Max - MYC associated factor X Gene

Rattus norvegicus

Gene ID: 60661 | Gene type: protein coding

About Max

Summary

Enables DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in several processes, including neuron apoptotic process; regulation of gene expression; and response to peptide hormone. Located in PML body; cytoplasm; and dendrite. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X). [provided by Alliance of Genome Resources, Apr 2022]

Max Products(2)

mRNA	Protein	Name
NM_001411963.1	NP_001398892.1	protein max isoform 2
NM_022210.2	NP_071546.1	protein max isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	17341548	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	7791753	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11891322	RGD
NOT enables protein-containing complex binding	IDA IDA: Inferred from direct assay	7791753	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	18271930	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17341548	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17341548	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to peptide hormone stimulus	IEP IEP: Inferred from expression pattern	10446908	RGD
involved in cellular response to starvation	IEP IEP: Inferred from expression pattern	10446908	RGD
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	7791753	RGD
involved in neuron apoptotic process	IEP IEP: Inferred from expression pattern	14603520	RGD
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	18271930	RGD
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17341548	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	14603520	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	10072196	RGD
involved in retina development in camera-type eye	IEP IEP: Inferred from expression pattern	14603520	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	15503302	RGD
located in dendrite	IDA IDA: Inferred from direct assay	14603520	RGD
located in nucleus	IDA IDA: Inferred from direct assay	14603520	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein max

myc-associated factor X

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145723A	MAX-40279 hydrochloride	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (48)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D0218	Thioflavin T		98.45%	Unkown
HY-12702	10058-F4	Inhibitor	99.77%	Unkown
HY-135969	Glycol chitosan	Inhibitor	61.22%	Unkown
HY-124675	MYCMI-6		98.14%	Unkown
HY-100996	10074-G5	Inhibitor	99.63%	Unkown
HY-100669	Mycro 3	Inhibitor	98.11%	Unkown
HY-12703	KSI-3716	Inhibitor	98.94%	Unkown
HY-122683	sAJM589	Inhibitor	99.47%	Unkown
HY-145723	MAX-40279	Inhibitor	97.04%	Unkown
HY-144878	VPC-70619	Inhibitor	99.93%	Unkown
HY-153064	MAX-10181	Inhibitor	98.07%	Unkown
HY-131021	Janelia Fluor® 549, Azide		/	Unkown
HY-150259	MDEG-541	Degrader	98.05%	Unkown
HY-N5072	Desmethylglycitein	Inhibitor	98.98%	Unkown
HY-126979	Mycro2	Inhibitor	99.81%	Unkown
HY-133536	PA Janelia Fluor® 549, SE		98.2%	Unkown
HY-W591768	(E)-4-(4-(Dimethylamino)styryl)-1-methylpyridin-1-ium iodide		99.66%	Unkown
HY-131022	Janelia Fluor® 549 TFA		96.56%	Unkown
HY-134975	NY2267	Inhibitor	98.53%	Unkown
HY-147291	VPC-70063		99.92%	Unkown
HY-22445	MY05	Inhibitor	99.30%	Unkown
HY-145723C	MAX-40279 hemiadipate	Inhibitor	99.26%	Unkown
HY-125978	JY-3-094	Inhibitor	97.04%	Unkown
HY-130736	Janelia Fluor® 549, SE		/	Unkown
HY-137551	Tiafenacil	Inhibitor	99.20%	Unkown
HY-N6878	Cauloside D		99.69%	Unkown
HY-N6919	Cauloside C	Inhibitor	99.66%	Unkown
HY-N7273	Soyasaponin III	Inducer	99.73%	Unkown
HY-171995	Rf470 TFA		/	Unkown
HY-145723B	MAX-40279 hemifumarate	Inhibitor	99.56%	Unkown
HY-115796	VU0477886	Activator	/	Unkown
HY-115839A	Detajmium L-tartrate	Inhibitor	/	Unkown
HY-125636	Mycro1	Inhibitor	/	Unkown
HY-131023	Janelia Fluor® 549, Maleimide TFA		/	Unkown
HY-131024	Janelia Fluor® 549, Tetrazine		/	Unkown
HY-136784	Rhod-2 potassium		/	Unkown
HY-169334	BDK-IN-1	Inhibitor	/	Unkown
HY-169921	c-Myc inhibitor 15	Inhibitor	/	Unkown
HY-N1228	Soyacerebroside I		/	Unkown
HY-N4074	6"-O-Malonylglycitin		/	Unkown
HY-P10699	MAX1		/	Unkown
HY-RS08177	MAX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174334	RXFP1 receptor agonist-9	Inhibitor	/	Unkown
HY-N12273	Soyasaponin Ae		/	Unkown
HY-RS17397	Max Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23852	Max Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W800768	BP Fluor 350 Azide Plus		/	Unkown
HY-W800769	BP Fluor 532 azide plus		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Max	NCBI	NCBI:4149

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