Pln - phospholamban Gene

Mus musculus

Also known as Plb

Gene ID: 18821 | Gene type: protein coding

About Pln

Summary

Enables protein homodimerization activity. Involved in negative regulation of calcium ion import into sarcoplasmic reticulum. Acts upstream of or within several processes, including negative regulation of calcium ion binding activity; regulation of calcium ion transport; and regulation of heart contraction. Located in sarcoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; ear; heart; nervous system; and skeleton. Used to study centronuclear myopathy and dilated cardiomyopathy 1P. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1P and hypertrophic cardiomyopathy 18. Orthologous to human PLN (phospholamban). [provided by Alliance of Genome Resources, Apr 2022]

Pln Products(2)

mRNA	Protein	Name
NM_001141927.1	NP_001135399.1	cardiac phospholamban
NM_023129.5	NP_075618.1	cardiac phospholamban

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase inhibitor activity	IDA IDA: Inferred from direct assay	22971924	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15201433	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	30299255	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	23117660	MGI
involved in acrosome assembly	IDA IDA: Inferred from direct assay	30733280	MGI
acts upstream of or within adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	IMP IMP: Inferred from mutant phenotype	10471356	MGI
acts upstream of or within cardiac muscle tissue development	IGI IGI: Inferred from genetic interaction	10555147	MGI
involved in circadian sleep/wake cycle, sleep	IMP IMP: Inferred from mutant phenotype	38493225	MGI
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	30733280	MGI
acts upstream of or within intracellular calcium ion homeostasis	IGI IGI: Inferred from genetic interaction	10555147	MGI
involved in locomotor rhythm	IMP IMP: Inferred from mutant phenotype	38493225	MGI
acts upstream of or within muscle cell cellular homeostasis	IGI IGI: Inferred from genetic interaction	10555147	MGI
acts upstream of or within negative regulation of ATPase-coupled calcium transmembrane transporter activity	IDA IDA: Inferred from direct assay	27923914	MGI
involved in negative regulation of ATPase-coupled calcium transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	30299255	MGI
acts upstream of or within negative regulation of calcium ion binding	IDA IDA: Inferred from direct assay	27923914	MGI
involved in negative regulation of calcium ion import into sarcoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	30299255	MGI
acts upstream of or within negative regulation of heart contraction	IGI IGI: Inferred from genetic interaction	10555147	MGI
acts upstream of or within negative regulation of heart contraction	IMP IMP: Inferred from mutant phenotype	8062415	MGI
acts upstream of or within regulation of calcium ion import	IMP IMP: Inferred from mutant phenotype	8620604	MGI
acts upstream of or within regulation of cardiac muscle cell contraction	IMP IMP: Inferred from mutant phenotype	8620604	MGI
acts upstream of or within regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IMP IMP: Inferred from mutant phenotype	8831698	MGI
acts upstream of or within regulation of heart contraction	IMP IMP: Inferred from mutant phenotype	8831698	MGI
acts upstream of or within regulation of relaxation of muscle	IMP IMP: Inferred from mutant phenotype	10024311	MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	9118481	MGI
acts upstream of or within regulation of ryanodine-sensitive calcium-release channel activity	IMP IMP: Inferred from mutant phenotype	10603936	MGI
acts upstream of or within regulation of the force of heart contraction	IGI IGI: Inferred from genetic interaction	10555147	MGI
acts upstream of or within regulation of the force of heart contraction	IMP IMP: Inferred from mutant phenotype	9118481	MGI
acts upstream of or within regulation of the force of heart contraction by cardiac conduction	IMP IMP: Inferred from mutant phenotype	10644605	MGI
involved in spermatogenesis	IDA IDA: Inferred from direct assay	30733280	MGI
involved in visual learning	IMP IMP: Inferred from mutant phenotype	38493225	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	30733280	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	27923914	MGI
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	9038922	MGI
located in sarcoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	26816378	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cardiac phospholamban

Pln Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Pln	P61014	CAMK2D	Homo sapiens	Q13557	Pull Down	32873725
Cross	Pln	P61014	CAMK2D	Homo sapiens	Q13557	Protein Kinase Assay	32873725
Cross	Pln	P61014	YWHAG	Homo sapiens	P61981	Pull Down	32873725
Intra	Pln	P61014	Prkaca	Mus musculus	P05132	Protein Kinase Assay	32873725
Intra	Pln	P61014	Prkaca	Mus musculus	P05132	Pull Down	32873725

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137561	Bexotegrast	Inhibitor	99.67%	Unkown
HY-47888	PLN-1474	Inhibitor	99.35%	Unkown
HY-137561A	Bexotegrast hydrochloride	Inhibitor	/	Unkown
HY-RS10727	PLN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17361	Pln Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23815	Pln Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pln	NCBI	NCBI:5350

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