1. Gene
  2. Sox2 - SRY-box transcription factor 2 Gene

Sox2 - SRY-box transcription factor 2 Gene

Rattus norvegicus

Also known as RGD1565646

Gene ID: 499593 | Gene type: protein coding

About Sox2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in several processes, including adenohypophysis development; positive regulation of transcription by RNA polymerase II; and tissue regeneration. Located in nucleus. Human ortholog(s) of this gene implicated in breast cancer; nasal cavity cancer; and syndromic microphthalmia 3. Orthologous to human SOX2 (SRY-box transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Sox2 Products(1)

mRNA Protein Name
NM_001109181.2 NP_001102651.1 transcription factor SOX-2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12637543 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12637543 RGD
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
12637543 RGD
Biological Process GO Annotation Evidence Reference Source
involved in adenohypophysis development IEP
IEP: Inferred from expression pattern
21815952 RGD
involved in positive regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
19161985 RGD
involved in positive regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
20869108 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12637543 RGD
involved in regulation of myofibroblast cell apoptotic process IMP
IMP: Inferred from mutant phenotype
34321385 RGD
involved in response to oxygen-glucose deprivation IMP
IMP: Inferred from mutant phenotype
34321385 RGD
involved in tissue regeneration IEP
IEP: Inferred from expression pattern
19845688 RGD
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
12637543 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor SOX-2

SRY (sex determining region Y)-box 2

SRY box 2

SRY-box containing gene 2

Orthologs Information

Species Symbol Source ID
Homo sapiens Sox2 NCBI NCBI:6657