Akap7 - A-kinase anchoring protein 7 Gene

Rattus norvegicus

Also known as Akap15; Akap18; AKAP-18; AKAP18d

Gene ID: 361458 | Gene type: protein coding

About Akap7

Summary

Enables several functions, including AMP binding activity; protein C-terminus binding activity; and protein kinase A regulatory subunit binding activity. Involved in regulation of protein kinase A signaling. Located in several cellular components, including T-tubule; apical plasma membrane; and sarcoplasmic reticulum. Part of protein-containing complex. Orthologous to human AKAP7 (A-kinase anchoring protein 7). [provided by Alliance of Genome Resources, Apr 2022]

Akap7 Products(1)

mRNA	Protein	Name
NM_001001801.4	NP_001001801.1	A-kinase anchor protein 7 isoforms delta and gamma

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables AMP binding	IDA IDA: Inferred from direct assay	18082768	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14569017	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	17901878	RGD
enables protein kinase A regulatory subunit binding	IDA IDA: Inferred from direct assay	15037626	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cAMP/PKA signal transduction	IMP IMP: Inferred from mutant phenotype	17901878	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	14569017	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15037626	RGD
located in exocytic vesicle	IDA IDA: Inferred from direct assay	15037626	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17901878	RGD
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	17901878	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

A-kinase anchor protein 7 isoforms delta and gamma

A kinase (PRKA) anchor protein 7	A-kinase anchor protein 18
A-kinase anchoring protein 18 ,isoform delta

Akap7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Akap7	Q6JP77	Pln	Rattus norvegicus	P61016	Anti Bait CoIP	17901878
Intra	Akap7	Q6JP77	Pln	Rattus norvegicus	P61016	Peptide Array	17901878

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00522	AKAP7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Akap7	NCBI	NCBI:9465

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