2. Neuronal Signaling
  3. Monoamine Oxidase
  4. Homopterocarpin

Homopterocarpin  (Synonyms: (-)-Homopterocarpin; 3,9-Dimethoxypterocarpan)

Cat. No.: HY-N4037
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Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective and antioxidant properties. Homopterocarpin is a competitive reversible inhibitor of human monoamine oxidase-B with an IC50 and a Ki of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress.

For research use only. We do not sell to patients.

Homopterocarpin

Homopterocarpin Chemical Structure

CAS No. : 606-91-7

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Based on 1 publication(s) in Google Scholar

Homopterocarpin Related Antibodies

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MAO-A MAO-B

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Description

Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective and antioxidant properties. Homopterocarpin is a competitive reversible inhibitor of human monoamine oxidase-B with an IC50 and a Ki of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress[1][2].

Cellular Effect
Cell Line Type Value Description References
B16 IC50
5.2 μg/mL
Compound: 3, homopterocarpin
Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay
[PMID: 15787450]
CCRF-CEM IC50
5.5 μg/mL
Compound: 3, homopterocarpin
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
[PMID: 15787450]
HCT-8 IC50
6.4 μg/mL
Compound: 3, homopterocarpin
Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay
[PMID: 15787450]
HL-60 IC50
3.9 μg/mL
Compound: 3, homopterocarpin
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 15787450]
MCF7 IC50
18.5 μg/mL
Compound: 3, homopterocarpin
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 15787450]
U-937 IC50
> 100 μM
Compound: 18, homopterocarpin
Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
[PMID: 17158054]
U-937 IC50
> 100 μM
Compound: 18, homopterocarpin
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
[PMID: 17158054]
U-937 IC50
> 100 μM
Compound: 18, homopterocarpin
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
[PMID: 17158054]
Molecular Weight

284.31

Formula

C17H16O4
CAS No.
SMILES

COC1=CC=C([C@@]2([H])[C@@](C3=CC=C(OC)C=C3O2)([H])CO4)C4=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Homopterocarpin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Homopterocarpin606-91-7(-)-Homopterocarpin 3,9-DimethoxypterocarpanMonoamine OxidaseMAOisoflavonoidhepatoprotectiveantioxidantPterocarpus erinaceusliver injuryInhibitorinhibitorinhibit

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