Pias3 - protein inhibitor of activated STAT, 3 Gene

Rattus norvegicus

Gene ID: 83614 | Gene type: protein coding

About Pias3

Summary

Enables Potassium Channel regulator activity; protein C-terminus binding activity; and protein N-terminus binding activity. Involved in positive regulation of gene expression; positive regulation of membrane potential; and response to hormone. Located in dendrite; nucleus; and synapse. Orthologous to human PIAS3 (protein inhibitor of activated STAT 3). [provided by Alliance of Genome Resources, Apr 2022]

Pias3 Products(1)

mRNA	Protein	Name
NM_031784.3	NP_113972.2	E3 SUMO-protein ligase PIAS3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	17486098	RGD
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	9565597	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10794667	RGD
enables transmembrane transporter binding	IDA IDA: Inferred from direct assay	9565597	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	9565597	RGD
involved in positive regulation of membrane potential	IDA IDA: Inferred from direct assay	9565597	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	11133009	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	17486098	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 SUMO-protein ligase PIAS3

E3 SUMO-protein transferase PIAS3	KChAP
potassium channel regulatory protein KChAP	potassium channel-associated protein
protein inhibitor of activated STAT protein 3

Pias3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Pias3	O70260	Grik2	Rattus norvegicus	P42260	Y2H	17486098

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10475	PIAS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21688	Pias3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pias3	NCBI	NCBI:10401

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