Polymyxin B1-d₇ TFA

Cat. No.: HY-A0248AS: Data Sheet Handling Instructions
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Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment.

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Polymyxin B1-d₇ TFA Chemical Structure

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Description	Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment^[1]^[2].
Application	1. This compound can be used as a tracer. 2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Polymyxin B1-d₇ TFA Related Antibodies
Molecular Weight	1780.64
Formula	C₅₆H₉₁D₇N₁₆O₁₃.5C₂HF₃O₂
Unlabeled CAS	4135-11-9
Sequence	{Dab(6-methyl-1-oxooctyl)}-Thr-{Dab}-{Dab}-{Dab}-{d-Phe}-Leu-{Dab}-{Dab}-Thr (Lactam bridge: Dab4-Thr10)
Sequence Shortening	{Dab(6-methyl-1-oxooctyl)}-T-{Dab}-{Dab}-{Dab}-{d-Phe}-L-{Dab}-{Dab}-T (Lactam bridge: Dab4-Thr10)
Structure Classification	Antibiotics Disease Research Antibacterial Antibiotics Other Antibiotics
Initial Source	Microorganisms Bacilus polymyxa
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (260 KB) Handling Instructions (2659 KB)
References	[1]. Kwa AL, et al. Pharmacokinetics of polymyxin B1 in patients with multidrug-resistant Gram-negative bacterial infections. Diagn Microbiol Infect Dis. 2008 Feb;60(2):163-7. [Content Brief] [2]. Berglund NA, et al. Interaction of the antimicrobial peptide polymyxin B1 with both membranes of E. coli: a molecular dynamics study. PLoS Comput Biol. 2015 Apr 17;11(4):e1004180. [Content Brief] [3]. Tam VH, et al. In vitro potency of various polymyxin B components. Antimicrob Agents Chemother. 2011 Sep;55(9):4490-1. [Content Brief] [4]. Alonso MA, et al. Compounds affecting membranes that inhibit protein synthesis in yeast. Antimicrob Agents Chemother. 1979 Dec;16(6):750-6. [Content Brief] [5]. Sivanesan S, et al. Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats. J Nat Prod. 2017 Jan 27;80(1):225-229. [Content Brief]