MAP3K11 - Map3k11 mitogen-activated protein kinase kinase kinase 11 Gene

Rattus norvegicus

Also known as Mlk3; RHOE; Mlk-3

Gene ID: 309168 | Gene type: protein coding

About MAP3K11

Summary

Enables ATP binding activity; JUN kinase kinase kinase activity; and enzyme binding activity. Involved in several processes, including JNK cascade; positive regulation of JNK cascade; and positive regulation of neuron apoptotic process. Predicted to be located in microtubule. Predicted to be active in centrosome. Orthologous to human MAP3K11 (mitogen-activated protein kinase kinase kinase 11). [provided by Alliance of Genome Resources, Apr 2022]

MAP3K11 Products(1)

mRNA	Protein	Name
NM_001013150.1	NP_001013168.1	mitogen-activated protein kinase kinase kinase 11

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11438570	RGD
enables JUN kinase kinase kinase activity	IDA IDA: Inferred from direct assay	17064355	RGD
enables MAP kinase kinase kinase activity	IDA IDA: Inferred from direct assay	11438570	RGD
enables mitogen-activated protein kinase kinase binding	IPI IPI: Inferred from physical interaction	14575811	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17348686	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	17161586	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	17161586	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IDA IDA: Inferred from direct assay	15680699	RGD
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	17064355	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15069087	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	11416147	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	17161586	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11438570	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 11

mixed lineage kinase 3

MAP3K11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Map3k11	Q66HA1	Grik2	Rattus norvegicus	P42260	Anti Bait CoIP	22483987

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08048	MAP3K11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20638	Map3k11 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27147	Map3k11 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	MAP3K11	NCBI	NCBI:4296

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