Mouse (His) is a recombinant mouse CCL3  (A24-A92) expressed by E.coil with a N-6*His tag.
Cat. No. Product Name Effect Purity