2. Neuronal Signaling
  3. Monoamine Oxidase
  4. Homopterocarpin

Homopterocarpin  (Synonyms: (-)-Homopterocarpin; 3,9-Dimethoxypterocarpan)

Cat. No.: HY-N4037
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Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective and antioxidant properties. Homopterocarpin is a competitive reversible inhibitor of human monoamine oxidase-B with an IC50 and a Ki of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress.

For research use only. We do not sell to patients.

Homopterocarpin Chemical Structure

Homopterocarpin Chemical Structure

CAS No. : 606-91-7

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Based on 1 publication(s) in Google Scholar

Homopterocarpin Related Antibodies

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MAO-A MAO-B

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Description

Homopterocarpin is an isoflavonoid that can be isolated from Pterocarpus erinaceus. Homopterocarpin has hepatoprotective and antioxidant properties. Homopterocarpin is a competitive reversible inhibitor of human monoamine oxidase-B with an IC50 and a Ki of 0.72 and 0.21 μM for hMAO-B, respectively. Homopterocarpin can be used for the research of liver injury and oxidative stress[1][2].

Cellular Effect
Cell Line Type Value Description References
B16 IC50
5.2 μg/mL
Compound: 3, homopterocarpin
Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16 cells after 72 hrs by MTT assay
[PMID: 15787450]
CCRF-CEM IC50
5.5 μg/mL
Compound: 3, homopterocarpin
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
Cytotoxicity against human CEM cells after 72 hrs by MTT assay
[PMID: 15787450]
HCT-8 IC50
6.4 μg/mL
Compound: 3, homopterocarpin
Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay
[PMID: 15787450]
HL-60 IC50
3.9 μg/mL
Compound: 3, homopterocarpin
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 15787450]
MCF7 IC50
18.5 μg/mL
Compound: 3, homopterocarpin
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 15787450]
U-937 IC50
> 100 μM
Compound: 18, homopterocarpin
Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
[PMID: 17158054]
U-937 IC50
> 100 μM
Compound: 18, homopterocarpin
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
[PMID: 17158054]
U-937 IC50
> 100 μM
Compound: 18, homopterocarpin
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
[PMID: 17158054]
Molecular Weight

284.31

Formula

C17H16O4
CAS No.
SMILES

COC1=CC=C([C@@]2([H])[C@@](C3=CC=C(OC)C=C3O2)([H])CO4)C4=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Homopterocarpin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Homopterocarpin606-91-7(-)-Homopterocarpin 3,9-DimethoxypterocarpanMonoamine OxidaseMAOisoflavonoidhepatoprotectiveantioxidantPterocarpus erinaceusliver injuryInhibitorinhibitorinhibit

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