Foxo3 - forkhead box O3 Gene

Mus musculus

Also known as Fkhr2; FKHRL1; Foxo3a; 1110048B16Rik; 2010203A17Rik

Gene ID: 56484 | Gene type: protein coding

About Foxo3

Summary

Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and mitochondrial transcription factor activity. Involved in several processes, including mitochondrial transcription; positive regulation of muscle atrophy; and positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within several processes, including extrinsic apoptotic signaling pathway in absence of ligand; female gonad development; and neuronal stem cell population maintenance. Located in cytosol; mitochondrial outer membrane; and nucleus. Part of protein-containing complex. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system. Used to study dermoid cyst of ovary. Orthologous to human FOXO3 (forkhead box O3). [provided by Alliance of Genome Resources, Apr 2022]

Foxo3 Products(2)

mRNA	Protein	Name
NM_001376967.1	NP_001363896.1	forkhead box protein O3
NM_019740.3	NP_062714.1	forkhead box protein O3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14966295	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19933931	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14966295	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	19896444	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17521387	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	17521387	MGI
enables mitochondrial transcription factor activity	IMP IMP: Inferred from mutant phenotype	23283301	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17521387	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11353388	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19933931	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA damage response, signal transduction by p53 class mediator	IDA IDA: Inferred from direct assay	15383658	MGI
acts upstream of or within antral ovarian follicle growth	IMP IMP: Inferred from mutant phenotype	14978268	MGI
acts upstream of or within brain morphogenesis	IGI IGI: Inferred from genetic interaction	24483844	MGI
acts upstream of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	19896444	MGI
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	17521387	MGI
acts upstream of or within cellular response to oxidative stress	IGI IGI: Inferred from genetic interaction	24483844	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IGI IGI: Inferred from genetic interaction	12431371	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	12855809	MGI
acts upstream of or within initiation of primordial ovarian follicle growth	IMP IMP: Inferred from mutant phenotype	12855809	MGI
involved in mitochondrial transcription	IMP IMP: Inferred from mutant phenotype	23283301	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	19896444	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21621563	MGI
acts upstream of or within neuronal stem cell population maintenance	IGI IGI: Inferred from genetic interaction	19896444	MGI
acts upstream of or within oocyte maturation	IMP IMP: Inferred from mutant phenotype	12855809	MGI
acts upstream of or within ovulation from ovarian follicle	IMP IMP: Inferred from mutant phenotype	12855809	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12048180	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18054315	MGI
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	18054315	MGI
involved in positive regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	19933931	MGI
involved in positive regulation of muscle atrophy	IDA IDA: Inferred from direct assay	18054315	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12930811	MGI
acts upstream of or within regulation of neural precursor cell proliferation	IGI IGI: Inferred from genetic interaction	19896444	MGI
acts upstream of or within regulation of reactive oxygen species metabolic process	IGI IGI: Inferred from genetic interaction	19896444	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17521387	MGI
involved in response to fatty acid	IDA IDA: Inferred from direct assay	32103177	MGI
involved in response to starvation	IDA IDA: Inferred from direct assay	18054315	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12857750	MGI
located in cytosol	IDA IDA: Inferred from direct assay	18054315	MGI
located in membrane	IDA IDA: Inferred from direct assay	15383658	MGI
colocalizes with mitochondrial matrix	IDA IDA: Inferred from direct assay	29445193	MGI
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	29445193	MGI
colocalizes with mitochondrion	IDA IDA: Inferred from direct assay	23283301	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12857750	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	23283301	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

forkhead box protein O3

forkhead box O3a

forkhead protein FKHR2

Foxo3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Foxo3	Q9WVH4	SETD7	Homo sapiens	Q8WTS6	Methyltransferase Ass	22402663
Cross	Foxo3	Q9WVH4	SETD7	Homo sapiens	Q8WTS6	Anti Tag CoIP	22402663
Intra	Foxo3	Q9WVH4	Fcor	Mus musculus	P0DJI6	Anti Tag CoIP	22510882

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-154919	DC-Y13-27	Activator	99.52%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxo3	NCBI	NCBI:2309

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