2. Gene
  3. Pln - phospholamban Gene

Pln - phospholamban Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Plm

Gene ID: 64672 | Gene type: protein coding

About Pln

Summary

Enables ATPase inhibitor activity and identical protein binding activity. Involved in several processes, including response to insulin; response to testosterone; and response to zinc ion. Located in sarcoplasmic reticulum and vesicle. Part of protein-containing complex. Used to study congestive heart failure; heart disease; and myocardial infarction. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1P and hypertrophic cardiomyopathy 18. Orthologous to human PLN (phospholamban). [provided by Alliance of Genome Resources, Apr 2022]

Pln Products(1)

mRNA Protein Name
NM_022707.2 NP_073198.1 cardiac phospholamban
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATPase inhibitor activity IDA
IDA: Inferred from direct assay
12403631 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
23458196 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17901878 RGD
Biological Process GO Annotation Evidence Reference Source
involved in calcium ion transport IMP
IMP: Inferred from mutant phenotype
12403631 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
22185592 RGD
involved in response to testosterone IDA
IDA: Inferred from direct assay
23203968 RGD
involved in response to zinc ion IDA
IDA: Inferred from direct assay
23812383 RGD
Cellular Component GO Annotation Evidence Reference Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
17901878 RGD
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
12403631 RGD
located in vesicle IDA
IDA: Inferred from direct assay
12403631 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cardiac phospholamban

PLB

Pln Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Pln P61016 Akap7 Rattus norvegicus Q6JP77
Anti Tag CoIP
17901878
Intra
Pln P61016 Akap7 Rattus norvegicus Q6JP77
Anti Bait CoIP
17901878
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-137561 Bexotegrast Inhibitor 99.67% Unkown
HY-47888 PLN-1474 Inhibitor 99.35% Unkown
HY-137561A Bexotegrast hydrochloride Inhibitor / Unkown
HY-RS10727 PLN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17361 Pln Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23815 Pln Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pln NCBI NCBI:5350
Mus musculus Pln NCBI NCBI:18821