2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CC Chemokines
  6. CCL22

CCL22

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CCL22, also known as macrophage-derived chemokine (MDC), a CC chemokine located on chromosome 16 in the human genome, is a protein encoded by the CCL22 gene that shares 37% identity with CCL17 at the amino acid level. CCL22 is secreted by dendritic cells and macrophages and can be upregulated by a variety of stimulatory factors, such as lipopolysaccharides, cytokines. Among them, the Th2 cytokines IL-4 and IL-13 induce CCL22 production in myeloid cells and can be inhibited by the Th1 cytokine IFN-γ. In addition to acting as a potent chemotactic agent for CCR4-expressing Th2 lymphocytes, monocytes, monocyte-derived dendritic cells, and natural killer cells, CCL22 can also affect its target cells by interacting with the chemokine receptor CCR4. CCL22 is a potent inducer of CCR4 internalization, and CCL22 binding to CCR4 reduces the subsequent functional response of CCR4. The interaction of CCL22 with CCR4 is involved in a variety of pathologies, ranging from allergic reactions and autoimmunity to tumor growth. In contrast, small molecule compounds and antibodies capable of blocking CCL17 and CCL22-mediated recruitment of Th2 and Treg cells have been shown to have positive effects in various disease models of asthma, atopic disease and tumor growth. In addition, an important role of CCL22 and its receptors in TH2 lymphocyte recruitment has been shown in models of allergic airway inflammation. It can also be involved in thymopoiesis by regulating the migration of mature thymocytes through this organ[1][2].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P72790
    MDC/CCL22 Protein, Human

    C-C motif chemokine 22; CCL22; MDC; SCYA22

    		Human E. coli
    MDC/CCL22 Protein, Human is a CC chemokine that acts as a ligand for the CCR4 receptor and is a chemoattractant for CCR4-expressing cells such as Th2 cells, playing an important role in homeostatic and inflammatory responses. MDC/CCL22 Protein, Human is a recombinant human MDC/CCL22 (G25-Q93) protein expressed by E. coli.
  • HY-P7248
    MDC/CCL22 Protein, Mouse (His)

    rMuMDC/CCL22; C-C motif chemokine 22; Abcd1; SCYA22

    		Mouse E. coli
    CCL22/MDC Protein,Mouse (His) is a CC chemokine that acts as a ligand for the CCR4 receptor and is a chemoattractant for CCR4-expressing cells such as Th2 cells, playing an important role in homeostatic and inflammatory responses. CCL22/MDC Protein, Mouse (His) is a recombinant mouse CCL22/MDC (G25-S92) protein expressed by E. coli with a his tag.
  • HY-P7248A
    MDC/CCL22 Protein, Mouse

    rMuMDC/CCL22; C-C motif chemokine 22; Abcd1; SCYA22

    		Mouse E. coli
    CCL22/MDC Protein,Mouse is a CC chemokine that acts as a ligand for the CCR4 receptor and is a chemoattractant for CCR4-expressing cells such as Th2 cells, playing an important role in homeostatic and inflammatory responses. CCL22/MDC Protein, Mouse (His) is a recombinant mouse CCL22/MDC (G25-S92) protein expressed by E. coli.
  • HY-P7249
    MDC/CCL22 Protein, Rat

    rRtMDC/CCL22; C-C motif chemokine 22; Abcd1; SCYA22

    		Rat E. coli
    CCL22/MDC Protein, Rat is a CC chemokine that acts as a ligand for the CCR4 receptor and is a chemoattractant for CCR4-expressing cells such as Th2 cells, playing an important role in homeostatic and inflammatory responses. CCL22/MDC Protein, Rat is a recombinant rat CCL22/MDC(G25-A92) protein expressed by E. coli.
  • HY-P704783
    MDC/CCL22 Protein, Human (HEK293, Fc)

    C-C motif chemokine 22; CCL22; MDC; SCYA22

    		Human HEK293
    CCL22 (CC motif chemokine ligand 22) plays a critical role in guiding activated/effector T lymphocytes to sites of inflammation and affects various aspects of T lymphocyte physiology. It has chemotactic activity against monocytes, dendritic cells, and natural killer cells, acts as a mild chemoattractant for primary activated T lymphocytes, and acts as a potent chemoattractant for chronically activated counterparts. MDC/CCL22 Protein, Human (HEK293, Fc) is the recombinant human-derived MDC/CCL22 protein, expressed by HEK293, with C-hFc labeled tag.
Cat. No. Product Name Effect Purity