2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton PI3K/Akt/mTOR Metabolic Enzyme/Protease Apoptosis
  3. ROCK Akt FOXO Apoptosis
  4. NSC126188

NSC126188 is a RhoB inducer. NSC126188 can induce apoptosis by inhibiting Akt/FoxO3 signaling. NSC126188 can be used for the research of cancer, such as prostate cancer.

For research use only. We do not sell to patients.

NSC126188

NSC126188 Chemical Structure

CAS No. : 31863-82-8

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NSC126188 Related Antibodies

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FOXO1 FOXO3

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Description

NSC126188 is a RhoB inducer. NSC126188 can induce apoptosis by inhibiting Akt/FoxO3 signaling. NSC126188 can be used for the research of cancer, such as prostate cancer[1].

IC50 & Target[1]

RhoB

 

FOXO3

 

In Vitro

NSC126188 (1-10 μM, 1-12 h) inhibits proliferation (GI50 = 0.7 μM) and induces apoptosis in human prostate cancer PC-3 cells[1].
NSC126188 (5 μM, 1 h) significantly reduces the phosphorylation levels of Akt at S473 and T308 sites in PC-3 cells NSC126188 (5 μM, 30 mins) completely blocks insulin-induced translocation of Akt to the plasma membrane in PC-3 cells transfected with GFP-Akt; NSC126188 (5 μM, 3-9 h) induces dephosphorylation of FoxO3a and upregulates RhoB expressionin PC-3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC126188 Related Antibodies

Western Blot Analysis[1]

Cell Line: PC-3 cells
Concentration: 1, 3, 5 and 10 μM
Incubation Time: 1, 3, 6, 9 and 12 h
Result: Increased caspase-3, cleaved PARP, p21 and RhoB proteins.
Downregulated cyclin D1 levels.
Molecular Weight

480.51

Formula

C22H45IN2O
CAS No.
SMILES

O=C(CCCCCCCCCCCCCCC)N1CC[N+](C)(CC1)C.[I-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NSC126188 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC12618831863-82-8NSC 126188NSC-126188ROCKAktFOXOApoptosisRho-associated protein kinaseRho-associated kinaseRho-kinaseROKPKBProtein kinase BForkhead box ORhoBAkt/FoxO3CancerapoptosisPC-3Inhibitorinhibitorinhibit

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