MDC/CCL22 Protein, Human (HEK293, Fc)

CCL22 (CC motif chemokine ligand 22) plays a critical role in guiding activated/effector T lymphocytes to sites of inflammation and affects various aspects of T lymphocyte physiology. It has chemotactic activity against monocytes, dendritic cells, and natural killer cells, acts as a mild chemoattractant for primary activated T lymphocytes, and acts as a potent chemoattractant for chronically activated counterparts. MDC/CCL22 Protein, Human (HEK293, Fc) is the recombinant human-derived MDC/CCL22 protein, expressed by HEK293, with C-hFc labeled tag.

CCL22 (C-C Motif Chemokine Ligand 22) emerges as a crucial player in orchestrating the intricate trafficking patterns of activated/effector T-lymphocytes, steering them towards inflammatory sites and influencing various facets of activated T-lymphocyte physiology. Exhibiting chemotactic prowess for monocytes, dendritic cells, and natural killer cells, CCL22 serves as a mild chemoattractant for primary activated T-lymphocytes and a potent one for chronically activated counterparts. Notably, it lacks chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. The chemotactic effects of CCL22 are mediated through its binding to the CCR4 receptor. Interestingly, processed forms MDC(3-69), MDC(5-69), and MDC(7-69) appear to be inactive, adding a layer of complexity to its regulatory role in immune cell migration.

Human

HEK293

C-hFc

O00626 (G25-Q93)

6367

Approximately 35-40 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from 0.22 μm filtered solution of PBS, 0.2 M Arginine, pH7.4 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.