Grik2 - glutamate ionotropic receptor kainate type subunit 2 Gene

Rattus norvegicus

Also known as GluK2; GluR6

Gene ID: 54257 | Gene type: protein coding

About Grik2

Summary

Enables several functions, including PDZ domain binding activity; enzyme binding activity; and kainate selective glutamate receptor activity. Involved in several processes, including negative regulation of glutamatergic synaptic transmission; positive regulation of neuron apoptotic process; and regulation of JNK cascade. Located in dendrite cytoplasm; perikaryon; and terminal bouton. Is integral component of plasma membrane. Part of ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in Huntington's disease and autosomal recessive non-syndromic intellectual disability. Orthologous to human GRIK2 (glutamate ionotropic receptor kainate type subunit 2). [provided by Alliance of Genome Resources, Apr 2022]

Grik2 Products(1)

mRNA	Protein	Name
NM_019309.2	NP_062182.1	glutamate receptor ionotropic, kainate 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	1127911	RGD
enables SNARE binding	IPI IPI: Inferred from physical interaction	12597860	RGD
enables glutamate receptor activity	IDA IDA: Inferred from direct assay	10627597	RGD
enables glutamate-gated calcium ion channel activity	IDA IDA: Inferred from direct assay	7681676	RGD
enables glutamate-gated receptor activity	IDA IDA: Inferred from direct assay	1322826	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	1648177	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	1648177	RGD
enables kainate selective glutamate receptor activity	IDA IDA: Inferred from direct assay	1648177	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9808460	RGD
enables scaffold protein binding	IDA IDA: Inferred from direct assay	12597860	RGD
enables ubiquitin conjugating enzyme binding	IPI IPI: Inferred from physical interaction	17486098	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	17486098	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	1648177	RGD
involved in modulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	12597860	RGD
involved in negative regulation of synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	16420445	RGD
involved in neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	11152698	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17639597	RGD
involved in receptor clustering	IDA IDA: Inferred from direct assay	9808460	RGD
involved in regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	11152698	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	15844209	RGD
located in dendrite	IDA IDA: Inferred from direct assay	9808460	RGD
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	15844209	RGD
part of ionotropic glutamate receptor complex	IDA IDA: Inferred from direct assay	10627597	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	15844209	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	8163463	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	15844209	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor ionotropic, kainate 2

gluR-6	glutamate receptor 6
glutamate receptor, ionotropic, kainate 2

Grik2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Grik2	P42260	Map3k11	Rattus norvegicus	Q66HA1	Anti Bait CoIP	22483987
Intra	Grik2	P42260	Sumo1	Rattus norvegicus	Q5I0H3	Anti Bait CoIP	17486098
Intra	Grik2	P42260	Sumo1	Rattus norvegicus	Q5I0H3	Anti Bait CoIP	22483987
Intra	Grik2	P42260	Sumo1	Rattus norvegicus	Q5I0H3	Anti Tag CoIP	22089239
Intra	Grik2	P42260	Grik2	Rattus norvegicus	P42260	Solution Sedimentation	19465914
Intra	Grik2	P42260	Grik2	Rattus norvegicus	P42260	Solution Sedimentation	17115050
Intra	Grik2	P42260	Grik2	Rattus norvegicus	P42260	Crosslink	20404149
Intra	Grik2	P42260	Grik2	Rattus norvegicus	P42260	GMS	25119039
Intra	Grik2	P42260	Grik2	Rattus norvegicus	P42260	X-Ray Diffraction	19465914
Intra	Grik2	P42260	Grik2	Rattus norvegicus	P42260	X-Ray Diffraction	17115050
Intra	Grik2	P42260	Ube2i	Rattus norvegicus	P63281	Y2H	17486098
Intra	Grik2	P42260	Grik2	Rattus norvegicus	P42260	Solution Sedimentation	19617541
Intra	Grik2	P42260	Grik2	Rattus norvegicus	P42260	3D-EM	25119039
Intra	Grik2	P42260	Grik5	Rattus norvegicus	Q63273	FRET	34706237
Intra	Grik2	P42260	Grik2	Rattus norvegicus	P42260	Light Scattering	19465914
Intra	Grik2	P42260	Grik2	Rattus norvegicus	P42260	GMS	19465914
Intra	Grik2	P42260	Pias3	Rattus norvegicus	O70260	Anti Bait CoIP	17486098
Intra	Grik2	P42260	Ube2i	Rattus norvegicus	P63281	Anti Bait CoIP	17486098

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05799	GRIK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20416	Grik2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26925	Grik2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grik2	NCBI	NCBI:2898

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