2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Chemokine & Receptors
  5. CC Chemokines
  6. MIP-1 beta/CCL4
  7. CCL4 Protein, Human (His)

CCL4 Protein, Human (His) is the recombinant human-derived CCL4 protein, expressed by E. coli, with C-His tag.

For research use only. We do not sell to patients.

Surface Plasmon Resonance (SPR) Assay Service   Protein Expression Service

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100 μg Get quote 3 - 4 weeks 2 - 3 weeks 2 - 3 weeks
> 100 μg   Get quote  
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Description

CCL4 Protein, Human (His) is the recombinant human-derived CCL4 protein, expressed by E. coli, with C-His tag.
Background

CCL4 beta is a monokine with inflammatory and chemokinetic properties that binds to CCR5. It is one of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the ability to induce down-modulation of CCR5 surface expression and inhibits CCR5-mediated HIV-1 entry into T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Species

Human
Source

E. coli
Tag

C-His
Accession

P13236-1 (A24-Q92)
Gene ID

6351
Molecular Construction
N-term
CCL4 (A24-Q92)
Accession # P13236-1
His
C-term
Synonyms
MIP-1β/CCL4; C-C motif chemokine 4; LAG-1; SCYA4
Predicted Molecular Mass
9.7 kDa
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CCL4 Protein, Human (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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CCL4 Protein, Human (His)
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