2. Anti-infection
  3. HIV Reverse Transcriptase
  4. NNRT-IN-14

NNRT-IN-14 is an HIV-1 reverse transcriptase inhibitor (IC50 = 0.175 µM). NNRT-IN-14 can form hydrogen bonds with LYS101, PRO225, and PHE227, and π–π stacking with TYR181 and TRP229. NNRT-IN-14 can be used for the study of HIV.

For research use only. We do not sell to patients.

NNRT-IN-14

NNRT-IN-14 Chemical Structure

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NNRT-IN-14 Related Antibodies

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Description

NNRT-IN-14 is an HIV-1 reverse transcriptase inhibitor (IC50 = 0.175 µM). NNRT-IN-14 can form hydrogen bonds with LYS101, PRO225, and PHE227, and π–π stacking with TYR181 and TRP229. NNRT-IN-14 can be used for the study of HIV[1].

IC50 & Target[1]

HIV-1

0.175 μM (IC50)

In Vitro

NNRT-IN-14 (Compound 19a) (1 μM, 1 h) shows an inhibition rate of 84.86% against HIV-1 RT, with an IC50 value of 0.175 μM[1].
NNRT-IN-14 (50 μg/mL, 48 h) shows no significant toxicity to either cancer cells or normal cells (IC50 > 119.5 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NNRT-IN-14 Related Antibodies
Molecular Weight

418.45

Formula

C25H18N6O
SMILES

CC1=C(OC2=C(C=NC=C3)C3=NC(NC4=CC=C(C#N)C=N4)=C2)C(C)=CC(/C=C/C#N)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NNRT-IN-14 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NNRT-IN-14HIVReverse TranscriptaseHuman immunodeficiency virusQuinolineNaphthyridineMolecular dockingHIV-1CytotoxicAnti-cancerInhibitorinhibitorinhibit

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